KR880001539B1 - 2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법 - Google Patents

2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법 Download PDF

Info

Publication number
KR880001539B1
KR880001539B1 KR1019810004622A KR810004622A KR880001539B1 KR 880001539 B1 KR880001539 B1 KR 880001539B1 KR 1019810004622 A KR1019810004622 A KR 1019810004622A KR 810004622 A KR810004622 A KR 810004622A KR 880001539 B1 KR880001539 B1 KR 880001539B1
Authority
KR
South Korea
Prior art keywords
compound
carbon atoms
group
lower alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810004622A
Other languages
English (en)
Korean (ko)
Other versions
KR830007487A (ko
Inventor
폴더블류.에르하르트
제이.보르그만 로버트
피.오도넬 존
Original Assignee
이. 아이. 듀퐁 드 네모아 앤드 캄파니
도날드 에이 호스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이. 아이. 듀퐁 드 네모아 앤드 캄파니, 도날드 에이 호스 filed Critical 이. 아이. 듀퐁 드 네모아 앤드 캄파니
Publication of KR830007487A publication Critical patent/KR830007487A/ko
Application granted granted Critical
Publication of KR880001539B1 publication Critical patent/KR880001539B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019810004622A 1980-11-28 1981-11-28 2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법 Expired KR880001539B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US211,345 1980-11-28
US06/211,345 US4387103A (en) 1980-11-28 1980-11-28 Method for treatment or prophylaxis of cardiac disorders

Publications (2)

Publication Number Publication Date
KR830007487A KR830007487A (ko) 1983-10-21
KR880001539B1 true KR880001539B1 (ko) 1988-08-20

Family

ID=22786543

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004622A Expired KR880001539B1 (ko) 1980-11-28 1981-11-28 2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법

Country Status (15)

Country Link
US (1) US4387103A (https=)
EP (2) EP0053435B1 (https=)
JP (1) JPS57502123A (https=)
KR (1) KR880001539B1 (https=)
AU (1) AU546424B2 (https=)
CA (1) CA1258868A (https=)
DK (1) DK164660C (https=)
EG (1) EG16108A (https=)
GR (1) GR76921B (https=)
IL (1) IL64345A (https=)
NZ (1) NZ198889A (https=)
PH (1) PH18384A (https=)
RO (1) RO85311A (https=)
WO (1) WO1982001869A1 (https=)
ZA (1) ZA817737B (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8004088L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya substituerade 3-fenoxi-l-alkoxikarbonylalkylamino-propanol-2-er med beta-receptorblockerande egenskaper samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma och metod att ...
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4454154A (en) * 1981-06-23 1984-06-12 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
DE3248835A1 (de) * 1981-06-23 1983-06-30 American Hospital Supply Corp Zusammensetzungen fuer die behandlung von glaukom
US4582855A (en) * 1981-11-12 1986-04-15 American Hospital Supply Corporation Aromatic and esters of hydroxypropylamines
US4508725A (en) * 1982-12-22 1985-04-02 American Hospital Supply Corporation Esters of 3-(3-substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazole derivatives
US4556668A (en) * 1983-07-15 1985-12-03 American Hospital Supply Corporation Ethylenediamine derivatives of aryloxypropanolamine aryl esters having various medicinal properties
US5334601A (en) * 1984-03-14 1994-08-02 Bodor Nicholas S Soft β-adrenergic blocking agents
US5135926A (en) * 1984-03-14 1992-08-04 Bodor Nicholas S Soft β-adrenergic blocking agents
US5202347A (en) * 1984-03-14 1993-04-13 Bodor Nicholas S Soft β-adrenergic blocking agents
EP0174956B1 (en) * 1984-03-14 1990-08-16 BODOR, Nicholas S. SOFT $g(b)-ADRENERGIC BLOCKING AGENTS
EP0179808B1 (en) * 1984-04-09 1991-10-30 The Du Pont Merck Pharmaceutical Company Pharmaceutical composition suitable for treatment or prophylaxis of cardiac disorders
US4579867A (en) * 1984-04-09 1986-04-01 American Hospital Supply Corporation Stable pharmaceutical compositions of short-acting β-adrenergic receptor blocking agents
EP0279844A4 (en) 1986-09-02 1990-06-05 Du Pont AFLÖSUNG VON DE dl-METHYL-3-4- (2-HYDROXY-3-ISOPROPYLAMINO) PROPOXY] PHENYLPROPIONAT (DL-ESMOLOL)].
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
US5536749A (en) * 1994-10-13 1996-07-16 Sl Pharmaceuticals, Inc. Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents
US6197817B1 (en) * 1999-01-22 2001-03-06 Selectus Pharmaceuticals, Inc. Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders
US6756047B2 (en) * 2000-05-12 2004-06-29 The University Of Toledo Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
US7049326B2 (en) * 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
US6750238B1 (en) 2000-05-12 2004-06-15 The University Of Toledo Aralkyl ester soft drugs
WO2002009760A2 (en) * 2000-07-27 2002-02-07 Pharmacia Corporation Epoxy-steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure
EP1417962A1 (de) 2002-11-06 2004-05-12 AOP Orphan Pharmaceuticals AG Verfahren zur Herstellung eines Arzneimittels enthaltend Esmolol
JP4816083B2 (ja) * 2003-08-08 2011-11-16 小野薬品工業株式会社 短時間型β遮断薬を有効成分とする心拍数減少剤
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US20080293814A1 (en) 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
WO2009120244A1 (en) * 2008-03-24 2009-10-01 The Board Of Regents Of The University Of Texas System Image-guided therapy of myocardial disease: composition, manufacturing and applications
CN117126070A (zh) * 2023-08-25 2023-11-28 海南灵康制药有限公司 一种盐酸艾司洛尔b晶型及其制备方法和应用
CN119613359A (zh) * 2024-11-21 2025-03-14 广东京豪生物制药有限公司 盐酸艾司洛尔关键中间体的制备

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637852A (en) * 1963-08-26 1972-01-25 Boehringer Sohn Ingelheim 1-phenoxy-2-hydroxy-3-isopropylamino-propanes and salts thereof
US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes
DE1643262C3 (de) * 1967-12-13 1975-06-26 C.H. Boehringer Sohn, 6507 Ingelheim i-Phenoxy^-hydroxy-S-alklyaminopropane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
NL163775C (nl) * 1967-12-18 1980-10-15 Boehringer Sohn Ingelheim Werkwijze ter bereiding van farmaceutische preparaten met beta-receptoren blokkerende werking, alsmede werkwijze ter bereiding van 1-(cyaanfenoxy)-2-hydroxy-3-(sec.alkylamino) propaanderivaten.
US3740444A (en) * 1968-01-25 1973-06-19 Boehringer Sohn Ingelheim Therapeutic compositions and method
CA945172A (en) * 1969-02-21 1974-04-09 Imperial Chemical Industries Limited Alkanolamine derivatives
GB1285038A (en) * 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
DE1937477C3 (de) * 1969-07-23 1980-04-10 C.H. Boehringer Sohn, 6507 Ingelheim I -Phenoxy-2-hydroxy-3-(l -methylcycloalkylamino)-propane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US3705907A (en) * 1970-02-19 1972-12-12 Sandoz Ltd 4-(2-hydroxy)-3-aminopropoxy)-indole derivatives
DE2130393C3 (de) * 1970-06-22 1981-02-26 E.R. Squibb & Sons Inc., New York, N.Y. (V.St.A.) 6,7-Dihydroxy -5,6,7,8-tetrahydronaphthyloxyaminopropanole und ihre Salze mit Säuren sowie ihre Verwendung bei der Bekämpfung von Herzerkrankungen
FR2192812A1 (en) * 1972-07-20 1974-02-15 Centre Etd Ind Pharma 2-(3-Amino 2-hydroxy propoxy) thymotic acid cpds - with local anaesth-etic, anti arrhythmic and antitussive activity
AT330150B (de) * 1973-02-28 1976-06-10 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen
US3857873A (en) * 1974-02-11 1974-12-31 Warner Lambert Co 3-hydroxy-5-(3-(substituted-amino)-2-hydroxypropoxy)-benzyl alcohols
US4165374A (en) * 1976-02-09 1979-08-21 Sandoz Ltd. Thieno[3,2-c]pyridines
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
US4119718A (en) * 1977-05-02 1978-10-10 Merck & Co., Inc. 3-Amino-2-oxy-propoxy-substituted isothiazoles
FR2415622A1 (fr) * 1978-01-25 1979-08-24 Lipha Amino alcools derives de l'ortho-hydroxy cinnamate de methyle applicables notamment comme medicaments
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
JPS55124742A (en) * 1979-03-20 1980-09-26 Kyowa Hakko Kogyo Co Ltd Novel aminoalcohol derivative
SE8004087L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ...
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders

Also Published As

Publication number Publication date
DK335082A (da) 1982-07-27
US4387103A (en) 1983-06-07
CA1258868A (en) 1989-08-29
IL64345A (en) 1986-02-28
JPS57502123A (https=) 1982-12-02
NZ198889A (en) 1985-08-16
GR76921B (https=) 1984-09-04
EP0065542A4 (en) 1983-04-25
WO1982001869A1 (en) 1982-06-10
ZA817737B (en) 1983-07-27
EP0053435A1 (en) 1982-06-09
DK164660B (da) 1992-07-27
EG16108A (en) 1986-12-30
EP0053435B1 (en) 1986-09-17
KR830007487A (ko) 1983-10-21
AU7893881A (en) 1982-06-17
RO85311A (ro) 1984-09-29
AU546424B2 (en) 1985-08-29
EP0065542B1 (en) 1986-07-23
EP0065542A1 (en) 1982-12-01
PH18384A (en) 1985-06-19
DK164660C (da) 1992-12-14

Similar Documents

Publication Publication Date Title
KR880001539B1 (ko) 2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법
KR840000926B1 (ko) N-알킬화된 아미노알콜의 제조방법
KR880002310B1 (ko) 펜에탄올 아민류의 제조방법
EP0040591B1 (fr) Dérivés de pyridoxine, leur procédé de préparation ainsi que leur utilisation en thérapeutique
US4081447A (en) 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CA2446747A1 (en) Thyroid hormone receptor antagonists for cardiac and metabolic disorders ii
JP2651043B2 (ja) ジフェニルメチルピペラジン誘導体
KR880001828B1 (ko) 2-하이드록시에틸아민 유도체 및 이의 제조방법
US4593119A (en) Method for treatment or prophylaxis of cardiac disorders
NO155880B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktivt 2-(2'hydroksy-3'-(1,1-dimetylpropylamino)-propoksy)-beta-fenylpropionfenon.
KR880001827B1 (ko) 2-하이드록시-3-아릴옥시프로필 아민 유도체 및 이의 제조방법
JPH05186459A (ja) ２−アミノ−５−シアノ−４−キノリン−１，４−ジヒドロピリジン類
US5288898A (en) N-methylphenylserine alkyl ester derivatives and uses thereof
CA1236116A (en) Process for the production of s(-)-3-/3-acetyl-4- (3-tert.butylamino-2-hydroxy-propoxy)-phenyl/-1,1- diethylurea and its salts
CS239948B2 (en) Processing of substitute n-carboxamidealkylfenoxypropanolamine
JPS5935387B2 (ja) ３−アミノ−２−ヒドロキシプロパンのジ−置換フエノ−ルエ−テル類、その製法ならびに医薬用途
US4071630A (en) 1-Substituted-amino-3-(4-furo[3,2-c]pyridinyloxy)-2-propanols
CA1215366A (en) Alkanolaminoxy derivatives of 3,4-dihydro-2h-1,4- benzothiazin-3-one, their production process, and their pharmaceutical use
US4338320A (en) Esters of 6'-hydroxycinchonine, and a method of treating arrythmia with them
US4406907A (en) Certain 2,5-disubstituted pyridine derivatives producing β-adrenergic blocking action
EP0937030B1 (en) 3-amino-propoxyphenyl derivatives (i)
JPH02258749A (ja) ポリヒドロキシベンジルオキシプロパノールアミン
EP0026168B1 (fr) Nouveaux dérivés de décahydroquinoléinol, leur procédé de préparation ainsi que leurs applications en thérapeutique
US4396629A (en) Compositions, processes and method
FI79296B (fi) Foerfarande foer framstaellning av 1-(2,4- diklorfenoxi)-3-(3,4-dimetoxi- -fenetylamino)-propanol-(2).

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19970821

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19970821