KR880005137A - 항균제-ⅱ - Google Patents

항균제-ⅱ Download PDF

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Publication number
KR880005137A
KR880005137A KR870011656A KR870011656A KR880005137A KR 880005137 A KR880005137 A KR 880005137A KR 870011656 A KR870011656 A KR 870011656A KR 870011656 A KR870011656 A KR 870011656A KR 880005137 A KR880005137 A KR 880005137A
Authority
KR
South Korea
Prior art keywords
amino
compound
alkyl
cyclopropyl
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR870011656A
Other languages
English (en)
Korean (ko)
Inventor
미카엘 도마갈라 존
프레드리히 미츠 토마스
피터 산체쯔 죠세프
Original Assignee
크리스틴 에이.트라우트웨인
워너-램버트 컴패니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 크리스틴 에이.트라우트웨인, 워너-램버트 컴패니 filed Critical 크리스틴 에이.트라우트웨인
Publication of KR880005137A publication Critical patent/KR880005137A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR870011656A 1986-10-20 1987-10-20 항균제-ⅱ Ceased KR880005137A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/920,536 US4822801A (en) 1984-07-20 1986-10-20 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US920536 1986-10-20

Publications (1)

Publication Number Publication Date
KR880005137A true KR880005137A (ko) 1988-06-28

Family

ID=25443916

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870011656A Ceased KR880005137A (ko) 1986-10-20 1987-10-20 항균제-ⅱ

Country Status (17)

Country Link
US (1) US4822801A (enExample)
EP (1) EP0265230B1 (enExample)
JP (2) JP2750117B2 (enExample)
KR (1) KR880005137A (enExample)
AT (1) ATE71375T1 (enExample)
AU (1) AU643489B2 (enExample)
CA (1) CA1336089C (enExample)
DE (1) DE3775882D1 (enExample)
DK (1) DK543787A (enExample)
ES (1) ES2040261T3 (enExample)
FI (1) FI874570A7 (enExample)
GR (1) GR3003548T3 (enExample)
IE (1) IE64492B1 (enExample)
NO (1) NO874350L (enExample)
PH (3) PH24199A (enExample)
PT (1) PT85943B (enExample)
ZA (1) ZA877887B (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
AU618823B2 (en) * 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
DK0525057T3 (da) 1990-04-18 2000-07-31 Procter & Gamble Pharma Antimikrobielle quinolonyllactamer
ES2167329T3 (es) * 1992-01-31 2002-05-16 Chugai Pharmaceutical Co Ltd Cristal de hidrato de derivado de acido quinolonacarboxilico.
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
KR970704693A (ko) * 1994-07-18 1997-09-06 나가히로 마오미 트리플루오로메틸퀴놀린카르복실산 유도체(trifluoromethylquinolinecarboxylic acid derivative)
US5602254A (en) * 1995-05-26 1997-02-11 Warner-Lambert Company Method for making quinoline carboxylic acids or naphthyridine carboxylic acids in free base form
DE19652239A1 (de) 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
ATE423776T1 (de) 1997-09-15 2009-03-15 Procter & Gamble Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) * 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
ATE443064T1 (de) * 2002-03-18 2009-10-15 Kyorin Seiyaku Kk 10-(3-cyclo propyl amino methyl-1-pyrrolidinyl) pyridobenzoxazin carbonsäure derivat mit wirkung gegen resistente bakterien
US6664267B1 (en) * 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
EP1660495B1 (en) 2003-09-04 2007-07-11 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
SI1666477T1 (sl) * 2003-09-10 2013-10-30 Kyorin Pharmaceutical Co., Ltd. Derivati 7-(4-substituiran 3-ciklopropilaminometil-1-pirolidinil) kinolonkarboksilne kisline
WO2005111030A1 (en) * 2004-05-12 2005-11-24 Warner-Lambert Company Llc Quinolone antibacterial agents
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
KR101419554B1 (ko) 2006-03-13 2014-07-17 교린 세이야꾸 가부시키 가이샤 Ｇｓｋ­３ 억제제로서 아미노퀴놀론
PT2001862E (pt) * 2006-03-28 2011-07-20 Warner Chilcott Co Llc Sais de malato e polimorfos do ácido (3s,5s)-7-[3- amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro- 8-metoxi-4-oxo-3-quinolinocarboxílico
WO2007110836A1 (en) * 2006-03-28 2007-10-04 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
BRPI0709220A2 (pt) * 2006-03-28 2011-07-12 Procter & Gamble processo de acoplamento para preparo de intermediários de quinolona
US8222407B2 (en) * 2007-05-24 2012-07-17 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
BRPI0816798A2 (pt) 2007-09-11 2016-10-11 Activx Biosciences Inc composto, composição farmacêutica, métodos para inibir a ação do glicogênio sintase cinase-3, e para tratar, prevenir ou melhorar uma doença, uso de um composto, e, artigo de fabricação
CN101855229A (zh) 2007-09-12 2010-10-06 埃迪威克斯生物科学公司 作为gsk-3抑制剂的螺环状氨基喹诺酮
EP2222662A4 (en) * 2007-11-15 2011-08-03 Univ Maryland INHIBITORS OF KYNURENINE AMINO TRANSFERASE
BRPI1008974A2 (pt) * 2009-03-11 2017-06-06 Kyorin Seiyaku Kk composto, composição farmacêutica, e, método para tratar, prevenir ou melhorar uma doença mediada com gsk-3
US9573902B2 (en) * 2013-02-15 2017-02-21 Laurus Labs Private Ltd. Process for the preparation of Ivacaftor and its intermediates
KR102213991B1 (ko) * 2014-05-20 2021-02-09 동화약품주식회사 개선된 자보플록사신의 제조방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049811A (en) * 1968-07-23 1977-09-20 Boehringer Mannheim G.M.B.H. Compositions using cycloalkano-quinolone derivatives and their method of use
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
US4604401A (en) * 1984-07-20 1986-08-05 Warner-Lambert Company Antibacterial agents III
AU576272B2 (en) * 1984-11-13 1988-08-18 Kyorin Pharmaceutical Co. Ltd. Quinolone carboxylic acid derivates
AU578793B2 (en) * 1985-02-15 1988-11-03 Dainippon Pharmaceutical Co. Ltd. Novel 1,8-naphthyridine derivatives and processes for preparation thereof
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPH0720940B2 (ja) * 1986-02-28 1995-03-08 大日本製薬株式会社 キノリン誘導体の製造法
US4780408A (en) * 1986-03-26 1988-10-25 Colorado State University Research Foundation Antibody for detection and quantification of trifluralin
JPH0720941B2 (ja) * 1986-03-28 1995-03-08 大日本製薬株式会社 新規キノロン誘導体、そのエステルおよびその塩
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
JPS63152318A (ja) * 1986-08-07 1988-06-24 Dainippon Pharmaceut Co Ltd 抗マイコプラズマ剤

Also Published As

Publication number Publication date
ATE71375T1 (de) 1992-01-15
IE64492B1 (en) 1995-08-09
NO874350L (no) 1988-04-21
AU7987987A (en) 1988-04-21
FI874570A7 (fi) 1988-04-21
PT85943A (en) 1987-11-01
IE872590L (en) 1988-04-20
PH25423A (en) 1991-07-01
JPH10114779A (ja) 1998-05-06
US4822801A (en) 1989-04-18
GR3003548T3 (enExample) 1993-03-16
JP3235539B2 (ja) 2001-12-04
EP0265230A1 (en) 1988-04-27
ZA877887B (en) 1989-05-30
DK543787A (da) 1988-04-21
DE3775882D1 (de) 1992-02-20
AU606618B2 (en) 1991-02-14
AU6920591A (en) 1991-03-28
CA1336089C (en) 1995-06-27
AU643489B2 (en) 1993-11-18
PT85943B (pt) 1990-07-31
JPS63104974A (ja) 1988-05-10
ES2040261T3 (es) 1993-10-16
PH24199A (en) 1990-04-10
EP0265230B1 (en) 1992-01-08
PH25459A (en) 1991-07-01
DK543787D0 (da) 1987-10-16
NO874350D0 (no) 1987-10-19
FI874570A0 (fi) 1987-10-16
JP2750117B2 (ja) 1998-05-13

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