KR840002003A - 결정성 3-세펨-4-카복실산 염산염의 제조방법 - Google Patents
결정성 3-세펨-4-카복실산 염산염의 제조방법 Download PDFInfo
- Publication number
- KR840002003A KR840002003A KR1019820004885A KR820004885A KR840002003A KR 840002003 A KR840002003 A KR 840002003A KR 1019820004885 A KR1019820004885 A KR 1019820004885A KR 820004885 A KR820004885 A KR 820004885A KR 840002003 A KR840002003 A KR 840002003A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- mixture
- hydrochloric acid
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 7
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 239000013078 crystal Substances 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 150000002923 oximes Chemical class 0.000 claims 2
- 239000003495 polar organic solvent Substances 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 238000010792 warming Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/316,615 US4400503A (en) | 1981-10-30 | 1981-10-30 | Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid |
| US316615 | 1981-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840002003A true KR840002003A (ko) | 1984-06-11 |
Family
ID=23229825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820004885A Ceased KR840002003A (ko) | 1981-10-30 | 1982-10-29 | 결정성 3-세펨-4-카복실산 염산염의 제조방법 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4400503A (enExample) |
| EP (1) | EP0078671A3 (enExample) |
| JP (1) | JPS5885892A (enExample) |
| KR (1) | KR840002003A (enExample) |
| CA (1) | CA1182810A (enExample) |
| DK (1) | DK480982A (enExample) |
| GB (1) | GB2108124B (enExample) |
| GR (1) | GR77359B (enExample) |
| HU (1) | HU189186B (enExample) |
| IL (1) | IL67099A (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2157254T3 (es) * | 1993-03-12 | 2001-08-16 | Upjohn Co | Ceftiofur (acido libre) cristalino. |
| US7842791B2 (en) * | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
| AU2002368494A1 (en) * | 2002-12-20 | 2004-07-14 | Lupin Limited | A process for the preparation of cefpodoxime proxetil |
| EP4169705B1 (de) | 2021-10-21 | 2025-12-17 | Folien + Druck GmbH | Anfaltbare sektflaschenkapsel |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
| US4298606A (en) * | 1974-12-19 | 1981-11-03 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido compounds |
| US4202893A (en) * | 1976-03-25 | 1980-05-13 | Roussel Uclaf | Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids |
| GR63088B (en) * | 1976-04-14 | 1979-08-09 | Takeda Chemical Industries Ltd | Preparation process of novel cephalosporins |
| JPS5579393A (en) * | 1978-12-11 | 1980-06-14 | Takeda Chem Ind Ltd | Cephalosporin derivative and its preparation |
| SE449996B (sv) * | 1979-10-02 | 1987-06-01 | Glaxo Group Ltd | (6r,7r)-7-/(z)-2-(2-aminotiazol-4-yl)-2-(2-karboxiprop-2-oxiimino)acetamidol/-3-(1-pyridiniummetyl)cef-3-em-4-karboxylat i form av en kristallin bishydroklorid farmaceutisk komposition derav samt anvendning som mellanpr |
| GR78221B (enExample) * | 1980-02-01 | 1984-09-26 | Ciba Geigy Ag |
-
1981
- 1981-10-30 US US06/316,615 patent/US4400503A/en not_active Expired - Fee Related
-
1982
- 1982-10-28 EP EP82305743A patent/EP0078671A3/en not_active Ceased
- 1982-10-28 HU HU823464A patent/HU189186B/hu unknown
- 1982-10-28 IL IL67099A patent/IL67099A/xx unknown
- 1982-10-28 GB GB08230756A patent/GB2108124B/en not_active Expired
- 1982-10-28 CA CA000414379A patent/CA1182810A/en not_active Expired
- 1982-10-28 JP JP57190677A patent/JPS5885892A/ja active Pending
- 1982-10-29 KR KR1019820004885A patent/KR840002003A/ko not_active Ceased
- 1982-10-29 DK DK480982A patent/DK480982A/da not_active Application Discontinuation
- 1982-10-29 GR GR69672A patent/GR77359B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL67099A (en) | 1986-07-31 |
| GB2108124A (en) | 1983-05-11 |
| US4400503A (en) | 1983-08-23 |
| EP0078671A2 (en) | 1983-05-11 |
| GR77359B (enExample) | 1984-09-11 |
| HU189186B (en) | 1986-06-30 |
| DK480982A (da) | 1983-05-01 |
| CA1182810A (en) | 1985-02-19 |
| JPS5885892A (ja) | 1983-05-23 |
| GB2108124B (en) | 1985-07-10 |
| EP0078671A3 (en) | 1984-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19821029 |
|
| PG1501 | Laying open of application | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19860128 Patent event code: PE09021S01D |
|
| PE0601 | Decision on rejection of patent |
Patent event date: 19860820 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19860128 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |
|
| PJ2001 | Appeal |
Appeal kind category: Appeal against decision to decline refusal Decision date: 19870331 Appeal identifier: 1986201000595 Request date: 19860916 |
|
| PE0601 | Decision on rejection of patent |
Patent event date: 19870414 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19860128 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |