AU2023243460A1 - Thiazolo [5,4-b] pyridine malt-1 inhibitors - Google Patents
Thiazolo [5,4-b] pyridine malt-1 inhibitors Download PDFInfo
- Publication number
- AU2023243460A1 AU2023243460A1 AU2023243460A AU2023243460A AU2023243460A1 AU 2023243460 A1 AU2023243460 A1 AU 2023243460A1 AU 2023243460 A AU2023243460 A AU 2023243460A AU 2023243460 A AU2023243460 A AU 2023243460A AU 2023243460 A1 AU2023243460 A1 AU 2023243460A1
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- pyridin
- thiazolo
- methoxyethyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940122339 MALT1 inhibitor Drugs 0.000 title description 3
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- IBIKHMZPHNKTHM-RDTXWAMCSA-N merck compound 25 Chemical compound C1C[C@@H](C(O)=O)[C@H](O)CN1C(C1=C(F)C=CC=C11)=NN1C(=O)C1=C(Cl)C=CC=C1C1CC1 IBIKHMZPHNKTHM-RDTXWAMCSA-N 0.000 description 1
- DOWWCCDWPKGNGX-RXMQYKEDSA-N methyl (4r)-2,2-dimethyl-1,3-dioxolane-4-carboxylate Chemical compound COC(=O)[C@H]1COC(C)(C)O1 DOWWCCDWPKGNGX-RXMQYKEDSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US202263362302P | 2022-03-31 | 2022-03-31 | |
| US63/362,302 | 2022-03-31 | ||
| PCT/US2023/065111 WO2023192913A1 (en) | 2022-03-31 | 2023-03-29 | Thiazolo [5,4-b] pyridine malt-1 inhibitors |
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| AU2023243460A1 true AU2023243460A1 (en) | 2024-10-24 |
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| AU2023243460A Pending AU2023243460A1 (en) | 2022-03-31 | 2023-03-29 | Thiazolo [5,4-b] pyridine malt-1 inhibitors |
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| EP (2) | EP4729059A2 (https=) |
| JP (2) | JP7723030B2 (https=) |
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| AR (2) | AR128917A1 (https=) |
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| IL (1) | IL316288A (https=) |
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| WO2025223516A1 (zh) * | 2024-04-24 | 2025-10-30 | 首药控股(北京)股份有限公司 | 一种抑制剂杂环化合物 |
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2023
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| AR128917A1 (es) | 2024-06-26 |
| EP4729059A2 (en) | 2026-04-22 |
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| MX2024012018A (es) | 2024-11-08 |
| CO2024014618A2 (es) | 2024-11-08 |
| CN119855821A (zh) | 2025-04-18 |
| WO2023192913A1 (en) | 2023-10-05 |
| US20250084099A1 (en) | 2025-03-13 |
| EP4499650A1 (en) | 2025-02-05 |
| JP2025156455A (ja) | 2025-10-14 |
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| IL316288A (en) | 2024-12-01 |
| AR134155A2 (es) | 2025-12-10 |
| JP2023152927A (ja) | 2023-10-17 |
| TW202345806A (zh) | 2023-12-01 |
| US11993613B2 (en) | 2024-05-28 |
| JP7723030B2 (ja) | 2025-08-13 |
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