KR880003985A - 블록 공중합체 및 시약운반시스템으로 이것의 사용 - Google Patents
블록 공중합체 및 시약운반시스템으로 이것의 사용 Download PDFInfo
- Publication number
- KR880003985A KR880003985A KR870009842A KR870009842A KR880003985A KR 880003985 A KR880003985 A KR 880003985A KR 870009842 A KR870009842 A KR 870009842A KR 870009842 A KR870009842 A KR 870009842A KR 880003985 A KR880003985 A KR 880003985A
- Authority
- KR
- South Korea
- Prior art keywords
- block
- copolymer
- oxide
- delivery system
- cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims 8
- 229920001400 block copolymer Polymers 0.000 title claims 7
- -1 glycolic acid ester Chemical class 0.000 claims 8
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 150000004292 cyclic ethers Chemical class 0.000 claims 3
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical group O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- 229920005604 random copolymer Polymers 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 102000018997 Growth Hormone Human genes 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 229920000428 triblock copolymer Polymers 0.000 claims 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/903,801 US4882168A (en) | 1986-09-05 | 1986-09-05 | Polyesters containing alkylene oxide blocks as drug delivery systems |
| US06/903,797 US4716203A (en) | 1986-09-05 | 1986-09-05 | Diblock and triblock copolymers |
| US903801 | 1986-09-05 | ||
| US903797 | 1986-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR880003985A true KR880003985A (ko) | 1988-05-31 |
Family
ID=27129378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR870009842A Ceased KR880003985A (ko) | 1986-09-05 | 1987-09-04 | 블록 공중합체 및 시약운반시스템으로 이것의 사용 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0258780B1 (enExample) |
| KR (1) | KR880003985A (enExample) |
| AU (1) | AU605172B2 (enExample) |
| BR (1) | BR8704648A (enExample) |
| CA (1) | CA1283988C (enExample) |
| DE (1) | DE3786309T2 (enExample) |
| DK (1) | DK462287A (enExample) |
| ES (1) | ES2058081T3 (enExample) |
| FI (1) | FI873840A7 (enExample) |
| GR (1) | GR3008526T3 (enExample) |
| HU (1) | HU205711B (enExample) |
| IL (1) | IL83764A (enExample) |
| NZ (1) | NZ221647A (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9401703A (nl) * | 1994-10-14 | 1996-05-01 | Rijksuniversiteit | Kauwgom. |
| US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
| US5702717A (en) * | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
| DE19726412A1 (de) * | 1997-06-21 | 1998-12-24 | Merck Patent Gmbh | Implantatmaterial mit einer Träger-Wirkstoff-Kombination |
| ATE290037T1 (de) * | 1997-10-03 | 2005-03-15 | Macromed Inc | Biologisch abbaubare triblock-poly(lactide-co- glycolide)-polyethylenglycol-copolymere mit umgekehrter thermischer gelierung |
| US6117949A (en) * | 1998-10-01 | 2000-09-12 | Macromed, Inc. | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6004573A (en) * | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6201072B1 (en) | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US7018645B1 (en) | 2000-04-27 | 2006-03-28 | Macromed, Inc. | Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties |
| WO2002076227A1 (en) | 2001-03-23 | 2002-10-03 | Gumlink A/S | Coated degradable chewing gum with improved shelf life and process for preparing same |
| US20040180111A1 (en) * | 2001-03-23 | 2004-09-16 | Lone Andersen | Degradable resin substitute for chewing gum |
| JP2004535431A (ja) | 2001-06-22 | 2004-11-25 | サザン バイオシステムズ, インコーポレイテッド | ゼロ次長期放出同軸インプラント |
| EP1476489B8 (en) * | 2002-02-15 | 2008-10-08 | Nektar Therapeutics Al, Corporation | Hydrolytically degradable alkylene oxide based polymers |
| WO2003092468A2 (en) | 2002-04-29 | 2003-11-13 | Gel-Del Technologies, Inc. | Biomatrix structural containment and fixation systems and methods of use thereof |
| CN1290893C (zh) * | 2002-05-03 | 2006-12-20 | 詹森药业有限公司 | 聚合物微乳状液 |
| US7649023B2 (en) | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
| BR122012021252B8 (pt) | 2002-09-06 | 2021-05-25 | Cerulean Pharma Inc | polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência |
| WO2004028266A1 (en) | 2002-09-24 | 2004-04-08 | Gumlink A/S | Biodegradable chewing gum comprising at least one high molecular weight biodegradable polymer |
| US8293295B2 (en) | 2002-09-24 | 2012-10-23 | Gumlink A/S | Chewing gum comprising at least two different biodegradable polymers |
| ATE405170T1 (de) | 2003-05-06 | 2008-09-15 | Gumlink As | Methode zur herstellung von kaugummigranulat und komprimierten kaugummiprodukten, sowie ein kaugummigranuliersystem |
| DK1474995T3 (da) | 2003-05-06 | 2013-02-18 | Gumlink As | Fremgangsmåde til fremstilling af tyggegummigranulater, et gummisammensætningsekstruder- og granuleringssystem og et tyggegummiprodukt |
| US8465537B2 (en) | 2003-06-17 | 2013-06-18 | Gel-Del Technologies, Inc. | Encapsulated or coated stent systems |
| EP1660013A4 (en) | 2003-08-26 | 2011-07-20 | Gel Del Technologies Inc | BIOMATERIAL AND PROTEIN BIOCOACERVATES, METHODS OF MAKING AND USING THEM |
| CA2548822C (en) | 2003-12-08 | 2015-08-11 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
| JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
| AU2008345047A1 (en) | 2007-12-26 | 2009-07-09 | Gel-Del Technologies, Inc. | Biocompatible protein particles, particle devices and methods thereof |
| WO2010057177A2 (en) | 2008-11-17 | 2010-05-20 | Gel-Del Technologies, Inc. | Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof |
| CA2774015A1 (en) | 2009-09-15 | 2011-03-24 | Cerulean Pharma Inc. | A cdp-camptothecin conjugate, particle or composition and uses thereof |
| CN103037903A (zh) | 2010-05-18 | 2013-04-10 | 天蓝制药公司 | 用于治疗自身免疫性疾病或其它疾病的组合物和方法 |
| WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
| US20230285576A1 (en) | 2020-08-05 | 2023-09-14 | Ellipses Pharma Ltd | Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3736646A (en) * | 1971-10-18 | 1973-06-05 | American Cyanamid Co | Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures |
| US4047533A (en) * | 1976-09-20 | 1977-09-13 | American Cyanamid Company | Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant |
| US4429080A (en) * | 1982-07-01 | 1984-01-31 | American Cyanamid Company | Synthetic copolymer surgical articles and method of manufacturing the same |
| US4438253A (en) * | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
| US4452973A (en) * | 1982-11-12 | 1984-06-05 | American Cyanamid Company | Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same |
-
1987
- 1987-08-25 ES ES87112279T patent/ES2058081T3/es not_active Expired - Lifetime
- 1987-08-25 EP EP87112279A patent/EP0258780B1/en not_active Expired - Lifetime
- 1987-08-25 DE DE87112279T patent/DE3786309T2/de not_active Expired - Fee Related
- 1987-09-02 NZ NZ221647A patent/NZ221647A/xx unknown
- 1987-09-03 IL IL83764A patent/IL83764A/xx not_active IP Right Cessation
- 1987-09-03 CA CA000546072A patent/CA1283988C/en not_active Expired - Fee Related
- 1987-09-04 BR BR8704648A patent/BR8704648A/pt not_active Application Discontinuation
- 1987-09-04 KR KR870009842A patent/KR880003985A/ko not_active Ceased
- 1987-09-04 DK DK462287A patent/DK462287A/da not_active Application Discontinuation
- 1987-09-04 HU HU873970A patent/HU205711B/hu not_active IP Right Cessation
- 1987-09-04 FI FI873840A patent/FI873840A7/fi not_active Application Discontinuation
- 1987-09-04 AU AU77970/87A patent/AU605172B2/en not_active Ceased
-
1993
- 1993-07-16 GR GR920403165T patent/GR3008526T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2058081T3 (es) | 1994-11-01 |
| FI873840L (fi) | 1988-03-06 |
| NZ221647A (en) | 1990-09-26 |
| HUT52945A (en) | 1990-09-28 |
| BR8704648A (pt) | 1988-04-26 |
| FI873840A7 (fi) | 1988-03-06 |
| FI873840A0 (fi) | 1987-09-04 |
| IL83764A0 (en) | 1988-02-29 |
| DE3786309D1 (de) | 1993-07-29 |
| CA1283988C (en) | 1991-05-07 |
| AU7797087A (en) | 1988-03-10 |
| EP0258780B1 (en) | 1993-06-23 |
| DK462287D0 (da) | 1987-09-04 |
| DK462287A (da) | 1988-03-06 |
| AU605172B2 (en) | 1991-01-10 |
| IL83764A (en) | 1991-05-12 |
| GR3008526T3 (enExample) | 1993-10-29 |
| DE3786309T2 (de) | 1994-02-10 |
| HU205711B (en) | 1992-06-29 |
| EP0258780A2 (en) | 1988-03-09 |
| EP0258780A3 (en) | 1988-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19870904 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19920831 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19870904 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19960418 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19960911 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19960418 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |