GB2096600B - Aroylimidazolones and analogues thereof - Google Patents

Aroylimidazolones and analogues thereof

Info

Publication number
GB2096600B
GB2096600B GB8206412A GB8206412A GB2096600B GB 2096600 B GB2096600 B GB 2096600B GB 8206412 A GB8206412 A GB 8206412A GB 8206412 A GB8206412 A GB 8206412A GB 2096600 B GB2096600 B GB 2096600B
Authority
GB
United Kingdom
Prior art keywords
aroylimidazolones
analogues
aroylimidazole
cardiotonics
ones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8206412A
Other languages
English (en)
Other versions
GB2096600A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of GB2096600A publication Critical patent/GB2096600A/en
Application granted granted Critical
Publication of GB2096600B publication Critical patent/GB2096600B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
GB8206412A 1981-03-05 1982-03-04 Aroylimidazolones and analogues thereof Expired GB2096600B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24088981A 1981-03-05 1981-03-05
US06/314,312 US4405628A (en) 1981-03-05 1981-10-23 4-Pyridylimidazolones and method of use

Publications (2)

Publication Number Publication Date
GB2096600A GB2096600A (en) 1982-10-20
GB2096600B true GB2096600B (en) 1985-06-05

Family

ID=26933806

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8206412A Expired GB2096600B (en) 1981-03-05 1982-03-04 Aroylimidazolones and analogues thereof

Country Status (18)

Country Link
US (1) US4405628A (enExample)
EP (1) EP0059948B1 (enExample)
KR (1) KR890000765B1 (enExample)
AT (1) ATE16489T1 (enExample)
AU (1) AU557590B2 (enExample)
CA (1) CA1190550A (enExample)
DE (1) DE3267352D1 (enExample)
DK (1) DK168627B1 (enExample)
ES (2) ES510087A0 (enExample)
GB (1) GB2096600B (enExample)
GR (1) GR76518B (enExample)
HK (1) HK61686A (enExample)
IE (1) IE52387B1 (enExample)
IL (1) IL65137A (enExample)
MY (1) MY8600700A (enExample)
NO (1) NO157175C (enExample)
NZ (1) NZ199885A (enExample)
PH (1) PH18345A (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4552880A (en) * 1983-02-15 1985-11-12 Merrell Dow Pharmaceuticals Inc. Aroylimidazolones
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity
US4556665A (en) * 1984-07-09 1985-12-03 Schering A.G. Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
US4803278A (en) * 1984-07-30 1989-02-07 Merrell Dow Pharmaceuticals, Inc. Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones
CA1262732C (en) * 1984-07-30 1989-11-07 PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES
ZA881807B (en) * 1987-03-20 1988-09-05 Merrell Dow Pharmaceuticals Inc. Method for reducing reperfusion injury with imidazol-2-thiones
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
ZA887662B (en) * 1987-10-19 1989-06-28 Merrell Dow Pharma Method for reducing reperfusion injury with imidazol-2-thione-carboxamides
WO1992000282A1 (en) * 1990-06-29 1992-01-09 The Upjohn Company Substituted 1-(alkoxyphenyl)piperazines with cns and antihypertensive activity
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (en) 2011-03-01 2024-03-05 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
HK1218629A1 (zh) 2013-02-25 2017-03-03 Bausch Health Ireland Limited 用於结肠清洁的鸟苷酸环化酶受体激动剂
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones
NZ193935A (en) * 1979-06-18 1985-05-31 Richardson Merrell Inc 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions
ZA803332B (en) * 1979-06-18 1981-01-28 Richardson Merrell Inc Novel 4-aroylimidazol-2-ones
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones

Also Published As

Publication number Publication date
NZ199885A (en) 1985-04-30
ES8402827A1 (es) 1984-03-01
GB2096600A (en) 1982-10-20
DK95482A (da) 1982-09-06
AU557590B2 (en) 1986-12-24
US4405628A (en) 1983-09-20
DK168627B1 (da) 1994-05-09
AU8103782A (en) 1982-09-09
EP0059948A1 (en) 1982-09-15
DE3267352D1 (en) 1985-12-19
IE820491L (en) 1982-09-05
PH18345A (en) 1985-06-05
NO157175B (no) 1987-10-26
EP0059948B1 (en) 1985-11-13
ATE16489T1 (de) 1985-11-15
HK61686A (en) 1986-08-29
IE52387B1 (en) 1987-10-14
NO820686L (no) 1982-09-06
NO157175C (no) 1988-02-03
KR890000765B1 (ko) 1989-04-05
GR76518B (enExample) 1984-08-10
ES8305352A1 (es) 1983-04-16
ES519254A0 (es) 1984-03-01
IL65137A0 (en) 1982-05-31
IL65137A (en) 1987-02-27
CA1190550A (en) 1985-07-16
MY8600700A (en) 1986-12-31
KR830009046A (ko) 1983-12-17
ES510087A0 (es) 1983-04-16

Similar Documents

Publication Publication Date Title
GB2096600B (en) Aroylimidazolones and analogues thereof
EP0179808A4 (en) MEDICINAL COMPOSITION SUITABLE FOR TREATING OR PROPHYLAXIS OF HEART DISORDERS.
ATE7387T1 (de) Herstellung des calciumsalzes von alpha-hydroxy- gamma-methylmercaptobuttersaeure.
JPS57122085A (en) Circulatory disease extirpenter and use
IE822519L (en) Phosphonic acid derivatives
DE3778587D1 (de) Herzschrittmacher zur stimulierung des menschlichen herzens.
DE3261760D1 (en) Pharmaceutical compositions for the treatment of skin
NZ218238A (en) Thiazolone derivatives and pharmaceutical compositions
DE3462688D1 (en) 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane useful in combating diseases
DE3373978D1 (en) Composition for the care or treatment of the human skin
DE3686472D1 (de) Cardiotonische phenyloxazolone.
IT8519042A0 (it) Impiego di chinoloni nel trattamento di malattie cardiache.!
ES8504182A1 (es) Procedimiento para preparar nuevos derivados de piperidina
GR75239B (enExample)
DE3776488D1 (enExample)
IT8324141A0 (it) Preparato per la cura delle ustioni.
DE3564763D1 (en) Appliance for the lung treatment of man or animal
FI871737A0 (fi) Kraftanlaeggning med foerbraenning i en fluidiserad baedd.
ES530605A0 (es) Procedimiento para fabricar compuestos piperidinonicos eficaces en el tratamiento de cardiopatias
IT1167065B (it) Procedimento per la produzione di callicreina umana

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20000304