KR840006622A - 1-아로일-5-옥소-2-피롤리딘 프로파논산 및 그의 에스테르의 제조방법 - Google Patents
1-아로일-5-옥소-2-피롤리딘 프로파논산 및 그의 에스테르의 제조방법 Download PDFInfo
- Publication number
- KR840006622A KR840006622A KR1019830005266A KR830005266A KR840006622A KR 840006622 A KR840006622 A KR 840006622A KR 1019830005266 A KR1019830005266 A KR 1019830005266A KR 830005266 A KR830005266 A KR 830005266A KR 840006622 A KR840006622 A KR 840006622A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- preparing
- aroyl
- oxo
- esters
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 150000002148 esters Chemical class 0.000 title 1
- 150000001412 amines Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- -1 amino compound Chemical class 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 238000010531 catalytic reduction reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 229910017464 nitrogen compound Inorganic materials 0.000 claims 1
- 150000002830 nitrogen compounds Chemical class 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 다음 일반식을다음 일반식의 활성화된 아로일화제와 반응시키고R이 벤질인 경우의 화합물을 접촉환원하여 R이 수소인 화합물로 전환시키는 것으로 구성된 다음 일반식을 가지는 화합물을 제조하는 방법.식중,
- 제1항에 있어서, 상응하는 질소화합물을 환원하고 임의적으로(a)형성된 아미노 화합물을 일킬화하고(b)아민을 형성하고(1)아민을 환원하거나 (2)아민을 알킬화하여 4차 이미노 그룹을 제거하는 것으로 구성되어 있으며, R,Z 및 n은 전술한바와 같고, X 및 Y는 아미노, 알킬아미노, 디알킬 아미노 또는 (CH2n)N- 인 화합물의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/441,335 US4452990A (en) | 1982-11-15 | 1982-11-15 | 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters |
| US441335 | 2003-05-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840006622A true KR840006622A (ko) | 1984-12-01 |
| KR900005018B1 KR900005018B1 (ko) | 1990-07-18 |
Family
ID=23752490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830005266A KR900005018B1 (ko) | 1982-11-15 | 1983-11-07 | 1-아로일-5-옥소-2-피롤리딘프로판산과 그의 에스테르 및 제조방법 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4452990A (ko) |
| EP (1) | EP0110575B1 (ko) |
| JP (1) | JPS59101461A (ko) |
| KR (1) | KR900005018B1 (ko) |
| AT (1) | ATE27272T1 (ko) |
| AU (1) | AU557068B2 (ko) |
| CA (1) | CA1215977A (ko) |
| DE (1) | DE3371628D1 (ko) |
| DK (1) | DK519783D0 (ko) |
| ES (1) | ES527241A0 (ko) |
| FI (1) | FI77443C (ko) |
| GR (1) | GR78737B (ko) |
| HU (1) | HU190916B (ko) |
| IE (1) | IE56126B1 (ko) |
| IL (1) | IL70082A (ko) |
| NO (1) | NO161491C (ko) |
| NZ (1) | NZ206256A (ko) |
| PH (1) | PH20393A (ko) |
| PT (1) | PT77653B (ko) |
| ZA (1) | ZA838126B (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5173489A (en) * | 1986-04-10 | 1992-12-22 | The Dupont Merck Pharmaceutical Co. | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers |
| US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
| US4876259A (en) * | 1987-01-05 | 1989-10-24 | E. I. Du Pont De Nemours And Company | 3,3-disubstituted indolines |
| EP0367393A3 (en) * | 1988-10-31 | 1991-03-27 | Takeda Chemical Industries, Ltd. | New heterocyclic compounds, production and use thereof |
| AT391692B (de) * | 1989-04-24 | 1990-11-12 | Fleischhacker Wilhelm Dr | Enantiomerenreine, in position 1 alkylierte 5-oxo-2-pyrrolidinpropansaeuren und deren ester, deren herstellung und verwendung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS535158A (en) * | 1976-07-05 | 1978-01-18 | Teijin Ltd | Preparation of optical active alpha-alkylvenzylalcohol and its intermediates |
-
1982
- 1982-11-15 US US06/441,335 patent/US4452990A/en not_active Expired - Fee Related
-
1983
- 1983-10-21 IE IE2475/83A patent/IE56126B1/en not_active IP Right Cessation
- 1983-10-24 CA CA000439583A patent/CA1215977A/en not_active Expired
- 1983-10-28 IL IL70082A patent/IL70082A/xx unknown
- 1983-10-31 AT AT83306607T patent/ATE27272T1/de not_active IP Right Cessation
- 1983-10-31 ZA ZA838126A patent/ZA838126B/xx unknown
- 1983-10-31 EP EP83306607A patent/EP0110575B1/en not_active Expired
- 1983-10-31 DE DE8383306607T patent/DE3371628D1/de not_active Expired
- 1983-11-01 AU AU20871/83A patent/AU557068B2/en not_active Ceased
- 1983-11-07 KR KR1019830005266A patent/KR900005018B1/ko not_active IP Right Cessation
- 1983-11-10 GR GR72941A patent/GR78737B/el unknown
- 1983-11-11 FI FI834136A patent/FI77443C/fi not_active IP Right Cessation
- 1983-11-11 PT PT77653A patent/PT77653B/pt not_active IP Right Cessation
- 1983-11-14 DK DK5197/83A patent/DK519783D0/da not_active Application Discontinuation
- 1983-11-14 HU HU833897A patent/HU190916B/hu not_active IP Right Cessation
- 1983-11-14 NZ NZ206256A patent/NZ206256A/en unknown
- 1983-11-14 PH PH29831A patent/PH20393A/en unknown
- 1983-11-14 JP JP58212636A patent/JPS59101461A/ja active Pending
- 1983-11-14 NO NO834149A patent/NO161491C/no unknown
- 1983-11-14 ES ES527241A patent/ES527241A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES8600238A1 (es) | 1985-04-16 |
| IL70082A0 (en) | 1984-01-31 |
| PH20393A (en) | 1986-12-12 |
| JPS59101461A (ja) | 1984-06-12 |
| AU2087183A (en) | 1984-05-24 |
| EP0110575B1 (en) | 1987-05-20 |
| FI834136A0 (fi) | 1983-11-11 |
| PT77653B (en) | 1986-04-17 |
| IE832475L (en) | 1984-05-15 |
| AU557068B2 (en) | 1986-12-04 |
| NO834149L (no) | 1984-05-16 |
| FI834136A (fi) | 1984-05-16 |
| GR78737B (ko) | 1984-10-02 |
| HU190916B (en) | 1986-12-28 |
| US4452990A (en) | 1984-06-05 |
| DE3371628D1 (en) | 1987-06-25 |
| EP0110575A1 (en) | 1984-06-13 |
| CA1215977A (en) | 1986-12-30 |
| NZ206256A (en) | 1985-09-13 |
| KR900005018B1 (ko) | 1990-07-18 |
| ZA838126B (en) | 1985-06-26 |
| NO161491B (no) | 1989-05-16 |
| PT77653A (en) | 1983-12-01 |
| NO161491C (no) | 1989-08-23 |
| FI77443C (fi) | 1989-03-10 |
| IL70082A (en) | 1987-07-31 |
| ATE27272T1 (de) | 1987-06-15 |
| FI77443B (fi) | 1988-11-30 |
| IE56126B1 (en) | 1991-04-24 |
| DK519783D0 (da) | 1983-11-14 |
| ES527241A0 (es) | 1985-04-16 |
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| Date | Code | Title | Description |
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| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |