KR20240064009A - 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자 - Google Patents

화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자 Download PDF

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KR20240064009A
KR20240064009A KR1020247013856A KR20247013856A KR20240064009A KR 20240064009 A KR20240064009 A KR 20240064009A KR 1020247013856 A KR1020247013856 A KR 1020247013856A KR 20247013856 A KR20247013856 A KR 20247013856A KR 20240064009 A KR20240064009 A KR 20240064009A
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drug
cancer
irinotecan
triethylammonium
carrier
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KR1020247013856A
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English (en)
Korean (ko)
Inventor
안드레 이 넬
환 멍
샹성 류
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더 리전트 오브 더 유니버시티 오브 캘리포니아
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Publication of KR20240064009A publication Critical patent/KR20240064009A/ko
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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KR1020247013856A 2016-01-08 2017-01-06 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자 Ceased KR20240064009A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662276634P 2016-01-08 2016-01-08
US62/276,634 2016-01-08
KR1020227019372A KR20220085840A (ko) 2016-01-08 2017-01-06 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자
PCT/US2017/012625 WO2017120537A1 (en) 2016-01-08 2017-01-06 Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery

Related Parent Applications (1)

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KR1020227019372A Division KR20220085840A (ko) 2016-01-08 2017-01-06 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자

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KR20240064009A true KR20240064009A (ko) 2024-05-10

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KR1020247013856A Ceased KR20240064009A (ko) 2016-01-08 2017-01-06 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자
KR1020187022622A Active KR102408525B1 (ko) 2016-01-08 2017-01-06 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자
KR1020227019372A Ceased KR20220085840A (ko) 2016-01-08 2017-01-06 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자

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KR1020227019372A Ceased KR20220085840A (ko) 2016-01-08 2017-01-06 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자

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US (5) US10143660B2 (https=)
EP (2) EP4218739A3 (https=)
JP (2) JP7068173B2 (https=)
KR (3) KR20240064009A (https=)
CN (1) CN108601746B (https=)
AU (3) AU2017206077B2 (https=)
CA (1) CA3010711A1 (https=)
WO (1) WO2017120537A1 (https=)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4378461A3 (en) 2013-03-05 2024-09-11 The Regents of University of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
EP4480902A3 (en) 2015-03-16 2025-03-12 PDX Pharmaceuticals, Inc. Cross-linked polymer modified nanoparticles
EP4218739A3 (en) 2016-01-08 2023-08-09 The Regents of The University of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
MX383920B (es) 2016-05-26 2025-03-14 Recurium Ip Holdings Llc Compuestos inhibidores de egfr.
AU2018230478B2 (en) 2017-03-09 2025-01-23 Diamedica Inc. Dosage forms of tissue kallikrein 1
EP3661513A4 (en) 2017-07-31 2021-07-14 January Therapeutics, Inc. ORGANOPHOSPHATE DERIVATIVES
US12383499B2 (en) 2018-01-01 2025-08-12 The Regents Of The University Of California Scale up synthesis of silicasome nanocarriers
CN108562737A (zh) * 2018-01-12 2018-09-21 天津大学 用阳离子脂质体包裹负载钙黄绿素的介孔二氧化硅纳米颗粒的制备方法
US12208138B2 (en) * 2018-02-19 2025-01-28 Boise State University Radiation-triggered liposomes
WO2019169324A1 (en) * 2018-03-02 2019-09-06 January Therapeutics, Inc. Nanoparticle compositions
EP3784213B1 (en) * 2018-04-23 2023-09-06 InspirMed Corp. Inhalable liposomal sustained release composition for use in treating pulmonary diseases
TWI786328B (zh) * 2018-09-10 2022-12-11 台灣微脂體股份有限公司 緩釋眼用藥物組合物及其用途
US12201956B2 (en) 2018-10-16 2025-01-21 Pharma In Silica Laboratories Inc. Tunable process for silica capsules/spheres preparation and their use
JP7477844B2 (ja) * 2018-10-17 2024-05-02 タイワン リポソーム カンパニー リミテッド 免疫調節剤を含む徐放性医薬組成物およびその使用
CN109557158B (zh) * 2018-12-12 2020-12-08 郑州大学 酶固定基质在有机磷杀虫剂生物检测领域中的应用
US12351653B1 (en) 2019-03-08 2025-07-08 Lisata Therapeutics, Inc. Pharmaceutical compositions comprising novel cyclic peptides
EP3714879A1 (en) 2019-03-28 2020-09-30 Sisaf Ltd Structured encapsulated silicon-containing particles
GB201904336D0 (en) 2019-03-28 2019-05-15 Sisaf Ltd A delivery system
GB201904338D0 (en) * 2019-03-28 2019-05-15 Sisaf Ltd Fluorouracil-containing formulations
GB201904334D0 (en) 2019-03-28 2019-05-15 Sisaf Ltd Carrier system for preparing herbaceous extracts
GB201904337D0 (en) 2019-03-28 2019-05-15 Sisaf Ltd A delivery system
EP4005583A4 (en) * 2019-04-01 2023-04-26 Industry - University Cooperation Foundation Hanyang University ANTI-CANCER AGAINST PEPTIDE-BASED CP2C
US12433909B2 (en) 2019-05-20 2025-10-07 Board Of Regents Of The University Of Texas System Formulations of cyclic macromolecule-based nanoparticles encapsulating small molecules
MX2022000541A (es) 2019-07-12 2022-04-18 Univ Oregon Health & Science Construcciones terapeuticas para la administracion conjunta de un inhibidor de la quinasa mitotica y un inhibidor de puntos de control inmunitario.
US20220249389A1 (en) 2019-07-12 2022-08-11 Oregon Health & Science University Immunotherapeutic constructs and methods of their use
US11708637B2 (en) 2019-08-13 2023-07-25 The Regents Of The University Of California Methods of supporting a graphene sheet disposed on a frame support
CN110548029B (zh) * 2019-10-09 2022-08-16 上海交通大学医学院 甲磺酸奥希替尼在制备治疗真菌感染药物中的应用
CN111074282B (zh) * 2019-10-15 2021-11-05 东营施普瑞石油工程技术有限公司 一种pH响应型可降解智能缓蚀剂、制备方法及其应用
CN110559280B (zh) * 2019-10-16 2021-06-25 中国人民解放军军事科学院军事医学研究院 治疗肺癌的载紫杉醇脂质体细菌吸入制剂
CN115867317A (zh) * 2020-05-04 2023-03-28 澳大利亚药品中心私人有限公司 用于治疗胰腺癌和其他实体瘤的方法
CN115605196A (zh) * 2020-05-06 2023-01-13 纳米科技制药公司（Us） 用于治疗癌症和癌症耐药性的脂质体制剂
WO2022006083A1 (en) * 2020-06-30 2022-01-06 The Regents Of The University Of California Gsk3 inhibitor-loaded nano formulations as a cancer immunotherapeutic
EP4247347A4 (en) * 2020-11-30 2024-05-22 Ege Universitesi Targeted nanoparticles carrying dual drugs in the treatment of melanoma
WO2022132748A1 (en) * 2020-12-14 2022-06-23 Bps Just Energy Technology, Llc Antimicrobial compositions with supramolecular structures
US20220378711A1 (en) * 2021-05-11 2022-12-01 United States Government As Represented By The Department Of Veterans Affairs PH-Responsive Nanoparticles for Treating Cancer
CN113521035B (zh) * 2021-08-05 2023-04-25 河南大学 化学免疫联合治疗纳米药物的制备方法及应用
CN115960160B (zh) * 2021-10-12 2024-07-16 南京大学 活细胞膜整合素αvβ3聚糖的原位糖链延长方法
WO2023064887A1 (en) 2021-10-15 2023-04-20 The Board Of Trustees Of The University Of Illinois Mechanochemical dynamic therapy for focal cancer treatment
CN114487083B (zh) * 2022-01-19 2024-05-07 中国地质大学（北京） 一种磁性羟基纳米材料Fe3O4@COFs及其在磺胺质谱检测领域的应用
EP4489793A4 (en) * 2022-03-10 2026-03-04 Univ California A drug nanocarrier system to deliver a combination of tlr agonists and/or a lipoxin plus immunogenic cell death inducing chemotherapeutic agents for cancer immunotherapy
CN114796055B (zh) * 2022-05-19 2023-08-15 广东艾粒生物科技有限责任公司 富含脂质体纳米粒的美白敷料及其制备方法
WO2024035784A1 (en) * 2022-08-10 2024-02-15 Auburn University Shrinking nanomaterial for biomedical applications
US20260069713A1 (en) * 2022-08-29 2026-03-12 Vivasor, Inc. Lipid-Coated Nanoparticles
CN115636885B (zh) * 2022-10-26 2023-08-11 湖北中医药大学 一种季铵环糊精及其制备方法和应用、银纳米粒子环糊精复合物及其制备方法和应用
EP4364726A1 (en) * 2022-11-02 2024-05-08 Nano Targeting & Therapy Biopharma Inc. Method for treating a cancer and/or cancer metastasis
JP2026501821A (ja) * 2023-01-08 2026-01-16 アティヴァーレ セラピューティクス インコーポレイテッド 免疫調節系としてメソポーラスシリカロッドを使用したサイトカインの腫瘍間送達および腫瘍内送達
MX2025012140A (es) * 2023-04-13 2026-02-03 Ideaya Biosciences Inc Terapia combinada que comprende un inhibidor de mat2a y un inhibidor de la topoisomerasa, un inhibidor del empalme sulfonamida, o un inhibidor de kif18
KR102666470B1 (ko) * 2023-05-04 2024-05-17 주식회사 아리바이오 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물
KR102666469B1 (ko) * 2023-05-04 2024-05-17 주식회사 아리바이오 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물
IT202300015396A1 (it) * 2023-07-21 2025-01-21 Torino Politecnico Nanoparticelle rivestite e loro uso per il trasporto di agenti terapeutici e diagnostici
US12102693B1 (en) * 2023-08-25 2024-10-01 Nanomedtrix, Llc Pharmaceutical composition with nanoparticle-based drug delivery combined with non-invasive radiographic monitoring model
KR102647264B1 (ko) * 2023-11-01 2024-03-14 주식회사 아리바이오 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물
WO2025100777A1 (ko) * 2023-11-08 2025-05-15 주식회사 엔테라퓨틱스 표면이 개질된 나노입자 및 이의 약물 전달 용도
CN117797833A (zh) * 2023-12-14 2024-04-02 苏州大学 含钼纳米材料作为脂氧合酶的应用
WO2025179264A1 (en) * 2024-02-22 2025-08-28 President And Fellows Of Harvard College Functionalized silica nanoparticles and methods of making and using the same
CN119236105B (zh) * 2024-09-29 2025-09-05 中南大学 一种基于铜死亡的多功能抗肿瘤纳米药物递送系统及其制备方法与应用
US12390420B1 (en) 2024-10-22 2025-08-19 Bryet Us, Inc. Compositions for targeted delivery of therapeutic agents and methods for the synthesis and use thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993754A (en) 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US4086257A (en) 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (https=) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4885172A (en) 1985-06-26 1989-12-05 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
GB2189699A (en) 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
DE4217353B4 (de) 1992-05-26 2008-02-21 Nimbus Biotechnologie Gmbh Verfahren zur säulenchromatographischen Trennung von Proteinen mittels Lipidbilayer-beschichteter Silicagele
US5827533A (en) 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
DE19814775C2 (de) 1998-04-02 2001-04-19 Nimbus Biotechnologie Gmbh Verfahren zur Bestimmung der Lipid-Bindungskonstanten von Substanzen in wässriger Lösung an Oberflächen aus amphiphilen Molekülen
US7943067B2 (en) 2001-08-16 2011-05-17 Polytechnic Institute Of New York University Nanogels and their production using liposomes as reactors
US20040005352A1 (en) 2002-04-16 2004-01-08 Lopez Gabriel P. Biologically functionalized porous microspheres
AU2003268087A1 (en) 2002-08-23 2004-03-11 Ian Ma Liposomal gemcitabine compositions for better drug delivery
US7563451B2 (en) 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
LT3173073T (lt) * 2004-05-03 2025-01-10 Ipsen Biopharm Ltd. Liposomos, skirtos vaistų pristatymui
EP1776196A2 (de) 2004-08-03 2007-04-25 Chemetall GmbH Verfahren zum schützen einer metallischen oberfläche mit einer korrosions-inhibierenden beschichtung
CA2581133A1 (en) 2004-09-20 2006-03-30 British Columbia Cancer Agency Free or liposomal gemcitabine alone or in combination with free or liposomal idarubicin
US20110104073A1 (en) 2007-01-18 2011-05-05 Qi Zeng Iron/Iron Oxide Nanoparticle and Use Thereof
US9993437B2 (en) 2007-12-06 2018-06-12 The Regents Of The University Of California Mesoporous silica nanoparticles for biomedical applications
US20100284924A1 (en) 2008-01-23 2010-11-11 The Regents Of The University Of California Nano-devices having impellers for capture and release of molecules
US20100310465A1 (en) 2008-01-23 2010-12-09 The Regents Of The University Of California Nano-devices having releasable seals for controlled release of molecules
US20120021034A1 (en) 2008-12-19 2012-01-26 The Regents Of The University Of California Structured silver-mesoporous silica nanoparticles having antimicrobial activity
US8734816B2 (en) 2009-01-05 2014-05-27 Stc.Unm Porous nanoparticle supported lipid bilayer nanostructures
US8992984B1 (en) * 2009-10-21 2015-03-31 Stc.Unm Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
TWI383808B (zh) 2009-11-23 2013-02-01 國立清華大學 磷脂質包覆中孔洞二氧化矽奈米球的合成與其生醫應用
WO2012009448A2 (en) 2010-07-13 2012-01-19 The Regents Of The University Of California Cationic polymer coated mesoporous silica nanoparticles and uses thereof
US20120207795A1 (en) 2010-07-13 2012-08-16 The Regents Of The University Of California Cationic polymer coated mesoporous silica nanoparticles and uses thereof
AU2012249474A1 (en) 2011-04-28 2013-11-07 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
US10220004B2 (en) 2011-07-14 2019-03-05 The Regents Of The University Of California Method of controlled delivery using sub-micron-scale machines
AU2012284147A1 (en) 2011-07-19 2014-02-27 Stc. Unm Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers
EP2765997A4 (en) * 2011-10-14 2015-06-24 Stc Unm POROUS NANOPARTICLE-SUPPORTED LIPID DOUBLE LAYERS (PROTOCOLS) FOR THE TARGETED RELEASE BY TRANSDERMAL RELEASE AND USE METHOD THEREFOR
US8926994B2 (en) 2011-12-07 2015-01-06 The Methodist Hospital Research Institute Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity
CA2891601A1 (en) 2012-11-20 2014-05-30 Mpt, Inc. Advertising media and method and system for applying advertising media
EP4378461A3 (en) 2013-03-05 2024-09-11 The Regents of University of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
EP4480902A3 (en) 2015-03-16 2025-03-12 PDX Pharmaceuticals, Inc. Cross-linked polymer modified nanoparticles
LU92784B1 (en) 2015-07-22 2017-01-31 Luxembourg Inst Of Science And Tech (List) Negatively charged self-assembling supported lipid bilayer on mesoporous silica nanoparticles, method of synthesis and use as a nanovector
EP4218739A3 (en) 2016-01-08 2023-08-09 The Regents of The University of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
US12383499B2 (en) 2018-01-01 2025-08-12 The Regents Of The University Of California Scale up synthesis of silicasome nanocarriers

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