KR890014548A - 포르피린과 암치료 - Google Patents

포르피린과 암치료 Download PDF

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Publication number
KR890014548A
KR890014548A KR1019890002955A KR890002955A KR890014548A KR 890014548 A KR890014548 A KR 890014548A KR 1019890002955 A KR1019890002955 A KR 1019890002955A KR 890002955 A KR890002955 A KR 890002955A KR 890014548 A KR890014548 A KR 890014548A
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KR
South Korea
Prior art keywords
compound
hydroxy
porphyrin
phenyl
tetra
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KR1019890002955A
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English (en)
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KR970011392B1 (ko
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본네트 레이몬드
크릴 버렌바움 모리스
Original Assignee
스테판 제랄드 웨트모어
에파몰 홀딩스 피엘씨
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Publication of KR890014548A publication Critical patent/KR890014548A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음.

Description

포르피린과 암치료
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 아래의 식으로 나타내는 약리적으로 허용되는 종양의 위치를 정하는 디히드로 또는 테트라-히드로 포르피린인 화합물 ; 상기 화합물이 투여되어 종양에 위치하고 이 화합물에 흡수된 파장 광선으로 종양을 조사하였을시 괴사에 민감한 종양치료용 약물 제조방법 및 상기 화합물을 제약적인 희석제 또는 매개체와 배합시켜 상기 화합물을 사용하는 방법 ; 상기와 같은 약물 및 치료법. 이 화합물의 화학식을 다음과 같다.
    위식에서, 각각의 Ar은 다르거나 같으며, 하나 또는 그 이상의 히드록시(-OH)치환기를 가진 방향족기임.
  2. 제1항에 있어서, 화합물이 다음식(IV) 또는 그 대용되는 테트라 히드로포르피린임을 특징으로 하는 상기 화합물.
    위식에서 n은 1∼3이고, 각각의 치환기 R은 같거나 다르며 각각의 치환페닐 링(ring)에서 같거나 다른 위치에 있고, 히드록시기임.
  3. 제2항에 있어서, 각 치환기는 O-히드록시페닐기, m-히드록시페닐기 또는 P-히드록시 페닐기인 상기 화합물.
  4. 제1,2 또는 3항중 어느 한 항에 있어서, 각각의 히드록시기는 치환형에서보다 더 유리(free)됨을 특징으로 하는 화합물.
  5. 제1항 2항 3항 또는 4항중 어느 한 항에 있어서, 화합물이 2,3-디히드로-5,10,15,20-테트라(P-히드록시-페닐)포르피린 ; 2,3-디히드로-5,10,15,20-테트라(m-히드록시-페닐)포르피린 ; 2,3-디히드로-5,10,15,20-테트라(o-히드록시-페닐)포르피린 및 7,8,17,18-테트라히드로-5,10,15,20-테트라(m-히드록시 페닐)포르피린을 합성시켜 합성시켜 얻어짐을 특징으로 하는 상기 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890002955A 1988-03-11 1989-03-10 포르피린과 암치료 KR970011392B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB88/05849 1988-03-11
GB8805849 1988-03-11
GB888805849A GB8805849D0 (en) 1988-03-11 1988-03-11 Porphyrins & cancer treatment

Publications (2)

Publication Number Publication Date
KR890014548A true KR890014548A (ko) 1989-10-24
KR970011392B1 KR970011392B1 (ko) 1997-07-10

Family

ID=10633278

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890002955A KR970011392B1 (ko) 1988-03-11 1989-03-10 포르피린과 암치료

Country Status (17)

Country Link
US (1) US4992257A (ko)
EP (1) EP0337601B1 (ko)
JP (1) JP2785033B2 (ko)
KR (1) KR970011392B1 (ko)
AT (1) ATE89002T1 (ko)
AU (1) AU611774C (ko)
BR (1) BR1100662A (ko)
CA (1) CA1338737C (ko)
DE (2) DE10299012I2 (ko)
ES (1) ES2055038T3 (ko)
GB (1) GB8805849D0 (ko)
HK (1) HK129693A (ko)
IE (1) IE63290B1 (ko)
LU (1) LU90907I2 (ko)
NL (1) NL300089I2 (ko)
NZ (1) NZ228225A (ko)
ZA (1) ZA891653B (ko)

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Also Published As

Publication number Publication date
AU611774B2 (en) 1991-06-20
HK129693A (en) 1993-12-03
ZA891653B (en) 1989-11-29
IE890687L (en) 1989-09-11
US4992257A (en) 1991-02-12
ES2055038T3 (es) 1994-08-16
KR970011392B1 (ko) 1997-07-10
DE68906301D1 (de) 1993-06-09
DE10299012I1 (de) 2002-07-18
NL300089I1 (nl) 2002-07-01
JPH01275528A (ja) 1989-11-06
DE10299012I2 (de) 2004-05-06
GB8805849D0 (en) 1988-04-13
CA1338737C (en) 1996-11-26
AU3097589A (en) 1989-09-14
NZ228225A (en) 1990-08-28
EP0337601B1 (en) 1993-05-05
NL300089I2 (nl) 2002-08-01
EP0337601A1 (en) 1989-10-18
JP2785033B2 (ja) 1998-08-13
ATE89002T1 (de) 1993-05-15
BR1100662A (pt) 1999-10-13
DE68906301T2 (de) 1993-09-30
LU90907I2 (fr) 2003-04-30
AU611774C (en) 2002-02-21
IE63290B1 (en) 1995-04-05

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