KR830009079A - 플루오로-프로 스타사이클린의 제조방법 - Google Patents
플루오로-프로 스타사이클린의 제조방법 Download PDFInfo
- Publication number
- KR830009079A KR830009079A KR1019820001052A KR820001052A KR830009079A KR 830009079 A KR830009079 A KR 830009079A KR 1019820001052 A KR1019820001052 A KR 1019820001052A KR 820001052 A KR820001052 A KR 820001052A KR 830009079 A KR830009079 A KR 830009079A
- Authority
- KR
- South Korea
- Prior art keywords
- fluoro
- methyl
- hydrogen
- compound
- preparing
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000012054 meals Nutrition 0.000 claims 2
- 150000004702 methyl esters Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 일반식(XII)의 화합물을 탈할로겐화 수소화시키고, 경우에 따라 에스테르 그룹 R6를 가수분해하며, 또한 경우에 따라 수득된 카복실산을 약제학적으로 허용되는 염으로 전환시킴을 특징으로 하여 일반식(I)의 화합물 그의 약제학적으로 허용되는 염, 광학적 대장체 또는 라세메이트를 제조하는 방법.상기식중점선으로 표시된 이중결합중의 하나는 4,5 또는 5,6 위치에 존재하고,R은 수소 또는 저급알킬이며R1은 메틸, 수소 또는 하이드록시이고,R2는 수소, 메틸 또는 플루오로이며,R21은 수소, 플루오로, 트리플루오로메틸 또는 메틸이며, 단, R21이 트리플루오로일 때 R2는 수소 또는 메틸이고, X는 할로겐이며, R6는 저급알킬이다.
- 제1항에 있어서, 일반식(IA)의 화합물을 제조하는 방법.상기식중R, R1, R2및 R21은 제1항에 정의된 바와 같다.
- 제1항에 있어서, 7-플루오로 치환체가 베타 배위인 일반식(I) 화합물을 제조하는 방법.
- 제1항에 있어서, R1이 하이드록시 또는 메틸이고 R2및 R21은 메틸이거나 R2는 수소이고 R21은 플루오로인 일반식(I)화합물을 제조하는 방법.
- 제1항에 있어서, (5Z, 7β, 9α, 11α, 13E, 15R)-7-플루오로-6,9-에폭시-11,15-디하이드록시16,16-디메틸-프로스타-5,13-디엔-1-오 산 나트륨염을 제조하는 방법.
- 제1항에 있어서, (5E, 7β, 9α, 11α, 13E, 15R)-7-플루오로-6,9-에폭시-11,15-디하이드록시-16,16-디메틸-프로스타-5,13-디엔-1-오 산 메틸 에스테르를 제조하는 방법.
- 제1항에 있어서, (5Z, 9S, 11R, 13E, 15R)-11,16, 16-트리메틸-15-하이드록시-6,0-에폭시-7-플루오로-프로스타-5,13-디엔-1-오 산 메틸 에스테르를 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24281881A | 1981-03-11 | 1981-03-11 | |
| US242818 | 1981-03-11 | ||
| US242,818 | 1981-03-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830009079A true KR830009079A (ko) | 1983-12-17 |
| KR860002049B1 KR860002049B1 (ko) | 1986-11-20 |
Family
ID=22916307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8201052A KR860002049B1 (ko) | 1981-03-11 | 1982-03-11 | 플루오로-프로스타사이클린의 제조방법 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS57171988A (ko) |
| KR (1) | KR860002049B1 (ko) |
| BE (1) | BE892434A (ko) |
| GR (1) | GR76075B (ko) |
| ZA (1) | ZA821449B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57200378A (en) * | 1981-06-02 | 1982-12-08 | Teijin Ltd | Halogenated pgi2 and its preparation |
| US4472428A (en) * | 1980-12-09 | 1984-09-18 | Teijin Limited | Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore |
| JPS57165382A (en) * | 1981-04-06 | 1982-10-12 | Teijin Ltd | Fluoro-pgi2 compound and its preparation |
| JPS58150583A (ja) * | 1982-03-04 | 1983-09-07 | Teijin Ltd | 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物 |
| JPS59227888A (ja) * | 1983-06-10 | 1984-12-21 | Asahi Glass Co Ltd | ７−フルオロプロスタグランジン類の製造方法 |
| DE69502517T2 (de) * | 1994-02-17 | 1998-10-01 | Asahi Glass Co Ltd | Difluorprostacycline, Zwischenprodukte und Verfahren zu deren Herstellung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU184917B (en) * | 1980-10-27 | 1984-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 7-substituted pgi down 2 derivatives |
| JPS57165382A (en) * | 1981-04-06 | 1982-10-12 | Teijin Ltd | Fluoro-pgi2 compound and its preparation |
-
1982
- 1982-03-04 ZA ZA821449A patent/ZA821449B/xx unknown
- 1982-03-09 GR GR67527A patent/GR76075B/el unknown
- 1982-03-09 JP JP57035978A patent/JPS57171988A/ja active Pending
- 1982-03-10 BE BE0/207519A patent/BE892434A/fr not_active IP Right Cessation
- 1982-03-11 KR KR8201052A patent/KR860002049B1/ko active
Also Published As
| Publication number | Publication date |
|---|---|
| KR860002049B1 (ko) | 1986-11-20 |
| ZA821449B (en) | 1983-01-26 |
| GR76075B (ko) | 1984-08-03 |
| JPS57171988A (en) | 1982-10-22 |
| BE892434A (fr) | 1982-09-10 |
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