KR20260011198A - 신규한 방법 - Google Patents

신규한 방법

Info

Publication number
KR20260011198A
KR20260011198A KR1020257043480A KR20257043480A KR20260011198A KR 20260011198 A KR20260011198 A KR 20260011198A KR 1020257043480 A KR1020257043480 A KR 1020257043480A KR 20257043480 A KR20257043480 A KR 20257043480A KR 20260011198 A KR20260011198 A KR 20260011198A
Authority
KR
South Korea
Prior art keywords
dosage form
lumateperone
acid
pharmaceutically acceptable
dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257043480A
Other languages
English (en)
Korean (ko)
Inventor
펭 리
로버트 데이비스
윌리엄 폴 핀들레이
Original Assignee
인트라-셀룰라 써래피스, 인코퍼레이티드.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인트라-셀룰라 써래피스, 인코퍼레이티드. filed Critical 인트라-셀룰라 써래피스, 인코퍼레이티드.
Publication of KR20260011198A publication Critical patent/KR20260011198A/ko
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020257043480A 2018-08-31 2019-08-30 신규한 방법 Pending KR20260011198A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862725944P 2018-08-31 2018-08-31
US62/725,944 2018-08-31
US201862779920P 2018-12-14 2018-12-14
US62/779,920 2018-12-14
PCT/US2019/049061 WO2020047407A1 (en) 2018-08-31 2019-08-30 Novel methods
KR1020217008081A KR102906995B1 (ko) 2018-08-31 2019-08-30 신규한 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217008081A Division KR102906995B1 (ko) 2018-08-31 2019-08-30 신규한 방법

Publications (1)

Publication Number Publication Date
KR20260011198A true KR20260011198A (ko) 2026-01-22

Family

ID=69644650

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020257043480A Pending KR20260011198A (ko) 2018-08-31 2019-08-30 신규한 방법
KR1020217008081A Active KR102906995B1 (ko) 2018-08-31 2019-08-30 신규한 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020217008081A Active KR102906995B1 (ko) 2018-08-31 2019-08-30 신규한 방법

Country Status (11)

Country Link
US (3) US11957791B2 (https=)
EP (1) EP3843738A4 (https=)
JP (1) JP7546546B2 (https=)
KR (2) KR20260011198A (https=)
CN (1) CN112584837A (https=)
AU (2) AU2019328528B2 (https=)
BR (1) BR112021003655A2 (https=)
CA (1) CA3108553A1 (https=)
IL (1) IL280912A (https=)
MX (1) MX2021002322A (https=)
WO (1) WO2020047407A1 (https=)

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EP4001281A1 (en) 2016-08-09 2022-05-25 Teva Pharmaceuticals International GmbH Solid state forms of lumateperone ditosylate salt and preparation thereof
US11331316B2 (en) 2016-10-12 2022-05-17 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
IL268970B2 (en) 2017-03-24 2023-12-01 Intra Cellular Therapies Inc Oral transmucosal formulations of substituted heterocycle fused gamma carbolines
CN111107847A (zh) 2017-09-26 2020-05-05 细胞内治疗公司 新的盐和晶体
WO2019178484A1 (en) 2018-03-16 2019-09-19 Intra-Cellular Therapies, Inc. Novel methods
CA3108558A1 (en) * 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
CN112584837A (zh) * 2018-08-31 2021-03-30 细胞内治疗公司 新方法
MX2021006886A (es) * 2018-12-14 2021-09-14 Intra Cellular Therapies Inc Dispersiones solidas amorfas.
WO2020132605A1 (en) 2018-12-21 2020-06-25 Intra-Cellular Therapies, Inc. Organic compounds
EP4034119A4 (en) * 2019-09-25 2023-10-18 Intra-Cellular Therapies, Inc. NOVEL METHODS
US12102636B2 (en) 2021-02-11 2024-10-01 Medtronic, Inc. Administration of antipsychotics
EP4469052A4 (en) * 2022-01-27 2026-02-11 Intra Cellular Therapies Inc NEW COMPOSITIONS
CN116919907A (zh) * 2022-04-01 2023-10-24 万特制药(海南)有限公司 一种卢美哌隆口崩片及其制备方法
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
EP4678165A1 (en) * 2023-03-03 2026-01-14 Sichuan Kelun Pharmaceutical Research Institute Co., Ltd. Long-acting and sustained-release preparation composition of lumateperone and preparation method therefor
WO2025240804A1 (en) 2024-05-16 2025-11-20 Intra-Cellular Therapies, Inc. Novel compositions, devices and methods
WO2025240802A1 (en) * 2024-05-16 2025-11-20 Intra-Cellular Therapies, Inc. Novel compositions, devices and methods
CN118557536B (zh) * 2024-07-30 2024-11-15 山东则正医药技术有限公司 一种卢美哌隆口崩片组合物及其制备方法和应用

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