AU2023249953A1 - Uracil derivative having viral growth inhibitory activity and pharmaceutical composition containing same - Google Patents

Uracil derivative having viral growth inhibitory activity and pharmaceutical composition containing same Download PDF

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Publication number
AU2023249953A1
AU2023249953A1 AU2023249953A AU2023249953A AU2023249953A1 AU 2023249953 A1 AU2023249953 A1 AU 2023249953A1 AU 2023249953 A AU2023249953 A AU 2023249953A AU 2023249953 A AU2023249953 A AU 2023249953A AU 2023249953 A1 AU2023249953 A1 AU 2023249953A1
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Prior art keywords
compound
mmol
coronavirus
substituted
unsubstituted
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AU2023249953A
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Inventor
Keiichiro Hirai
Eiichi Kojima
Kana Kurahashi
Jun Sato
Hiromitsu SHIBAYAMA
Shota Uehara
Yuto UNOH
Shuji Yonezawa
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
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    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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AU2023249953A 2022-04-08 2023-04-07 Uracil derivative having viral growth inhibitory activity and pharmaceutical composition containing same Pending AU2023249953A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2022-064593 2022-04-08
JP2022064593 2022-04-08
JP2022-094627 2022-06-10
JP2022094627 2022-06-10
JP2022207187 2022-12-23
JP2022-207187 2022-12-23
PCT/JP2023/014318 WO2023195530A1 (ja) 2022-04-08 2023-04-07 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物

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AU2023249953A1 true AU2023249953A1 (en) 2024-10-24

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AU2023249953A Pending AU2023249953A1 (en) 2022-04-08 2023-04-07 Uracil derivative having viral growth inhibitory activity and pharmaceutical composition containing same

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Country Link
US (1) US12545687B2 (https=)
EP (1) EP4506342A1 (https=)
JP (2) JP7624093B2 (https=)
KR (1) KR20250004704A (https=)
CN (1) CN117510472B (https=)
AU (1) AU2023249953A1 (https=)
CA (1) CA3246981A1 (https=)
CO (1) CO2024013781A2 (https=)
IL (1) IL315710A (https=)
MX (1) MX2024012320A (https=)
TW (1) TW202345801A (https=)
WO (2) WO2023195529A1 (https=)
ZA (1) ZA202407589B (https=)

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JP7624093B2 (ja) * 2022-04-08 2025-01-29 塩野義製薬株式会社 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物
WO2024031089A1 (en) 2022-08-05 2024-02-08 Gilead Sciences, Inc. Sars-cov2 main protease inhibitors
WO2025074997A1 (ja) * 2023-10-02 2025-04-10 塩野義製薬株式会社 ウイルス増殖阻害活性を有する縮合複素環誘導体およびそれらを含有する医薬組成物
AU2024307335A1 (en) * 2023-10-05 2026-04-16 Shionogi & Co., Ltd. Pharmaceutical composition containing uracil derivative
AU2024309726A1 (en) * 2023-10-05 2026-04-16 Shionogi & Co., Ltd. Preparation containing uracil derivative
WO2025018428A2 (ja) * 2023-10-05 2025-01-23 塩野義製薬株式会社 ウラシル誘導体の製造方法

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CN113735838B (zh) 2021-09-27 2022-07-08 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物、其制备方法及用途
CN113620888B (zh) * 2021-09-27 2023-06-06 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物及其制备方法和应用
CN113666914B (zh) 2021-09-27 2022-06-07 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物及其制备方法和用途
CN113773300B (zh) 2021-09-27 2022-10-11 成都施贝康生物医药科技有限公司 磺酰胺类化合物、其制备方法及用途
JP7624093B2 (ja) * 2022-04-08 2025-01-29 塩野義製薬株式会社 ウイルス増殖阻害活性を有するウラシル誘導体およびそれらを含有する医薬組成物

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