KR830007826A - 인체 콜로니 자극인자의 제조방법 - Google Patents
인체 콜로니 자극인자의 제조방법 Download PDFInfo
- Publication number
- KR830007826A KR830007826A KR1019810005159A KR810005159A KR830007826A KR 830007826 A KR830007826 A KR 830007826A KR 1019810005159 A KR1019810005159 A KR 1019810005159A KR 810005159 A KR810005159 A KR 810005159A KR 830007826 A KR830007826 A KR 830007826A
- Authority
- KR
- South Korea
- Prior art keywords
- human
- cells
- lymphoblasts
- fused
- stimulating factor
- Prior art date
Links
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 title claims 5
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 11
- 241001465754 Metazoa Species 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 108010028006 B-Cell Activating Factor Proteins 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 241000272201 Columbiformes Species 0.000 claims 1
- 241000699800 Cricetinae Species 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241000699660 Mus musculus Species 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 235000013330 chicken meat Nutrition 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000001926 lymphatic effect Effects 0.000 claims 1
- -1 merogen Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 229920005615 natural polymer Polymers 0.000 claims 1
- 238000011580 nude mouse model Methods 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 인체 콜로니 자극인자 산생능이 들어있는 인체의 세포와 인체 림프아세포와를 융합시키고, 이 융합 세포를 인체 이외의 온혈동물의 체내에 이식하여, 그 온혈동물의 체액의 공급을 받으면서 증식시켜서 획득하는 세포에서 인체콜로니 자극인자를 산생시키는 것을 특징으로 하는 인체 콜로니 자극인자의 제조방법.
- 제1항에 있어서, 인체 림프아세포가 인체 폐암세포와 융합하는 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.
- 제1항에 있어서, 인체 림프아세포가 인체 B-림프구와 융합하는 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.
- 제1항에 있어서, 인체 림프아세포가 인체 턱밑암세포와 융합하는 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.
- 제1항에 있어서, 인체 림프아세포가 인체 위암세포와 융합하는 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.
- 제1항에 있어서, 인체 림프아세포가 인체 신장암세포와 융합하는 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.
- 제1항에 있어서, 인체 림프아가 인체콜로니 자극인자 산생능을 가지는 인체 림프아세포와 융합을 하는 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.
- 제7항에 있어서, 인체 림프아가 인체 림프아구인 청구범위 제7항의 인체콜로니 자극인자의 제조방법.
- 제1항에 있어서, 인체 림프아세포가 Namalwa 세포, BALL-1 세포, NALL-1세포, TALL-1 세포 또는 JBL 세포인 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.
- 제1항에 있어서, 융합세포의 라항은 증식이 천연 2중쇄 RNA, 합성이중쇄 RNA, 미생물을 산생하는 리포다당, 머로우겐, 화학적 모조자연중합체, 합성중합체, 양이온성 저분자화합물, 엔도록신과 리튬 화합물 중에서 하나 또는 그 이상의 공존하에서 인체 콜로니 자극인자를 산생시키는 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.
- 제1항에 있어서, 인체 이외의 온혈동물이라 함은 닭, 비둘기, 개, 고양이, 원숭이, 산양, 돼지, 소, 말, 토끼, 몰모트, 쥐, 햄스터, 보통마우스, 누우드마우스인 청구범위 제1항의 인체 콜로니 자극인자의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP185732 | 1980-12-31 | ||
JP55185732A JPS6030654B2 (ja) | 1980-12-31 | 1980-12-31 | ヒトコロニ−刺激因子の製造方法 |
JP80-185732 | 1980-12-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830007826A true KR830007826A (ko) | 1983-11-07 |
KR870001149B1 KR870001149B1 (ko) | 1987-06-11 |
Family
ID=16175883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810005159A KR870001149B1 (ko) | 1980-12-31 | 1981-12-28 | 인체 콜로니 자극인자의 제조방법 |
Country Status (7)
Country | Link |
---|---|
US (1) | US4621050A (ko) |
JP (1) | JPS6030654B2 (ko) |
KR (1) | KR870001149B1 (ko) |
CH (1) | CH649786A5 (ko) |
FR (1) | FR2497099A1 (ko) |
GB (1) | GB2092159B (ko) |
IT (1) | IT1148022B (ko) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS609795B2 (ja) * | 1980-12-11 | 1985-03-13 | 株式会社林原生物化学研究所 | ヒト上皮細胞成長因子の製造方法 |
WO1986000639A1 (en) * | 1984-07-06 | 1986-01-30 | Sandoz Ag | Lymphokine production and purification |
JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
UA29377C2 (uk) * | 1984-09-19 | 2000-11-15 | Новартіс Аг | Спосіб отримання білка з активністю колонієстимулювального фактора гранулоцитів та макрофагів(gm-csf) приматів |
US4968618A (en) * | 1984-11-16 | 1990-11-06 | University Of Florida | Composition and method for promoting growth of granulocytes |
US5573930A (en) * | 1985-02-05 | 1996-11-12 | Cetus Oncology Corporation | DNA encoding various forms of colony stimulating factor-1 |
US6117422A (en) * | 1985-02-05 | 2000-09-12 | Chiron Corporation | N∇2-CSF-1(long form) and carboxy truncated fragments thereof |
US4847201A (en) * | 1985-02-05 | 1989-07-11 | Cetus Corporation | DNA encoding for CSF-1 and accompanying recombinant systems |
US6156300A (en) * | 1985-02-05 | 2000-12-05 | Chiron Corporation | Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof |
AU594045B2 (en) * | 1985-02-05 | 1990-03-01 | Chiron Corporation | Recombinant colony stimulating factor-1 |
WO1986004605A1 (en) * | 1985-02-08 | 1986-08-14 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
US5532341A (en) * | 1985-03-28 | 1996-07-02 | Sloan-Kettering Institute For Cancer Research | Human pluripotent hematopoietic colony stimulating factor |
JPS63502795A (ja) * | 1985-10-03 | 1988-10-20 | バイオジェン インコーポレイテッド | 顆粒球‐マクロファージコロニー刺激因子‐様ポリペプチド、dna配列、組換えdna分子並びに微生物細胞中でヒト顆粒球−マクロファ−ジコロニ−刺激因子−様ポリペプチドを高収量で生産する方法 |
JPH0618778B2 (ja) * | 1985-10-04 | 1994-03-16 | 中外製薬株式会社 | 白血球減少症治療剤 |
NZ218336A (en) * | 1985-12-09 | 1991-08-27 | Kirin Amgen Inc | Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf) |
JPH0618779B2 (ja) * | 1986-01-22 | 1994-03-16 | 中外製薬株式会社 | 造血機能回復促進剤 |
JPH0618780B2 (ja) * | 1986-01-22 | 1994-03-16 | 中外製薬株式会社 | 骨髄性白血病抑制剤 |
ZA874410B (en) * | 1986-06-24 | 1988-04-27 | Merrell Dow Pharma | Fusion products |
US5162111A (en) * | 1986-07-30 | 1992-11-10 | Grabstein Kenneth H | Treatment of bacterial diseases with granulocyte-macrophage colony stimulating factor |
JPH0618781B2 (ja) * | 1986-10-18 | 1994-03-16 | 中外製薬株式会社 | 感染症治療剤 |
JPS63245667A (ja) * | 1987-03-31 | 1988-10-12 | Ube Ind Ltd | 肥満細胞成長活性を有するヒトil−3産生ヒト細胞および肥満細胞成長活性を有するヒトil−3の製造方法 |
US7094400B1 (en) * | 1987-05-01 | 2006-08-22 | Shire Human Genetic Therapies, Inc. | Transkaryotic implantation |
JPS6439855A (en) * | 1987-08-05 | 1989-02-10 | Nec Corp | Surface acoustic wave device |
US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
JPH02211748A (ja) * | 1989-02-10 | 1990-08-23 | Nec Eng Ltd | 直交変調回路 |
US5148267A (en) * | 1989-09-08 | 1992-09-15 | Hewlett-Packard Company | Double heterostructure step recovery diode with internal drift field |
JPH03241947A (ja) * | 1990-02-20 | 1991-10-29 | Murata Mfg Co Ltd | 4相位相変調器 |
CA2044468C (en) * | 1990-11-21 | 2006-08-22 | Richard A. Nash | Canine granulocyte macrophage colony stimulating factor |
US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
US6974571B2 (en) * | 1995-03-28 | 2005-12-13 | Thomas Jefferson University | Isolated stromal cells and methods of using the same |
US20030044398A1 (en) * | 2001-03-20 | 2003-03-06 | Robl James M. | Methods for producing antibodies in mammals |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2016015B (en) * | 1978-01-22 | 1982-05-06 | Hayashibara Co | Method of preparing interferon and preparations containing interferon |
US4242460A (en) * | 1978-12-26 | 1980-12-30 | Chick William L | Cell culture device |
JPS5598118A (en) * | 1979-01-18 | 1980-07-25 | Hayashibara Takeshi | Preparation of type-2 interferon and drug containing the same |
US4342828A (en) * | 1979-07-20 | 1982-08-03 | Morinaga Milk Industry Co., Ltd. | Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells |
US4328207A (en) * | 1979-12-27 | 1982-05-04 | Ken Hayashibara | Process for preparing mouse interferon |
JPS586475B2 (ja) * | 1980-08-23 | 1983-02-04 | 株式会社 林原生物化学研究所 | ヒト絨毛性性腺刺激ホルモンの製造方法 |
JPS6045849B2 (ja) * | 1980-08-25 | 1985-10-12 | 林原 健 | ヒトエリトロポエチンの製造方法 |
JPS585671B2 (ja) * | 1980-08-27 | 1983-02-01 | 株式会社 林原生物化学研究所 | ヒト卵胞刺激ホルモンの製造方法 |
JPS5743696A (en) * | 1980-08-27 | 1982-03-11 | Hayashibara Biochem Lab Inc | Preparation of human luteinizing hormone |
-
1980
- 1980-12-31 JP JP55185732A patent/JPS6030654B2/ja not_active Expired
-
1981
- 1981-12-22 GB GB8138591A patent/GB2092159B/en not_active Expired
- 1981-12-23 IT IT49993/81A patent/IT1148022B/it active
- 1981-12-28 KR KR1019810005159A patent/KR870001149B1/ko active
- 1981-12-29 FR FR8124363A patent/FR2497099A1/fr active Granted
- 1981-12-30 CH CH8352/81A patent/CH649786A5/fr not_active IP Right Cessation
-
1984
- 1984-03-05 US US06/585,617 patent/US4621050A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPS57114525A (en) | 1982-07-16 |
IT1148022B (it) | 1986-11-26 |
JPS6030654B2 (ja) | 1985-07-17 |
FR2497099B1 (ko) | 1984-11-09 |
GB2092159B (en) | 1984-07-18 |
FR2497099A1 (fr) | 1982-07-02 |
GB2092159A (en) | 1982-08-11 |
CH649786A5 (fr) | 1985-06-14 |
KR870001149B1 (ko) | 1987-06-11 |
US4621050A (en) | 1986-11-04 |
IT8149993A0 (it) | 1981-12-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR830007826A (ko) | 인체 콜로니 자극인자의 제조방법 | |
KR830007084A (ko) | 인체 우로가스트론의 제조방법 | |
ATE280217T1 (de) | Hundecoronavirus | |
GB2026933B (en) | Process for the production of an ion exchange membrane | |
FI830718A0 (fi) | Foerfarande foer oeverdragning av laekemedelsformer med ett i vatten dispergerbart oeverdrag | |
DE68926508D1 (de) | Erzeugung von antikörpern aus transgenen tieren | |
NO144692C (no) | Urinsamler med uretralkateter. | |
KR830007821A (ko) | 휴민 유로키나아제의 제조방법 | |
IT8019540A0 (it) | Bioconversione di scarti agricoli in alimenti proteinici perl'alimentazione animale. | |
SE7805648L (sv) | Hegn for havsdjur, i synnerhet fisk, samt fiskfarm med minst ett hegn for djupa vatten | |
FI900708A0 (fi) | Maenniskans immunsystem i ett djur. | |
KR830005866A (ko) | 인체 인슐린의 제조방법 | |
IT1152480B (it) | Foraggi e mangimi e additivi per foraggi e mangimi,atti a promuovere l'incremento di peso di animali di allevamento,e procedimento per la loro produzione | |
KR830007089A (ko) | 인체 세포증식 촉진인자의 제조방법 | |
BR8107908A (pt) | Mistura de polietileno linear de baixa densidade,pelotizado | |
KR830007086A (ko) | 인체 캘시토닌의 제조방법 | |
KR830007085A (ko) | 인체 상피소체 호르몬의 제조방법 | |
SU927205A1 (ru) | Животноводческое помещение | |
KR830007090A (ko) | 인체 부신피질 자극호르몬의 제법방법 | |
DK161657C (da) | Dyrefoder | |
JPS57129654A (en) | Feed for domestic animals | |
GB2016890A (en) | Animal basket | |
ES268831U (es) | Colector de excrementos para gatos. | |
AR227829Q (es) | Jeringa de inyeccion,especialmente para inseminacion artificial de animales domesticos | |
Luschekin | The role of the species-specific acoustic signals in" home" orientation of intact and anosmic kittens. |