JP7624093B2 - ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物 - Google Patents

ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物 Download PDF

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JP7624093B2
JP7624093B2 JP2023560418A JP2023560418A JP7624093B2 JP 7624093 B2 JP7624093 B2 JP 7624093B2 JP 2023560418 A JP2023560418 A JP 2023560418A JP 2023560418 A JP2023560418 A JP 2023560418A JP 7624093 B2 JP7624093 B2 JP 7624093B2
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JPWO2023195530A1 (https=
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淳 佐藤
啓允 芝山
啓一朗 平井
佑斗 宇納
彰太 上原
秀爾 米澤
香菜 倉橋
栄一 児嶋
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Shionogi and Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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JP2023560418A 2022-04-08 2023-04-07 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物 Active JP7624093B2 (ja)

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Application Number Priority Date Filing Date Title
JP2022064593 2022-04-08
JP2022064593 2022-04-08
JP2022094627 2022-06-10
JP2022094627 2022-06-10
JP2022207187 2022-12-23
JP2022207187 2022-12-23
PCT/JP2023/014318 WO2023195530A1 (ja) 2022-04-08 2023-04-07 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物

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JPWO2023195530A1 JPWO2023195530A1 (https=) 2023-10-12
JPWO2023195530A5 JPWO2023195530A5 (https=) 2025-01-14
JP7624093B2 true JP7624093B2 (ja) 2025-01-29

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JP (2) JP7624093B2 (https=)
KR (1) KR20250004704A (https=)
CN (1) CN117510472B (https=)
AU (1) AU2023249953A1 (https=)
CA (1) CA3246981A1 (https=)
CO (1) CO2024013781A2 (https=)
IL (1) IL315710A (https=)
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JP7624093B2 (ja) * 2022-04-08 2025-01-29 塩野義製薬株式会社 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物
WO2024031089A1 (en) 2022-08-05 2024-02-08 Gilead Sciences, Inc. Sars-cov2 main protease inhibitors
WO2025074997A1 (ja) * 2023-10-02 2025-04-10 塩野義製薬株式会社 ウイルス増殖阻害活性を有する縮合複素環誘導体およびそれらを含有する医薬組成物
AU2024307335A1 (en) * 2023-10-05 2026-04-16 Shionogi & Co., Ltd. Pharmaceutical composition containing uracil derivative
AU2024309726A1 (en) * 2023-10-05 2026-04-16 Shionogi & Co., Ltd. Preparation containing uracil derivative
WO2025018428A2 (ja) * 2023-10-05 2025-01-23 塩野義製薬株式会社 ウラシル誘導体の製造方法

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WO2012020742A1 (ja) 2010-08-10 2012-02-16 塩野義製薬株式会社 新規複素環誘導体およびそれらを含有する医薬組成物
WO2013118855A1 (ja) 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
CN113620888A (zh) 2021-09-27 2021-11-09 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物及其制备方法和应用
CN113666914A (zh) 2021-09-27 2021-11-19 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物及其制备方法和用途
CN113735838A (zh) 2021-09-27 2021-12-03 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物、其制备方法及用途
WO2021250648A1 (en) 2020-09-03 2021-12-16 Pfizer Inc. Nitrile-containing antiviral compounds
CN113801097A (zh) 2021-09-27 2021-12-17 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物、其制备方法及用途
WO2023195529A1 (ja) 2022-04-08 2023-10-12 塩野義製薬株式会社 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物

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