KR830007834A - 항생물질 BMG 162-aF2, 그것의 제조방법 및 유효성분으로 이 항생물질을 함유한 항종 양약제 - Google Patents

항생물질 BMG 162-aF2, 그것의 제조방법 및 유효성분으로 이 항생물질을 함유한 항종 양약제 Download PDF

Info

Publication number
KR830007834A
KR830007834A KR1019810003293A KR810003293A KR830007834A KR 830007834 A KR830007834 A KR 830007834A KR 1019810003293 A KR1019810003293 A KR 1019810003293A KR 810003293 A KR810003293 A KR 810003293A KR 830007834 A KR830007834 A KR 830007834A
Authority
KR
South Korea
Prior art keywords
bmg
antibiotic
weight
salt
medicament
Prior art date
Application number
KR1019810003293A
Other languages
English (en)
Other versions
KR870001373B1 (ko
Inventor
하마오 우메자와
도미오 다께우찌
히로시 나가나와
히로노부 이이누마
세쓰고 구니모도
Original Assignee
이찌가와 도꾸지
자이단 호오진 비세이부쓰 가가꾸 겡뀨우가이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이찌가와 도꾸지, 자이단 호오진 비세이부쓰 가가꾸 겡뀨우가이 filed Critical 이찌가와 도꾸지
Publication of KR830007834A publication Critical patent/KR830007834A/ko
Application granted granted Critical
Publication of KR870001373B1 publication Critical patent/KR870001373B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

항생물질 BMG 162-aF2, 그것의 제조방법 및 유효성분으로 이 항생물질을 함유한 항종 양약제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 BMG 162-aF2 하이드로클로라이드의1H-NMR 스펙트럼(CD3)2SO에서의 100MHz 내부 대조:TMS).
제2도는 BMG 162-aF2 하이드로클로라이드의13 13C-NMR 스펙트럼(D2O에서의 25Mhz 바깥표준 : TMS).
제3도는 BMG 162-aF2 하이드로클로라이드의15-NMR스펙트럼(D2O에서의 10MHz,바깥표준 : TMS)
제4도는 KBr중의 BGM 162-aF2의 흡수 스펙트럼.

Claims (18)

  1. 일반식 :
    의 항생물질 BMG 162-aF2 또는 약제로 사용할 수 있는 그것의 염.
  2. 약제로 사용할 수 있는 염이 하이드로 클로라이드인 청구범위 제1항의 항생물질 BMG 162-aF2.
  3. 배양기에서 간균속에 속하는 BMG 162-aF2 생산균주를 배양해서 BMG 162-aF2를 생산 축적하고 이 배양에서,
    일반식 :
    의 항생물질 BMG 162-aF2를 회수하는 것으로 된 항생물질 BMG 162-aF2의 제조방법.
  4. BMG 162-aF2 생산균주가 래터로스포러스 간균 BMG 162-aF2 FERM-P 5230, ATCC 31932인 청구범위 제3항의 방법.
  5. 배양기가 질소원, 탄소원 및 무기염을 함유한 것인 청구범위 제3항의 방법.
  6. 배양을 충분한 량의 BMG 162-aF2를 축적하는데 충분한 시간동안 pH 5.0 내지 8.2에서 15°내지 40℃로 액상배양기에서 호기성으로 수행하는 청구범위 제3항의 방법.
  7. 방양기로부터의 BMG 162-aF2의 회수를 활성기로서 카르복시산을 가진 약한 양이온의 이온교환수지를 사용해서 컬럼크로마토그래피 방법으로 수행하는 청구범위 제3항의 방법.
  8. 수지에 흡착된 BMG 162-aF2가 산수용액이나 염수용액으로 용리되는 청구범위 제7항의 방법.
  9. 약학적으로 유효량의 일반식 :
    의 항생물질 BMG 162-aF2와 약제로 사용할 수 있는 그것의 염 및 약제로 사용할 수 있는 중량제로된 항종양 조성물.
  10. 전술한 항생물질 BMG 162-aF2와 전술한 중량제의 비례가 각각 중량으로 0.1 내지 70% 및 중량으로 99.1 내지 30%인 청구범위 제9항의 조성물.
  11. 주사제, 분말, 과립, 정제 및 좌약상으로된 청구범위 제9항의 조성물.
  12. 중량으로 0.1 내지 95.0%의 일반식:
    의 항생물질 BMG 162-aF2나 그것의 수용성염, 중량으로 5.0 내지 99.9%의 당 및 중량으로 0 내지 94.9%의 염화나트륨으로 된 주사용 조성물.
  13. 당이만니톨인 청구범위 제12항의 조성물.
  14. 중량으로 0.1 내지 95.1부의 일반식 :
    의 항생물질, BMG 162-aF2나 그것의 수용성 염, 중량으로 5.0 내지 99.9%의 당 및 중량으로 0 내지 94.9%의 염화나트륨을 증류수에서 용해하고, 이와같이 해서 된 용액을 작은 수용물에 넣어 이를 동결 건조하는 것으로 된 주사용 조성물의 제조방법.
  15. 당이 만니톨인 청구범위 제14항의 방법.
  16. 전술한 동물에 약학적으로 유효량의 일반식 :
    의 항생물질 BMG 162-aF2나 그것의 약제로 사용할 수 있는 염을 투여하는 것으로 된 온혈동물의 종양을 치료하는 방법.
  17. 약학적인 유효량이 0.01 내지 800mg/일/성인인 청구범위 제15항의 방법.
  18. 약제로 사용할 수 있는 염이 하이드로클로라이드인 청구범위 제15항의 방법.
    ※ 참고사항 : 최초출원에 내용에 의하여 공개하는 것임.
KR1019810003293A 1980-09-08 1981-09-04 항생물질 BMG 162-aF2의 제조방법 KR870001373B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP80/123585 1980-09-08
JP55123585A JPS5748957A (en) 1980-09-08 1980-09-08 Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient

Publications (2)

Publication Number Publication Date
KR830007834A true KR830007834A (ko) 1983-11-07
KR870001373B1 KR870001373B1 (ko) 1987-07-24

Family

ID=14864227

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003293A KR870001373B1 (ko) 1980-09-08 1981-09-04 항생물질 BMG 162-aF2의 제조방법

Country Status (18)

Country Link
US (2) US4416899A (ko)
JP (1) JPS5748957A (ko)
KR (1) KR870001373B1 (ko)
AT (1) AT376239B (ko)
AU (1) AU523222B2 (ko)
BE (1) BE890229A (ko)
CA (1) CA1175763A (ko)
CH (1) CH655498B (ko)
CS (1) CS226036B2 (ko)
DE (1) DE3134353C2 (ko)
DK (1) DK157890C (ko)
ES (1) ES505256A0 (ko)
FR (1) FR2489819A1 (ko)
GB (1) GB2084999B (ko)
HU (1) HU188077B (ko)
IT (1) IT1209896B (ko)
NL (1) NL8104069A (ko)
SE (1) SE450836B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
US4851446A (en) * 1984-11-13 1989-07-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Immunosuppressing method
JPS61134312A (ja) * 1984-12-06 1986-06-21 Microbial Chem Res Found 移植免疫抑制剤並びに抗アレルギ−剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
ES2039213T3 (es) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation Procedimiento para producir nuevos compuestos relacionados con espergualina.
JP2873340B2 (ja) * 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質ｔａｎ―１０５７，その製造法および用途
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
JPH0263181U (ko) * 1988-10-27 1990-05-11
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
US5162581A (en) * 1989-05-29 1992-11-10 Takaru Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2998438A (en) * 1958-03-31 1961-08-29 Merck & Co Inc Eulicin and process for production
US3617448A (en) * 1967-10-03 1971-11-02 Research Corp Antibiotic and methods of producing and using it
US3743580A (en) * 1970-04-28 1973-07-03 Microbial Chem Res Found Antibiotic,negamycin,and processes for the preparation thereof
US4163796A (en) * 1977-12-14 1979-08-07 The Dow Chemical Company Stabilized aqueous amide antimicrobial composition
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
US4226808A (en) * 1979-08-17 1980-10-07 Schering Corporation 1-Aryl-2-dihalogenodeuterioalkanoylamido-1,3-propanediol antibacterial agents

Also Published As

Publication number Publication date
NL8104069A (nl) 1982-04-01
HU188077B (en) 1986-03-28
DK157890C (da) 1990-07-23
SE450836B (sv) 1987-08-03
US4416899A (en) 1983-11-22
FR2489819B1 (ko) 1985-02-15
CA1175763A (en) 1984-10-09
ES8302090A1 (es) 1983-01-01
FR2489819A1 (fr) 1982-03-12
GB2084999B (en) 1984-06-13
ES505256A0 (es) 1983-01-01
ATA386081A (de) 1984-03-15
IT1209896B (it) 1989-08-30
BE890229A (fr) 1982-01-04
SE8105079L (sv) 1982-03-09
KR870001373B1 (ko) 1987-07-24
AU523222B2 (en) 1982-07-15
JPS5748957A (en) 1982-03-20
CH655498B (ko) 1986-04-30
DK394281A (da) 1982-03-09
AT376239B (de) 1984-10-25
DK157890B (da) 1990-02-26
AU7489281A (en) 1982-03-18
DE3134353C2 (de) 1986-03-13
JPS6316380B2 (ko) 1988-04-08
US4474880A (en) 1984-10-02
CS226036B2 (en) 1984-03-19
GB2084999A (en) 1982-04-21
IT8149237A0 (it) 1981-09-04
DE3134353A1 (de) 1982-04-22

Similar Documents

Publication Publication Date Title
KR830007834A (ko) 항생물질 BMG 162-aF2, 그것의 제조방법 및 유효성분으로 이 항생물질을 함유한 항종 양약제
Dombernowsky et al. Schedule dependency of the antileukemic activity of the podophyllotoxin‐derivative VP 16–213 (NSC‐141540) in L1210 leukemia
Morello Induction of DDT-metabolizing enzymes in microsomes of rat liver after administration of DDT
DE69126009T2 (de) Zyklische (Hetero)Acetale nitrosubstituierter Benzaldehyde mit Wirkung gegen Krebs
KR890003791A (ko) 안정된 안트라사이클린의 제법
JPH02502543A (ja) 新規６置換マイトマイシン類似体
Littman et al. Acceleration of growth of sarcoma 180 with pyridoxamine and retardation with penicillamine.
US4578383A (en) CL 1565 antibiotic compounds
Paronetto Adjuvant arthritis induced by Corynebacterium rubrum
KR900008247B1 (ko) 새로운 생리활성물질 아르파메닌(Arphamenine)의 제조방법
Sebek The synthesis of neomycin-C14 by Streptomyces fradiae
KR880001821A (ko) 글리코펩티드 항생물질
TAKAHASHI et al. Carcinogenicity and mutagenicity of 4-nitropyridine 1-oxide derivatives
AU641950B2 (en) (1R,2R)-2-(3-pyridyl)-tetrahydrothiopyran-2-carbothioamide 1-oxides, process for their preparation and pharmaceutical compositions containing them
DE4327226A1 (de) Chelatoren, ihre Herstellung aus den Antibiotika Salmycin A, B oder C und deren Verwendung
US3714142A (en) Erythromycine
JPS6135988B2 (ko)
US3394178A (en) Nu-ethyloxytetracycline
JP3819132B2 (ja) 新規生理活性物質ｎａ２２５９８ｂ１及びｂ２、その製造法およびその用途
JPS61280472A (ja) β−ガラクトシダ−ゼ阻害物質ガラクトスタチン類およびその製造方法
US3801465A (en) Erythromycin e
US4696912A (en) Stabilized compositions
KR890000479A (ko) 8α-아실아미노 에르고린, 그것의 제법 및 그것을 함유하는 약학적 조성물
Jasmin Effect of histamine liberators on urinary excretion of 5-hydroxyindolacetic acid.
US3010879A (en) Growing c. neoformans in capsular form