KR20230152783A - Mic 항체 및 결합제 및 이의 사용 방법 - Google Patents

Mic 항체 및 결합제 및 이의 사용 방법 Download PDF

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Publication number
KR20230152783A
KR20230152783A KR1020237036123A KR20237036123A KR20230152783A KR 20230152783 A KR20230152783 A KR 20230152783A KR 1020237036123 A KR1020237036123 A KR 1020237036123A KR 20237036123 A KR20237036123 A KR 20237036123A KR 20230152783 A KR20230152783 A KR 20230152783A
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KR
South Korea
Prior art keywords
binding agent
amino acid
seq
ser
acid sequence
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Pending
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KR1020237036123A
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English (en)
Korean (ko)
Inventor
제니퍼 동란 우
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칸큐어 엘엘씨
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Application filed by 칸큐어 엘엘씨 filed Critical 칸큐어 엘엘씨
Publication of KR20230152783A publication Critical patent/KR20230152783A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
KR1020237036123A 2020-07-07 2021-07-06 Mic 항체 및 결합제 및 이의 사용 방법 Pending KR20230152783A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063049012P 2020-07-07 2020-07-07
US63/049,012 2020-07-07
KR1020227046132A KR102594083B1 (ko) 2020-07-07 2021-07-06 Mic 항체 및 결합제 및 이의 사용 방법
PCT/US2021/040445 WO2022010847A1 (en) 2020-07-07 2021-07-06 Mic antibodies and binding agents and methods of using the same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020227046132A Division KR102594083B1 (ko) 2020-07-07 2021-07-06 Mic 항체 및 결합제 및 이의 사용 방법

Publications (1)

Publication Number Publication Date
KR20230152783A true KR20230152783A (ko) 2023-11-03

Family

ID=77127088

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237036123A Pending KR20230152783A (ko) 2020-07-07 2021-07-06 Mic 항체 및 결합제 및 이의 사용 방법
KR1020227046132A Active KR102594083B1 (ko) 2020-07-07 2021-07-06 Mic 항체 및 결합제 및 이의 사용 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020227046132A Active KR102594083B1 (ko) 2020-07-07 2021-07-06 Mic 항체 및 결합제 및 이의 사용 방법

Country Status (9)

Country Link
US (2) US12139539B2 (https=)
EP (1) EP4178678A1 (https=)
JP (1) JP2026021336A (https=)
KR (2) KR20230152783A (https=)
CN (1) CN116249716A (https=)
AU (1) AU2021305084A1 (https=)
CA (1) CA3184940A1 (https=)
TW (1) TW202216776A (https=)
WO (1) WO2022010847A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250230246A1 (en) * 2021-10-27 2025-07-17 Samyang Biopharm Usa Inc. Anti-mic antibodies with variant fc domains
WO2023225626A2 (en) * 2022-05-20 2023-11-23 Adanate, Inc. Multi-targeting lilrb antibodies and uses thereof

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Also Published As

Publication number Publication date
CN116249716A (zh) 2023-06-09
JP2026021336A (ja) 2026-02-10
JP2023532852A (ja) 2023-08-01
TW202216776A (zh) 2022-05-01
US12139539B2 (en) 2024-11-12
KR20230012072A (ko) 2023-01-25
KR102594083B1 (ko) 2023-10-25
EP4178678A1 (en) 2023-05-17
AU2021305084A1 (en) 2023-02-02
US20250026837A1 (en) 2025-01-23
WO2022010847A1 (en) 2022-01-13
CA3184940A1 (en) 2022-01-13
US20230235065A1 (en) 2023-07-27

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Patent event date: 20231020

Application number text: 1020227046132

Filing date: 20221228

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