KR20240031957A - 스테이플화된 펩티드 및 이의 방법 - Google Patents

스테이플화된 펩티드 및 이의 방법 Download PDF

Info

Publication number
KR20240031957A
KR20240031957A KR1020237042998A KR20237042998A KR20240031957A KR 20240031957 A KR20240031957 A KR 20240031957A KR 1020237042998 A KR1020237042998 A KR 1020237042998A KR 20237042998 A KR20237042998 A KR 20237042998A KR 20240031957 A KR20240031957 A KR 20240031957A
Authority
KR
South Korea
Prior art keywords
agent
independently
group
amino acid
staple
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237042998A
Other languages
English (en)
Korean (ko)
Inventor
브라이언 핼버트 화이트
다니엘 승덕 라
로렌소 호수에 알파로-로페스
폴라 크리스티나 오르텟
사라 이자벨 카푸치
지 리
존 헤니 맥기
마틴 로버트 트렘블레이
그레고리 엘 버딘
야광 시
케빈 링
페이청 두
조나단 배리 휴로브
Original Assignee
포그 파마슈티컬스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 포그 파마슈티컬스 인코포레이티드 filed Critical 포그 파마슈티컬스 인코포레이티드
Publication of KR20240031957A publication Critical patent/KR20240031957A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020237042998A 2021-06-08 2022-06-08 스테이플화된 펩티드 및 이의 방법 Pending KR20240031957A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163208487P 2021-06-08 2021-06-08
US63/208,487 2021-06-08
US202163224834P 2021-07-22 2021-07-22
US63/224,834 2021-07-22
US202263303952P 2022-01-27 2022-01-27
US63/303,952 2022-01-27
PCT/US2022/032738 WO2022261257A1 (en) 2021-06-08 2022-06-08 Stapled peptides and methods thereof

Publications (1)

Publication Number Publication Date
KR20240031957A true KR20240031957A (ko) 2024-03-08

Family

ID=84425507

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237042998A Pending KR20240031957A (ko) 2021-06-08 2022-06-08 스테이플화된 펩티드 및 이의 방법

Country Status (9)

Country Link
US (1) US20240360179A1 (https=)
EP (1) EP4355350A4 (https=)
JP (1) JP2024522368A (https=)
KR (1) KR20240031957A (https=)
BR (1) BR112023025528A2 (https=)
CA (1) CA3218824A1 (https=)
IL (1) IL308790A (https=)
MX (1) MX2023014679A (https=)
WO (1) WO2022261257A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018329956A1 (en) 2017-09-07 2020-08-20 Fog Pharmaceuticals, Inc. Agents modulating beta-catenin functions and methods thereof
MX2021001943A (es) 2018-08-20 2021-07-15 Fog Pharmaceuticals Inc Colecciones de péptidos, agentes peptídicos y métodos de uso de los mismos.
WO2024130217A1 (en) * 2022-12-15 2024-06-20 Fog Pharmaceuticals, Inc. Stapled peptides and methods thereof
CN120529912A (zh) * 2022-12-15 2025-08-22 帕拉比利斯药物公司 订书钉化肽及其方法
WO2024130224A2 (en) * 2022-12-16 2024-06-20 Purdue Research Foundation Stapled peptides for sensitization of cancer to treatment
KR20260035134A (ko) * 2023-06-06 2026-03-12 파라빌리스 메디슨즈 인코포레이티드 스테이플화 펩티드 및 이의 방법
WO2025265097A1 (en) * 2024-06-20 2025-12-26 Parabilis Medicines, Inc. Stapled peptides and methods thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3549951A3 (en) * 2008-12-09 2019-11-20 Dana Farber Cancer Institute, Inc. Methods and compositions for specific modulation of mcl-1
WO2012040459A2 (en) * 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
EP3391898A3 (en) * 2013-03-13 2019-02-13 President and Fellows of Harvard College Stapled and stitched polypeptides and uses thereof
WO2016085280A1 (ko) * 2014-11-28 2016-06-02 서울대학교산학협력단 세포 투과성 스테이플 펩타이드, 이의 제조방법 및 그 용도
US10011631B2 (en) * 2015-12-01 2018-07-03 The University Of Hong Kong Stapled helical peptides and methods of synthesis
AU2018329956A1 (en) * 2017-09-07 2020-08-20 Fog Pharmaceuticals, Inc. Agents modulating beta-catenin functions and methods thereof
CN117567639A (zh) * 2017-10-27 2024-02-20 俄亥俄州国家创新基金会 用于细胞内递送装订肽的多肽缀合物
MX2021001943A (es) * 2018-08-20 2021-07-15 Fog Pharmaceuticals Inc Colecciones de péptidos, agentes peptídicos y métodos de uso de los mismos.
AU2021314310A1 (en) * 2020-07-22 2023-03-16 Fog Pharmaceuticals, Inc. Stapled peptides and methods thereof

Also Published As

Publication number Publication date
CA3218824A1 (en) 2022-12-15
US20240360179A1 (en) 2024-10-31
IL308790A (en) 2024-01-01
BR112023025528A2 (pt) 2024-02-27
EP4355350A1 (en) 2024-04-24
WO2022261257A1 (en) 2022-12-15
MX2023014679A (es) 2024-01-15
JP2024522368A (ja) 2024-06-18
EP4355350A4 (en) 2025-10-01

Similar Documents

Publication Publication Date Title
KR20240031957A (ko) 스테이플화된 펩티드 및 이의 방법
JP6494631B2 (ja) コルチスタチン類縁体並びにその合成及び使用
KR20230057350A (ko) 스테이플화된 펩티드 및 이의 방법
KR20220119671A (ko) 전사 증진 회합 도메인 (tead) 전사 인자 억제제 및 그의 용도
US10961216B2 (en) Small molecule modulators of the androgen receptor
JP2021514958A (ja) 選択的なタンパク質分解を誘導するための低分子およびその使用法
JP2023530231A (ja) 転写増強アソシエートドメイン（ｔｅａｄ）阻害剤及びその使用
JP2023501720A (ja) 指向性コンジュゲーション技術
CN119136833A (zh) 膜易位结构域及其用途
JP2022539258A (ja) Ｃｄ３８に結合する薬剤およびその使用
CN115697415A (zh) 用于预防或治疗感染的技术
WO2024015958A1 (en) Cyclic peptide inhibitors of il-23
JP2025541246A (ja) ステープルペプチドおよびその方法
JP2025541247A (ja) ステープルペプチドおよびその方法
AU2019318046B2 (en) Histone demethylase 5 inhibitors and uses thereof
US9714265B2 (en) Mutagenic nucleoside analogs and uses thereof
CN117794560A (zh) 订书钉化肽及其方法
HK40108355A (zh) 订书钉化肽及其方法
WO2022092295A1 (ja) βストランド型架橋ペプチド
HK40129655A (zh) 订书钉化肽及其方法
HK40128981A (zh) 订书钉化肽及其方法
US20250188083A1 (en) Modulators of Histone Acetyltransferase 1 and Methods of Treatment Thereof
WO2025265097A1 (en) Stapled peptides and methods thereof
US10273240B2 (en) Cortistatin analogues, syntheses, and uses thereof
CN121620379A (zh) 订书钉化肽及其方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20231212

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250529

Comment text: Request for Examination of Application