KR870006009A - N-비닐아졸류 - Google Patents

N-비닐아졸류 Download PDF

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KR870006009A
KR870006009A KR860011231A KR860011231A KR870006009A KR 870006009 A KR870006009 A KR 870006009A KR 860011231 A KR860011231 A KR 860011231A KR 860011231 A KR860011231 A KR 860011231A KR 870006009 A KR870006009 A KR 870006009A
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optionally substituted
compound
alkyl
unsubstituted
group
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KR860011231A
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마사루 오가따
가쯔야 다와라
모또히꼬 우에다
고사브로 사또
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요시또시 가즈오
시오노기 세이야꾸 가부시끼가이샤
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Publication of KR870006009A publication Critical patent/KR870006009A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

N-비닐아졸류
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(I)의 화합물 또는 그의 산부가염.
    (식 중 R은 할로겐원자, 히드록시, 수소원자 C1-5의 알콕시, C2-5의 알케닐옥시 및 임의로 치환 또는 비치환된 벤질옥시, 테트라히드로피라닐옥시, 디플루오로메톡시, 2-(2,4-디클로로페닐)-2-(1H-이미다졸-1-일메틸)-1,3-디옥소란-4-일메틸옥시 또는 -O-(CH2)n-A-B-X이고
    A는 〉 CO, -(CH2)p-, 〉CH-OH 또는이고;
    B는 -(CH2)p-, 〉NH, -N(CH3)CH2- 또는 -O-이며; X는 임의로 치환 또는 비치환된 C6-10의 아릴, 이미다졸릴, 트리아졸릴, 4-메틸-2-옥소-1,3-디옥소란-5-일메틸 또는 프탈이미도이고; n은 1 내지 3의 정수이며; p는 0 또는 1이고; q는 0 또는 1이며; R1는 수소원자, 할로겐원자, C1-5의 알칸, C1-5의 알콕시, C1-5의 알카노일 또는 페닐기이고; R2와 R3는 각각 수소원자, 할로겐원자, 포르밀, 이미다졸릴, 트리아졸릴, 임의로 치환 또는 비치환된 페녹시 C1-5의 알킬, 임의로 치환 또는 비치환된 페닐기, -(CH2)a-N(R4)R5, -(CH2)b-Y-R6, -(CH2)e-S-(CH2)f-R7또는 R2와 R3는 함께 C2-6의 알킬렌을 형성하는 것이며; a,b,c 및 f의 각각은 1 내지 5의 정수이고; R4및 R5의 각각은 C1-5의 알킬, C6-10의 아릴 또는 R4와 R5는 함께 5 내지 6원의 복소환 그룹을 형성하는 것이고; R6는 C1-5의 알킬, 수산기로 치환된 C1-6의 알킬, 테트라히드로푸란일옥시에틸, 페닐 또는 할로페닐이며 R7은 C1-5의 알킬, 히드록시, 테트라히드로프란일옥시, 이미다졸릴, 할로겐 또는 임의로 치환 또는 비치환된 페닐이고; m=1 또는 2이며; Az는 1-이미다졸릴, 1-피라졸릴 또는 1,2,4-트리아졸-1-일로써, 히드록시기, 니트로기, 히드라조노메틸 및 티오카바모일히드라지노데틸로 이루어진 그룹으로부터 선택된 하나 또는 그 이상의 것으로 각각 임의로 치환되어진 것을 나타냄).
  2. 제1항에 의한 최소한 하나의 화합물질의 항진균제로써의 유효 용량과, 하나 또는 그 이상의 약제학적으로 유용한 담체, 희석제 및/또는 부형제를 특징으로 하는 약제학적 조성물.
  3. 제1항에 의한 최소한 하나의 화합물질의 강심제로써의 유효 용량과, 하나 또는 그 이상의 약제학적으로 유용한 담체, 희석제 및/또는 부형제를 특징으로 하는 약제학적 조성물.
  4. 제1항에 의한 최소한 하나의 화합물질의 항바이러스제로써의 유효 용량과, 하나 또는 그 이상의 약제학적으로 유용한 담체, 희석제 및/또는 부형제를 특징으로 하는 약제학적 조성물.
  5. 제1항에 의한 화합물질을 제조하는 방법에 있어서, (1) 하기 일반식(II)의 화합물질
    (식 중, R, R1, R2, R3및 m은 각각 상기의 정의와 동일함) 과 일반식(III)
    (식 중, Q는 -SO-Az, -CO-Az 또는 -SO-Hal이고, Hal은 할로겐이고, Az는 상기 정의와 같음)로 표시되는 아졸도입시약과 용매중 반응시키거나, (2) 하기 일반식(Ia)의 화합물질
    (식 중, Az, R1, R2, R3및 m은 각각 상기 정의와 같음) 과 일반식(IV)
    Ra-W (IV)
    (식 중, Ra는 C1-5의 알킬, C2-5의 알케닐, 임의로 치환 또는 비치환된 벤질, 테트라히드로피라닐, 트리플루오로메틸, -(CH2)n-A-B-X 또는 2-(2,4-디클로로페닐) -2-(1H-이미다졸-1-일메틸)-1, 3-디옥소란-4-일메틸이고, W는 할로겐원자 또는 토실옥시임)을 용매 중에서 염기의 존재하에 반응하여 하기 일반식(Ib):
    (식 중, Az, R1, R2, R3, Ra 및 m은 상기 정의와 같음) 로 나타내는 화합물 제조함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR860011231A 1985-12-25 1986-12-24 N-비닐아졸류 KR870006009A (ko)

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JP60294905A JPS62149666A (ja) 1985-12-25 1985-12-25 Ｎ−ビニルアゾ−ル類
JP294905 1985-12-25

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KR870006009A true KR870006009A (ko) 1987-07-08

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EP (1) EP0227100B1 (ko)
JP (1) JPS62149666A (ko)
KR (1) KR870006009A (ko)
DE (1) DE3678541D1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0645604B2 (ja) * 1985-12-23 1994-06-15 エスエス製薬株式会社 イミダゾ−ル誘導体
DE3923153A1 (de) * 1989-07-13 1991-01-24 Basf Ag 1-halogen-vinylazole und diese enthaltende fungizide
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
WO1993012782A1 (en) 1991-10-31 1993-07-08 Elford Howard L Method of treating viral diseases
ES2226156T3 (es) * 1997-07-25 2005-03-16 Nippon Kayaku Kabushiki Kaisha Nuevo compuesto con actividad promotora de la diferenciacion de neuronas.
TWI360535B (en) 2007-08-30 2012-03-21 Univ Nat Sun Yat Sen Sulfur-containing compound, method of preparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK157860C (da) * 1979-06-07 1990-07-30 Shionogi & Co Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf
JPS6036427B2 (ja) * 1980-12-05 1985-08-20 塩野義製薬株式会社 １−ベンジルイミダゾ−ル誘導体
CA1206970A (en) * 1981-10-01 1986-07-02 Hak-Foon Chan Substituted ethylenic imidazoles and triazoles
EP0079856A1 (de) * 1981-11-12 1983-05-25 Ciba-Geigy Ag Mikrobizide Triazolyl-vinyläther
DE3313499A1 (de) * 1983-04-14 1984-10-18 Hoechst Ag, 6230 Frankfurt 1,2,4-triazol-1-yl-vinylether, ihre herstellung und ihre verwendung als pflanzenbehandlungsmittel
US4539325A (en) * 1983-11-07 1985-09-03 Janssen Pharmaceutica N.V. 1-(2-Aryl-2-halo-1-ethenyl)-1H-azoles, and anticonvulsant use thereof
JPS60155163A (ja) * 1984-01-09 1985-08-15 Mitsui Toatsu Chem Inc イミダゾ−ル誘導体
US4629795A (en) * 1984-05-25 1986-12-16 Shionogi & Co., Ltd. Process for preparing imidazole derivatives
DE3533823A1 (de) * 1985-09-23 1987-04-02 Hoechst Ag Alkenylazole, verfahren zu ihrer herstellung und ihre verwendung
JPH0645604B2 (ja) * 1985-12-23 1994-06-15 エスエス製薬株式会社 イミダゾ−ル誘導体

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EP0227100A3 (en) 1988-06-22
DE3678541D1 (de) 1991-05-08
JPS62149666A (ja) 1987-07-03
EP0227100A2 (en) 1987-07-01
EP0227100B1 (en) 1991-04-03

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