KR890014125A - 생물학적으로 활성인 단백질 - Google Patents

생물학적으로 활성인 단백질 Download PDF

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Publication number
KR890014125A
KR890014125A KR1019890004087A KR890004087A KR890014125A KR 890014125 A KR890014125 A KR 890014125A KR 1019890004087 A KR1019890004087 A KR 1019890004087A KR 890004087 A KR890004087 A KR 890004087A KR 890014125 A KR890014125 A KR 890014125A
Authority
KR
South Korea
Prior art keywords
protein
tnfα
tnf
inhibitor
binding
Prior art date
Application number
KR1019890004087A
Other languages
English (en)
Korean (ko)
Inventor
다이어 진-마이클
류시엔 세킹거 필립
Original Assignee
비. 애이. 뉴샘
글락소 그룹 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 비. 애이. 뉴샘, 글락소 그룹 리미티드 filed Critical 비. 애이. 뉴샘
Publication of KR890014125A publication Critical patent/KR890014125A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019890004087A 1988-03-31 1989-03-30 생물학적으로 활성인 단백질 KR890014125A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8807803.5 1988-03-31
GB888807803A GB8807803D0 (en) 1988-03-31 1988-03-31 Biochemical product

Publications (1)

Publication Number Publication Date
KR890014125A true KR890014125A (ko) 1989-10-21

Family

ID=10634493

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890004087A KR890014125A (ko) 1988-03-31 1989-03-30 생물학적으로 활성인 단백질

Country Status (12)

Country Link
JP (1) JPH02117700A (fr)
KR (1) KR890014125A (fr)
AU (1) AU3228789A (fr)
BE (1) BE1001845A4 (fr)
DE (1) DE3910323A1 (fr)
DK (1) DK156589A (fr)
FR (1) FR2629345A1 (fr)
GB (2) GB8807803D0 (fr)
IL (1) IL89804A0 (fr)
IT (1) IT1232827B (fr)
NL (1) NL8900779A (fr)
SE (1) SE8901115L (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83878A (en) * 1987-09-13 1995-07-31 Yeda Res & Dev Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it
US5811261A (en) * 1988-09-12 1998-09-22 Yeda Research And Development Co. Ltd. Expression of the recombinant tumor necrosis factor binding protein I (TBP-I)
US7264944B1 (en) 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
EP0393438B1 (fr) * 1989-04-21 2005-02-16 Amgen Inc. Récepteur du TNF, protéine liant le TNF at ADN codant pour ceux-ci
US6221675B1 (en) 1989-04-21 2001-04-24 Amgen, Inc. TNF receptors, TNF binding proteins and DNAs coding for them
IL95031A (en) * 1989-07-18 2007-03-08 Amgen Inc A method of producing a recombinant human necrotic factor absorber
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
US5945397A (en) * 1989-09-05 1999-08-31 Immunex Corporation Purified p75 (type II) tumor necrosis factor receptor polypeptides
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
CA2485553A1 (fr) * 1989-09-05 1991-03-21 Immunex Corporation Recepteurs .alpha. et .beta. de facteur de necrose tumorale
US5395760A (en) * 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
EP0417563B1 (fr) * 1989-09-12 2000-07-05 F. Hoffmann-La Roche Ag Protéines qui lient le TNF
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
WO1992001002A1 (fr) * 1990-07-11 1992-01-23 Teijin Limited Inhibiteur de l'activite du facteur de la necrose tumorale et son procede de preparation
US5304634A (en) * 1990-10-12 1994-04-19 Hoechst Aktiengesellschaft Inhibitors for the formation of tumor necrosis factor
WO1992013095A1 (fr) * 1991-01-18 1992-08-06 Synergen, Inc. Procedes pour traiter les maladies induites par facteur de necrose tumorale
WO1993004375A1 (fr) * 1991-08-23 1993-03-04 Nchip, Inc. Techniques de gravure par le feu destinees a des circuits integres non conditionnes
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
AU5696198A (en) 1996-12-06 1998-06-29 Amgen, Inc. Combination therapy using a tnf binding protein for treating tnf-mediated diseases
WO1998024477A1 (fr) 1996-12-06 1998-06-11 Amgen Inc. Therapie combinee utilisant un inhibiteur de l'il-1 pour traiter les maladies induites par l'il-1
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
DK2295081T3 (en) 2001-06-26 2019-02-18 Amgen Inc Antibodies to OPGL
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
WO2004060911A2 (fr) 2002-12-30 2004-07-22 Amgen Inc. Polytherapie a facteurs costimulants
US7833527B2 (en) 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
TW201117824A (en) 2009-10-12 2011-06-01 Amgen Inc Use of IL-17 receptor a antigen binding proteins
HUE035618T2 (en) 2010-01-15 2018-05-28 Kirin Amgen Inc Antibody presentation and therapeutic regimens
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
CA2944605C (fr) 2014-03-31 2023-10-17 Kirin-Amgen, Inc. Procedes de traitement du psoriasis des ongles et du cuir chevelu

Also Published As

Publication number Publication date
GB8807803D0 (en) 1988-05-05
FR2629345A1 (fr) 1989-10-06
SE8901115L (sv) 1989-10-01
SE8901115D0 (sv) 1989-03-30
DK156589D0 (da) 1989-03-30
BE1001845A4 (fr) 1990-03-20
NL8900779A (nl) 1989-10-16
GB2218101A (en) 1989-11-08
DE3910323A1 (de) 1989-10-19
IL89804A0 (en) 1989-09-28
IT1232827B (it) 1992-03-05
JPH02117700A (ja) 1990-05-02
AU3228789A (en) 1989-10-05
IT8947794A0 (it) 1989-03-30
DK156589A (da) 1989-10-01
GB8907148D0 (en) 1989-05-10

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