KR20260069752A - 과립 및 그것을 이용한 제제 - Google Patents

과립 및 그것을 이용한 제제

Info

Publication number
KR20260069752A
KR20260069752A KR1020267012329A KR20267012329A KR20260069752A KR 20260069752 A KR20260069752 A KR 20260069752A KR 1020267012329 A KR1020267012329 A KR 1020267012329A KR 20267012329 A KR20267012329 A KR 20267012329A KR 20260069752 A KR20260069752 A KR 20260069752A
Authority
KR
South Korea
Prior art keywords
molten component
layer
molten
component
granules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020267012329A
Other languages
English (en)
Korean (ko)
Inventor
나오키 요시하라
쇼타 하시모토
료타 키마타
Original Assignee
사와이세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 사와이세이야쿠 가부시키가이샤 filed Critical 사와이세이야쿠 가부시키가이샤
Publication of KR20260069752A publication Critical patent/KR20260069752A/ko
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
KR1020267012329A 2020-03-11 2021-03-09 과립 및 그것을 이용한 제제 Pending KR20260069752A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062988077P 2020-03-11 2020-03-11
US62/988,077 2020-03-11
KR1020227026911A KR20220124747A (ko) 2020-03-11 2021-03-09 과립 및 그것을 이용한 제제
PCT/JP2021/009297 WO2021182469A1 (ja) 2020-03-11 2021-03-09 顆粒及びそれを用いた製剤

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020227026911A Division KR20220124747A (ko) 2020-03-11 2021-03-09 과립 및 그것을 이용한 제제

Publications (1)

Publication Number Publication Date
KR20260069752A true KR20260069752A (ko) 2026-05-15

Family

ID=77670626

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020267012329A Pending KR20260069752A (ko) 2020-03-11 2021-03-09 과립 및 그것을 이용한 제제
KR1020267012304A Pending KR20260059682A (ko) 2020-03-11 2021-03-09 과립 및 그것을 이용한 제제
KR1020227026911A Ceased KR20220124747A (ko) 2020-03-11 2021-03-09 과립 및 그것을 이용한 제제

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020267012304A Pending KR20260059682A (ko) 2020-03-11 2021-03-09 과립 및 그것을 이용한 제제
KR1020227026911A Ceased KR20220124747A (ko) 2020-03-11 2021-03-09 과립 및 그것을 이용한 제제

Country Status (7)

Country Link
US (1) US20230000777A1 (enExample)
EP (1) EP4119130A4 (enExample)
JP (2) JP7467596B2 (enExample)
KR (3) KR20260069752A (enExample)
CN (1) CN115209877B (enExample)
TW (1) TWI859428B (enExample)
WO (1) WO2021182469A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115209877B (zh) * 2020-03-11 2025-02-11 泽井制药株式会社 颗粒和使用该颗粒的制剂
JP7817300B2 (ja) * 2023-02-14 2026-02-18 沢井製薬株式会社 コーティング顆粒、コーティング顆粒を含む製剤及びそれらの製造方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290569A (en) * 1990-04-12 1994-03-01 Shionogi & Co., Ltd. Coated composition and its preparation process
ES2096624T3 (es) * 1990-04-12 1997-03-16 Shionogi & Co Composicion revestida y su procedimiento de preparacion.
JPH06256169A (ja) * 1993-02-18 1994-09-13 Amano Pharmaceut Co Ltd 顆粒の製造法
JP3685625B2 (ja) 1998-09-09 2005-08-24 株式会社パウレック 加熱により溶融する物質を用いた粒子加工方法
JP4521654B2 (ja) 2003-04-24 2010-08-11 株式会社ダルトン 造粒物および造粒方法
JP2005075826A (ja) 2003-08-29 2005-03-24 Boehringer Ingelheim Internatl Gmbh 多孔質シリカ担体を含有する徐放性製剤
CN100528233C (zh) * 2003-10-29 2009-08-19 盐野义制药株式会社 不愉快味道改善了的包覆制剂的制造方法
JP2009541337A (ja) * 2006-06-19 2009-11-26 マクニール−ピーピーシー・インコーポレーテツド 活性成分を含有する腸溶性の被覆された粒子
JP2012087073A (ja) * 2010-10-15 2012-05-10 Pharma Polytech:Kk コーティング粒子の製造方法、及び該製造方法で製造されたコーティング粒子
JP2015071542A (ja) 2012-09-10 2015-04-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 固体分散体の製造方法
FR2999937B1 (fr) * 2012-12-21 2015-01-09 Sanofi Sa Unite solide a haute teneur en fexofenadine et son procede de preparation
KR101553348B1 (ko) 2013-12-18 2015-09-15 김예주 주먹밥 포장 시트와 이를 이용한 스틱 주먹밥의 제조 방법
WO2015152190A1 (ja) * 2014-03-31 2015-10-08 富山化学工業株式会社 セファロスポリンエステルを含む粒状固形製剤およびその製造方法
JP2015199721A (ja) 2014-03-31 2015-11-12 富山化学工業株式会社 セファロスポリンエステルを含む粒状固形製剤およびその製造方法
JP6360007B2 (ja) * 2015-06-12 2018-07-18 富士フイルム株式会社 薬物含有粒子の製造方法
KR20170001999A (ko) 2015-06-29 2017-01-06 주식회사 엘지유플러스 셋탑 단말, 셋탑 단말을 위한 어플리케이션, 및 서버의 동작 방법
EP3413937A4 (en) * 2016-02-08 2019-10-30 The Johns Hopkins University COMPOSITIONS AND METHODS OF PREPARING COMPOSITE POLYMER COATINGS ON MEDICAL IMPLANTS AND THEIR USE FOR THE CO-ADMINISTRATION OF SEVERAL ANTIMICROBIAL ACTIVITIES
CN115209877B (zh) * 2020-03-11 2025-02-11 泽井制药株式会社 颗粒和使用该颗粒的制剂

Also Published As

Publication number Publication date
CN115209877B (zh) 2025-02-11
TWI859428B (zh) 2024-10-21
JP7467596B2 (ja) 2024-04-15
JPWO2021182469A1 (enExample) 2021-09-16
EP4119130A1 (en) 2023-01-18
WO2021182469A1 (ja) 2021-09-16
KR20220124747A (ko) 2022-09-14
CN115209877A (zh) 2022-10-18
TW202200117A (zh) 2022-01-01
EP4119130A4 (en) 2024-01-31
JP2024081778A (ja) 2024-06-18
US20230000777A1 (en) 2023-01-05
JP7738697B2 (ja) 2025-09-12
KR20260059682A (ko) 2026-04-30

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Legal Events

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A16 Divisional, continuation or continuation in part application filed

Free format text: ST27 STATUS EVENT CODE: A-0-1-A10-A16-DIV-PA0104 (AS PROVIDED BY THE NATIONAL OFFICE)

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A16-div-PA0104

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

Q12 Application published

Free format text: ST27 STATUS EVENT CODE: A-1-1-Q10-Q12-NAP-PG1501 (AS PROVIDED BY THE NATIONAL OFFICE)