ES2038669T3 - Formulacion farmaceutica. - Google Patents
Formulacion farmaceutica.Info
- Publication number
- ES2038669T3 ES2038669T3 ES198787307973T ES87307973T ES2038669T3 ES 2038669 T3 ES2038669 T3 ES 2038669T3 ES 198787307973 T ES198787307973 T ES 198787307973T ES 87307973 T ES87307973 T ES 87307973T ES 2038669 T3 ES2038669 T3 ES 2038669T3
- Authority
- ES
- Spain
- Prior art keywords
- units
- density
- pharmaceutical formulation
- baric
- liberation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Abstract
EL TIEMPO DE RESIDENCIA EN EL ESTOMAGO HUMANO DE UNIDADES SOLIDAS FARMACEUTICAS DE LIBERACION GASTRICA CONTROLADA, AUMENTA SIGNIFICATIVAMENTE SI LAS UNIDADES TIENEN UNA DENSIDAD QUE ES MUCHO MAS ALTA QUE LA NORMAL. UNA FORMA DE ADMINISTRACION ORAL PREFERIDA CONFORME A LA INVENCION COMPRENDE UNA CAPSULA U OTRA FORMA DE DOSIFICACION QUE TIENENUNA DIMENSION SUPERIOR A 2 MM Y CONTIENE UNO O MAS DE DICHAS UNIDADES. LA DENSIDAD DE CADA UNIDAD ES PREFERIBLEMENTE POR LO MENOS 2,5 Y USUALMENTE POR LO MENOS 2,7 G/ML Y PUEDEN CONSEGUIRSE DE FORMA CONVENIENTE INCLUYENDO AL MENOS EL 50% EN PESO DE UN AGENTE DE CARGA TAL COMO EL SULFATO BARICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868622482A GB8622482D0 (en) | 1986-09-18 | 1986-09-18 | Pharmaceutical formulation |
GB878708011A GB8708011D0 (en) | 1987-04-03 | 1987-04-03 | Pharmaceutical formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2038669T3 true ES2038669T3 (es) | 1993-08-01 |
Family
ID=26291305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787307973T Expired - Lifetime ES2038669T3 (es) | 1986-09-18 | 1987-09-09 | Formulacion farmaceutica. |
Country Status (19)
Country | Link |
---|---|
US (1) | US4938967A (es) |
EP (1) | EP0265061B1 (es) |
KR (1) | KR890004686B1 (es) |
AT (1) | ATE71293T1 (es) |
AU (1) | AU606353B2 (es) |
BE (1) | BE1000616A5 (es) |
CA (1) | CA1302259C (es) |
CH (1) | CH674146A5 (es) |
DE (1) | DE3775880D1 (es) |
DK (1) | DK488287A (es) |
ES (1) | ES2038669T3 (es) |
FR (1) | FR2604090B1 (es) |
GB (1) | GB2196252B (es) |
GR (1) | GR3004268T3 (es) |
HU (1) | HU202101B (es) |
IL (1) | IL83897A (es) |
IT (1) | IT1211484B (es) |
NZ (1) | NZ221805A (es) |
PT (1) | PT85747B (es) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4983400A (en) * | 1986-06-16 | 1991-01-08 | Merck & Co., Inc. | Controlled release combination of carbidopa/levodopa |
US5374430A (en) * | 1986-09-18 | 1994-12-20 | London School Of Pharmacy | Pharmaceutical formulation |
GB8707416D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
IE64726B1 (en) * | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
IE63986B1 (en) * | 1989-12-30 | 1995-06-28 | Akzo Nv | Pharmaceutical preparation for oral administration in fluid form |
DK165090D0 (da) * | 1990-07-09 | 1990-07-09 | Kem En Tec As | Konglomererede partikler |
GB9018839D0 (en) * | 1990-08-29 | 1990-10-10 | Newton John M | Slow release compositions |
US5166145A (en) * | 1990-09-10 | 1992-11-24 | Alza Corporation | Antiemetic therapy |
SE9101149D0 (sv) | 1991-04-17 | 1991-04-17 | Pharmacia Lkb Biotech | Beads for down stream processing |
US5198229A (en) * | 1991-06-05 | 1993-03-30 | Alza Corporation | Self-retaining gastrointestinal delivery device |
US5252337A (en) * | 1991-06-25 | 1993-10-12 | Eurand America, Inc. | Controlled release calcium channel blocker microcapsules |
US5288505A (en) * | 1991-06-26 | 1994-02-22 | Galephar P.R., Inc., Ltd. | Extended release form of diltiazem |
IT1251153B (it) * | 1991-08-06 | 1995-05-04 | Vectorpharma Int | Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica |
US5350584A (en) * | 1992-06-26 | 1994-09-27 | Merck & Co., Inc. | Spheronization process using charged resins |
MX9304638A (es) * | 1992-07-31 | 1994-05-31 | Neose Pharm Inc | Composicion para tratar e inhibir las ulceras gastricas y duodenales. |
WO1994003184A1 (en) * | 1992-07-31 | 1994-02-17 | Neose Pharmaceuticals, Inc. | Compositions for treating and inhibiting gastric and duodenal ulcers |
AU677220B2 (en) * | 1992-08-04 | 1997-04-17 | James M. Dunn | Controlled release pharmaceutical formulations of 3'azido-3'-deoxythymidine and methods of use |
FR2703908B1 (fr) * | 1993-04-13 | 1995-06-02 | Asta Medica Ag | Forme pharmaceutique pour administration rectale de composés pharmacologiquement actifs. |
US6706188B2 (en) | 1993-05-03 | 2004-03-16 | Amersham Biociences Ab | Process and means for down stream processing |
US8828432B2 (en) * | 1996-10-28 | 2014-09-09 | General Mills, Inc. | Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles |
US7179486B1 (en) | 1997-04-01 | 2007-02-20 | Nostrum Pharmaceuticals, Inc. | Process for preparing sustained release tablets |
WO1999048372A1 (en) * | 1998-03-23 | 1999-09-30 | General Mills, Inc. | Encapsulation of components into edible products |
US10973397B2 (en) | 1999-03-01 | 2021-04-13 | West View Research, Llc | Computerized information collection and processing apparatus |
US8636648B2 (en) | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
US20050079214A1 (en) * | 1999-09-01 | 2005-04-14 | John Cooker | Oral delivery system and method for making same |
US20040101540A1 (en) * | 1999-09-01 | 2004-05-27 | John Cooker | Oral delivery system and method for making same |
JP2003508420A (ja) | 1999-09-02 | 2003-03-04 | ノストラム・ファーマスーティカルズ・インコーポレイテッド | 経口投与に適した、制御された放出の経口用量 |
US20060153914A1 (en) * | 1999-12-10 | 2006-07-13 | Biovail Laboratories International S.R.L. | Chronotherapeutic diltiazem formulations and the administration thereof |
US7108866B1 (en) | 1999-12-10 | 2006-09-19 | Biovall Laboratories International Srl | Chronotherapeutic diltiazem formulations and the administration thereof |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US6544646B2 (en) | 2000-04-27 | 2003-04-08 | Verion Inc. | Zero order release and temperature-controlled microcapsules and process for the preparation thereof |
DE10031043A1 (de) | 2000-06-26 | 2002-02-14 | Bayer Ag | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
FI121528B (fi) * | 2000-10-30 | 2010-12-31 | Biohit Oyj | Farmaseuttinen koostumus syöpään sairastumisen riskin vähentämiseen paikallisesti sitomalla asetaldehydi syljessä, mahalaukussa tai paksusuolessa |
US20110171296A1 (en) * | 2000-10-30 | 2011-07-14 | Biohit Oyj | Method and preparation for binding acetaldehyde in saliva, the stomach and the large intestine |
US6569808B2 (en) * | 2001-07-30 | 2003-05-27 | Lee F. Klinger | Methods and compositions useful for bryophyte remediation to improve forest health and growth |
AUPR951501A0 (en) * | 2001-12-14 | 2002-01-24 | Smart Drug Systems Inc | Modified sustained release pharmaceutical system |
US7131997B2 (en) | 2002-03-29 | 2006-11-07 | Scimed Life Systems, Inc. | Tissue treatment |
US7094369B2 (en) | 2002-03-29 | 2006-08-22 | Scimed Life Systems, Inc. | Processes for manufacturing polymeric microspheres |
US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
GB0214013D0 (en) * | 2002-06-18 | 2002-07-31 | Euro Celtique Sa | Pharmaceutical product |
US20040029959A1 (en) * | 2002-08-08 | 2004-02-12 | John Devane | Isosorbide mononitrate compositions and methods of their use |
US20040076582A1 (en) * | 2002-08-30 | 2004-04-22 | Dimatteo Kristian | Agent delivery particle |
US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
US7976823B2 (en) | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
US20070102672A1 (en) * | 2004-12-06 | 2007-05-10 | Hamilton Judd D | Ceramic radiation shielding material and method of preparation |
KR20070115918A (ko) * | 2005-01-31 | 2007-12-06 | 교린 세이야꾸 가부시키 가이샤 | 멀티플 유닛형 경구 서방성 제제 및 그 제조방법 |
US20070087056A1 (en) * | 2005-08-09 | 2007-04-19 | Claudia Guthmann | Pharmaceutical form with sustained pH-independent active ingredient release for active ingredients having strong pH-dependent solubility |
US7803413B2 (en) * | 2005-10-31 | 2010-09-28 | General Mills Ip Holdings Ii, Llc. | Encapsulation of readily oxidizable components |
SI1976532T1 (sl) | 2006-01-27 | 2016-04-29 | Yale University | Hitro delujoči zaviralec izločanja želodčne kisline |
US8512761B2 (en) | 2006-01-27 | 2013-08-20 | Yale University | Fast acting inhibitor of gastric acid secretion |
ES2533359T3 (es) * | 2007-09-07 | 2015-04-09 | Mati Therapeutics Inc. | Núcleos de fármaco para liberación sostenida de agentes terapéuticos |
WO2010011712A1 (en) * | 2008-07-22 | 2010-01-28 | General Mills, Inc. | Fruit products containing omega-3 fatty acids |
AU2010219449B2 (en) | 2009-03-04 | 2014-12-18 | Orexo Ab | Abuse resistant formulation |
MX2011011829A (es) | 2009-05-08 | 2012-02-21 | Orexo Ab | Composicion para suministro sostenido de farmaco que comprende un aglutinante geopolimerico. |
US20100310728A1 (en) * | 2009-06-05 | 2010-12-09 | General Mills, Inc. | Encapsulated omega-3 fatty acids for baked goods production |
AU2011300524B2 (en) | 2010-09-07 | 2014-10-23 | Orexo Ab | A transdermal drug administration device |
US20170172946A1 (en) * | 2015-12-21 | 2017-06-22 | Stephan Hau | Micro-solid phase extraction |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO98024A (es) * | 1956-11-05 | |||
GB936386A (en) * | 1959-01-16 | 1963-09-11 | Wellcome Found | Pellets for supplying biologically active substances to ruminants |
CH582002A5 (es) * | 1972-06-09 | 1976-11-30 | Purdue Research Foundation | |
GB1590573A (en) * | 1976-08-06 | 1981-06-03 | Atomic Energy Authority Uk | Biologically active gels |
GB1590574A (en) * | 1976-08-06 | 1981-06-03 | Atomic Energy Authority Uk | Biologically active gels |
GB1576376A (en) * | 1977-03-30 | 1980-10-08 | Benzon As Alfred | Multiple-unit drug dose |
GB2015875B (en) * | 1978-02-24 | 1982-10-20 | Novex Foreign Trade Co Ltd | Solid oral pharaceutical product with increased efficacy and predetermined steady state of solubility |
JPS6024767B2 (ja) * | 1979-08-24 | 1985-06-14 | 塩野義製薬株式会社 | 腸溶性硬カプセル剤 |
AR221964A1 (es) * | 1979-09-12 | 1981-03-31 | Lilly Co Eli | Dispositivo para rumiantes |
GB2100602B (en) * | 1981-06-24 | 1984-11-14 | May & Baker Ltd | Device for delivering biologically active substances to the digestive tract. |
ZA825384B (en) * | 1981-07-31 | 1983-05-25 | Tillott J B Ltd | Orally administrable pharmaceutical compositions |
GB2123690A (en) * | 1982-07-20 | 1984-02-08 | Nat Res Dev | Sustained release device |
GB2123693B (en) * | 1982-07-20 | 1987-05-13 | Nat Res Dev | Sustained release device |
DE3306250A1 (de) * | 1983-02-23 | 1984-08-23 | Basf Ag, 6700 Ludwigshafen | Sphaerische einkristalle fuer pharmazeutische zwecke |
FR2560768A1 (fr) * | 1984-03-07 | 1985-09-13 | Crb Virbac Sa | Dispositif a liberation programmee |
DE3431861A1 (de) * | 1984-08-30 | 1986-03-13 | Troponwerke GmbH & Co KG, 5000 Köln | Pellet-zubereitung |
US4609374A (en) * | 1985-04-22 | 1986-09-02 | Alza Corporation | Osmotic device comprising means for governing initial time of agent release therefrom |
-
1987
- 1987-09-09 AT AT87307973T patent/ATE71293T1/de active
- 1987-09-09 EP EP87307973A patent/EP0265061B1/en not_active Expired - Lifetime
- 1987-09-09 GB GB8721186A patent/GB2196252B/en not_active Expired - Fee Related
- 1987-09-09 DE DE87307973T patent/DE3775880D1/de not_active Expired - Fee Related
- 1987-09-09 ES ES198787307973T patent/ES2038669T3/es not_active Expired - Lifetime
- 1987-09-14 IL IL83897A patent/IL83897A/xx not_active IP Right Cessation
- 1987-09-14 NZ NZ221805A patent/NZ221805A/xx unknown
- 1987-09-15 CA CA000546905A patent/CA1302259C/en not_active Expired - Fee Related
- 1987-09-15 FR FR8712782A patent/FR2604090B1/fr not_active Expired - Fee Related
- 1987-09-17 PT PT85747A patent/PT85747B/pt not_active IP Right Cessation
- 1987-09-17 BE BE8701047A patent/BE1000616A5/fr not_active IP Right Cessation
- 1987-09-17 HU HU874139A patent/HU202101B/hu not_active IP Right Cessation
- 1987-09-17 DK DK488287A patent/DK488287A/da not_active Application Discontinuation
- 1987-09-17 US US07/097,943 patent/US4938967A/en not_active Expired - Fee Related
- 1987-09-17 IT IT8767796A patent/IT1211484B/it active
- 1987-09-17 CH CH3591/87A patent/CH674146A5/fr not_active IP Right Cessation
- 1987-09-17 AU AU78481/87A patent/AU606353B2/en not_active Ceased
- 1987-09-18 KR KR1019870010376A patent/KR890004686B1/ko not_active IP Right Cessation
-
1992
- 1992-04-02 GR GR920400623T patent/GR3004268T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA1302259C (en) | 1992-06-02 |
AU7848187A (en) | 1988-03-24 |
GR3004268T3 (es) | 1993-03-31 |
EP0265061B1 (en) | 1992-01-08 |
DK488287D0 (da) | 1987-09-17 |
KR890004686B1 (ko) | 1989-11-25 |
PT85747A (en) | 1987-10-01 |
IT1211484B (it) | 1989-11-03 |
EP0265061A1 (en) | 1988-04-27 |
GB8721186D0 (en) | 1987-10-14 |
DK488287A (da) | 1988-03-19 |
CH674146A5 (es) | 1990-05-15 |
AU606353B2 (en) | 1991-02-07 |
IT8767796A0 (it) | 1987-09-17 |
NZ221805A (en) | 1991-02-26 |
KR880003617A (ko) | 1988-05-28 |
IL83897A (en) | 1991-06-10 |
DE3775880D1 (es) | 1992-02-20 |
PT85747B (pt) | 1991-02-08 |
IL83897A0 (en) | 1988-02-29 |
HU202101B (en) | 1991-02-28 |
FR2604090B1 (fr) | 1990-06-15 |
BE1000616A5 (fr) | 1989-02-21 |
FR2604090A1 (fr) | 1988-03-25 |
ATE71293T1 (de) | 1992-01-15 |
US4938967A (en) | 1990-07-03 |
HUT45194A (en) | 1988-06-28 |
GB2196252B (en) | 1990-10-17 |
GB2196252A (en) | 1988-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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