KR830007668A - 6-아미노페니실란산 유도체의 제조방법 - Google Patents
6-아미노페니실란산 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830007668A KR830007668A KR1019810003874A KR810003874A KR830007668A KR 830007668 A KR830007668 A KR 830007668A KR 1019810003874 A KR1019810003874 A KR 1019810003874A KR 810003874 A KR810003874 A KR 810003874A KR 830007668 A KR830007668 A KR 830007668A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- group
- necessary
- preparing
- acid derivative
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 239000002253 acid Substances 0.000 title claims 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 title 1
- 229910000077 silane Inorganic materials 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 다음 일반식(Ⅱ)의 화합물 또는 이의 염을 촉매적으로 수첨분해시키고 필요에 따라, 수득된 일반식(I)의 에스테르를 분리시키거나, 필요에 따라 수득된 일반식(I)의 카복실산을 에스테르그룹 R을 생성하는 시약으로 처리하거나, 필요에 따라 수득된 일반식(I) 화합물을 이의 약학적으로 허용되는 염으로 전환시킴을 특징으로 하는 6-아미노-페니실란산유도체의 제조방법.상기 일반식에서R은 수소 또는 용이하게 가수분해될 수 있는 에스테르그룹이고R1은 수첨분해적으로 분리될 수 있는 그룹이다.
- 제1항에 있어서, R1이 벤질그룹인 방법.
- 제1항 또는 2항에 있어서, 촉매로서 팔라듐/탄소를 사용하는 방법.
- 제1항 내지 제3항 중 어느하나에 있어서, 출발물질로서 R이 피팔로일옥시메틸 그룹인 일반식(Ⅱ)의 화합물을 사용하여 피발로일옥시메틸 6-[(헥사하이드로-1H-아제핀-1-일)-메틸렌아미노페니실리네이트 또는 이의 염을 분리시키는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH7700/80? | 1980-10-15 | ||
| CH770080 | 1980-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830007668A true KR830007668A (ko) | 1983-11-04 |
Family
ID=4329211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810003874A KR830007668A (ko) | 1980-10-15 | 1981-10-14 | 6-아미노페니실란산 유도체의 제조방법 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0049891B1 (ko) |
| JP (1) | JPS5795991A (ko) |
| KR (1) | KR830007668A (ko) |
| AT (1) | ATE11540T1 (ko) |
| CA (1) | CA1171407A (ko) |
| DK (1) | DK456681A (ko) |
| ES (1) | ES506236A0 (ko) |
| FI (1) | FI813202L (ko) |
| GR (1) | GR75822B (ko) |
| PT (1) | PT73822B (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162523A (en) * | 1989-07-21 | 1992-11-10 | Hoffmann-La Roche Inc. | Cephalosporin antibacterial compounds |
| US5159077A (en) * | 1989-07-21 | 1992-10-27 | Hoffmann-La Roche Inc. | Penam antibacterial compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7216268A (ko) * | 1971-12-16 | 1973-06-19 |
-
1981
- 1981-10-12 EP EP81108244A patent/EP0049891B1/de not_active Expired
- 1981-10-12 AT AT81108244T patent/ATE11540T1/de not_active IP Right Cessation
- 1981-10-13 GR GR66262A patent/GR75822B/el unknown
- 1981-10-14 CA CA000387840A patent/CA1171407A/en not_active Expired
- 1981-10-14 JP JP56162882A patent/JPS5795991A/ja active Pending
- 1981-10-14 ES ES506236A patent/ES506236A0/es active Granted
- 1981-10-14 KR KR1019810003874A patent/KR830007668A/ko unknown
- 1981-10-14 PT PT73822A patent/PT73822B/pt unknown
- 1981-10-14 DK DK456681A patent/DK456681A/da not_active Application Discontinuation
- 1981-10-14 FI FI813202A patent/FI813202L/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK456681A (da) | 1982-04-16 |
| ATE11540T1 (de) | 1985-02-15 |
| EP0049891B1 (de) | 1985-01-30 |
| CA1171407A (en) | 1984-07-24 |
| ES8206529A1 (es) | 1982-08-16 |
| EP0049891A1 (de) | 1982-04-21 |
| PT73822B (en) | 1983-11-07 |
| FI813202L (fi) | 1982-04-16 |
| ES506236A0 (es) | 1982-08-16 |
| PT73822A (en) | 1981-11-01 |
| GR75822B (ko) | 1984-08-02 |
| JPS5795991A (en) | 1982-06-15 |
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