KR850001730A - 벤즈아미딘 유도체 및 그의 염의 제조방법 - Google Patents

벤즈아미딘 유도체 및 그의 염의 제조방법 Download PDF

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KR850001730A
KR850001730A KR1019840004587A KR840004587A KR850001730A KR 850001730 A KR850001730 A KR 850001730A KR 1019840004587 A KR1019840004587 A KR 1019840004587A KR 840004587 A KR840004587 A KR 840004587A KR 850001730 A KR850001730 A KR 850001730A
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South Korea
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compound
group
direct bond
converting
pharmaceutically acceptable
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KR1019840004587A
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KR920000373B1 (ko
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모스(외 2) 마데레이느
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미쉘드 아스
소시에떼 아노닐 사노피
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C07C33/20—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용없음

Description

벤즈아미딘 유도체 및 그의 염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

1) 하기 일반식(Ⅳ)의 화합물을 촉매 수소화 반응시켜 그에 상응하는 아닐린 유도체를 생성하고 2) 산성 매질에서 아질산 나트륨을 상기 아닐린 유도체에 첨가시켜 그에 상응하는 디아조늄 화합물을 형성하고 3) 상기디아조늄 화합물을 시안화 제일구리와 반응시켜 벤조니트릴로 변환시키고, 4) 생성된 벤조니트릴을 일반식(Ⅰ)의 화합물로 변환시키고,5) 필요하다면, 상기 생성 화합물을 약학적으로 수용 가능한 염으로 변환시킴을 특징으로 하는 하기 일반식(Ⅰ)에 상응하는 벤즈아미딘 유도체 및 그의 약학적으로 수용 가능한 염의 제조방법.
식중, A는 3 내지 9탄소원자를 함유하는 직쇄 또는 측쇄 알킬이고, X는 산소원자 또는 직접결합(X가 직접 결합이며, 벤즈아미딘은 알카놀기의 파라 위치에 존재한다)이다.
제1항에 있어서, X는 직접 결합이고, A-OH는 -(CH2)3OH;-(CH2)2-CHOH-CH3;-C(C3H7)2CH2OH;-(CH2)4OH;-(CH2)5OH;CH2-CH(OH)nC3H7및 -C(CH3)|2CH2OH의 기들중에서 선택된 기인 방법.
제1항에 있어서, X는 산소이고, A-OH는 -(CH2)3OH;-(CH2)4OH 및 -C(CH2)5OH의 기중에서 선택된 기인 방법.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840004587A 1983-08-03 1984-08-01 벤즈아미딘 유도체 및 그의 염의 제조방법 KR920000373B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8312824 1983-08-03
FR8312824A FR2550192B1 (fr) 1983-08-03 1983-08-03 Nouveaux derives de la benzamidine a activite antimicrobienne, leur procede de preparation, leur utilisation en tant que medicaments desinfectants ou conservateurs
FR12824 1983-08-03

Publications (2)

Publication Number Publication Date
KR850001730A true KR850001730A (ko) 1985-04-01
KR920000373B1 KR920000373B1 (ko) 1992-01-13

Family

ID=9291379

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840004587A KR920000373B1 (ko) 1983-08-03 1984-08-01 벤즈아미딘 유도체 및 그의 염의 제조방법

Country Status (25)

Country Link
US (1) US4720581A (ko)
EP (1) EP0136195B1 (ko)
JP (1) JPS6054351A (ko)
KR (1) KR920000373B1 (ko)
AR (1) AR242556A1 (ko)
AT (1) ATE27952T1 (ko)
AU (1) AU563648B2 (ko)
CA (1) CA1238922A (ko)
CS (1) CS246088B2 (ko)
DD (1) DD220025A5 (ko)
DE (1) DE3464362D1 (ko)
DK (1) DK158662C (ko)
ES (1) ES8504112A1 (ko)
FI (1) FI77020C (ko)
FR (1) FR2550192B1 (ko)
GR (1) GR82449B (ko)
HU (1) HU192567B (ko)
IL (1) IL72480A (ko)
MA (1) MA20180A1 (ko)
NO (1) NO157618C (ko)
NZ (1) NZ209092A (ko)
PT (1) PT79003B (ko)
SU (1) SU1319784A3 (ko)
YU (1) YU127684A (ko)
ZA (1) ZA845682B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100704992B1 (ko) * 2004-07-05 2007-04-09 동화약품공업주식회사 Ｎ-히드록시-4-｛5-[4-(5-이소프로필-2-메틸-1,3-티아졸-4-일)페녹시]펜톡시｝벤즈아미딘의 개선된 제조방법

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2504361Y2 (ja) * 1990-12-14 1996-07-10 大和ハウス工業株式会社 建物の配管固定構造
DE4447361A1 (de) * 1994-12-21 1996-06-27 Schuelke & Mayr Gmbh Biozide Alkohole, ihre Herstellung und ihre Verwendung
CN100439336C (zh) * 2003-02-19 2008-12-03 卫材R&D管理有限公司 制备环状苯甲脒衍生物的方法
CN111362834B (zh) * 2020-02-26 2021-04-02 湖南大学 一种具有抗耐药性的抗菌脒类低聚物及其制作方法和用途
CN114773250A (zh) * 2021-08-02 2022-07-22 湖南大学 具有抗耐药性的抗菌脒类低聚物及其制作方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2934438A (en) * 1958-03-20 1960-04-26 Michener Harold David Preservation process with alkyl guanidines
US3769427A (en) * 1970-10-01 1973-10-30 Armour Pharma Pharmaceutical compositions and methods of using same
IT1153988B (it) * 1981-10-05 1987-01-21 Medea Res Srl Composizioni ad attivita' antimicrobica

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100704992B1 (ko) * 2004-07-05 2007-04-09 동화약품공업주식회사 Ｎ-히드록시-4-｛5-[4-(5-이소프로필-2-메틸-1,3-티아졸-4-일)페녹시]펜톡시｝벤즈아미딘의 개선된 제조방법

Also Published As

Publication number Publication date
HUT34724A (en) 1985-04-28
AU3079084A (en) 1985-02-07
US4720581A (en) 1988-01-19
NZ209092A (en) 1987-03-06
JPS6054351A (ja) 1985-03-28
KR920000373B1 (ko) 1992-01-13
SU1319784A3 (ru) 1987-06-23
FI77020B (fi) 1988-09-30
GR82449B (ko) 1984-12-13
YU127684A (en) 1986-12-31
DK362384D0 (da) 1984-07-24
DK362384A (da) 1985-02-04
ATE27952T1 (de) 1987-07-15
NO157618C (no) 1988-04-20
IL72480A0 (en) 1984-11-30
IL72480A (en) 1987-10-30
CA1238922A (en) 1988-07-05
ES534828A0 (es) 1985-04-16
DK158662B (da) 1990-07-02
DK158662C (da) 1990-12-10
AR242556A1 (es) 1993-04-30
CS584184A2 (en) 1985-12-16
NO843114L (no) 1985-02-04
HU192567B (en) 1987-06-29
FI843061A (fi) 1985-02-04
EP0136195B1 (fr) 1987-06-24
ZA845682B (en) 1985-02-27
FI843061A0 (fi) 1984-08-02
DD220025A5 (de) 1985-03-20
PT79003B (fr) 1986-06-18
DE3464362D1 (en) 1987-07-30
PT79003A (fr) 1984-08-01
NO157618B (no) 1988-01-11
FR2550192B1 (fr) 1986-04-04
FR2550192A1 (fr) 1985-02-08
MA20180A1 (fr) 1985-04-01
ES8504112A1 (es) 1985-04-16
AU563648B2 (en) 1987-07-16
CS246088B2 (en) 1986-10-16
EP0136195A1 (fr) 1985-04-03
FI77020C (fi) 1989-01-10

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