MX2022000541A - Construcciones terapeuticas para la administracion conjunta de un inhibidor de la quinasa mitotica y un inhibidor de puntos de control inmunitario. - Google Patents
Construcciones terapeuticas para la administracion conjunta de un inhibidor de la quinasa mitotica y un inhibidor de puntos de control inmunitario.Info
- Publication number
- MX2022000541A MX2022000541A MX2022000541A MX2022000541A MX2022000541A MX 2022000541 A MX2022000541 A MX 2022000541A MX 2022000541 A MX2022000541 A MX 2022000541A MX 2022000541 A MX2022000541 A MX 2022000541A MX 2022000541 A MX2022000541 A MX 2022000541A
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic
- cancer
- immune checkpoint
- inhibitor
- delivery
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 5
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 title abstract 3
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 title abstract 3
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 title abstract 3
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 title abstract 3
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 3
- 230000000394 mitotic effect Effects 0.000 title abstract 3
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 5
- 201000011510 cancer Diseases 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 231100001274 therapeutic index Toxicity 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
En el presente documento se divulgan construcciones terapéuticas que incluyen una partícula de administración, al menos un inhibidor de la quinasa mitótica y al menos un inhibidor de puntos de control inmunitario. Asimismo se divulgan construcciones terapéuticas que incluyen un inhibidor de la quinasa mitótica, un inhibidor de puntos de control inmunitario y un enlazador químico. Estas construcciones terapéuticas provocan la muerte del cáncer por efectos tanto terapéuticos como inmunitarios y promueven la administración selectiva de más fármacos a las células cancerosas supervivientes en un bucle de retroalimentación positiva. Mejoran el índice terapéutico de los fármacos libres y se pueden utilizar por vía intratumoral o sistémica. Esta estrategia puede tratar una gran cantidad de tipos de cáncer y es especialmente útil para el cáncer sin receptores obvios para la administración dirigida de terapias que de otro modo serían tóxicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962873770P | 2019-07-12 | 2019-07-12 | |
PCT/US2020/041852 WO2021011501A1 (en) | 2019-07-12 | 2020-07-13 | Therapeutic constructs for co-delivery of mitotic kinase inhibitor and immune checkpoint inhibitor |
Publications (1)
Publication Number | Publication Date |
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MX2022000541A true MX2022000541A (es) | 2022-04-18 |
Family
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WO2021011501A1 (en) * | 2019-07-12 | 2021-01-21 | Oregon Health & Science University | Therapeutic constructs for co-delivery of mitotic kinase inhibitor and immune checkpoint inhibitor |
US20220249389A1 (en) * | 2019-07-12 | 2022-08-11 | Oregon Health & Science University | Immunotherapeutic constructs and methods of their use |
CN114958338B (zh) * | 2022-05-11 | 2023-07-14 | 北京兴德通医药科技股份有限公司 | 采用氧化碳纳米角猝灭荧光探针对蛋白激酶a检测方法 |
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KR20220035161A (ko) | 2022-03-21 |
US20220071906A1 (en) | 2022-03-10 |
CA3139714A1 (en) | 2021-01-21 |
EP3996750A1 (en) | 2022-05-18 |
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