GB2108124B - Novel cephalosporin salt and its use in a purification process - Google Patents

Novel cephalosporin salt and its use in a purification process

Info

Publication number
GB2108124B
GB2108124B GB08230756A GB8230756A GB2108124B GB 2108124 B GB2108124 B GB 2108124B GB 08230756 A GB08230756 A GB 08230756A GB 8230756 A GB8230756 A GB 8230756A GB 2108124 B GB2108124 B GB 2108124B
Authority
GB
United Kingdom
Prior art keywords
purification process
novel cephalosporin
cephalosporin salt
salt
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08230756A
Other languages
English (en)
Other versions
GB2108124A (en
Inventor
Kuo Shang Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB2108124A publication Critical patent/GB2108124A/en
Application granted granted Critical
Publication of GB2108124B publication Critical patent/GB2108124B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB08230756A 1981-10-30 1982-10-28 Novel cephalosporin salt and its use in a purification process Expired GB2108124B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/316,615 US4400503A (en) 1981-10-30 1981-10-30 Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid

Publications (2)

Publication Number Publication Date
GB2108124A GB2108124A (en) 1983-05-11
GB2108124B true GB2108124B (en) 1985-07-10

Family

ID=23229825

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08230756A Expired GB2108124B (en) 1981-10-30 1982-10-28 Novel cephalosporin salt and its use in a purification process

Country Status (10)

Country Link
US (1) US4400503A (enExample)
EP (1) EP0078671A3 (enExample)
JP (1) JPS5885892A (enExample)
KR (1) KR840002003A (enExample)
CA (1) CA1182810A (enExample)
DK (1) DK480982A (enExample)
GB (1) GB2108124B (enExample)
GR (1) GR77359B (enExample)
HU (1) HU189186B (enExample)
IL (1) IL67099A (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2157254T3 (es) * 1993-03-12 2001-08-16 Upjohn Co Ceftiofur (acido libre) cristalino.
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
AU2002368494A1 (en) * 2002-12-20 2004-07-14 Lupin Limited A process for the preparation of cefpodoxime proxetil
EP4169705B1 (de) 2021-10-21 2025-12-17 Folien + Druck GmbH Anfaltbare sektflaschenkapsel

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
US4202893A (en) * 1976-03-25 1980-05-13 Roussel Uclaf Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
SE449996B (sv) * 1979-10-02 1987-06-01 Glaxo Group Ltd (6r,7r)-7-/(z)-2-(2-aminotiazol-4-yl)-2-(2-karboxiprop-2-oxiimino)acetamidol/-3-(1-pyridiniummetyl)cef-3-em-4-karboxylat i form av en kristallin bishydroklorid farmaceutisk komposition derav samt anvendning som mellanpr
GR78221B (enExample) * 1980-02-01 1984-09-26 Ciba Geigy Ag

Also Published As

Publication number Publication date
IL67099A (en) 1986-07-31
GB2108124A (en) 1983-05-11
US4400503A (en) 1983-08-23
EP0078671A2 (en) 1983-05-11
GR77359B (enExample) 1984-09-11
HU189186B (en) 1986-06-30
DK480982A (da) 1983-05-01
CA1182810A (en) 1985-02-19
JPS5885892A (ja) 1983-05-23
EP0078671A3 (en) 1984-08-08
KR840002003A (ko) 1984-06-11

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee