KR870001986B1 - 세팔로스포린 유도체의 제조방법 - Google Patents

세팔로스포린 유도체의 제조방법 Download PDF

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Publication number
KR870001986B1
KR870001986B1 KR1019830000871A KR830000871A KR870001986B1 KR 870001986 B1 KR870001986 B1 KR 870001986B1 KR 1019830000871 A KR1019830000871 A KR 1019830000871A KR 830000871 A KR830000871 A KR 830000871A KR 870001986 B1 KR870001986 B1 KR 870001986B1
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KR
South Korea
Prior art keywords
methyl
compound
formula
group
carboxylate
Prior art date
Application number
KR1019830000871A
Other languages
English (en)
Korean (ko)
Other versions
KR840004118A (ko
Inventor
아부라키 심페이
카마치 하지메
나리타 유키오
준오쿠무라
유키나이토 타카
Original Assignee
브리스톨-마이어즈 리써어치 인스티튜트 리미티드
지우리오 비타
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/354,851 external-priority patent/US4406899A/en
Application filed by 브리스톨-마이어즈 리써어치 인스티튜트 리미티드, 지우리오 비타 filed Critical 브리스톨-마이어즈 리써어치 인스티튜트 리미티드
Publication of KR840004118A publication Critical patent/KR840004118A/ko
Application granted granted Critical
Publication of KR870001986B1 publication Critical patent/KR870001986B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019830000871A 1982-03-04 1983-03-04 세팔로스포린 유도체의 제조방법 KR870001986B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US06/354,851 US4406899A (en) 1982-03-04 1982-03-04 Cephalosporins
US354851 1982-03-04
US354,851 1982-03-04
US35753482A 1982-03-12 1982-03-12
US357,534 1982-03-12
US357534 1982-03-12

Publications (2)

Publication Number Publication Date
KR840004118A KR840004118A (ko) 1984-10-06
KR870001986B1 true KR870001986B1 (ko) 1987-10-24

Family

ID=26998584

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830000871A KR870001986B1 (ko) 1982-03-04 1983-03-04 세팔로스포린 유도체의 제조방법

Country Status (29)

Country Link
KR (1) KR870001986B1 (de)
AT (2) AT382155B (de)
AU (1) AU562776B2 (de)
BE (1) BE896086A (de)
CA (1) CA1213882A (de)
CH (1) CH654313A5 (de)
CS (1) CS249512B2 (de)
DD (1) DD210280A5 (de)
DE (1) DE3307550A1 (de)
DK (1) DK156900C (de)
EG (1) EG15934A (de)
ES (2) ES8403919A1 (de)
FI (1) FI74973C (de)
FR (1) FR2522659B1 (de)
GB (1) GB2116180B (de)
GR (1) GR77916B (de)
HU (1) HU193158B (de)
IE (1) IE56647B1 (de)
IL (1) IL68011A0 (de)
IT (1) IT1170307B (de)
LU (1) LU84674A1 (de)
MY (1) MY8700943A (de)
NL (2) NL193284C (de)
NZ (1) NZ203312A (de)
PH (1) PH18002A (de)
PT (1) PT76330B (de)
SE (1) SE453091B (de)
SU (1) SU1250173A3 (de)
YU (2) YU43822B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409431A1 (de) * 1983-10-08 1985-04-18 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3404906A1 (de) * 1984-02-11 1985-08-14 Bayer Ag, 5090 Leverkusen 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung
DE3419013A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
US4698336A (en) * 1985-01-30 1987-10-06 Eisai Co., Ltd. 3-(pyrrolidinio)methyl-3-cephem derivatives
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
EP0237735B1 (de) * 1986-03-17 1994-03-30 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituierte-3-Cephemverbindungen und Verfahren zu ihrer Herstellung
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
ATE201025T1 (de) 1991-03-08 2001-05-15 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen und zwischenprodukte in diesem verfahren
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
ES2298850T3 (es) * 2003-12-23 2008-05-16 Sandoz Gmbh Proceso para la produccion de intermedios para utilizar en la sintesis de la cefalosporina.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
IT1164746B (it) * 1978-10-27 1987-04-15 Glaxo Group Ltd Antibiotici cefalosporinici,composizioni che li contengono e procedimento per produrli
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds

Also Published As

Publication number Publication date
AU562776B2 (en) 1987-06-18
PT76330B (en) 1986-02-04
YU43822B (en) 1989-12-31
YU52383A (en) 1986-02-28
NL193284B (nl) 1999-01-04
AT384612B (de) 1987-12-10
SE8301178D0 (sv) 1983-03-03
NL990039I1 (nl) 2000-01-03
CS249512B2 (en) 1987-03-12
IE830455L (en) 1983-09-04
NL193284C (nl) 1999-05-06
BE896086A (fr) 1983-09-05
SE453091B (sv) 1988-01-11
YU44777B (en) 1991-02-28
DK86283A (da) 1983-09-05
NL8300755A (nl) 1983-10-03
FI74973C (fi) 1988-04-11
EG15934A (en) 1987-10-30
IL68011A0 (en) 1983-06-15
CA1213882A (en) 1986-11-12
IT8347826A0 (it) 1983-03-01
ES526397A0 (es) 1985-09-16
ES8507557A1 (es) 1985-09-16
LU84674A1 (fr) 1983-11-17
GB2116180B (en) 1985-09-18
PT76330A (en) 1983-04-01
FI74973B (fi) 1987-12-31
PH18002A (en) 1985-02-28
MY8700943A (en) 1987-12-31
ES520224A0 (es) 1984-04-01
SU1250173A3 (ru) 1986-08-07
NL990039I2 (nl) 2000-04-03
CH654313A5 (de) 1986-02-14
FI830689A0 (fi) 1983-03-01
NZ203312A (en) 1985-12-13
GR77916B (de) 1984-09-25
DK86283D0 (da) 1983-02-24
ES8403919A1 (es) 1984-04-01
KR840004118A (ko) 1984-10-06
YU149685A (en) 1986-02-28
SE8301178L (sv) 1983-09-05
GB8305940D0 (en) 1983-04-07
AU1130483A (en) 1983-09-08
IE56647B1 (en) 1991-10-23
AT382155B (de) 1987-01-26
FR2522659A1 (fr) 1983-09-09
DE3307550A1 (de) 1983-09-15
IT1170307B (it) 1987-06-03
HU193158B (en) 1987-08-28
GB2116180A (en) 1983-09-21
FI830689L (fi) 1983-09-05
DE3307550C2 (de) 1988-11-24
FR2522659B1 (fr) 1986-10-24
ATA228285A (de) 1987-05-15
DD210280A5 (de) 1984-06-06
DK156900C (da) 1990-03-12
ATA76183A (de) 1986-06-15
DK156900B (da) 1989-10-16

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