KR880011158A - 기관지확장제의 치환된 1,2,4- 트리아조로[1,5-a] 트리아진 - Google Patents

기관지확장제의 치환된 1,2,4- 트리아조로[1,5-a] 트리아진 Download PDF

Info

Publication number
KR880011158A
KR880011158A KR1019880002150A KR880002150A KR880011158A KR 880011158 A KR880011158 A KR 880011158A KR 1019880002150 A KR1019880002150 A KR 1019880002150A KR 880002150 A KR880002150 A KR 880002150A KR 880011158 A KR880011158 A KR 880011158A
Authority
KR
South Korea
Prior art keywords
triazolo
triazine
ethyl
compound
methyl
Prior art date
Application number
KR1019880002150A
Other languages
English (en)
Other versions
KR960010791B1 (ko
Inventor
조셉 웨이드 제임스
Original Assignee
윌리암 조오지 메레디스
라이커 레보러토리스, 인코오포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 윌리암 조오지 메레디스, 라이커 레보러토리스, 인코오포레이티드 filed Critical 윌리암 조오지 메레디스
Publication of KR880011158A publication Critical patent/KR880011158A/ko
Application granted granted Critical
Publication of KR960010791B1 publication Critical patent/KR960010791B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

기관지확장제의 치환된 1,2,4-트리아조로[1,5-a]트리아진
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기식의 화합물 또는 그것이 약학적 허용산-부가 염
    (이식에서 R2는 수소, 저급알킬 또는 페닐; R5는 저급알킬; R7은 메톡시, 메틸티오 또는이며 X는 각각 산소, 황, 메틸렌, 아미도 또는 저급 N-알킬이미도 임)
  2. 제1항에 있어서, X가 황 또는 산소인 화합물.
  3. 제1항에 있어서, 5-에틸-7-(4-티오로르프리노)-1,2,4-트리아조로[1,5-a] 트리아진, 5-에틸-7-(4-모르포리노)-1,2,4-트리아조로[1,5-a]트리아진, 5-메틸-7-메틸티오-1,2,4-트리아조로[1,5-a]트리아진, 5-메틸-7[1-(4-메틸피페라지노)]-1,2,4-트리아조로[1,5-a]트리아진, 5-에틸-2-메틸-7-메틸티오-1,2,4-트리아조로[1,5-a]트리아진, 5-에틸-2-메틸-7-(모르포리노)-1,2,4-트리아조로[1,5-a]트리아진, 5-에틸-7-[1-(4-메틸피페라지노)-1,2,4-트리아조로[1,5-a]트리아진, 5-에틸-2-메틸-7-(4-티오모르포리노)-1,2,4-트리아조로[1,5-a]트리아진, 5-에틸-2-메틸-7-[1-(4-메틸피페라지노)]-1,2,4-트리아조로[1,5-a]트리아진, 5-에틸-7-메톡시-1,2,4-트리아조로[1,5-a]트리아진, 2,5-디메틸-7-(4-티오모르포리노)-1,2,4-트리아조로[1,5-a]트리아진, 2,5-디에틸-7-(4-모르포리노)-1,2,4-트리아조로[1,5-a]르리아진, 2,5-디에틸-7-(4-티오모르포리노)-1,2,4-트리아조로[1,5-a]트리아진으로부터 선택되는 화합물.
  4. 기관지 확장을 유도하기에 충분한 양의 제1항에서의 화합물과 약학적 허용 담체를 포함하는 기관지 확장제 약학 조성물.
  5. 하기식의 화합물 또는 그것의 약학적 허용산부가염을 기관지 확장을 유도하기에 충분한 양으로 투여하여 포유동물에서 기관지 확장을 유도하는 방법.
    (이식에서 R2는 수소, 저급알킬 또는 페닐; R5는 저급알킬 ; R7은 메톡시, 메틸티오 또는로, X는 산소, 황메틸렌, 이미도 또는 저급 N-아킬이미도 임)
  6. 제5항에 있어서, X가 황 또는 산소인 것을 특징으로 하는 방법.
  7. 제5항에 있어서, 그 화합물이 경구적으로 투여됨을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880002150A 1987-03-02 1988-03-02 기관지확장제로서의 치환된 1,2,4-트리아졸로[1,5-a]트리아진 KR960010791B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/020,861 US4734413A (en) 1987-03-02 1987-03-02 Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators
US020,861 1987-03-02
US020861 1987-03-03

Publications (2)

Publication Number Publication Date
KR880011158A true KR880011158A (ko) 1988-10-26
KR960010791B1 KR960010791B1 (ko) 1996-08-08

Family

ID=21800994

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880002150A KR960010791B1 (ko) 1987-03-02 1988-03-02 기관지확장제로서의 치환된 1,2,4-트리아졸로[1,5-a]트리아진

Country Status (5)

Country Link
US (1) US4734413A (ko)
EP (1) EP0281367B1 (ko)
KR (1) KR960010791B1 (ko)
CA (1) CA1311753C (ko)
DE (1) DE3889362T2 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592734B2 (en) 2008-03-17 2013-11-26 Lg Electronics Inc. Heater holder and electric hob including the same

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981850A (en) * 1988-02-05 1991-01-01 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators
IE64917B1 (en) * 1988-02-05 1995-09-20 Riker Laboratories Inc Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators
US5089493A (en) * 1988-02-05 1992-02-18 Riker Laboratories, Inc. Triazolo[1,5-C]pyrimido[1,4]azines as bronchodilators
US5166343A (en) * 1988-02-05 1992-11-24 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimido[1,4]-azines as bronchodilators
EP0459702A1 (en) * 1990-05-29 1991-12-04 Zeneca Limited Azole Derivatives
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9125002D0 (en) * 1991-11-25 1992-01-22 Ici Plc Azole derivatives
US6423844B1 (en) 2001-06-06 2002-07-23 The United States Of America As Represented By The Secretary Of The Navy Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine
DE102006033572A1 (de) * 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1579932A (en) * 1976-05-12 1980-11-26 Ici Ltd Herbicidal triazolotriazines
DD205905A1 (de) * 1982-08-17 1984-01-11 Univ Rostock Verfahren zur herstellung von substituierten 1,2,4-triazolo (2,3-a)-1,3,5-triazinen
AU2192683A (en) * 1982-12-30 1984-07-05 Biomeasure Incorporated Pyrazolo(1,5-alpha)-1,3,5-triazines
US4572910A (en) * 1983-03-03 1986-02-25 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4685958A (en) * 1986-05-06 1987-08-11 The Dow Chemical Company Sulfonamides derived from substituted 2-amino-1,2,4-triazolo[1,5-a]-1,3,5-triazines and compositions and methods of controlling undesired vegetation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592734B2 (en) 2008-03-17 2013-11-26 Lg Electronics Inc. Heater holder and electric hob including the same

Also Published As

Publication number Publication date
CA1311753C (en) 1992-12-22
DE3889362T2 (de) 1994-11-17
KR960010791B1 (ko) 1996-08-08
US4734413A (en) 1988-03-29
DE3889362D1 (de) 1994-06-09
EP0281367A1 (en) 1988-09-07
EP0281367B1 (en) 1994-05-04

Similar Documents

Publication Publication Date Title
KR880011158A (ko) 기관지확장제의 치환된 1,2,4- 트리아조로[1,5-a] 트리아진
KR880011142A (ko) 피페라지닐-헤테로 시클릭 화합물
ATE60761T1 (de) Chinazolinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
FI945706A (fi) Proteiinikinaasi C-inhibiittoreita
ATE51231T1 (de) Pyrimidopyrimidinderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als antiallergische mittel.
KR930702312A (ko) 피리미딘 유도체 및 의약
ATE4709T1 (de) Substituierte imidazole, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
SE8703169D0 (sv) 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h-2,3-benzodiazepine, acid addition salts thereof and process for preparing same
DK0598770T3 (da) Pyrazinderivater samt fremstilling og anvendelse deraf
KR840006475A (ko) 나프탈렌 유도체의 제조방법
KR840005076A (ko) A-21978c 사이클릭펩티드 유도체의 제조방법
DE3686979D1 (de) Cephemverbindungen und verfahren zu ihrer herstellung.
DK282285A (da) Hidtil ukendte 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidiner,deres fremstilling og laegemidler indeholdende disse forbindelser
KR890014542A (ko) 4-치환된 피라졸로[3,4-d] 피리미딘 유도체
DK0461574T3 (da) Lægemidler indeholdende 3,7-diazabicyclo(3,3,1)-nonanforbindelser
PT82175A (de) Neue 3-pyridylmethylnaphthylderivate verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE139441T1 (de) Verwendung von 2-iminothiazolidin-4-onderivaten als neuartige arzneimittelwirkstoffe
PT89000A (pt) Processo para a preparacao de composicoes farmaceuticas e veterinarias analgesicas contendo pirimidinas
ATE42291T1 (de) Spiro(indolo(1,7-ab>(1,5>benzodiazepin-2,4'piperidine> und zwischenprodukte, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.
DE3764918D1 (de) 2,6-piperazin-dion-derivate, ihre verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
FI934854A0 (fi) Lagerstabila loesningar av karboniserad magnesiumetylat i etanol, samt deras framstaellning och anvaendning
AU7934182A (en) Tricyclic compounds
ATE25968T1 (de) 1,1-diphenylpropanol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE27278T1 (de) Thieno(2,3-6)pyrrolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
DK298085A (da) Pyrrolo(1,2-b)(1,2,5)triazepiner, deres fremstilling og anvendelse som laegemiddel, samt ved fremstillingen anvendelige mellemprodukter

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee