KR890012636A - 다층 과립 - Google Patents

다층 과립 Download PDF

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Publication number
KR890012636A
KR890012636A KR1019890001165A KR890001165A KR890012636A KR 890012636 A KR890012636 A KR 890012636A KR 1019890001165 A KR1019890001165 A KR 1019890001165A KR 890001165 A KR890001165 A KR 890001165A KR 890012636 A KR890012636 A KR 890012636A
Authority
KR
South Korea
Prior art keywords
release layer
layer
intermediate layer
rapid
releasing layer
Prior art date
Application number
KR1019890001165A
Other languages
English (en)
Other versions
KR910004582B1 (ko
Inventor
시게루 아오끼
게이조오 우에스기
시게루 사까시다
마사요시 가사이
마사노리 가야노
Original Assignee
나이또오 하루오
에자이 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 나이또오 하루오, 에자이 가부시끼가이샤 filed Critical 나이또오 하루오
Publication of KR890012636A publication Critical patent/KR890012636A/ko
Application granted granted Critical
Publication of KR910004582B1 publication Critical patent/KR910004582B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Glass Compositions (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

다층 과립
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 내부 서방성 층, 외부 급방성 층 및 상기 서방성 층과 상기 급방성 층 사이에 형성되고 경화유와 히드록시프로필 셀룰로스 또는 메틸 세룰로스를 포함하는 중간층으로 이루어지는 다층 과립.
  2. 제1항에 있어서, 중간층이 20 내지 90중량 퍼센트의 경화유와 1 내지 10중량 퍼센트의 히드록시프로필 셀룰로스 또는 메틸 셀룰로스를 포함하는 것을 특징으로 하는 과립.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890001165A 1988-02-03 1989-02-01 다층 과립 KR910004582B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63023215A JP2643222B2 (ja) 1988-02-03 1988-02-03 多重層顆粒
JP63-23215 1988-02-03

Publications (2)

Publication Number Publication Date
KR890012636A true KR890012636A (ko) 1989-09-18
KR910004582B1 KR910004582B1 (ko) 1991-07-06

Family

ID=12104439

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890001165A KR910004582B1 (ko) 1988-02-03 1989-02-01 다층 과립

Country Status (11)

Country Link
US (1) US4994279A (ko)
EP (1) EP0327086B1 (ko)
JP (1) JP2643222B2 (ko)
KR (1) KR910004582B1 (ko)
CN (1) CN1031036C (ko)
AT (1) ATE75607T1 (ko)
CA (1) CA1337899C (ko)
DE (1) DE68901384D1 (ko)
ES (1) ES2031290T3 (ko)
PH (1) PH26515A (ko)
PT (1) PT89600B (ko)

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JP2008525313A (ja) * 2004-12-27 2008-07-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗痴呆薬の安定化方法
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KR20140079441A (ko) 2006-06-19 2014-06-26 알파마 파머슈티컬스 엘엘씨 약제학적 조성물
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Also Published As

Publication number Publication date
US4994279A (en) 1991-02-19
CN1031036C (zh) 1996-02-21
JP2643222B2 (ja) 1997-08-20
EP0327086A2 (en) 1989-08-09
PT89600B (pt) 1994-01-31
JPH01197433A (ja) 1989-08-09
PT89600A (pt) 1989-10-04
ES2031290T3 (es) 1992-12-01
DE68901384D1 (de) 1992-06-11
ATE75607T1 (de) 1992-05-15
PH26515A (en) 1992-08-07
CA1337899C (en) 1996-01-09
EP0327086B1 (en) 1992-05-06
CN1037082A (zh) 1989-11-15
EP0327086A3 (en) 1989-09-06
KR910004582B1 (ko) 1991-07-06

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