KR880001539B1 - 2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법 - Google Patents

2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법 Download PDF

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Publication number
KR880001539B1
KR880001539B1 KR1019810004622A KR810004622A KR880001539B1 KR 880001539 B1 KR880001539 B1 KR 880001539B1 KR 1019810004622 A KR1019810004622 A KR 1019810004622A KR 810004622 A KR810004622 A KR 810004622A KR 880001539 B1 KR880001539 B1 KR 880001539B1
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KR
South Korea
Prior art keywords
compound
carbon atoms
group
lower alkyl
formula
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Expired
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KR1019810004622A
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English (en)
Korean (ko)
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KR830007487A (ko
Inventor
폴더블류.에르하르트
제이.보르그만 로버트
피.오도넬 존
Original Assignee
이. 아이. 듀퐁 드 네모아 앤드 캄파니
도날드 에이 호스
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Publication of KR830007487A publication Critical patent/KR830007487A/ko
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Publication of KR880001539B1 publication Critical patent/KR880001539B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019810004622A 1980-11-28 1981-11-28 2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법 Expired KR880001539B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/211,345 US4387103A (en) 1980-11-28 1980-11-28 Method for treatment or prophylaxis of cardiac disorders
US211,345 1980-11-28

Publications (2)

Publication Number Publication Date
KR830007487A KR830007487A (ko) 1983-10-21
KR880001539B1 true KR880001539B1 (ko) 1988-08-20

Family

ID=22786543

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004622A Expired KR880001539B1 (ko) 1980-11-28 1981-11-28 2-하이드록시-3-(치환된아미노)-프로폭시벤젠유도체 및 이의 제조방법

Country Status (15)

Country Link
US (1) US4387103A (cg-RX-API-DMAC7.html)
EP (2) EP0053435B1 (cg-RX-API-DMAC7.html)
JP (1) JPS57502123A (cg-RX-API-DMAC7.html)
KR (1) KR880001539B1 (cg-RX-API-DMAC7.html)
AU (1) AU546424B2 (cg-RX-API-DMAC7.html)
CA (1) CA1258868A (cg-RX-API-DMAC7.html)
DK (1) DK164660C (cg-RX-API-DMAC7.html)
EG (1) EG16108A (cg-RX-API-DMAC7.html)
GR (1) GR76921B (cg-RX-API-DMAC7.html)
IL (1) IL64345A (cg-RX-API-DMAC7.html)
NZ (1) NZ198889A (cg-RX-API-DMAC7.html)
PH (1) PH18384A (cg-RX-API-DMAC7.html)
RO (1) RO85311A (cg-RX-API-DMAC7.html)
WO (1) WO1982001869A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA817737B (cg-RX-API-DMAC7.html)

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SE8004088L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya substituerade 3-fenoxi-l-alkoxikarbonylalkylamino-propanol-2-er med beta-receptorblockerande egenskaper samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma och metod att ...
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4454154A (en) * 1981-06-23 1984-06-12 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
DE3248835A1 (de) * 1981-06-23 1983-06-30 American Hospital Supply Corp Zusammensetzungen fuer die behandlung von glaukom
US4582855A (en) * 1981-11-12 1986-04-15 American Hospital Supply Corporation Aromatic and esters of hydroxypropylamines
US4508725A (en) * 1982-12-22 1985-04-02 American Hospital Supply Corporation Esters of 3-(3-substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazole derivatives
US4556668A (en) * 1983-07-15 1985-12-03 American Hospital Supply Corporation Ethylenediamine derivatives of aryloxypropanolamine aryl esters having various medicinal properties
US5334601A (en) * 1984-03-14 1994-08-02 Bodor Nicholas S Soft β-adrenergic blocking agents
US5135926A (en) * 1984-03-14 1992-08-04 Bodor Nicholas S Soft β-adrenergic blocking agents
US5202347A (en) * 1984-03-14 1993-04-13 Bodor Nicholas S Soft β-adrenergic blocking agents
EP0174956B1 (en) * 1984-03-14 1990-08-16 BODOR, Nicholas S. SOFT $g(b)-ADRENERGIC BLOCKING AGENTS
AU575153B2 (en) * 1984-04-09 1988-07-21 Du Pont Merck Pharmaceutical Company, The Pharmaceutical compositions and method for treatment for prophylaxis of cardiac disorders
US4579867A (en) * 1984-04-09 1986-04-01 American Hospital Supply Corporation Stable pharmaceutical compositions of short-acting β-adrenergic receptor blocking agents
AU607437B2 (en) * 1986-09-02 1991-03-07 Du Pont Pharmaceuticals Company Resolution of dl-methyl 3-(4-(2-hydroxy-3-isopropylamino) propoxy)phenylpropionate((dl-esmolol))
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
US5536749A (en) * 1994-10-13 1996-07-16 Sl Pharmaceuticals, Inc. Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents
US6197817B1 (en) * 1999-01-22 2001-03-06 Selectus Pharmaceuticals, Inc. Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders
US6756047B2 (en) * 2000-05-12 2004-06-29 The University Of Toledo Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
US6750238B1 (en) * 2000-05-12 2004-06-15 The University Of Toledo Aralkyl ester soft drugs
US7049326B2 (en) * 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
US20040235809A1 (en) * 2000-07-27 2004-11-25 Alexander John C Epoxy steroidal aldosterone antagonist and beta-adremergic antagonist combination therepy for treatment of congestive heart failure
EP1417962A1 (de) 2002-11-06 2004-05-12 AOP Orphan Pharmaceuticals AG Verfahren zur Herstellung eines Arzneimittels enthaltend Esmolol
ATE533509T1 (de) * 2003-08-08 2011-12-15 Ono Pharmaceutical Co Herzverlangsamender arzneistoff mit beta-blockern mit kurzzeitwirkung als wirkstoff
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US20080293814A1 (en) 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
KR20100127845A (ko) * 2008-03-24 2010-12-06 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 심근 질환의 영상-유도된 치료: 조성물, 제조 및 적용
CN117126070B (zh) * 2023-08-25 2026-07-17 海南灵康制药有限公司 一种盐酸艾司洛尔b晶型及其制备方法和应用
CN119613359A (zh) * 2024-11-21 2025-03-14 广东京豪生物制药有限公司 盐酸艾司洛尔关键中间体的制备

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US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes
US3637852A (en) * 1963-08-26 1972-01-25 Boehringer Sohn Ingelheim 1-phenoxy-2-hydroxy-3-isopropylamino-propanes and salts thereof
DE1643262C3 (de) * 1967-12-13 1975-06-26 C.H. Boehringer Sohn, 6507 Ingelheim i-Phenoxy^-hydroxy-S-alklyaminopropane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE358382B (cg-RX-API-DMAC7.html) * 1967-12-18 1973-07-30 Boehringer Sohn Ingelheim
US3740444A (en) * 1968-01-25 1973-06-19 Boehringer Sohn Ingelheim Therapeutic compositions and method
GB1285038A (en) * 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
CA945172A (en) * 1969-02-21 1974-04-09 Imperial Chemical Industries Limited Alkanolamine derivatives
DE1937477C3 (de) * 1969-07-23 1980-04-10 C.H. Boehringer Sohn, 6507 Ingelheim I -Phenoxy-2-hydroxy-3-(l -methylcycloalkylamino)-propane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US3705907A (en) * 1970-02-19 1972-12-12 Sandoz Ltd 4-(2-hydroxy)-3-aminopropoxy)-indole derivatives
DE2130393C3 (de) * 1970-06-22 1981-02-26 E.R. Squibb & Sons Inc., New York, N.Y. (V.St.A.) 6,7-Dihydroxy -5,6,7,8-tetrahydronaphthyloxyaminopropanole und ihre Salze mit Säuren sowie ihre Verwendung bei der Bekämpfung von Herzerkrankungen
FR2192812A1 (en) * 1972-07-20 1974-02-15 Centre Etd Ind Pharma 2-(3-Amino 2-hydroxy propoxy) thymotic acid cpds - with local anaesth-etic, anti arrhythmic and antitussive activity
AT330150B (de) * 1973-02-28 1976-06-10 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen
US3857873A (en) * 1974-02-11 1974-12-31 Warner Lambert Co 3-hydroxy-5-(3-(substituted-amino)-2-hydroxypropoxy)-benzyl alcohols
US4165374A (en) * 1976-02-09 1979-08-21 Sandoz Ltd. Thieno[3,2-c]pyridines
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
US4119718A (en) * 1977-05-02 1978-10-10 Merck & Co., Inc. 3-Amino-2-oxy-propoxy-substituted isothiazoles
FR2415622A1 (fr) * 1978-01-25 1979-08-24 Lipha Amino alcools derives de l'ortho-hydroxy cinnamate de methyle applicables notamment comme medicaments
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
JPS55124742A (en) * 1979-03-20 1980-09-26 Kyowa Hakko Kogyo Co Ltd Novel aminoalcohol derivative
SE8004087L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ...
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders

Also Published As

Publication number Publication date
US4387103A (en) 1983-06-07
RO85311A (ro) 1984-09-29
EG16108A (en) 1986-12-30
EP0053435B1 (en) 1986-09-17
EP0065542B1 (en) 1986-07-23
WO1982001869A1 (en) 1982-06-10
ZA817737B (en) 1983-07-27
GR76921B (cg-RX-API-DMAC7.html) 1984-09-04
EP0053435A1 (en) 1982-06-09
JPS57502123A (cg-RX-API-DMAC7.html) 1982-12-02
EP0065542A4 (en) 1983-04-25
IL64345A (en) 1986-02-28
NZ198889A (en) 1985-08-16
KR830007487A (ko) 1983-10-21
PH18384A (en) 1985-06-19
DK164660B (da) 1992-07-27
AU546424B2 (en) 1985-08-29
CA1258868A (en) 1989-08-29
DK335082A (da) 1982-07-27
AU7893881A (en) 1982-06-17
EP0065542A1 (en) 1982-12-01
DK164660C (da) 1992-12-14

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