KR890000765B1 - 아로일이미다졸론 및 그의 제조방법 - Google Patents

아로일이미다졸론 및 그의 제조방법 Download PDF

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Publication number
KR890000765B1
KR890000765B1 KR8200933A KR820000933A KR890000765B1 KR 890000765 B1 KR890000765 B1 KR 890000765B1 KR 8200933 A KR8200933 A KR 8200933A KR 820000933 A KR820000933 A KR 820000933A KR 890000765 B1 KR890000765 B1 KR 890000765B1
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KR
South Korea
Prior art keywords
hydrogen
pyridyl
dihydro
methyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8200933A
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English (en)
Korean (ko)
Other versions
KR830009046A (ko
Inventor
리차드 시. 데이지
프랭크 피. 팔로폴리
리차드 에이. 쉔틀러
제이.마아틴 그리사
Original Assignee
조세프 지. 템플, 제이 알.
메렐 다우 파마슈티칼스 인코포레이티드
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Filing date
Publication date
Application filed by 조세프 지. 템플, 제이 알., 메렐 다우 파마슈티칼스 인코포레이티드 filed Critical 조세프 지. 템플, 제이 알.
Publication of KR830009046A publication Critical patent/KR830009046A/ko
Application granted granted Critical
Publication of KR890000765B1 publication Critical patent/KR890000765B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR8200933A 1981-03-05 1982-03-04 아로일이미다졸론 및 그의 제조방법 Expired KR890000765B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24088981A 1981-03-05 1981-03-05
US240889 1981-03-05
US314312 1981-10-23
US06/314,312 US4405628A (en) 1981-03-05 1981-10-23 4-Pyridylimidazolones and method of use

Publications (2)

Publication Number Publication Date
KR830009046A KR830009046A (ko) 1983-12-17
KR890000765B1 true KR890000765B1 (ko) 1989-04-05

Family

ID=26933806

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8200933A Expired KR890000765B1 (ko) 1981-03-05 1982-03-04 아로일이미다졸론 및 그의 제조방법

Country Status (18)

Country Link
US (1) US4405628A (enExample)
EP (1) EP0059948B1 (enExample)
KR (1) KR890000765B1 (enExample)
AT (1) ATE16489T1 (enExample)
AU (1) AU557590B2 (enExample)
CA (1) CA1190550A (enExample)
DE (1) DE3267352D1 (enExample)
DK (1) DK168627B1 (enExample)
ES (2) ES510087A0 (enExample)
GB (1) GB2096600B (enExample)
GR (1) GR76518B (enExample)
HK (1) HK61686A (enExample)
IE (1) IE52387B1 (enExample)
IL (1) IL65137A (enExample)
MY (1) MY8600700A (enExample)
NO (1) NO157175C (enExample)
NZ (1) NZ199885A (enExample)
PH (1) PH18345A (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4552880A (en) * 1983-02-15 1985-11-12 Merrell Dow Pharmaceuticals Inc. Aroylimidazolones
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity
US4556665A (en) * 1984-07-09 1985-12-03 Schering A.G. Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
US4803278A (en) * 1984-07-30 1989-02-07 Merrell Dow Pharmaceuticals, Inc. Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones
IL75902A (en) * 1984-07-30 1988-10-31 Merrell Dow Pharma Preparation of 1,3-dihydro-4-pyridoyl-2h-imidazol-2-ones
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
ZA881807B (en) * 1987-03-20 1988-09-05 Merrell Dow Pharmaceuticals Inc. Method for reducing reperfusion injury with imidazol-2-thiones
ZA887662B (en) * 1987-10-19 1989-06-28 Merrell Dow Pharma Method for reducing reperfusion injury with imidazol-2-thione-carboxamides
AU8212491A (en) * 1990-06-29 1992-01-23 Upjohn Company, The Substituted 1-(alkoxyphenyl)piperazines with cns and antihypertensive activity
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP3718557A3 (en) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
HK1220696A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 鸟苷酸环化酶激动剂及其用途
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones
NZ193935A (en) * 1979-06-18 1985-05-31 Richardson Merrell Inc 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions
ZA803332B (en) * 1979-06-18 1981-01-28 Richardson Merrell Inc Novel 4-aroylimidazol-2-ones
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones

Also Published As

Publication number Publication date
PH18345A (en) 1985-06-05
DK168627B1 (da) 1994-05-09
ES8305352A1 (es) 1983-04-16
GR76518B (enExample) 1984-08-10
ES510087A0 (es) 1983-04-16
NO157175B (no) 1987-10-26
AU557590B2 (en) 1986-12-24
ATE16489T1 (de) 1985-11-15
NO157175C (no) 1988-02-03
IL65137A (en) 1987-02-27
HK61686A (en) 1986-08-29
EP0059948A1 (en) 1982-09-15
EP0059948B1 (en) 1985-11-13
GB2096600B (en) 1985-06-05
ES519254A0 (es) 1984-03-01
NO820686L (no) 1982-09-06
NZ199885A (en) 1985-04-30
US4405628A (en) 1983-09-20
AU8103782A (en) 1982-09-09
ES8402827A1 (es) 1984-03-01
MY8600700A (en) 1986-12-31
KR830009046A (ko) 1983-12-17
GB2096600A (en) 1982-10-20
CA1190550A (en) 1985-07-16
DK95482A (da) 1982-09-06
IE820491L (en) 1982-09-05
IE52387B1 (en) 1987-10-14
DE3267352D1 (en) 1985-12-19
IL65137A0 (en) 1982-05-31

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