CN120380162A - 包括用于翻译在特定位置处具有氧原子的氨基酸的步骤的肽生产方法 - Google Patents

包括用于翻译在特定位置处具有氧原子的氨基酸的步骤的肽生产方法

Info

Publication number
CN120380162A
CN120380162A CN202380084750.9A CN202380084750A CN120380162A CN 120380162 A CN120380162 A CN 120380162A CN 202380084750 A CN202380084750 A CN 202380084750A CN 120380162 A CN120380162 A CN 120380162A
Authority
CN
China
Prior art keywords
amino acid
group
unnatural amino
formula
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380084750.9A
Other languages
English (en)
Chinese (zh)
Inventor
田中翔太
筱原正次郎
中野效彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of CN120380162A publication Critical patent/CN120380162A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202380084750.9A 2022-12-12 2023-12-11 包括用于翻译在特定位置处具有氧原子的氨基酸的步骤的肽生产方法 Pending CN120380162A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022-198158 2022-12-12
JP2022198158 2022-12-12
PCT/JP2023/044244 WO2024128195A1 (ja) 2022-12-12 2023-12-11 特定位置に酸素原子を有するアミノ酸を翻訳する工程を含む、ペプチドの製造方法

Publications (1)

Publication Number Publication Date
CN120380162A true CN120380162A (zh) 2025-07-25

Family

ID=91484996

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380084750.9A Pending CN120380162A (zh) 2022-12-12 2023-12-11 包括用于翻译在特定位置处具有氧原子的氨基酸的步骤的肽生产方法

Country Status (6)

Country Link
EP (1) EP4628592A1 (https=)
JP (1) JPWO2024128195A1 (https=)
KR (1) KR20250124834A (https=)
CN (1) CN120380162A (https=)
TW (1) TW202440942A (https=)
WO (1) WO2024128195A1 (https=)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5605602B2 (ja) 2007-03-26 2014-10-15 国立大学法人 東京大学 環状ペプチド化合物の合成方法
EP2647721B1 (en) 2010-12-03 2019-02-27 The University of Tokyo Peptide with safer secondary structure, peptide library, and production methods for same
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
EP4166664A1 (en) 2015-03-13 2023-04-19 Chugai Seiyaku Kabushiki Kaisha Modified aminoacyl-trna synthetase and use thereof
JP7187323B2 (ja) 2017-01-31 2022-12-12 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
EP3699276A4 (en) 2017-10-16 2021-07-28 The University Of Tokyo MODIFICATION OF ARM D AND T ARNT IMPROVING DAMINO ACID AND BETA AMINO ACID CAPTURE
EP3904568A4 (en) 2018-12-26 2024-03-20 Chugai Seiyaku Kabushiki Kaisha Mutated trna for codon expansion
JP7267458B2 (ja) 2019-12-12 2023-05-01 中外製薬株式会社 非天然アミノ酸を含むペプチドの製造方法
JPWO2021261577A1 (https=) * 2020-06-25 2021-12-30

Also Published As

Publication number Publication date
EP4628592A1 (en) 2025-10-08
TW202440942A (zh) 2024-10-16
JPWO2024128195A1 (https=) 2024-06-20
WO2024128195A1 (ja) 2024-06-20
KR20250124834A (ko) 2025-08-20

Similar Documents

Publication Publication Date Title
JP7526243B2 (ja) 無細胞翻訳系におけるペプチドの合成方法
JP7611279B2 (ja) 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ
JP7351968B2 (ja) チオール基をアミノ基近傍に有するアミノ酸をｎ末端に持つ非環状ペプチド－核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド－核酸複合体ライブラリーの製造方法
CN113423877B (zh) 用于密码子扩展的突变tRNA
JP7702985B2 (ja) 非天然アミノ酸を含むペプチドの製造方法
EP3896056A1 (en) Amino acid having functional group capable of intermolecular hydrogen bonding, peptide compound containing same and method for production thereof
JP7744244B2 (ja) 翻訳用組成物及びペプチドの製造方法
CN120380162A (zh) 包括用于翻译在特定位置处具有氧原子的氨基酸的步骤的肽生产方法
HK40121840A (zh) 包括用於翻译在特定位置处具有氧原子的氨基酸的步骤的肽生产方法
Zhang et al. Facilitated synthesis of proteins containing modified dipeptides
WO2016199801A1 (ja) アミノ酸修飾核酸とその利用
CN117980308A (zh) 具有光开裂性部位的化合物、连结体和应用其的筛选方法
HK40069794A (en) Method for producing peptide containing non-natural amino acid
Katoh Engineering the Ribosomal Translation System to Introduce Non‐proteinogenic Amino Acids into Peptides
WO2003059926A2 (en) METHODS AND COMPOSITIONS FOR AMINOACYL-tRNA SYNTHESIS

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40121840

Country of ref document: HK