KR880001598A - 사이클로알킬-치환 4- 피리딜 유도체 및 이의 제조방법 - Google Patents

사이클로알킬-치환 4- 피리딜 유도체 및 이의 제조방법 Download PDF

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KR880001598A
KR880001598A KR1019870007741A KR870007741A KR880001598A KR 880001598 A KR880001598 A KR 880001598A KR 1019870007741 A KR1019870007741 A KR 1019870007741A KR 870007741 A KR870007741 A KR 870007741A KR 880001598 A KR880001598 A KR 880001598A
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cyclohexyl
dimethylpyrid
methylpyrid
ethyl
formula
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KR1019870007741A
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크루그놀라 안젤로
디 살레 엔리코
롬바르디 파올로
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비토리노 페라리오
파미탈리아 카를로 에르바 에스.피.에이.
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Priority claimed from GB868617596A external-priority patent/GB8617596D0/en
Priority claimed from GB868628029A external-priority patent/GB8628029D0/en
Application filed by 비토리노 페라리오, 파미탈리아 카를로 에르바 에스.피.에이. filed Critical 비토리노 페라리오
Publication of KR880001598A publication Critical patent/KR880001598A/ko

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

사이클로알킬-치환 4-피리딜 유도체 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식(Ⅰ)의 사이클로알킬-치환4-피리딜 유도체 및 약제학적으로 허용되는 이의 염.
    상기식에서,
    R은 C1-C4알킬이고 ;
    R1및 R2는 각기 독립적으로 수소또는 C1-C4알킬이며 ;
    n은 1내지 5의 정수이고 ;
    (a)A는이고 B는 -0-, -NH- 또는 -CH2- 이거나;
    (b)A는 -CH2-이고 B는 -0-, -NH-, -CH2- 또는 C=0이거나 ;
    (c)A는 -0- 이고 B는또는 -CH2- 이거나 ;
    (d)A는 -NH-이고 B는또는 -CH2- DLEK.
  2. 제 1항에 있어서, R의 C1-C4알킬이며;
    R1및 R2가 각기 독립적으로, 수소 또는 C1-C4알킬이며:
    n이 1내지 5의 정수이며 : A 가또는 -CH2- 이고, B가 독립적으로 -0-, -NH- 또는 -CH2- 인 일반식(Ⅰ)의 사이클로 알킬 치환된 4-피리딜 유도체 및 약제학적으로 허용되는 이의 염.
  3. 제 1항 또는 2항에 있어서, 일반식(Ⅰ)의 유도체가 일반식(Ia)의 에난티오머의 화합물.
    상기식에서,
    R, R1, R2, n, A 및 B는 제 1항 또는 2항에 정의한 바와 같다.
  4. 제 1항 내지 3항중 어느 한 항에 있어서, R1및 R2가 둘다 수소 또는 둘다 메틸이거나, 이중 하나가 수소이고 나머지가 메틸이며, n이 3 또는 4인 화합물.
  5. 사이클로 헥실(2-(4'-피리딜)프로피오네이트;
    사이클로 헥실(2-(2'-메틸피리드-4'-일)프로피오네이트;
    사이클로 헥실(2-(3'-메틸피리드-4'-일)프로피오네이트;
    사이클로 헥실(2-(2',6'-티메틸피리드-4'-일)프로피오네이트;
    사이클로 헥실(2-(2',5'-티메틸피리드-4'-일)프로피오네이트;
    사이클로 헥실(2-(2',3'-티메틸피리드-4'-일)프로피오네이트;
    사이클로 헥실(2-(2',5'-티메틸피리드-4'-일)프로피오네이트;
    N-사이클로헥실-2-(4'-피리딜)프로판아미드 ;
    N-사이클로헥실-2-(2'-메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(3'-메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(2',6'-디메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(2',5'-디메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(2',3'-디메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(2',5'-디메틸피리드-4'-일)프로판아미드 ;
    2-(4'-피리딜)프로필사이클로헥실에테르 ;
    2-(2'-메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    2-(3'-메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    2-(2',6'-디메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    2-(2',5'-디메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    2-(2',3'-디메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    2-(2',3'-디메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    2-(2',5'-디메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    N-사이클로헥실-2-(4'-피리딜)프로필아민 ;
    N-사이클로헥실-2-(2'-메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(3'-메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(2',6'-디메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(2',5'-디메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(2',3'-디메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(2',5'-디메틸피리드-4'-일)프로필아민 ;
    1-사이클로헥실-3-(4'-피리딜)-2-부탄온 ;
    1-사이클로헥실-3-(2'-메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(3'-메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(2',6'-디메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(2',5'-디메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(2',3'-디메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(3',5'-디메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(4'-피리딜)부탄 ;
    1-사이클로헥실-3-(2',-메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(3',-메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(2',6'-디메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(2',5'-디메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(2',3'-디메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(3',5'-디메틸피리드-4'-일)부탄 ;
    1-(4'-피리딜)에틸 사이클로헥산카복실레이트 ;
    1-(2'-메틸피리드-4'-일)에틸 사이클로헥산카복실레이트 ;
    1-(3'-메틸피리드-4'-일)에틸 사이클로헥산카복실레이트 ;
    1-(2',6'-디메틸피리드-4'-일)에틸 사이클로헥산카복실레이트 ;
    1-(2',5'-디메틸피리드-4'-일)에틸 사이클로헥산카복실레이트 ;
    1-(2',3'-디메틸피리드-4'-일)에틸 사이클로헥산카복실레이트 ;
    1-(3',5'-디메틸피리드-4'-일)에틸 사이클로헥산카복실레이트 ;
    1-(4'-피리딜)에틸 사이클로헥실메틸에테르 ;
    1-(2'메틸피리드-4'-일)에틸 사이클로헥실메틸 에테르 ;
    1-(3'메틸피리드-4'-일)에틸 사이클로헥실메틸 에테르 ;
    1-(2',6'-디메틸피리드-4'-일)에틸 사이클로헥실메틸 에테르 ;
    1-(2',5'-디메틸피리드-4'-일)에틸 사이클로헥실메틸 에테르 ;
    1-(2',3'-디메틸피리드-4'-일)에틸 사이클로헥실메틸 에테르 ;
    1-(3',4'-디메틸피리드-4'-일)에틸 사이클로헥실메틸 에테르 ;
    N-[1-4'-피리딜)에틸]사이클로헥산카복시아미드 ;
    N-[1-(2'-메틸피리드-4'-일)에틸]사이클로헥산카복시아미드 ;
    N-[1-(3'-메틸피리드-4'-일)에틸]사이클로헥산카복시아미드 ;
    N-[1-(2',6'-디메틸피리드-4'-일)에틸]사이클로헥산카복시아미드 ;
    N-[1-(2',5'-디메틸피리드-4'-일)에틸]사이클로헥산카복시아미드 ;
    N-[1-(2',3'-디메틸피리드-4'-일)에틸]사이클로헥산카복시아미드 ;
    N-[1-(3',5'-디메틸피리드-4'-일)에틸]사이클로헥산카복시아미드 ;
    N-[1-(4'-피리딜)에틸]사이클로헥실메틸아민 ;
    N-[1-(2'-메틸피리드-4'-일)에틸]사이클로헥실메틸아민 ;
    N-[1-(3'-메틸피리드-4'-일)에틸]사이클로헥실메틸아민 ;
    N-[1-(2',6'-디메틸피리드-4'-일)에틸]사이클로헥실메틸아민 ;
    N-[1-(2',5'-디메틸피리드-4'-일)에틸]사이클로헥실메틸아민 ;
    N-[1-(2',3'-디메틸피리드-4'-일)에틸]사이클로헥실메틸아민 ;
    N-[1-(3',5'-디메틸피리드-4'-일)에틸]사이클로헥실메틸아민 ;
    2-(4'-피리딜)프로필사이클로헥실케톤 ;
    2-(2'-메틸피리드-4'-일)프로필사이클로헥실케톤 ;
    2-(3'-메틸피리드-4'-일)프로필사이클로헥실케톤 ;
    2-(2',6'-디메틸피리드-4'-일)프로필사이클로헥실케톤 ;
    2-(2',5'-디메틸피리드-4'-일)프로필사이클로헥실케톤 ;
    2-(2',3'-디메틸피리드-4'-일)프로필사이클로헥실케톤 ;
    2-(3',5'-디메틸피리드-4'-일)프로필사이클로헥실케톤 ;
    중에서 선택된 단일 에난티오머로서 또는 라세미 혼합물서의 화합물 및 약제학적으로 허용되는 이의 염.
  6. 사이클로헥실2-(4'-피리딜)프로피오네이트 ;
    사이클로헥실2-(2'-메틸피리드-4'-일)프로피오네이트 ;
    사이클로헥실2-(3'-메틸피리드-4'-일)프로피오네이트 ;
    사이클로헥실2-(2',6'-디메틸피리드-4'-일)프로피오네이트 ;
    사이클로헥실2-(2',5'-디메틸피리드-4'-일)프로피오네이트 ;
    사이클로헥실2-(2',3'-디메틸피리드-4'-일)프로피오네이트 ;
    사이클로헥실2-(2',5'-디메틸피리드-4'-일)프로피오네이트 ;
    N-사이클로헥실-2-(4'-프리딜)프로판아미드 ;
    N-사이클로헥실-2-(2'-메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(3'-메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(2',6'-디메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(2',5'-디메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(2',3'-디메틸피리드-4'-일)프로판아미드 ;
    N-사이클로헥실-2-(3',5'-디메틸피리드-4'-일)프로판아미드 ;
    2-(4'-피리딜)프로필사이클로헥실 에테르 ;
    2-(2'-메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    2-(3'-메틸피리드-4'-일)프로필사이클로헥실 에테르 ;
    2-(2',6'-디메틸피리드-45-註)프로필사이클로헥실 에테르 ;
    2-(2',5'-디메틸피리드-45-註)프로필사이클로헥실 에테르 ;
    2-(2',3'-디메틸피리드-45-註)프로필사이클로헥실 에테르 ;
    2-(2',5'-디메틸피리드-45-註)프로필사이클로헥실 에테르 ;
    N-사이클로헥실-2-(4'-피리딜)프로필아민 ;
    N-사이클로헥실-2-(2'-메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(3'-메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(2',6'-디메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(2',5'-디메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(2',3'-디메틸피리드-4'-일)프로필아민 ;
    N-사이클로헥실-2-(3',5'-디메틸피리드-4'-일)프로필아민 ;
    1-사이클로헥실-3-(4'-피리딜)-2-부탄온 ;
    1-사이클로헥실-3-(2'-메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(3'-메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(2',6'-디메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(2',5'-디메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(2',3'-디메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(3',5'-디메틸피리드-4'-일)-2-부탄온 ;
    1-사이클로헥실-3-(4'-피리딜)부탄 ;
    1-사이클로헥실-3-(2'-메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(3'-메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(2',6'-디메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(3',5'-디메틸피리드-4'-일)부탄 ;
    1-사이클로헥실-3-(2',3'-디메틸피리드-4'-일)부탄 ; 및
    1-사이클로헥실-3-(2',5'-디메틸피리드-4'-일)부탄 ;
    중에서 선택된 단일 에난티오머로서 또는 라세미 혼합물로서의 화합물 및 약제학적으로 허용되는 이의 염.
  7. 제 5항 또는 6항에 있어서, 염이 하이드로클로라이드인 화합물의 염.
  8. (1)알킬화 반응에 의해 그룹 R을 일반식(Ⅱ)의 화합물에 도입시켜 일반식(Ⅰ)의 화합물[여기에서, R, R1,R2, 및 n은 제 1항에 정의한 바와 같고, A는이며 B는 -0-, -NH- 또는 -CH2- 이다] 을 수득하거나 ;
    (2)일반식 (Ⅲ)의 화합물 또는 이의 반응성 유도체를 일반식(Ⅳ)의 화합물과 반응시켜 일반식(Ⅰ)의화합물 [여기에서, R,R1,R2, 및 n 은 제 1항에서 정의한 바와 같고, A는 -0-, -NH- 또는 -CH2- 이며, B는 O=이다]을 수득하거나 ;
    (3)일반식(Ⅰ)의 화합물[여기에서, R, R1, R2및 n은 제1항에서 정의한 바와 같고 (i)A는 C=O이고 B는-0- 또는 NH이거나 (ⅱ) A는 -0- 또는 -NH- 이고 B는이다]을 환원시켜 상응하는 일반식(Ⅰ)의화합물[여기에서, (ⅰ')A는 -CH2-이고 B는 -0- 또는 -NH- 이거나 (ⅱ') A는 -0- 또는 NH 이고 B는 -CH2- 이다]을 수득하거나 ;
    (4) 일반식(Ⅰ)의 화합물 [여기에서, R, R1, R2, 및 n은 제1항에서 정의한 바와 같고, A는이고 B는 -CH2-이거나 A는 -CH2-이고 B는이다]을 수득하고: 필요한 경우, 일반식(I)의 화합물을 염화(Salifying)시키거나 이의 염으로 부터 일반식(I)의 유리 화합물을 수득하고/하거나, 필요한 경우, 일반식(I)의 이성체 혼합물을 단독 이성체로 분리시킴을 특징으로 하여 제1항에 따른 필요한 일반식(I)의 화합물 또는 이의 염을 제조하는 방법.
    상기식에서, B는 -0-, NH- 또는 -CH2-이고, Y는 -OH-, NH2또는 그룹 -CH2-M-X(여기에서, M은 금속이고 X는 할로겐이다)이며, R, R1, R2및 n 은 제1항에서 정의한 바와 같다.
  9. 불활성 담체 및/ 또는 희석제 및 , 활성물질로서 제 1항에 따른 일반식(Ⅰ)의 화합물, 또는 약제학적으로 허용되는 이의 염을 함유하는 약제학적 조성물.
  10. 제1항에 있어서, 아로마타제 억제제로서, 및 홀몬-의존 종양 및 전립선 중생(hyperplasia)의 치료에 사용하기 위한 일반식(Ⅰ)의 화합물 또는 이의 염.
  11. 제 9항에 있어서, 아로마타제 억제제로서, 및 홀몬-의존 종양 및 전립선 증생의 치료에 사용하기 위한 약제학적 조성물.
  12. 아로마타제 억제, 및 홀몬-의존 종양 및 전립선 중생의 치료에 활성을 갖는 제9항에 따른 약제학적 조성물의 제조에 있어서, 제1항에 따른 일반식 (Ⅰ)의 화합물 및 이의 염의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870007741A 1986-07-18 1987-07-16 사이클로알킬-치환 4- 피리딜 유도체 및 이의 제조방법 KR880001598A (ko)

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GB868617596A GB8617596D0 (en) 1986-07-18 1986-07-18 Cycloalkyl-substituted 4-pyridyl derivatives
GB8617596 1986-07-18
GB868628029A GB8628029D0 (en) 1986-11-24 1986-11-24 Cycloalkyl-substituted 4-pyridyl derivatives
GB8628029 1986-11-24

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CA (1) CA1294624C (ko)
DK (1) DK375987A (ko)
FI (1) FI873144A (ko)
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GB8701080D0 (en) * 1987-01-19 1987-02-18 Erba Farmitalia Cycloalkyl-substituted 4-aminophenyl halo derivatives
NZ242054A (en) * 1991-03-22 1993-11-25 British Tech Group Pyridine derivatives having a bridged alicyclic group; medicaments
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
KR100235976B1 (ko) * 1992-05-15 1999-12-15 말콤 카터, 리차드 케이쓰 퍼시 치환된 피리딘 화합물,이것들의 제조방법 및 약제학적 사용방법
JP3298883B2 (ja) * 1992-06-30 2002-07-08 ポハン アイアン アンド スチール カンパニー リミテッド 強力なｐａｆ拮抗剤としての新規な環式脂質誘導体
ATE287390T1 (de) 1994-10-21 2005-02-15 Nps Pharma Inc Kalzium-rezeptor aktive verbindungen
ATE430123T1 (de) 1996-05-01 2009-05-15 Nps Pharma Inc Inorganische am ionen-rezeptor aktive verbindungen
JP5383191B2 (ja) * 2005-08-15 2014-01-08 ジボダン エス エー 清涼化合物
CN108530347A (zh) * 2018-05-29 2018-09-14 湖南华腾制药有限公司 一种2-取代-4-吡啶乙酸盐酸盐的化合物及其制备方法

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GB842996A (en) * 1956-06-22 1960-08-04 Irwin Neisler & Co Pyridine derivatives
JPS5071646A (ko) * 1973-11-05 1975-06-13
GB2080808B (en) * 1980-01-25 1984-01-04 Reanal Finomvegyszergyar Process for the preparation of n-aryl-n-(mono- or disubstituted)-urea derivatives
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
MA20552A1 (fr) * 1985-10-11 1986-07-01 Pan Medica Sa Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations

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IL83163A (en) 1991-06-10
CA1294624C (en) 1992-01-21
FI873144A (fi) 1988-01-19
IL83163A0 (en) 1987-12-31
EP0253681A3 (en) 1989-08-02
HU201013B (en) 1990-09-28
PT85337A (en) 1987-08-01
NZ221059A (en) 1989-10-27
EP0253681A2 (en) 1988-01-20
DK375987A (da) 1988-01-19
HUT44506A (en) 1988-03-28
AU597691B2 (en) 1990-06-07
FI873144A0 (fi) 1987-07-16
SU1639428A3 (ru) 1991-03-30
PT85337B (pt) 1990-04-30
AU7569087A (en) 1988-01-21

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