KR20230156159A - Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법 - Google Patents

Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법 Download PDF

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Publication number
KR20230156159A
KR20230156159A KR1020237037485A KR20237037485A KR20230156159A KR 20230156159 A KR20230156159 A KR 20230156159A KR 1020237037485 A KR1020237037485 A KR 1020237037485A KR 20237037485 A KR20237037485 A KR 20237037485A KR 20230156159 A KR20230156159 A KR 20230156159A
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South Korea
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compound
subject
treatment
dose
biomarker
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English (en)
Korean (ko)
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레베카 타웁
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마드리갈 파마슈티칼스, 인크.
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Publication of KR20230156159A publication Critical patent/KR20230156159A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237037485A 2016-10-18 2017-10-18 Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법 Pending KR20230156159A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662409833P 2016-10-18 2016-10-18
US62/409,833 2016-10-18
US201762516594P 2017-06-07 2017-06-07
US62/516,594 2017-06-07
PCT/US2017/057203 WO2018075650A1 (en) 2016-10-18 2017-10-18 Methods of treating liver disorders or lipid disorders with a thr-beta agonist
KR1020197014495A KR20190109387A (ko) 2016-10-18 2017-10-18 Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197014495A Division KR20190109387A (ko) 2016-10-18 2017-10-18 Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법

Publications (1)

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KR20230156159A true KR20230156159A (ko) 2023-11-13

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KR1020237037485A Pending KR20230156159A (ko) 2016-10-18 2017-10-18 Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법
KR1020197014495A Ceased KR20190109387A (ko) 2016-10-18 2017-10-18 Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법

Family Applications After (1)

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KR1020197014495A Ceased KR20190109387A (ko) 2016-10-18 2017-10-18 Thr-베타 아고니스트로 간 질환 또는 지질 질환을 치료하는 방법

Country Status (12)

Country Link
US (3) US11090308B2 (https=)
EP (2) EP3528817B1 (https=)
JP (3) JP2019533019A (https=)
KR (2) KR20230156159A (https=)
CN (1) CN110167557A (https=)
AU (1) AU2017346871B2 (https=)
CA (1) CA3040888A1 (https=)
DK (1) DK3528817T3 (https=)
ES (1) ES2924257T3 (https=)
IL (2) IL302336B2 (https=)
MX (1) MX394463B (https=)
WO (1) WO2018075650A1 (https=)

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PT3911647T (pt) * 2019-01-15 2024-03-04 Gilead Sciences Inc Composto de isoxazole como agonista de fxr e composições farmacêuticas que o contenham
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KR20220017917A (ko) 2019-05-08 2022-02-14 알리고스 테라퓨틱스 인코포레이티드 Thr-베타의 조절제 및 이의 사용 방법
AU2020336272A1 (en) * 2019-08-23 2022-04-14 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
WO2021050945A1 (en) * 2019-09-12 2021-03-18 Terns, Inc. Thyroid hormone receptor beta agonist compounds
WO2021063367A1 (zh) * 2019-09-30 2021-04-08 苏州科睿思制药有限公司 一种Resmetirom晶型及其制备方法和用途
WO2021104288A1 (zh) * 2019-11-26 2021-06-03 昆药集团股份有限公司 1，2，4-三嗪-3，5-二酮类化合物及其制备方法和应用
CN111562321B (zh) * 2020-04-16 2022-10-28 广东省结核病控制中心 用于检测活动性肺结核的粪便代谢物及其检测系统
WO2022052822A1 (zh) * 2020-09-10 2022-03-17 苏州科睿思制药有限公司 Resmetirom的晶型及其制备方法和用途
EP4204419A1 (en) 2020-10-19 2023-07-05 Teva Pharmaceuticals International GmbH Solid state forms of resmetirom
KR20230142523A (ko) * 2021-02-01 2023-10-11 마드리갈 파마슈티칼스, 인크. 간 장애 또는 지질 장애의 치료를 위한 로수바스타틴 및 레스메티롬의 치료용 조합
US20250000836A1 (en) * 2021-07-21 2025-01-02 Cyta Therapeutics, Inc. Particle delivery of thyroid hormone receptor agonists and antagonists
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IL302336A (en) 2023-06-01
MX394463B (es) 2025-03-19
JP2025122012A (ja) 2025-08-20
AU2017346871B2 (en) 2023-08-03
CA3040888A1 (en) 2018-04-26
JP2024001055A (ja) 2024-01-09
DK3528817T3 (da) 2022-08-08
IL266054A (en) 2019-06-30
EP4112056A1 (en) 2023-01-04
AU2017346871A1 (en) 2019-05-02
EP3528817A1 (en) 2019-08-28
IL266054B2 (en) 2023-10-01
MX2019004492A (es) 2019-11-18
US20210330675A1 (en) 2021-10-28
CN110167557A (zh) 2019-08-23
IL302336B1 (en) 2025-07-01
JP2019533019A (ja) 2019-11-14
ES2924257T3 (es) 2022-10-05
IL302336B2 (en) 2025-11-01
US11090308B2 (en) 2021-08-17
EP4112056B1 (en) 2026-01-21
US20240156826A1 (en) 2024-05-16
KR20190109387A (ko) 2019-09-25
WO2018075650A1 (en) 2018-04-26
IL266054B1 (en) 2023-06-01
US20200230146A1 (en) 2020-07-23
US11806353B2 (en) 2023-11-07
EP3528817B1 (en) 2022-05-25

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