KR870002846A - 백금계 항암화합물의 안정한 동결건조물의 제조방법 - Google Patents
백금계 항암화합물의 안정한 동결건조물의 제조방법 Download PDFInfo
- Publication number
- KR870002846A KR870002846A KR1019860007940A KR860007940A KR870002846A KR 870002846 A KR870002846 A KR 870002846A KR 1019860007940 A KR1019860007940 A KR 1019860007940A KR 860007940 A KR860007940 A KR 860007940A KR 870002846 A KR870002846 A KR 870002846A
- Authority
- KR
- South Korea
- Prior art keywords
- water soluble
- glucan
- weight
- stabilizer
- derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 글리콜레이토-시스-디아민백금(Ⅱ) 1중량부 및 안정제 0.05내지 5중량부를 주사용 증류수에 녹이고 무균적으로 여과하여 약 -80°C내지 -20°C로 냉각한 후에, 약 -3°C 또는 그 이하로 온도를 올려 같은 온도로 5내지 72시간 동안 감압하에서 승화시켜 동결건조제제를 제조하는 방법.
- 제 1항에 있어서, 상기 안정제가 글루칸, 수용성 비닐중합체, 폴리에틸렌글리콜 또는 그들의 혼합물임을 특징으로 하는 방법.
- 제 2항에 있어서, 글루칸이 수용성 중성 글루칸임을 특징으로 하는 방법.
- 제 2항에 있어서, 글루칸이 수용성 가공녹말 또는 그의 유도체임을 특징으로 하는 방법.
- 제 2항에 있어서, 글루칸이 수용성 셀룰로오즈 유도체임을 특징으로 하는 방법.
- 제 3항에 있어서 수용성 중성 글루칸이 덱스트란, 풀루란, 또는 아밀로즈임을 특징으로 하는 방법.
- 제 3항에 있어서 수용성 중성 글루칸이 덱스트란을 특징으로 하는 방법
- 제 4항에 있어서, 수용성 가공녹말 또는 그의 유도체가 덱스트린, 시클로데스트린, 가용성 녹말 또는 수산화에틸 녹말임을 특징으로 하는 방법.
- 제 5항에 있어서, 수용성 셀룰로오즈 유도체가 메틸 셀룰로오즈, 수산화에틸 셀룰로오즈, 수산화프로필메틸 셀룰로오즈 또는 카르복시메틸 셀룰로오즈 소디움염임을 특징으로 하는 방법.
- 제 2항에 있어서, 수용성 비닐 중합체가 폴리 비닐 알코올 또는 폴리비닐피롤리딘임을 특징으로 하는 방법
- 제 1항에 있어서, 상기 안정제가 상기 활성 성분 1중량부에 대하여 0.05~5중량부의 비율로 가입됨을 특징으로 하는 방법.
- .제 1항에 있어서, 상기 안정제가 상기 활성 성분 1중량부에 대하여 0.1~3중량부의 비율로 가입됨을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP213180 | 1985-09-25 | ||
JP60-213180 | 1985-09-25 | ||
JP60213180A JPH0665648B2 (ja) | 1985-09-25 | 1985-09-25 | 白金系抗癌物質の安定な凍結真空乾燥製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870002846A true KR870002846A (ko) | 1987-04-13 |
KR930010623B1 KR930010623B1 (ko) | 1993-11-02 |
Family
ID=16634867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860007940A KR930010623B1 (ko) | 1985-09-25 | 1986-09-23 | 백금계 항암화합물의 안정한 동결건조물의 제조방법 |
Country Status (9)
Country | Link |
---|---|
US (1) | US4767874A (ko) |
EP (1) | EP0216362B1 (ko) |
JP (1) | JPH0665648B2 (ko) |
KR (1) | KR930010623B1 (ko) |
AU (1) | AU593839B2 (ko) |
CA (1) | CA1265745A (ko) |
DE (1) | DE3669107D1 (ko) |
DK (1) | DK165356C (ko) |
GB (1) | GB2180839B (ko) |
Families Citing this family (40)
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US5100877A (en) * | 1986-05-21 | 1992-03-31 | Kuraray Co., Ltd. | Platinum containing pullulan derivatives and pharmaceutical compositions comprising the same |
EP0307827A3 (en) * | 1987-09-15 | 1989-12-27 | Kuraray Co., Ltd. | Novel macromolecular complexes, process for producing same and medicinal use of such complexes |
JPH01146826A (ja) * | 1987-12-03 | 1989-06-08 | Nippon Kayaku Co Ltd | 白金化合物の凍結乾燥製剤 |
US4931553A (en) * | 1988-05-11 | 1990-06-05 | Gill Devinder S | Platinum-polymer complexes and their use as antitumor agents |
WO1990003402A1 (en) * | 1988-09-27 | 1990-04-05 | Kuraray Co., Ltd. | Novel composite, process for its preparation and medicinal use thereof |
DE3923270A1 (de) * | 1989-07-14 | 1991-01-17 | Medac Klinische Spezialpraep | Wasserloesliche pharmazeutische metallocen-komplex-zusammensetzung |
EP0516026A1 (en) * | 1991-05-28 | 1992-12-02 | Takeda Chemical Industries, Ltd. | Hydrogel and method of producing same |
EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
JP2005502653A (ja) * | 2001-08-20 | 2005-01-27 | トランセーヴ・インコーポレーテッド | 肺ガンの治療方法 |
WO2003015521A1 (en) * | 2001-08-20 | 2003-02-27 | Transave, Inc. | Treatment of cancers by inhalation of stable platinum-containing formulations |
WO2003075890A1 (en) * | 2002-03-05 | 2003-09-18 | Transave, Inc. | Methods for entrapment of bioactive agent in a liposome or lipid complex |
MXPA05001312A (es) * | 2002-08-02 | 2005-08-03 | Transave Inc | Agregados de platino y proceso para producir los mismos. |
US9186322B2 (en) * | 2002-08-02 | 2015-11-17 | Insmed Incorporated | Platinum aggregates and process for producing the same |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
ES2831305T3 (es) * | 2002-10-29 | 2021-06-08 | Insmed Inc | Liposomas que comprenden un aminoglucósido para el tratamiento de infecciones pulmonares |
DE10327674A1 (de) * | 2003-06-20 | 2005-01-05 | Awd.Pharma Gmbh & Co. Kg | Injizierbare Darreichungsform von Flupirtin |
WO2005089448A2 (en) * | 2004-03-18 | 2005-09-29 | Transave, Inc. | Administration of cisplatin by inhalation |
US20060034906A1 (en) * | 2004-05-21 | 2006-02-16 | Transave, Inc. | Treatment of lung diseases and pre-lung disease conditions |
WO2006055352A2 (en) * | 2004-11-08 | 2006-05-26 | Transave, Inc. | Methods of treating cancer with lipid-based platinum compound formulations administered intraperitoneally |
US20060283742A1 (en) * | 2005-06-16 | 2006-12-21 | Canel Lightning Co. Ltd. | Multi-lamp display packaging for lamps with collapsible lampshades |
US9107824B2 (en) | 2005-11-08 | 2015-08-18 | Insmed Incorporated | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
US20070190180A1 (en) * | 2005-11-08 | 2007-08-16 | Pilkiewicz Frank G | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intravenously |
US20070190181A1 (en) * | 2005-11-08 | 2007-08-16 | Pilkiewicz Frank G | Methods of treating cancer with lipid-based platinum compound forumulations administered intravenously |
WO2007056264A2 (en) * | 2005-11-08 | 2007-05-18 | Transave, Inc. | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
US20070122350A1 (en) * | 2005-11-30 | 2007-05-31 | Transave, Inc. | Safe and effective methods of administering therapeutic agents |
EP3718532A1 (en) | 2005-12-08 | 2020-10-07 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
US20100196455A1 (en) | 2007-05-04 | 2010-08-05 | Transave, Inc. | Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
CN102307568B (zh) * | 2009-02-04 | 2014-12-24 | 帝斯曼知识产权资产管理有限公司 | 白藜芦醇组合物 |
CN101953805B (zh) * | 2010-09-29 | 2012-05-30 | 贵州益佰制药股份有限公司 | 一种抗肿瘤药物制剂的制备方法 |
EP2852391B1 (en) | 2012-05-21 | 2021-11-17 | Insmed Incorporated | Systems for treating pulmonary infections |
WO2014039533A2 (en) | 2012-09-04 | 2014-03-13 | Eleison Pharmaceuticals, Llc | Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin |
RU2018135921A (ru) | 2012-11-29 | 2019-02-05 | Инсмед Инкорпорейтед | Стабилизированные составы ванкомицина |
CN103315967B (zh) * | 2013-06-18 | 2015-09-30 | 江苏奥赛康药业股份有限公司 | 一种含奈达铂的冻干组合物、用途及其制备方法 |
CN103599079B (zh) * | 2013-11-25 | 2016-06-08 | 江苏奥赛康药业股份有限公司 | 注射用洛铂药物组合物及其制备方法 |
ES2755941T3 (es) | 2014-05-15 | 2020-04-24 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas |
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Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51118817A (en) * | 1975-04-08 | 1976-10-19 | Nippon Shinyaku Co Ltd | A process for preparing absorbable steroid glycoside pharmaceutical |
DE2925009A1 (de) * | 1979-06-21 | 1981-01-08 | Basf Ag | Zubereitung fuer substanzen, verfahren zu deren herstellung und deren verwendung |
JPS57123198A (en) * | 1981-01-23 | 1982-07-31 | Shionogi & Co Ltd | Novel platinum complex |
IT1153974B (it) * | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
US4598091A (en) * | 1983-02-18 | 1986-07-01 | Degussa Aktiengesellschaft | (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds |
JPS59222498A (ja) * | 1983-06-01 | 1984-12-14 | Shionogi & Co Ltd | 新規グリコ−ル酸系白金錯体および抗悪性腫瘍剤 |
JPS617283A (ja) * | 1984-06-20 | 1986-01-13 | Shionogi & Co Ltd | 新規白金錯体および抗悪性腫瘍剤 |
ATE63919T1 (de) * | 1984-06-27 | 1991-06-15 | Johnson Matthey Plc | Platinkoordinationsverbindungen. |
ES8801168A1 (es) * | 1984-11-02 | 1987-02-16 | Johnson Matthey Plc | Procedimiento para la obtencion de un compuesto de platino para utilizar en quimioterapia del cancer. |
US4737589A (en) * | 1985-08-27 | 1988-04-12 | Nippon Kayaku Kabushiki Kaisha | Platinum Complexes |
DK166825B1 (da) * | 1985-09-06 | 1993-07-19 | Sankyo Co | Antitumor-platinkomplekser og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse |
-
1985
- 1985-09-25 JP JP60213180A patent/JPH0665648B2/ja not_active Expired - Lifetime
-
1986
- 1986-09-10 US US06/905,456 patent/US4767874A/en not_active Expired - Lifetime
- 1986-09-17 CA CA000518387A patent/CA1265745A/en not_active Expired - Fee Related
- 1986-09-23 KR KR1019860007940A patent/KR930010623B1/ko not_active IP Right Cessation
- 1986-09-24 EP EP86113122A patent/EP0216362B1/en not_active Expired - Lifetime
- 1986-09-24 AU AU63105/86A patent/AU593839B2/en not_active Ceased
- 1986-09-24 DK DK456886A patent/DK165356C/da not_active IP Right Cessation
- 1986-09-24 DE DE8686113122T patent/DE3669107D1/de not_active Expired - Fee Related
- 1986-09-25 GB GB8623117A patent/GB2180839B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB2180839B (en) | 1989-09-20 |
EP0216362A2 (en) | 1987-04-01 |
EP0216362B1 (en) | 1990-02-28 |
CA1265745A (en) | 1990-02-13 |
KR930010623B1 (ko) | 1993-11-02 |
DE3669107D1 (de) | 1990-04-05 |
DK456886D0 (da) | 1986-09-24 |
GB8623117D0 (en) | 1986-10-29 |
DK165356C (da) | 1993-04-05 |
DK165356B (da) | 1992-11-16 |
DK456886A (da) | 1987-03-26 |
US4767874A (en) | 1988-08-30 |
JPS6272615A (ja) | 1987-04-03 |
AU6310586A (en) | 1987-03-26 |
EP0216362A3 (en) | 1987-07-29 |
AU593839B2 (en) | 1990-02-22 |
GB2180839A (en) | 1987-04-08 |
JPH0665648B2 (ja) | 1994-08-24 |
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