KR870009981A - 2,3,4,5-테트라플루오로벤조일 아세테이트의 제조방법 - Google Patents

2,3,4,5-테트라플루오로벤조일 아세테이트의 제조방법 Download PDF

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Publication number
KR870009981A
KR870009981A KR870002876A KR870002876A KR870009981A KR 870009981 A KR870009981 A KR 870009981A KR 870002876 A KR870002876 A KR 870002876A KR 870002876 A KR870002876 A KR 870002876A KR 870009981 A KR870009981 A KR 870009981A
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KR
South Korea
Prior art keywords
malonate
dialkyl
preparing
dialkylmalonate
toluene
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KR870002876A
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English (en)
Inventor
게늑 베이린 브라디미어
프라카쉬 고엘 옴
Original Assignee
크리스틴 에이·트라우트웨인
워너 람버트 컴퍼니
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Application filed by 크리스틴 에이·트라우트웨인, 워너 람버트 컴퍼니 filed Critical 크리스틴 에이·트라우트웨인
Publication of KR870009981A publication Critical patent/KR870009981A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

내용 없음

Description

2,3,4,5-테트라플루오로벤조일 아세테이트의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. (a) 디알킬말로네이트를 톨루엔 및 디메틸포름아디드 존재에서 무수 소듐 메톡시드에 부가해 상응하는 소듐 디알킬 말로네이트를 포함하는 이상유동체를 생성하여 (b)테트라플루오로벤조일염화물을 상기이상유동체에 부가하고 10-50℃에서 1-4시간 동안 교반하면서 상응하는 소듐 에놀레이트를 형성하고 (c)에놀레이트를 물에 추출한 후 수성층을 제거하고 강산으로 pH2-3까지 산성화시켜 상응하는 벤조일 디알킬 말로네이트를 형성시켜 (d) 벤조일 디알킬 말로네이트를 물로 가수분해하고 기존의 방법으로 일반식(1)의 화합물을 회수하며 (e)가수분해시 부생성물 테트라플루오로벤조산을 분리하고 상기 단계(b)내의 재순환을 위해 기존방법에 의해 테트라플루오로벤조일 염화물로 전환하는 것으로 구성되는, 다음 일반식(1)화합물을 제조하는 방법.
    [식중, R은 C1-4직쇄 또는 분지쇄알킬
  2. 제 1항에 있어서, 단계 (a)에서 디알킬말로네이트가 디메틸말로네이트인 방법.
  3. 제 1항에 있어서, 단계 (b)에서 혼합물을 18-20°C에서 2-3시간 동안 교반하는 방법.
  4. 제 1항에 있어서, 단계 (a)에서 톨루엔 대 디메틸포름아미드 부피비가 30대 1 내지 70대 1인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870002876A 1986-04-01 1987-03-28 2,3,4,5-테트라플루오로벤조일 아세테이트의 제조방법 KR870009981A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/846,695 US4689423A (en) 1986-04-01 1986-04-01 Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates
US846695 1992-03-06

Publications (1)

Publication Number Publication Date
KR870009981A true KR870009981A (ko) 1987-11-30

Family

ID=25298676

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870002876A KR870009981A (ko) 1986-04-01 1987-03-28 2,3,4,5-테트라플루오로벤조일 아세테이트의 제조방법

Country Status (22)

Country Link
US (1) US4689423A (ko)
EP (1) EP0239992B1 (ko)
JP (1) JPS62238239A (ko)
KR (1) KR870009981A (ko)
AT (1) ATE46142T1 (ko)
AU (1) AU591247B2 (ko)
CA (1) CA1264329A (ko)
CS (1) CS268827B2 (ko)
DD (1) DD255731A5 (ko)
DE (1) DE3760531D1 (ko)
DK (1) DK147887A (ko)
ES (1) ES2010197B3 (ko)
FI (1) FI871368A (ko)
GR (1) GR3000166T3 (ko)
HU (1) HU195758B (ko)
IL (1) IL82006A (ko)
NO (1) NO165834C (ko)
NZ (1) NZ219819A (ko)
OA (1) OA08509A (ko)
PH (1) PH23779A (ko)
PT (1) PT84591B (ko)
ZA (1) ZA871729B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
HU198292B (en) * 1987-09-25 1989-09-28 Richter Gedeon Vegyeszet Process for producing salicilates and pharmaceutical compositions comprising such active ingredient
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
CA2153984C (en) * 1993-01-23 2008-08-05 Martin Karpf Process for the manufacture of a tricyclic compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2088354A (en) * 1980-11-07 1982-06-09 Shell Int Research Preparation of a-pivaloyl acetic esters
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
JPS60123837A (ja) * 1983-12-09 1985-07-02 Mitsubishi Paper Mills Ltd ハロゲン化銀写真乳剤
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
DE3578424D1 (de) * 1984-04-26 1990-08-02 Abbott Lab Quino-benzothiazin-antibakterielle verbindungen.
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
EP0181521A1 (en) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds

Also Published As

Publication number Publication date
IL82006A (en) 1991-07-18
AU6995087A (en) 1987-10-08
EP0239992A1 (en) 1987-10-07
ZA871729B (en) 1988-10-26
NO165834B (no) 1991-01-07
PT84591A (en) 1987-04-01
NZ219819A (en) 1989-09-27
IL82006A0 (en) 1987-10-20
NO871351D0 (no) 1987-03-31
CA1264329A (en) 1990-01-09
JPS62238239A (ja) 1987-10-19
EP0239992B1 (en) 1989-09-06
ES2010197B3 (es) 1989-11-01
OA08509A (en) 1988-07-29
HU195758B (en) 1988-07-28
FI871368A (fi) 1987-10-02
DE3760531D1 (en) 1989-10-12
DD255731A5 (de) 1988-04-13
DK147887D0 (da) 1987-03-23
PH23779A (en) 1989-11-03
GR3000166T3 (en) 1990-12-31
AU591247B2 (en) 1989-11-30
FI871368A0 (fi) 1987-03-27
ATE46142T1 (de) 1989-09-15
HUT43807A (en) 1987-12-28
PT84591B (pt) 1989-11-30
DK147887A (da) 1987-10-02
US4689423A (en) 1987-08-25
CS207487A2 (en) 1989-09-12
NO871351L (no) 1987-10-02
CS268827B2 (en) 1990-04-11
NO165834C (no) 1991-04-17

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