KR20240168420A - 티아졸로[5,4-b]피리딘 MALT-1 억제제 - Google Patents

티아졸로[5,4-b]피리딘 MALT-1 억제제 Download PDF

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Publication number
KR20240168420A
KR20240168420A KR1020247035987A KR20247035987A KR20240168420A KR 20240168420 A KR20240168420 A KR 20240168420A KR 1020247035987 A KR1020247035987 A KR 1020247035987A KR 20247035987 A KR20247035987 A KR 20247035987A KR 20240168420 A KR20240168420 A KR 20240168420A
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KR
South Korea
Prior art keywords
methyl
pyridin
thiazolo
methoxyethyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020247035987A
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English (en)
Korean (ko)
Inventor
다니엘 츠비 코헨
제인 공
타룬 자인
푸네트 쿠마르
다춘 류
안토니 마스트라치오
마크 밀스
앤드류 윌리엄 필립스
존 케이. 프래트
스리니바스 푼나
제니퍼 앤 스톡웰
러 왕
이윈 유
Original Assignee
애브비 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 애브비 인코포레이티드 filed Critical 애브비 인코포레이티드
Publication of KR20240168420A publication Critical patent/KR20240168420A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020247035987A 2022-03-31 2023-03-29 티아졸로[5,4-b]피리딘 MALT-1 억제제 Pending KR20240168420A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263362302P 2022-03-31 2022-03-31
US63/362,302 2022-03-31
PCT/US2023/065111 WO2023192913A1 (en) 2022-03-31 2023-03-29 Thiazolo [5,4-b] pyridine malt-1 inhibitors

Publications (1)

Publication Number Publication Date
KR20240168420A true KR20240168420A (ko) 2024-11-29

Family

ID=86185307

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247035987A Pending KR20240168420A (ko) 2022-03-31 2023-03-29 티아졸로[5,4-b]피리딘 MALT-1 억제제

Country Status (13)

Country Link
US (2) US11993613B2 (https=)
EP (2) EP4729059A2 (https=)
JP (2) JP7723030B2 (https=)
KR (1) KR20240168420A (https=)
CN (1) CN119855821A (https=)
AR (2) AR128917A1 (https=)
AU (1) AU2023243460A1 (https=)
CA (1) CA3246085A1 (https=)
CO (1) CO2024014618A2 (https=)
IL (1) IL316288A (https=)
MX (1) MX2024012018A (https=)
TW (1) TW202345806A (https=)
WO (1) WO2023192913A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202345806A (zh) 2022-03-31 2023-12-01 美商艾伯維有限公司 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑
WO2025223516A1 (zh) * 2024-04-24 2025-10-30 首药控股(北京)股份有限公司 一种抑制剂杂环化合物

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CA3246085A1 (en) 2023-10-05
AR128917A1 (es) 2024-06-26
EP4729059A2 (en) 2026-04-22
US20230312601A1 (en) 2023-10-05
MX2024012018A (es) 2024-11-08
AU2023243460A1 (en) 2024-10-24
CO2024014618A2 (es) 2024-11-08
CN119855821A (zh) 2025-04-18
WO2023192913A1 (en) 2023-10-05
US20250084099A1 (en) 2025-03-13
EP4499650A1 (en) 2025-02-05
JP2025156455A (ja) 2025-10-14
IL316288A (en) 2024-12-01
AR134155A2 (es) 2025-12-10
JP2023152927A (ja) 2023-10-17
TW202345806A (zh) 2023-12-01
US11993613B2 (en) 2024-05-28
JP7723030B2 (ja) 2025-08-13

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