CN117510472B - 具有病毒增殖抑制活性的尿嘧啶衍生物及含有其的医药组合物 - Google Patents

具有病毒增殖抑制活性的尿嘧啶衍生物及含有其的医药组合物

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Publication number
CN117510472B
CN117510472B CN202311441304.7A CN202311441304A CN117510472B CN 117510472 B CN117510472 B CN 117510472B CN 202311441304 A CN202311441304 A CN 202311441304A CN 117510472 B CN117510472 B CN 117510472B
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CN117510472A (zh
Inventor
佐藤淳
芝山启允
平井启一朗
宇纳佑斗
上原彰太
米泽秀尔
仓桥香菜
儿嶋荣一
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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CN202311441304.7A 2022-04-08 2023-04-07 具有病毒增殖抑制活性的尿嘧啶衍生物及含有其的医药组合物 Active CN117510472B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP2022-064593 2022-04-08
JP2022064593 2022-04-08
JP2022-094627 2022-06-10
JP2022094627 2022-06-10
JP2022207187 2022-12-23
JP2022-207187 2022-12-23
CN202380010896.9A CN117203195A (zh) 2022-04-08 2023-04-07 具有病毒增殖抑制活性的尿嘧啶衍生物及含有其的医药组合物
PCT/JP2023/014316 WO2023195529A1 (ja) 2022-04-08 2023-04-07 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物

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CN202380010896.9A Division CN117203195A (zh) 2022-04-08 2023-04-07 具有病毒增殖抑制活性的尿嘧啶衍生物及含有其的医药组合物

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CN117510472A CN117510472A (zh) 2024-02-06
CN117510472B true CN117510472B (zh) 2026-03-13

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US (1) US12545687B2 (https=)
EP (1) EP4506342A1 (https=)
JP (2) JP7624093B2 (https=)
KR (1) KR20250004704A (https=)
CN (1) CN117510472B (https=)
AU (1) AU2023249953A1 (https=)
CA (1) CA3246981A1 (https=)
CO (1) CO2024013781A2 (https=)
IL (1) IL315710A (https=)
MX (1) MX2024012320A (https=)
TW (1) TW202345801A (https=)
WO (2) WO2023195529A1 (https=)
ZA (1) ZA202407589B (https=)

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JP7624093B2 (ja) * 2022-04-08 2025-01-29 塩野義製薬株式会社 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物
WO2024031089A1 (en) 2022-08-05 2024-02-08 Gilead Sciences, Inc. Sars-cov2 main protease inhibitors
WO2025074997A1 (ja) * 2023-10-02 2025-04-10 塩野義製薬株式会社 ウイルス増殖阻害活性を有する縮合複素環誘導体およびそれらを含有する医薬組成物
AU2024307335A1 (en) * 2023-10-05 2026-04-16 Shionogi & Co., Ltd. Pharmaceutical composition containing uracil derivative
AU2024309726A1 (en) * 2023-10-05 2026-04-16 Shionogi & Co., Ltd. Preparation containing uracil derivative
WO2025018428A2 (ja) * 2023-10-05 2025-01-23 塩野義製薬株式会社 ウラシル誘導体の製造方法

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CN1965833A (zh) * 2005-11-18 2007-05-23 北京大学 非肽类sars冠状病毒3cl蛋白酶抑制剂及其用途
CN113801187A (zh) * 2020-06-12 2021-12-17 南开大学 靶向新型冠状病毒的迈克尔受体类主蛋白酶抑制剂的制备及用途

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KR20110089463A (ko) 2006-07-24 2011-08-08 한국화학연구원 신규 ｈｉｖ 역전사 효소 억제제
ES2533863T3 (es) 2007-06-29 2015-04-15 Korea Research Institute Of Chemical Technology Inhibidores novedosos de la transcriptasa inversa de VIH
JP6075621B2 (ja) 2010-08-10 2017-02-08 塩野義製薬株式会社 新規複素環誘導体およびそれらを含有する医薬組成物
WO2013118855A1 (ja) * 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
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