KR890008166A - 융합 단백질의 선택적 분해 방법 - Google Patents

융합 단백질의 선택적 분해 방법 Download PDF

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Publication number
KR890008166A
KR890008166A KR1019880015202A KR880015202A KR890008166A KR 890008166 A KR890008166 A KR 890008166A KR 1019880015202 A KR1019880015202 A KR 1019880015202A KR 880015202 A KR880015202 A KR 880015202A KR 890008166 A KR890008166 A KR 890008166A
Authority
KR
South Korea
Prior art keywords
gly
represent
fusion proteins
selective degradation
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019880015202A
Other languages
English (en)
Korean (ko)
Inventor
되르쉬그 미카엘
하르트 사이프케 게르
Original Assignee
베른 하르트 벡크, 하인리히 벡커
훽스트 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베른 하르트 벡크, 하인리히 벡커, 훽스트 아크티엔게젤샤프트 filed Critical 베른 하르트 벡크, 하인리히 벡커
Publication of KR890008166A publication Critical patent/KR890008166A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Techniques For Improving Reliability Of Storages (AREA)
  • Fuses (AREA)
  • Welding Or Cutting Using Electron Beams (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Machines For Manufacturing Corrugated Board In Mechanical Paper-Making Processes (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1019880015202A 1987-11-20 1988-11-18 융합 단백질의 선택적 분해 방법 Ceased KR890008166A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3739347.2 1987-11-20
DE19873739347 DE3739347A1 (de) 1987-11-20 1987-11-20 Verfahren zur selektiven spaltung von fusionsproteinen

Publications (1)

Publication Number Publication Date
KR890008166A true KR890008166A (ko) 1989-07-10

Family

ID=6340882

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880015202A Ceased KR890008166A (ko) 1987-11-20 1988-11-18 융합 단백질의 선택적 분해 방법

Country Status (19)

Country Link
EP (1) EP0316748B1 (enExample)
JP (1) JPH01160496A (enExample)
KR (1) KR890008166A (enExample)
CN (1) CN1033184A (enExample)
AT (1) ATE78873T1 (enExample)
AU (1) AU618035B2 (enExample)
CA (1) CA1337283C (enExample)
DE (2) DE3739347A1 (enExample)
DK (1) DK645588A (enExample)
ES (1) ES2051816T3 (enExample)
FI (1) FI885328A7 (enExample)
GR (1) GR3006045T3 (enExample)
HU (1) HU204894B (enExample)
IE (1) IE62228B1 (enExample)
IL (1) IL88413A (enExample)
NO (1) NO173194C (enExample)
NZ (1) NZ226998A (enExample)
PT (1) PT89019B (enExample)
ZA (1) ZA888650B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780285A (en) * 1995-03-03 1998-07-14 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing dibasic residues
US5837516A (en) * 1995-03-03 1998-11-17 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing basic residues
PT821006E (pt) 1996-07-26 2004-09-30 Aventis Pharma Gmbh Derivados de insulina com ligacao a zinco aumentada
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
EP1494706A4 (en) * 2002-03-26 2006-10-25 Biosynexus Inc ANTIMICROBIAL POLYMER CONJUGATES
CN101717449B (zh) * 2008-10-09 2013-06-19 重庆富进生物医药有限公司 重组TRAIL-Fc融合蛋白及其制备和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523701A1 (de) * 1985-07-03 1987-01-08 Bayer Ag Verfahren zur herstellung von proteinen und polypeptiden

Also Published As

Publication number Publication date
JPH01160496A (ja) 1989-06-23
PT89019B (pt) 1993-02-26
PT89019A (pt) 1988-12-01
NZ226998A (en) 1991-06-25
NO173194B (no) 1993-08-02
IE62228B1 (en) 1995-01-11
DK645588A (da) 1989-05-21
ES2051816T3 (es) 1994-07-01
AU618035B2 (en) 1991-12-12
FI885328L (fi) 1989-05-21
IL88413A0 (en) 1989-06-30
NO885154L (no) 1989-05-22
HUT50514A (en) 1990-02-28
HU204894B (en) 1992-02-28
IL88413A (en) 1993-07-08
DK645588D0 (da) 1988-11-18
DE3873273D1 (de) 1992-09-03
CN1033184A (zh) 1989-05-31
EP0316748B1 (de) 1992-07-29
ZA888650B (en) 1989-07-26
EP0316748A3 (en) 1990-08-29
NO885154D0 (no) 1988-11-18
GR3006045T3 (enExample) 1993-06-21
ATE78873T1 (de) 1992-08-15
NO173194C (no) 1993-11-10
CA1337283C (en) 1995-10-10
IE883462L (en) 1989-05-20
AU2569588A (en) 1989-06-29
FI885328A7 (fi) 1989-05-21
EP0316748A2 (de) 1989-05-24
DE3739347A1 (de) 1989-06-01
FI885328A0 (fi) 1988-11-17

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19881118

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19931108

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19881118

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19970217

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19970520

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19970217

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I