KR20250124834A - 특정 위치에 산소 원자를 갖는 아미노산을 번역하는 단계를 포함하는 펩타이드의 제조 방법 - Google Patents

특정 위치에 산소 원자를 갖는 아미노산을 번역하는 단계를 포함하는 펩타이드의 제조 방법

Info

Publication number
KR20250124834A
KR20250124834A KR1020257021523A KR20257021523A KR20250124834A KR 20250124834 A KR20250124834 A KR 20250124834A KR 1020257021523 A KR1020257021523 A KR 1020257021523A KR 20257021523 A KR20257021523 A KR 20257021523A KR 20250124834 A KR20250124834 A KR 20250124834A
Authority
KR
South Korea
Prior art keywords
amino acid
group
natural amino
chemical formula
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257021523A
Other languages
English (en)
Korean (ko)
Inventor
쇼타 다나카
쇼지로 시노하라
가즈히코 나카노
Original Assignee
추가이 세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추가이 세이야쿠 가부시키가이샤 filed Critical 추가이 세이야쿠 가부시키가이샤
Publication of KR20250124834A publication Critical patent/KR20250124834A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020257021523A 2022-12-12 2023-12-11 특정 위치에 산소 원자를 갖는 아미노산을 번역하는 단계를 포함하는 펩타이드의 제조 방법 Pending KR20250124834A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022198158 2022-12-12
JPJP-P-2022-198158 2022-12-12
PCT/JP2023/044244 WO2024128195A1 (ja) 2022-12-12 2023-12-11 特定位置に酸素原子を有するアミノ酸を翻訳する工程を含む、ペプチドの製造方法

Publications (1)

Publication Number Publication Date
KR20250124834A true KR20250124834A (ko) 2025-08-20

Family

ID=91484996

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020257021523A Pending KR20250124834A (ko) 2022-12-12 2023-12-11 특정 위치에 산소 원자를 갖는 아미노산을 번역하는 단계를 포함하는 펩타이드의 제조 방법

Country Status (6)

Country Link
EP (1) EP4628592A1 (https=)
JP (1) JPWO2024128195A1 (https=)
KR (1) KR20250124834A (https=)
CN (1) CN120380162A (https=)
TW (1) TW202440942A (https=)
WO (1) WO2024128195A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016148044A1 (ja) 2015-03-13 2016-09-22 中外製薬株式会社 改変アミノアシルｔＲＮＡ合成酵素およびその用途
WO2019077887A1 (ja) 2017-10-16 2019-04-25 国立大学法人東京大学 Ｄ－アミノ酸及びβ－アミノ酸の取り込みを増強するｔＲＮＡのＤ及びＴアームの改変

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5605602B2 (ja) 2007-03-26 2014-10-15 国立大学法人 東京大学 環状ペプチド化合物の合成方法
EP2647721B1 (en) 2010-12-03 2019-02-27 The University of Tokyo Peptide with safer secondary structure, peptide library, and production methods for same
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
JP7187323B2 (ja) 2017-01-31 2022-12-12 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
EP3904568A4 (en) 2018-12-26 2024-03-20 Chugai Seiyaku Kabushiki Kaisha Mutated trna for codon expansion
JP7267458B2 (ja) 2019-12-12 2023-05-01 中外製薬株式会社 非天然アミノ酸を含むペプチドの製造方法
JPWO2021261577A1 (https=) * 2020-06-25 2021-12-30

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016148044A1 (ja) 2015-03-13 2016-09-22 中外製薬株式会社 改変アミノアシルｔＲＮＡ合成酵素およびその用途
WO2019077887A1 (ja) 2017-10-16 2019-04-25 国立大学法人東京大学 Ｄ－アミノ酸及びβ－アミノ酸の取り込みを増強するｔＲＮＡのＤ及びＴアームの改変

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
ACS Chem. Biol. 2021, 16, 1011-1018
ACS Chem. Biol. 2021, 16, 1325
Biochemistry 2006, 45, 51, 15541
Bioorganic & Medicinal Chemistry 21 (2013) 1088
Cell Chem. Biol. 24, 46-54 (2017)
Int J Mol Sci. 2019, 20, 522
J. Am. Chem. Soc. 2007, 129, 46, 14458.
J. Am. Chem. Soc. 2013, 135, 5, 1830
J. Am. Chem. Soc. 2016, 138, 6, 1962
J. Am. Chem. Soc. 2018, 140, 12159
J. Am. Chem. Soc. 2020, 142, 11, 4965
J. Am. Chem. Soc. 2020, 142, 39, 16518
Nature Chemistry volume 12, 1081
Nature Communications volume 7, Article number: 11657 (2016)
Nucleic Acids Research, 2015, Vol. 43, No. 12, 5687
Nucleic Acids Research, 2017, Vol. 45, No. 22, 12601

Also Published As

Publication number Publication date
CN120380162A (zh) 2025-07-25
EP4628592A1 (en) 2025-10-08
TW202440942A (zh) 2024-10-16
JPWO2024128195A1 (https=) 2024-06-20
WO2024128195A1 (ja) 2024-06-20

Similar Documents

Publication Publication Date Title
JP7526243B2 (ja) 無細胞翻訳系におけるペプチドの合成方法
JP7611279B2 (ja) 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ
CN113423877B (zh) 用于密码子扩展的突变tRNA
JP7351968B2 (ja) チオール基をアミノ基近傍に有するアミノ酸をｎ末端に持つ非環状ペプチド－核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド－核酸複合体ライブラリーの製造方法
JP7702985B2 (ja) 非天然アミノ酸を含むペプチドの製造方法
EP3896056A1 (en) Amino acid having functional group capable of intermolecular hydrogen bonding, peptide compound containing same and method for production thereof
JP7744244B2 (ja) 翻訳用組成物及びペプチドの製造方法
JP2008125396A (ja) Ｎ末端に非天然骨格をもつポリペプチドの翻訳合成とその応用
EP4628592A1 (en) Peptide production method comprising step for translating amino acid having oxygen atom at specific position
HK40121840A (zh) 包括用於翻译在特定位置处具有氧原子的氨基酸的步骤的肽生产方法
HK40069794A (en) Method for producing peptide containing non-natural amino acid
Katoh Engineering the Ribosomal Translation System to Introduce Non‐proteinogenic Amino Acids into Peptides
WO2003059926A2 (en) METHODS AND COMPOSITIONS FOR AMINOACYL-tRNA SYNTHESIS
HK40068807A (en) Composition for translation, and method for producing peptide
WO2005075639A1 (ja) 拡張コドンを利用した糖タンパク質の作製方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

Q12 Application published

Free format text: ST27 STATUS EVENT CODE: A-1-1-Q10-Q12-NAP-PG1501 (AS PROVIDED BY THE NATIONAL OFFICE)