KR20250004704A - 바이러스 증식 저해 활성을 갖는 유라실 유도체 및 그들을 함유하는 의약 조성물 - Google Patents

바이러스 증식 저해 활성을 갖는 유라실 유도체 및 그들을 함유하는 의약 조성물 Download PDF

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KR20250004704A
KR20250004704A KR1020247036205A KR20247036205A KR20250004704A KR 20250004704 A KR20250004704 A KR 20250004704A KR 1020247036205 A KR1020247036205 A KR 1020247036205A KR 20247036205 A KR20247036205 A KR 20247036205A KR 20250004704 A KR20250004704 A KR 20250004704A
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compound
mmol
coronavirus
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unsubstituted
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준 사토
히로미쓰 시바야마
게이이치로 히라이
유토 우노
쇼타 우에하라
슈지 요네자와
가나 구라하시
에이이치 고지마
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시오노기 앤드 컴파니, 리미티드
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Publication of KR20250004704A publication Critical patent/KR20250004704A/ko
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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  • Chemical & Material Sciences (AREA)
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KR1020247036205A 2022-04-08 2023-04-07 바이러스 증식 저해 활성을 갖는 유라실 유도체 및 그들을 함유하는 의약 조성물 Pending KR20250004704A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2022064593 2022-04-08
JPJP-P-2022-064593 2022-04-08
JPJP-P-2022-094627 2022-06-10
JP2022094627 2022-06-10
JP2022207187 2022-12-23
JPJP-P-2022-207187 2022-12-23
PCT/JP2023/014318 WO2023195530A1 (ja) 2022-04-08 2023-04-07 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物

Publications (1)

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KR20250004704A true KR20250004704A (ko) 2025-01-08

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KR1020247036205A Pending KR20250004704A (ko) 2022-04-08 2023-04-07 바이러스 증식 저해 활성을 갖는 유라실 유도체 및 그들을 함유하는 의약 조성물

Country Status (13)

Country Link
US (1) US12545687B2 (https=)
EP (1) EP4506342A1 (https=)
JP (2) JP7624093B2 (https=)
KR (1) KR20250004704A (https=)
CN (1) CN117510472B (https=)
AU (1) AU2023249953A1 (https=)
CA (1) CA3246981A1 (https=)
CO (1) CO2024013781A2 (https=)
IL (1) IL315710A (https=)
MX (1) MX2024012320A (https=)
TW (1) TW202345801A (https=)
WO (2) WO2023195529A1 (https=)
ZA (1) ZA202407589B (https=)

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JP7624093B2 (ja) * 2022-04-08 2025-01-29 塩野義製薬株式会社 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物
WO2024031089A1 (en) 2022-08-05 2024-02-08 Gilead Sciences, Inc. Sars-cov2 main protease inhibitors
WO2025074997A1 (ja) * 2023-10-02 2025-04-10 塩野義製薬株式会社 ウイルス増殖阻害活性を有する縮合複素環誘導体およびそれらを含有する医薬組成物
AU2024307335A1 (en) * 2023-10-05 2026-04-16 Shionogi & Co., Ltd. Pharmaceutical composition containing uracil derivative
AU2024309726A1 (en) * 2023-10-05 2026-04-16 Shionogi & Co., Ltd. Preparation containing uracil derivative
WO2025018428A2 (ja) * 2023-10-05 2025-01-23 塩野義製薬株式会社 ウラシル誘導体の製造方法

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WO2013118855A1 (ja) 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
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