KR20250022067A - Fapi 합성을 위한 중간체 및 그 제조방법과 응용 - Google Patents
Fapi 합성을 위한 중간체 및 그 제조방법과 응용 Download PDFInfo
- Publication number
- KR20250022067A KR20250022067A KR1020247043121A KR20247043121A KR20250022067A KR 20250022067 A KR20250022067 A KR 20250022067A KR 1020247043121 A KR1020247043121 A KR 1020247043121A KR 20247043121 A KR20247043121 A KR 20247043121A KR 20250022067 A KR20250022067 A KR 20250022067A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- article
- acid
- amino
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310124318.XA CN115838393B (zh) | 2023-02-16 | 2023-02-16 | 用于fapi合成的中间体及其制备方法和应用 |
| CN202310124318.X | 2023-02-16 | ||
| PCT/CN2024/077215 WO2024169973A1 (zh) | 2023-02-16 | 2024-02-15 | 用于fapi合成的中间体及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20250022067A true KR20250022067A (ko) | 2025-02-14 |
Family
ID=85579761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247043121A Pending KR20250022067A (ko) | 2023-02-16 | 2024-02-15 | Fapi 합성을 위한 중간체 및 그 제조방법과 응용 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250382329A1 (https=) |
| EP (1) | EP4585607A4 (https=) |
| JP (1) | JP7838187B2 (https=) |
| KR (1) | KR20250022067A (https=) |
| CN (1) | CN115838393B (https=) |
| CA (1) | CA3255143A1 (https=) |
| TW (1) | TWI871182B (https=) |
| WO (1) | WO2024169973A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115838393B (zh) * | 2023-02-16 | 2023-05-05 | 烟台蓝纳成生物技术有限公司 | 用于fapi合成的中间体及其制备方法和应用 |
| WO2025091141A1 (zh) * | 2023-10-30 | 2025-05-08 | 烟台蓝纳成生物技术有限公司 | 用放射性标记的截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂治疗甲状腺癌的方法 |
| CN118754875B (zh) * | 2024-09-06 | 2024-12-13 | 烟台蓝纳成生物技术有限公司 | 一种fapi前体化合物的制备工艺及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10696631B2 (en) * | 2016-05-09 | 2020-06-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents |
| EP3749663A1 (en) * | 2018-02-06 | 2020-12-16 | Universität Heidelberg | Fap inhibitor |
| CN109485642A (zh) * | 2018-11-21 | 2019-03-19 | 希施生物科技（上海）有限公司 | 一种制备伊文氏蓝衍生物的方法 |
| EP4126053A4 (en) * | 2020-03-24 | 2024-11-20 | Trustees Of Tufts College | IMAGING AGENTS AND RADIOPHARMACEUTICALS TARGETING FAP, AND USES THEREOF |
| CN113582975A (zh) * | 2021-07-03 | 2021-11-02 | 上海蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| WO2022170732A1 (zh) * | 2021-02-10 | 2022-08-18 | 上海蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| CN114369084B (zh) * | 2021-02-10 | 2023-02-03 | 烟台蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| CN113004371A (zh) * | 2021-03-01 | 2021-06-22 | 上海蓝纳成生物技术有限公司 | 一种长循环半衰期的前列腺特异性膜抗原靶向化合物及其制备方法和应用 |
| CN113603678A (zh) * | 2021-08-10 | 2021-11-05 | 上海蓝纳成生物技术有限公司 | 一种靶向成纤维细胞活化蛋白的诊断药物及其制备方法 |
| CN113621021A (zh) * | 2021-08-10 | 2021-11-09 | 上海蓝纳成生物技术有限公司 | 一种靶向成纤维细胞活化蛋白的治疗药物及其制备方法 |
| CN115677829A (zh) * | 2022-10-19 | 2023-02-03 | 广州华复生物科技有限公司 | 一种糖基化靶向fap化合物、靶向fap标记配合物及其制备方法与应用 |
| CN115838393B (zh) * | 2023-02-16 | 2023-05-05 | 烟台蓝纳成生物技术有限公司 | 用于fapi合成的中间体及其制备方法和应用 |
-
2023
- 2023-02-16 CN CN202310124318.XA patent/CN115838393B/zh active Active
-
2024
- 2024-02-15 KR KR1020247043121A patent/KR20250022067A/ko active Pending
- 2024-02-15 WO PCT/CN2024/077215 patent/WO2024169973A1/zh not_active Ceased
- 2024-02-15 US US18/861,835 patent/US20250382329A1/en active Pending
- 2024-02-15 TW TW113105190A patent/TWI871182B/zh active
- 2024-02-15 CA CA3255143A patent/CA3255143A1/en active Pending
- 2024-02-15 JP JP2025522077A patent/JP7838187B2/ja active Active
- 2024-02-15 EP EP24756343.0A patent/EP4585607A4/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024169973A1 (zh) | 2024-08-22 |
| TW202434565A (zh) | 2024-09-01 |
| EP4585607A4 (en) | 2026-03-25 |
| CA3255143A1 (en) | 2025-03-28 |
| US20250382329A1 (en) | 2025-12-18 |
| JP7838187B2 (ja) | 2026-03-31 |
| EP4585607A1 (en) | 2025-07-16 |
| CN115838393B (zh) | 2023-05-05 |
| JP2025534068A (ja) | 2025-10-09 |
| TWI871182B (zh) | 2025-01-21 |
| CN115838393A (zh) | 2023-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20241226 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20250108 Comment text: Request for Examination of Application |
|
| PG1501 | Laying open of application |