KR870002162A - α-hANP-(17-28)의 제조방법 - Google Patents

α-hANP-(17-28)의 제조방법 Download PDF

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KR870002162A
KR870002162A KR1019850006108A KR850006108A KR870002162A KR 870002162 A KR870002162 A KR 870002162A KR 1019850006108 A KR1019850006108 A KR 1019850006108A KR 850006108 A KR850006108 A KR 850006108A KR 870002162 A KR870002162 A KR 870002162A
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hanp
protecting group
production method
amino
group
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KR1019850006108A
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KR900006573B1 (ko
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요시아끼 기조
가즈와 나까오
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요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
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  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

α-hANP-(17-28)의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 α,-hANP-(1-28) (●-●로 표시)의 표준 곡선, α-rANP-(1-28) (△-△로 표시) 및 α-hANP-(24-28) (○-○로 표시)의 교차 곡선을 나타낸다. 종축은 결합항원(125I 표식 α-hANP)(B)의 유리항원(F)에 대한 비율을 나타내고 횡축은 α-ANP(pg/시험관)의 농도를 나타낸다.

Claims (1)

  1. 하기의 반응 공정에 따라 반응시킴을 특징으로 하는 α-hANP-(17-28) 및 그 염의 제조방법.
    식중 X1는 N-말단 아이노산의 아미노 보호기를 나타내고, X2는 티올 보호기를 나타내고, X3는 구아니딜 보호기를 나타내고, AE는 활성 에스테르 잔기를 나타내고, Y는 C-말만 아미노기의 카르복시 보호기를나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850006108A 1984-08-24 1985-08-23 α-hANP-(17-28)의 제조방법 KR900006573B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP176953/1984 1984-08-24
JP59176953A JPH0672155B2 (ja) 1984-08-24 1984-08-24 α−ｈＡＮＰ抗血清作製用ポリペプチド
JP176953 1984-08-24

Publications (2)

Publication Number Publication Date
KR870002162A true KR870002162A (ko) 1987-03-30
KR900006573B1 KR900006573B1 (ko) 1990-09-13

Family

ID=16022607

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850006108A KR900006573B1 (ko) 1984-08-24 1985-08-23 α-hANP-(17-28)의 제조방법

Country Status (9)

Country Link
US (1) US4673732A (ko)
EP (1) EP0173384B1 (ko)
JP (1) JPH0672155B2 (ko)
KR (1) KR900006573B1 (ko)
CN (1) CN85106564A (ko)
CA (1) CA1264900A (ko)
DE (1) DE3581336D1 (ko)
DK (1) DK383985A (ko)
GB (1) GB2164044B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212286A (en) * 1984-04-19 1993-05-18 Scios Nova Inc. Atrial natriuretic/vasodilator peptide compounds
US4804650A (en) * 1986-10-28 1989-02-14 Biotechnology Research Associates, J.V. Analogs of atrial natriuretic peptides
DK175535B1 (da) * 1987-03-04 2004-11-29 Daiichi Suntory Pharma Co Ltd Fremgangsmåde til fremstilling af et fysiologisk aktivt cysteinholdigt peptid
US4816443A (en) * 1987-05-19 1989-03-28 Merck & Co., Inc. Piptides having ANF activity
JP2873586B2 (ja) * 1988-07-15 1999-03-24 武田薬品工業株式会社 抗体およびこれを用いる免疫化学的測定方法
JPH0667319B2 (ja) * 1989-04-19 1994-08-31 塩野義製薬株式会社 Ａｎｐのｃ端側を認識するモノクローナル抗体
JPH0748071B2 (ja) * 1989-05-31 1995-05-24 株式会社ミドリ十字 ｈＡＮＰ抗体及びｈＡＮＰの免疫学的測定法
US5846932A (en) * 1993-11-12 1998-12-08 Genentech, Inc. Receptor specific atrial natriuretic peptides
US5665704A (en) * 1993-11-12 1997-09-09 Genentech, Inc. Receptor specific atrial natriuretic peptides
US6525022B1 (en) 1993-11-12 2003-02-25 Genentech, Inc. Receptor specific atrial natriuretic peptides
AT407674B (de) * 1998-09-29 2001-05-25 Biomedica Gmbh Verfahren zur bestimmung von atrialem natriuretischem peptid (anp)
AU2007233123A1 (en) * 2006-03-30 2007-10-11 Palatin Technologies, Inc. Linear natriuretic peptide constructs
CA2647143A1 (en) 2006-03-30 2007-10-11 Palatin Technologies, Inc. Cyclic natriuretic peptide constructs
US8580746B2 (en) * 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
CN103204923B (zh) * 2013-03-21 2016-06-22 深圳翰宇药业股份有限公司 固相片段法制备卡培立肽

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572173B2 (en) * 1983-08-29 1988-05-05 Institut De Recherches Cliniques De Montreal Natriuretic factors
DE3346953A1 (de) * 1983-12-24 1985-08-14 Organogen Medizinisch-Molekularbiologische Forschungsgesellschaft mbH, 6900 Heidelberg Cardiodilatin, ein neues peptidhormon und verfahren zu seiner herstellung
JPS60136596A (ja) * 1983-12-26 1985-07-20 Suntory Ltd ペプチド及びこれを有効成分とする利尿剤
US4952561A (en) * 1984-02-07 1990-08-28 Merck & Co., Inc. Cardiac atrial peptides
ATE120759T1 (de) * 1984-04-19 1995-04-15 Scios Nova Inc Atrielle natriumuretische/gefässerweiterende polypeptide.
NZ212291A (en) * 1984-06-08 1991-10-25 Suntory Ltd Peptide from human atrium cordis having diuretic action, dna coding therefor and pharmaceutical compositions thereof
EP0166585A3 (en) * 1984-06-22 1987-06-24 Suntory Limited Novel peptide and gene coding for same

Also Published As

Publication number Publication date
DK383985D0 (da) 1985-08-23
KR900006573B1 (ko) 1990-09-13
JPH0672155B2 (ja) 1994-09-14
CA1264900A (en) 1990-01-23
EP0173384A2 (en) 1986-03-05
GB8521137D0 (en) 1985-10-02
CN85106564A (zh) 1987-03-18
EP0173384A3 (en) 1987-12-16
US4673732A (en) 1987-06-16
EP0173384B1 (en) 1991-01-16
JPS6153299A (ja) 1986-03-17
GB2164044B (en) 1988-11-16
DK383985A (da) 1986-02-25
DE3581336D1 (de) 1991-02-21
GB2164044A (en) 1986-03-12

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