CA2485553A1 - Recepteurs .alpha. et .beta. de facteur de necrose tumorale - Google Patents

Recepteurs .alpha. et .beta. de facteur de necrose tumorale Download PDF

Info

Publication number
CA2485553A1
CA2485553A1 CA002485553A CA2485553A CA2485553A1 CA 2485553 A1 CA2485553 A1 CA 2485553A1 CA 002485553 A CA002485553 A CA 002485553A CA 2485553 A CA2485553 A CA 2485553A CA 2485553 A1 CA2485553 A1 CA 2485553A1
Authority
CA
Canada
Prior art keywords
tnf
antibody
dna
cells
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002485553A
Other languages
English (en)
Inventor
Craig A. Smith
Raymond G. Goodwin
Patricia M. Beckmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2485553A1 publication Critical patent/CA2485553A1/fr
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002485553A 1989-09-05 1990-07-17 Recepteurs .alpha. et .beta. de facteur de necrose tumorale Expired - Lifetime CA2485553A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US40324189A 1989-09-05 1989-09-05
US403,241 1989-09-05
US40537089A 1989-09-11 1989-09-11
US405,370 1989-09-11
US42141789A 1989-10-13 1989-10-13
US421,417 1989-10-13
CA002065346A CA2065346C (fr) 1989-09-05 1990-07-17 Recepteurs .alpha. et .beta. de facteur de necrose tumorale

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002065346A Division CA2065346C (fr) 1989-09-05 1990-07-17 Recepteurs .alpha. et .beta. de facteur de necrose tumorale

Publications (1)

Publication Number Publication Date
CA2485553A1 true CA2485553A1 (fr) 1991-03-21

Family

ID=46201946

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002485553A Expired - Lifetime CA2485553A1 (fr) 1989-09-05 1990-07-17 Recepteurs .alpha. et .beta. de facteur de necrose tumorale
CA002065346A Expired - Lifetime CA2065346C (fr) 1989-09-05 1990-07-17 Recepteurs .alpha. et .beta. de facteur de necrose tumorale

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002065346A Expired - Lifetime CA2065346C (fr) 1989-09-05 1990-07-17 Recepteurs .alpha. et .beta. de facteur de necrose tumorale

Country Status (3)

Country Link
AU (1) AU630497B2 (fr)
CA (2) CA2485553A1 (fr)
WO (1) WO1991003553A1 (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221675B1 (en) 1989-04-21 2001-04-24 Amgen, Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US7264944B1 (en) 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
DE59010941D1 (de) 1989-04-21 2005-03-24 Amgen Inc TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc A method of producing a recombinant human necrotic factor absorber
DK0417563T3 (da) 1989-09-12 2000-11-06 Hoffmann La Roche TNF-bindende proteiner
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
DE69130262T2 (de) * 1991-03-29 1999-03-18 Immunex Corp Isolierte virale proteine als cytokinantagonisten
WO1993006128A1 (fr) * 1991-09-16 1993-04-01 Peptide Technology Limited Peptides antagonistes du facteur de necrose tumorale
WO1993007863A1 (fr) * 1991-10-15 1993-04-29 Mullarkey Michael F Procedes et compositions servant a traiter des reactions allergiques
NZ256293A (en) * 1992-09-15 1997-06-24 Immunex Corp Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist
JPH08508035A (ja) * 1993-03-19 1996-08-27 イミュネックス・コーポレーション 可溶性レセプターと複合化したリガンドを含む医薬組成物
NZ278607A (en) * 1994-02-07 1999-05-28 Knoll Ag Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above
KR20040010739A (ko) 1996-02-09 2004-01-31 암젠 인코포레이티드 인터루킨-1 수용체 길항물질을 포함하는 융합 단백질 및 이를 포함하는 제약학적 조성물
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
AU736876B2 (en) 1996-12-06 2001-08-02 Amgen, Inc. Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases
JP2001513754A (ja) 1996-12-06 2001-09-04 アムジェン インコーポレイテッド Tnf媒介疾患を処置するためのtnf結合タンパク質を使用する組み合わせ治療
US6893838B1 (en) 1998-04-07 2005-05-17 Genetics Institute Llc DADD, death activator death domain protein
US20080213778A1 (en) 1998-12-30 2008-09-04 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
US7041474B2 (en) * 1998-12-30 2006-05-09 Millennium Pharmaceuticals, Inc. Nucleic acid encoding human tango 509
ES2241599T3 (es) * 1999-05-10 2005-11-01 Chugai Seiyaku Kabushiki Kaisha Metodo de cultivo de celulas.
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
WO2001092340A2 (fr) 2000-05-26 2001-12-06 Immunex Corporation Utilisation d'antagonistes vis-a-vis de l'interleukine-4 (il-4) et compositions correspondantes
US7364736B2 (en) 2001-06-26 2008-04-29 Amgen Inc. Antibodies to OPGL
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
CN102764436A (zh) 2002-07-19 2012-11-07 艾博特生物技术有限公司 TNF α相关疾病的治疗
TWI556829B (zh) 2004-04-09 2016-11-11 艾伯維生物技術有限責任公司 用於治療TNFα相關失調症之多重可變劑量療法
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
TWI399384B (zh) 2005-05-16 2013-06-21 Abbott Biotech Ltd TNFα抑制劑於治療侵蝕型多發性關節炎之用途
US20070041905A1 (en) 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
CN101663048A (zh) 2005-11-01 2010-03-03 艾博特生物技术有限公司 使用生物标志物诊断强直性脊柱炎的方法和组合物
US8007790B2 (en) 2006-04-03 2011-08-30 Stowers Institute For Medical Research Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
EP2666479A3 (fr) 2006-04-10 2014-03-26 Abbott Biotechnology Ltd Utilisations et compositions pour le traitement de l'arthrite rhumatoïde juvénile
EP2666472A3 (fr) 2006-04-10 2014-04-02 Abbott Biotechnology Ltd Utilisations et compositions pour le traitement de l'arthrite psoriasique
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
CA2564435A1 (fr) 2006-04-10 2007-10-10 Abbott Biotechnology Ltd. Methodes de controle et de traitement des troubles intestinaux
TWI542374B (zh) 2006-06-30 2016-07-21 艾伯維生物技術有限責任公司 自動注射裝置
EP2061803B2 (fr) 2006-08-28 2022-11-16 Ares Trading S.A. Procédé de purification de protéines contenant fc
US7833527B2 (en) 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
EP2679995A1 (fr) 2007-05-31 2014-01-01 AbbVie Inc. Biomarqueurs prédictifs de la réactivité aux inhibiteurs TNF-alfa dans des troubles auto-immuns
WO2008154543A2 (fr) 2007-06-11 2008-12-18 Abbott Biotechnology Ltd. Procédés de traitement de l'arthrite idiopathique juvénile
MX2011007030A (es) 2008-12-30 2011-07-20 Centocor Ortho Biotech Inc Marcadores sericos que predicen la respuesta clinica a los anticuerpos anti-factor de necrosis tumoral alfa en pacientes con espondilitis anquilosante.
EP2424594A4 (fr) 2009-04-29 2014-12-24 Abbvie Biotechnology Ltd Dispositif d'injection automatique
TW201117824A (en) 2009-10-12 2011-06-01 Amgen Inc Use of IL-17 receptor a antigen binding proteins
US20110150891A1 (en) 2009-12-16 2011-06-23 Philip Bosch Methods of Treating Interstitial Cystitis
HUE035618T2 (en) 2010-01-15 2018-05-28 Kirin Amgen Inc Antibody presentation and therapeutic regimens
CA2789168A1 (fr) 2010-02-02 2011-08-11 Abbott Biotechnology Ltd. Procedes et compositions de prediction de la reponse a un traitement avec un inhibiteur du tnf-.alpha.
NZ702172A (en) 2010-04-21 2016-03-31 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
WO2011146727A1 (fr) 2010-05-19 2011-11-24 Philip Bosch Méthodes de traitement de la cystite interstitielle
PT2575884T (pt) 2010-06-03 2018-10-31 Abbvie Biotechnology Ltd Utilizações e composições para o tratamento de hidradenite supurativa (hs)
EP2490024A1 (fr) 2010-12-22 2012-08-22 Proteomika, S.L. Procédé pour optimiser le traitement de patients au moyen de médicaments biologiques
JP6478214B2 (ja) 2011-01-24 2019-03-06 アッヴィ バイオテクノロジー リミテッド オーバーモールド把持面を有する自動注射器
US20120233834A1 (en) 2011-03-18 2012-09-20 Abbott Biotechnology Ltd. Systems, devices and methods for assembling automatic injection devices and sub-assemblies thereof
MX2013011263A (es) 2011-03-29 2014-03-27 Abbvie Inc Despliegue de cubierta mejorado en dispositivos de inyeccion automaticos.
EP4299093A3 (fr) 2011-04-21 2024-03-13 AbbVie Inc. Dispositif d'injection automatique portable pour l'administration contrôlée d'agents thérapeutiques
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
JP2016511747A (ja) 2013-01-04 2016-04-21 マサチューセッツ インスティテュート オブ テクノロジー ナノ粒子表面結合に基づく薬物の組織への送達
ES2760002T3 (es) 2014-03-31 2020-05-12 Amgen K A Inc Métodos de tratamiento de la psoriasis de uñas y cuero cabelludo
ES2833506T3 (es) 2014-12-22 2021-06-15 Ares Trading Sa Composición farmacéutica líquida
JP2019513737A (ja) 2016-04-08 2019-05-30 ギリアード サイエンシーズ, インコーポレイテッド がん、炎症性疾患および自己免疫疾患を処置するための組成物および方法
US20180193003A1 (en) 2016-12-07 2018-07-12 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
EP3554342A1 (fr) 2016-12-14 2019-10-23 Progenity, Inc. Traitement d'une maladie du tractus gastro-intestinal avec un inhibiteur du tnf
JOP20190162A1 (ar) 2016-12-30 2019-06-27 Biocad Joint Stock Co تركيبة صيدلانية مائية من جسم مضاد لـ tnf? أحادي النسيلة معاود الارتباط الجيني
EP3810095A1 (fr) 2018-06-20 2021-04-28 Progenity, Inc. Traitement d'une maladie du tractus gastro-intestinal avec un inhibiteur du tnf
JP2021529780A (ja) 2018-07-03 2021-11-04 ノバルティス アーゲー Nlrp3アンタゴニストを使用するtnf阻害剤に対して抵抗性の対象のための治療の方法又は治療を選択する方法
WO2020086728A1 (fr) 2018-10-24 2020-04-30 Novartis Inflammasome Research, Inc. Composés et compositions pour traiter des états associés à l'activité d'un nlrp
CN113166081A (zh) 2018-11-13 2021-07-23 诺华股份有限公司 用于治疗与nlrp活性相关的病症的化合物和组合物
JP2022506891A (ja) 2018-11-13 2022-01-17 ノバルティス アーゲー Nlrp活性に関連する状態を処置するための化合物及び組成物
US20220249814A1 (en) 2018-11-19 2022-08-11 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
JP2022533287A (ja) 2019-01-22 2022-07-22 ノバルティス アーゲー Nlrp活性に関連する状態を処置するための化合物及び組成物
WO2021002887A1 (fr) 2019-07-02 2021-01-07 Novartis Inflammasome Research, Inc. Antagonistes de nlrp3 ciblant l'intestin et leur utilisation en thérapie
EP3870261B1 (fr) 2019-12-13 2024-01-31 Biora Therapeutics, Inc. Dispositif ingestible pour la livraison d'un agent thérapeutique au système gastro-intestinal
WO2024054934A1 (fr) 2022-09-07 2024-03-14 Mdx Management Llc Inhibiteurs de shp-1 pour le traitement du cancer
WO2024097804A1 (fr) 2022-11-02 2024-05-10 Mdx Management Llc Combinaison d'un inhibiteur de tyrosine kinase et d'un agent pro-inflammatoire pour le traitement du cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83878A (en) * 1987-09-13 1995-07-31 Yeda Res & Dev Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it
GB8806339D0 (en) * 1988-03-17 1988-04-13 Hoffmann La Roche Monoclonal antibodies
GB8807803D0 (en) * 1988-03-31 1988-05-05 Glaxo Group Ltd Biochemical product

Also Published As

Publication number Publication date
CA2065346A1 (fr) 1991-03-06
CA2065346C (fr) 2005-03-29
WO1991003553A1 (fr) 1991-03-21
AU6178190A (en) 1991-04-08
AU630497B2 (en) 1992-10-29

Similar Documents

Publication Publication Date Title
US5712155A (en) DNA encoding tumor necrosis factor-α and -β receptors
EP0418014B1 (fr) Récepteurs pour le facteur de nécrose de tumeur alpha et beta
CA2065346C (fr) Recepteurs .alpha. et .beta. de facteur de necrose tumorale
US5945397A (en) Purified p75 (type II) tumor necrosis factor receptor polypeptides
US6541610B1 (en) Fusion proteins comprising tumor necrosis factor receptor
EP0604418B1 (fr) Antagonistes de cytokines a base de proteines virales isolees
US20060275868A1 (en) Fusion proteins comprising tumor necrosis factor receptor
IE914333A1 (en) Leukemia inhibitory factor receptors
EP0403114B1 (fr) Récepteurs d'interleukine 7
EP0494260B1 (fr) Recepteurs de facteurs stimulant les colonies de granulocytes
US5194375A (en) Dna encoding interleukin-7 receptors and methods of use
FI105099B (fi) Menetelmä biologisesti aktiivisen nisäkkään kasvainkuoliotekijäreseptoriproteiinin valmistamiseksi ja tätä koodittava DNA-sekvenssi

Legal Events

Date Code Title Description
EEER Examination request
AZWI Withdrawn application
MKEX Expiry
AZWI Withdrawn application

Effective date: 20100629