KR890004686B1 - 방출조절성 경구용 고형제형과 그의 제조방법 - Google Patents

방출조절성 경구용 고형제형과 그의 제조방법 Download PDF

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Publication number
KR890004686B1
KR890004686B1 KR1019870010376A KR870010376A KR890004686B1 KR 890004686 B1 KR890004686 B1 KR 890004686B1 KR 1019870010376 A KR1019870010376 A KR 1019870010376A KR 870010376 A KR870010376 A KR 870010376A KR 890004686 B1 KR890004686 B1 KR 890004686B1
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KR
South Korea
Prior art keywords
release
unit
formulation
density
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019870010376A
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English (en)
Korean (ko)
Other versions
KR880003617A (ko
Inventor
마이클 뉴톤 존
엘리자베스 듀버룩스 제인
Original Assignee
런던 스쿨 오브 파머시 인노베이션스 리미티드
프란시스 피시, 브라이언 데이비드로버츠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from GB868622482A external-priority patent/GB8622482D0/en
Priority claimed from GB878708011A external-priority patent/GB8708011D0/en
Application filed by 런던 스쿨 오브 파머시 인노베이션스 리미티드, 프란시스 피시, 브라이언 데이비드로버츠 filed Critical 런던 스쿨 오브 파머시 인노베이션스 리미티드
Publication of KR880003617A publication Critical patent/KR880003617A/ko
Application granted granted Critical
Publication of KR890004686B1 publication Critical patent/KR890004686B1/ko
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019870010376A 1986-09-18 1987-09-18 방출조절성 경구용 고형제형과 그의 제조방법 Expired KR890004686B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP8622482 1986-09-18
GB8622482 1986-09-18
GB868622482A GB8622482D0 (en) 1986-09-18 1986-09-18 Pharmaceutical formulation
JP8708011 1987-04-03
GB878708011A GB8708011D0 (en) 1987-04-03 1987-04-03 Pharmaceutical formulation
GB8708011 1987-04-03

Publications (2)

Publication Number Publication Date
KR880003617A KR880003617A (ko) 1988-05-28
KR890004686B1 true KR890004686B1 (ko) 1989-11-25

Family

ID=26291305

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870010376A Expired KR890004686B1 (ko) 1986-09-18 1987-09-18 방출조절성 경구용 고형제형과 그의 제조방법

Country Status (19)

Country Link
US (1) US4938967A (enExample)
EP (1) EP0265061B1 (enExample)
KR (1) KR890004686B1 (enExample)
AT (1) ATE71293T1 (enExample)
AU (1) AU606353B2 (enExample)
BE (1) BE1000616A5 (enExample)
CA (1) CA1302259C (enExample)
CH (1) CH674146A5 (enExample)
DE (1) DE3775880D1 (enExample)
DK (1) DK488287A (enExample)
ES (1) ES2038669T3 (enExample)
FR (1) FR2604090B1 (enExample)
GB (1) GB2196252B (enExample)
GR (1) GR3004268T3 (enExample)
HU (1) HU202101B (enExample)
IL (1) IL83897A (enExample)
IT (1) IT1211484B (enExample)
NZ (1) NZ221805A (enExample)
PT (1) PT85747B (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983400A (en) * 1986-06-16 1991-01-08 Merck & Co., Inc. Controlled release combination of carbidopa/levodopa
US5374430A (en) * 1986-09-18 1994-12-20 London School Of Pharmacy Pharmaceutical formulation
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
IE64726B1 (en) * 1987-11-20 1995-08-23 Elan Corp Plc Pharmaceutical formulations for preventing drug tolerance
IE63986B1 (en) * 1989-12-30 1995-06-28 Akzo Nv Pharmaceutical preparation for oral administration in fluid form
DK165090D0 (da) * 1990-07-09 1990-07-09 Kem En Tec As Konglomererede partikler
GB9018839D0 (en) * 1990-08-29 1990-10-10 Newton John M Slow release compositions
US5166145A (en) * 1990-09-10 1992-11-24 Alza Corporation Antiemetic therapy
SE9101149D0 (sv) 1991-04-17 1991-04-17 Pharmacia Lkb Biotech Beads for down stream processing
US5198229A (en) * 1991-06-05 1993-03-30 Alza Corporation Self-retaining gastrointestinal delivery device
US5252337A (en) * 1991-06-25 1993-10-12 Eurand America, Inc. Controlled release calcium channel blocker microcapsules
US5288505A (en) * 1991-06-26 1994-02-22 Galephar P.R., Inc., Ltd. Extended release form of diltiazem
IT1251153B (it) * 1991-08-06 1995-05-04 Vectorpharma Int Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
WO1994003184A1 (en) * 1992-07-31 1994-02-17 Neose Pharmaceuticals, Inc. Compositions for treating and inhibiting gastric and duodenal ulcers
MX9304638A (es) * 1992-07-31 1994-05-31 Neose Pharm Inc Composicion para tratar e inhibir las ulceras gastricas y duodenales.
US5681581A (en) * 1992-08-04 1997-10-28 Dunn; James M. Controlled release pharmaceutical formulations of 3'-azido-3'-deoxythymidine and methods of use
FR2703908B1 (fr) * 1993-04-13 1995-06-02 Asta Medica Ag Forme pharmaceutique pour administration rectale de composés pharmacologiquement actifs.
US6706188B2 (en) 1993-05-03 2004-03-16 Amersham Biociences Ab Process and means for down stream processing
US8828432B2 (en) * 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
US7179486B1 (en) 1997-04-01 2007-02-20 Nostrum Pharmaceuticals, Inc. Process for preparing sustained release tablets
CA2322641C (en) * 1998-03-23 2010-02-16 General Mills, Inc. Encapsulation of components into edible products
US10973397B2 (en) 1999-03-01 2021-04-13 West View Research, Llc Computerized information collection and processing apparatus
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US20050079214A1 (en) * 1999-09-01 2005-04-14 John Cooker Oral delivery system and method for making same
US20040101540A1 (en) * 1999-09-01 2004-05-27 John Cooker Oral delivery system and method for making same
CA2383212C (en) 1999-09-02 2008-11-25 Nostrum Pharmaceuticals, Inc. Controlled release oral dosage suitable for oral administration
US20060153914A1 (en) * 1999-12-10 2006-07-13 Biovail Laboratories International S.R.L. Chronotherapeutic diltiazem formulations and the administration thereof
US7108866B1 (en) 1999-12-10 2006-09-19 Biovall Laboratories International Srl Chronotherapeutic diltiazem formulations and the administration thereof
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
CA2407154A1 (en) 2000-04-27 2001-11-01 Verion, Inc Zero order release and temperature-controlled microcapsules and process for the preparation thereof
DE10031043A1 (de) 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20110171296A1 (en) * 2000-10-30 2011-07-14 Biohit Oyj Method and preparation for binding acetaldehyde in saliva, the stomach and the large intestine
FI121528B (fi) * 2000-10-30 2010-12-31 Biohit Oyj Farmaseuttinen koostumus syöpään sairastumisen riskin vähentämiseen paikallisesti sitomalla asetaldehydi syljessä, mahalaukussa tai paksusuolessa
US6569808B2 (en) * 2001-07-30 2003-05-27 Lee F. Klinger Methods and compositions useful for bryophyte remediation to improve forest health and growth
AUPR951501A0 (en) * 2001-12-14 2002-01-24 Smart Drug Systems Inc Modified sustained release pharmaceutical system
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
GB0214013D0 (en) * 2002-06-18 2002-07-31 Euro Celtique Sa Pharmaceutical product
US20040029959A1 (en) * 2002-08-08 2004-02-12 John Devane Isosorbide mononitrate compositions and methods of their use
US20040076582A1 (en) * 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20070102672A1 (en) * 2004-12-06 2007-05-10 Hamilton Judd D Ceramic radiation shielding material and method of preparation
CA2596548A1 (en) * 2005-01-31 2006-08-03 Kyorin Pharmaceutical Co., Ltd. Multiple unit oral sustained release preparation and process for production of the same
US20070087056A1 (en) * 2005-08-09 2007-04-19 Claudia Guthmann Pharmaceutical form with sustained pH-independent active ingredient release for active ingredients having strong pH-dependent solubility
US7803413B2 (en) 2005-10-31 2010-09-28 General Mills Ip Holdings Ii, Llc. Encapsulation of readily oxidizable components
US8512761B2 (en) 2006-01-27 2013-08-20 Yale University Fast acting inhibitor of gastric acid secretion
JP5469865B2 (ja) 2006-01-27 2014-04-16 エール ユニバーシティー 胃酸分泌の即効性阻害剤
ES2538838T3 (es) * 2007-09-07 2015-06-24 Mati Therapeutics Inc. Método para preparar insertos de fármacos para liberación sostenida de agentes terapéuticos
WO2010011712A1 (en) * 2008-07-22 2010-01-28 General Mills, Inc. Fruit products containing omega-3 fatty acids
NO2403482T3 (enExample) * 2009-03-04 2018-05-26
PL2427177T3 (pl) 2009-05-08 2018-09-28 Emplicure Ab Kompozycja do przedłużonego podawania leku zawierająca geopolimerowy środek wiążący
CN102458138B (zh) * 2009-06-05 2014-08-20 通用工厂公司 用于制备烘烤食品的胶囊化的ω-3脂肪酸
US10251834B2 (en) 2010-09-07 2019-04-09 Emplicure Ab Transdermal drug administration device
US20170172946A1 (en) * 2015-12-21 2017-06-22 Stephan Hau Micro-solid phase extraction

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO98024A (enExample) * 1956-11-05
GB936386A (en) * 1959-01-16 1963-09-11 Wellcome Found Pellets for supplying biologically active substances to ruminants
CH582002A5 (enExample) * 1972-06-09 1976-11-30 Purdue Research Foundation
GB1590574A (en) * 1976-08-06 1981-06-03 Atomic Energy Authority Uk Biologically active gels
GB1590573A (en) * 1976-08-06 1981-06-03 Atomic Energy Authority Uk Biologically active gels
GB1576376A (en) * 1977-03-30 1980-10-08 Benzon As Alfred Multiple-unit drug dose
GB2015875B (en) * 1978-02-24 1982-10-20 Novex Foreign Trade Co Ltd Solid oral pharaceutical product with increased efficacy and predetermined steady state of solubility
JPS6024767B2 (ja) * 1979-08-24 1985-06-14 塩野義製薬株式会社 腸溶性硬カプセル剤
NZ194901A (en) * 1979-09-12 1983-07-15 Lilly Co Eli Device for oral delivery of drug to reticulorumen of ruminant
GB2100602B (en) * 1981-06-24 1984-11-14 May & Baker Ltd Device for delivering biologically active substances to the digestive tract.
ZA825384B (en) * 1981-07-31 1983-05-25 Tillott J B Ltd Orally administrable pharmaceutical compositions
GB2123690A (en) * 1982-07-20 1984-02-08 Nat Res Dev Sustained release device
GB2123693B (en) * 1982-07-20 1987-05-13 Nat Res Dev Sustained release device
DE3306250A1 (de) * 1983-02-23 1984-08-23 Basf Ag, 6700 Ludwigshafen Sphaerische einkristalle fuer pharmazeutische zwecke
FR2560768A1 (fr) * 1984-03-07 1985-09-13 Crb Virbac Sa Dispositif a liberation programmee
DE3431861A1 (de) * 1984-08-30 1986-03-13 Troponwerke GmbH & Co KG, 5000 Köln Pellet-zubereitung
US4609374A (en) * 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom

Also Published As

Publication number Publication date
GB8721186D0 (en) 1987-10-14
GR3004268T3 (enExample) 1993-03-31
DK488287A (da) 1988-03-19
PT85747A (en) 1987-10-01
ES2038669T3 (es) 1993-08-01
DK488287D0 (da) 1987-09-17
EP0265061A1 (en) 1988-04-27
IL83897A0 (en) 1988-02-29
AU606353B2 (en) 1991-02-07
PT85747B (pt) 1991-02-08
IT1211484B (it) 1989-11-03
FR2604090A1 (fr) 1988-03-25
DE3775880D1 (enExample) 1992-02-20
HU202101B (en) 1991-02-28
EP0265061B1 (en) 1992-01-08
AU7848187A (en) 1988-03-24
KR880003617A (ko) 1988-05-28
IL83897A (en) 1991-06-10
IT8767796A0 (it) 1987-09-17
ATE71293T1 (de) 1992-01-15
NZ221805A (en) 1991-02-26
CH674146A5 (enExample) 1990-05-15
GB2196252B (en) 1990-10-17
BE1000616A5 (fr) 1989-02-21
GB2196252A (en) 1988-04-27
FR2604090B1 (fr) 1990-06-15
HUT45194A (en) 1988-06-28
CA1302259C (en) 1992-06-02
US4938967A (en) 1990-07-03

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