KR840005335A - 자유-흐름 에팁셀룰로스 미세 캡슈울의 제조방법 - Google Patents

자유-흐름 에팁셀룰로스 미세 캡슈울의 제조방법 Download PDF

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KR840005335A
KR840005335A KR1019830003176A KR830003176A KR840005335A KR 840005335 A KR840005335 A KR 840005335A KR 1019830003176 A KR1019830003176 A KR 1019830003176A KR 830003176 A KR830003176 A KR 830003176A KR 840005335 A KR840005335 A KR 840005335A
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cyclohexane
hydrocarbon compound
hydrocarbon
per
amount
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KR1019830003176A
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KR890000828B1 (ko
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사사요시 사메지마 (외 2)
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마쓰바라 이찌로오
다나베 세이야구 가부시기 가이샤
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

자유-흐름 에팁셀룰로스 미세 캡슈울의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (19)

  1. 다음과 같은 과정을 포함하는 자유-흐름 미세 캡슈울의 제조방법.
    (1) 에틸셀룰로스와 탄화수소 화합물을 함유하는 시클로헥산에 중심물질을 분산시킨다. 단, 상기 탄화수소 화합물은 시클로헥산에 가용성이고 분자량이 150내지 3,000이며, 용해도 매개변수(δ,25℃에서) 7내지 10(cal/㎤)1/2이다, (2) 분산으로 부터 에틸셀룰로스가 분리되어 나와 상기 중심물질 주위에 피막벽을 형성할때까지 분산을 냉각시킨다. 그리고, (3) 상기와 같이 하여 형성된 미세 캡슈울들을 수집한다.
  2. 제1항에 있어서 상기 탄화수소의 용해도 매개변수가 7.5내지 9.5 (cal/㎤) 1/2인 방법.
  3. 제1항에 있어서 상기 탄화수소 화합물의 용해도 매개변수가 8.0내지 9.2 (cal/㎤) 1.2인 방법.
  4. 제1항에 있어서 상기 탄화수소 화합물이 액체 파라핀, 와세린, 세레신, 파라핀, 미세결정 왁스, 스쿠알란, 스쿠알렌, 프리스탄, 폴리부타디엔(분자량: 500내지 3,000), 폴리부텐(분자량: 200내지 3,000), 폴리이소프렌(분자량: 1,000내지 3,000) 및 부타디엔-스티렌공중합체(분자량: 1500내지 3000)로 구성된 그룹으로 부터 선택된 일원인 방법.
  5. 제1항에 있어서 상기 탄화수소 화화물이 액체 파라핀, 파라핀 및 폴리부렌(분자량: 200내지 2,500)으로 구성된 그룹으로 부터 선택된 일원인 방법.
  6. 제1항에 있어서 상기 탄화수소 화합물이 액체 파라핀인 방법.
  7. 제1항에 있어서 탄화수소 화합물이 시클로헥산 100ml당 0.1내지 20g의 양으로 사용되는 방법.
  8. 제1항에 있어서 탄화수소 화합물이 시클로헥산 100ml당 1내지 10g의 양으로 사용되는 방법.
  9. 제1항에 있어서 탄화수소 화합물이 시클로헥산 100ml당 1내지 3g의 양으로 사용되는 방법.
  10. 제7항에 있어서 에톡시 함량이 46.5내지 55w/w%인 에틸셀룰로스가 사용되는 방법.
  11. 제7항에 있어서 에톡시 함량이 46.5내지 55w/w%이고, 점도(톨루엔-에탄올(4:1)에서 5w/w%용액에 대해 25℃에서 측정)가 3내지 500cP인 에틸셀룰로스가 사용되는 방법.
  12. 제10항에 있어서 에틸셀룰로스가 중심물질 1g당 0.03내지 5g의 양으로 사용되는 방법.
  13. 제12항에 있어서 탄화수소 화합물이 액체 파라핀인 방법.
  14. 제4항에 있어서, 에틸셀룰로스, 탄화수소 화합물 그리고 중심물질을 시클로헥산에 부가하고 그 혼합물을 75°내지 80℃로 가열함으로써 분산과정(1)이 실행되는 방법.
  15. 제4항에 있어서 에틸셀룰로스와 탄화수소 화합물을 75°내지 80℃에서 시클로헥산에 용해시킨 다음 중심물질을 교반하에 그 용액에 분산시킴으로써 분산과정(1)이 실행되는 방법.
  16. 제4항에 있어서 탄화수소 화합물이 부틸고무, 폴리부타디엔, 폴리에틸렌 및 폴리이소부틸렌으로 구성된 그룹으로 부터 선택된 탄화수소 중합체와 함께 사용되는 방법.
  17. 제4항에 있어서 탄화수소 화합물이 티메틸폴리실록산, 메틸페닐폴리실록산, 디페닐폴리실록산 및 폴리스티렌-폴리디메틸실록산 블록 공중합체로 구성된 그룹으로 부터 선택된 오르가노폴리실록산과 함께 사용되는 방법.
  18. 제16항에 있어서 탄화수소 화합물이 시클로헥산 100ml당 0.1내지 20g의 양으로 사용되고 탄화수소 중합체는 시클로헥산 100ml당 0.1내지 10g의 양으로 사용되는 방법.
  19. 제17항에 있어서 탄화수소 화합물이 시클로헥산 100ml당 0.1내지 20g의 양으로 사용되고 오르가노 폴리실록산은 시클로헥산 100ml당 0.01내지 10g의 양으로 사용되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003176A 1982-07-16 1983-07-12 비응집성 에틸셀룰로스의 미세 캡슈율(Free-flowing ethylcelrulose micro capsule)의 제조방법 KR890000828B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP124829 1982-07-16
JP82-124829 1982-07-16
JP57124829A JPS5916821A (ja) 1982-07-16 1982-07-16 非凝集性マイクロカプセルの製法

Publications (2)

Publication Number Publication Date
KR840005335A true KR840005335A (ko) 1984-11-12
KR890000828B1 KR890000828B1 (ko) 1989-04-10

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KR1019830003176A KR890000828B1 (ko) 1982-07-16 1983-07-12 비응집성 에틸셀룰로스의 미세 캡슈율(Free-flowing ethylcelrulose micro capsule)의 제조방법

Country Status (11)

Country Link
US (1) US4542042A (ko)
EP (1) EP0099109B1 (ko)
JP (1) JPS5916821A (ko)
KR (1) KR890000828B1 (ko)
AT (1) ATE18863T1 (ko)
CA (1) CA1212868A (ko)
DE (1) DE3362784D1 (ko)
DK (1) DK161744C (ko)
ES (1) ES524175A0 (ko)
HK (1) HK16988A (ko)
SG (1) SG81287G (ko)

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Publication number Publication date
ATE18863T1 (de) 1986-04-15
US4542042A (en) 1985-09-17
DK327583A (da) 1984-01-17
HK16988A (en) 1988-03-11
EP0099109B1 (en) 1986-04-02
JPS6259971B2 (ko) 1987-12-14
DK161744B (da) 1991-08-12
ES8405640A1 (es) 1984-06-16
DE3362784D1 (en) 1986-05-07
EP0099109A1 (en) 1984-01-25
KR890000828B1 (ko) 1989-04-10
SG81287G (en) 1988-04-15
CA1212868A (en) 1986-10-21
DK327583D0 (da) 1983-07-15
DK161744C (da) 1992-02-17
ES524175A0 (es) 1984-06-16
JPS5916821A (ja) 1984-01-28

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