KR20230075559A - Skin soothing and anti-pollution composition of persicaria perfoliata extract - Google Patents
Skin soothing and anti-pollution composition of persicaria perfoliata extract Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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Abstract
Description
본 발명은 며느리배꼽 추출물을 유효성분으로 포함하는 피부 진정 및 안티폴루션용 화장료 조성물에 관한 것이다. 보다 상세하게는 며느리배꼽 추출물을 유효성분으로 포함하여 피부세포의 손상 개선 및 진정 효능이 우수하여, 미세먼지, 황사와 같은 환경 유해인자로부터 피부 건강을 유지할 수 있는 안티폴루션 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition for skin soothing and anti-pollution comprising a daughter-in-law's navel extract as an active ingredient. More specifically, it relates to an anti-pollution cosmetic composition that contains daughter-in-law's navel extract as an active ingredient and has excellent skin cell damage improvement and soothing effects, thereby maintaining skin health from environmental harmful factors such as fine dust and yellow dust.
화장료는 아름답고 건강한 피부를 유지하도록 도움을 주는 물질로, 피부의 산화적 손상을 방지하는 항산화 기능, 피부 주름 형성을 장지하는 주름 개선 기능, 자외선에 의한 피부 손상을 방지할 수 있는 자외선 차단 기능, 피부에 충분한 수분을 공급하는 보습 기능 등과 이외에도 피부를 개선할 수 있는 다양한 기능을 포함한다. 최근에는 합성 화학물질 등에 의한 피부 자극을 줄이기 위해 피부에 부작용이 적을 뿐만 아니라 안정성과 생리 활성이 우수한 다양한 천연물을 소재로 활용한 화장료에 대한 연구가 활발히 진행되고 있다.Cosmetics are substances that help maintain beautiful and healthy skin. Antioxidant function to prevent oxidative damage to the skin, wrinkle improvement function to prevent skin wrinkle formation, UV protection function to prevent skin damage caused by UV rays, skin In addition to the moisturizing function that supplies sufficient moisture to the skin, it also includes various functions that can improve the skin. Recently, in order to reduce skin irritation caused by synthetic chemicals, etc., studies on cosmetics using various natural substances with excellent stability and physiological activity as well as low side effects on the skin have been actively conducted.
화장품 산업은 소득수준의 향상과 인구 고령화에 따른 미에 대한 관심 증가와 젊고 탄력 있는 피부를 갈구하는 시대적인 욕구 증가로 그 수요가 지속적으로 증가하고 있다. Demand for the cosmetics industry is continuously increasing due to an increase in interest in beauty due to an increase in income level and an aging population, and an increase in the era's demand for youthful and elastic skin.
또한, 피부는 신체의 바깥쪽을 둘러싸고 있는 얇은 막으로서, 외부 환경의 물리적, 화학적인 자극으로부터 인체를 보호해주는 기능을 하며, 체내 수분의 증발을 억제하면서도 외부로부터 오염원의 과잉 침투를 방지한다. 하지만, 아무리 외부로부터의 바이러스 침투를 막아내는 피부일지라도 과도한 자외선, 오염된 환경 등 외부로부터 받는 스트레스는 피부 자극을 유발하게 되고, 결국에는 피부 노화로 이어지게 된다.In addition, the skin is a thin film that surrounds the outside of the body, and functions to protect the human body from physical and chemical stimuli of the external environment, and prevents excessive penetration of pollutants from the outside while suppressing evaporation of moisture in the body. However, no matter how much the skin blocks virus penetration from the outside, stress from the outside, such as excessive ultraviolet rays and a polluted environment, causes skin irritation and eventually leads to skin aging.
특히 자외선과 같은 외부자극에 의한 각질층의 손상이 반복되거나, 정상적인 각질층의 복원이 지연되면 피부노화가 가속화되거나 피부질환으로 진행될 수 있다. 외부손상에 의한 각질층의 신속한 복원은 피부건조, 피부노화, 가려움 등을 경감시킬 수 있으며, 이는 사람의 각질형성세포의 정상적인 분화 및 증식을 유도하는 피부재생을 촉진함으로써 예방할 수 있다.In particular, when damage to the stratum corneum is repeated due to external stimuli such as ultraviolet rays or restoration of the normal stratum corneum is delayed, skin aging may be accelerated or skin diseases may progress. Rapid restoration of the stratum corneum due to external damage can relieve skin dryness, skin aging, itching, and the like, which can be prevented by promoting skin regeneration that induces normal differentiation and proliferation of human keratinocytes.
최근 화학물질의 사용이 증가되면서 이의 제조, 사용, 폐기과정에서 발생되는 방향족 탄화수소류, 알데히드류, 질소산화물류, 질산염류, 미세먼지 등의 환경 오염원에 피부가 노출됨에 따라, 홍반, 부족, 가려움, 두드러기, 염증 등의 가벼운 피부 트러블과 아토피, 건선, 피부암 등의 피부병의 발병률이 높이지고 있다.Recently, as the use of chemicals has increased, the skin has been exposed to environmental pollutants such as aromatic hydrocarbons, aldehydes, nitrogen oxides, nitrates, and fine dust generated in the process of manufacturing, using, and discarding them, resulting in erythema, scarcity, and itching. The incidence of mild skin troubles such as , hives and inflammation and skin diseases such as atopy, psoriasis, and skin cancer is increasing.
상기 미세먼지는 여러 가지 성분을 가진 대기 부유 물질로 눈에 보이지 않은 지름 10 μm 이하의 작은 먼지를 가리키며, 알데히드류, 황산염, 질산염 등과 같은 독성 물질을 포함하고 있다. 또한, 미세먼지는 황사, 자동차 매연 및 공장 굴뚝에서 배출되는 중금속 등이 대기 중에서 광화학 반응을 일으켜 만들어지며, 고농도의 미세먼지 환경에 노출되면 기침, 안구 따가움, 피부 트러블 및 폐 염증이 발생한다.The fine dust refers to small dust with an invisible diameter of 10 μm or less as airborne substances having various components, and includes toxic substances such as aldehydes, sulfates, and nitrates. In addition, fine dust is produced by a photochemical reaction in the air of yellow dust, automobile soot, and heavy metals emitted from factory chimneys. When exposed to a high-concentration fine dust environment, coughing, eye irritation, skin trouble, and lung inflammation occur.
미세먼지에는 휘발성 유기화합물(Volatile Organic Compounds; VOCs)이 포함되어 있는데, 이러한 휘발성 유기화합물은 끓는점이 낮아 대기 중으로 쉽게 증발되는 액체 또는 기체상 유기화합물을 총칭한다. 휘발성 유기화합물은 산업체에서 많이 사용하는 용매에서 플라스틱 건조공정에서 배출되는 유기가스에 이르기까지 매우 다양하며 끓는점이 낮은 액체연료, 파라핀, 올레핀, 방향족화합물 등 주변에서 흔히 사용하는 탄화수소류 대부분이 해당된다.Fine dust contains volatile organic compounds (VOCs), which collectively refer to liquid or gaseous organic compounds that easily evaporate into the air due to their low boiling point. Volatile organic compounds are very diverse, ranging from solvents widely used in industry to organic gases emitted from plastic drying processes, and most of the hydrocarbons commonly used in the surroundings, such as low-boiling liquid fuels, paraffins, olefins, and aromatic compounds, are applicable.
휘발성 유기 화합물 중 대표적 오염물질인 포름알데히드(formaldehyde, FA)는 자극적인 냄새가 나며, 무색의 수용성 기체로서 요소계와 페놀계의 합성 수지의 생산에 이용된다. 포름알데히드는 상부 기도, 눈 등의 점막과 피부에 자극을 일으키며 장기간 노출될 경우 호흡기계 폐쇄성 폐질환 및 폐암의 발병과 관련 있다고 보고되어 있다. Formaldehyde (FA), a representative contaminant among volatile organic compounds, has a pungent odor and is a colorless, water-soluble gas that is used in the production of urea-based and phenol-based synthetic resins. Formaldehyde causes irritation to the mucous membranes and skin of the upper respiratory tract, eyes, etc., and long-term exposure has been reported to be associated with respiratory obstructive pulmonary disease and lung cancer.
미세먼지에는 대부분 중금속도 포함되는데, 중금속은 납, 수은, 카드뮴, 아연, 니켈 등 비중 4 이상의 무거운 금속원소를 가리키며, 이러한 중금속은 미량이라도 체내에 축적되면 잘 배설되지 않고 우리 몸 속의 단백질에 쌓여 장기간에 걸쳐 부작용을 나타내기 때문에 매우 위험한 것으로 인식되고 있다. 또한, 대기 중에서 화학반응을 일으켜 질소산화물(NO)과 같은 유해 물질을 추가로 생성해 피부의 염증, 아토피, 피부 트러블을 유발할 수 있다고 보고되어 있다.Fine dust also includes most heavy metals. Heavy metals refer to heavy metal elements with a specific gravity of 4 or higher, such as lead, mercury, cadmium, zinc, and nickel. When these heavy metals accumulate in the body even in small amounts, they are not excreted well and accumulate in proteins in our body for a long time. It is recognized as very dangerous because it shows side effects throughout. In addition, it has been reported that chemical reactions in the air can cause additional harmful substances such as nitrogen oxides (NO) to cause skin inflammation, atopy, and skin troubles.
현재 체내 중금속 제거 방법은 EDTA(ethylene diamine tetraacetate) 및 BAL(British Anti-Lewisite)과 같은 착화합물 형성물질을 주사하여 체내에 축적되어 있는 중금속과 결합하게 함으로써, 중금속을 체외로 배출시키는 방법 등이 알려져 있으나 아직까지는 효과적이고 용이하게 중금속으로부터 피부를 보호하는 방법은 알려진 바가 없다.Currently, methods for removing heavy metals from the body are known, such as injecting complex compound-forming substances such as EDTA (ethylene diamine tetraacetate) and BAL (British Anti-Lewisite) to combine with heavy metals accumulated in the body to excrete heavy metals from the body. Until now, there is no known method for effectively and easily protecting the skin from heavy metals.
또한, 최근 국민들의 생활수준이 향상되면서 각광받고 있는 환경 유해인자들로부터 피부를 보호할 수 있는 새로운 천연 물질에 대한 피부와 관련된 기능성 화장품에 대한 관심과 수요가 급증하고 있지만, 합성소재 기능성 화장품과 관련된 부작용이 지속적으로 제기되면서 효과적이면서도 독성이 없는 천연물을 이용한 화장품 개발연구가 활발히 진행되고 있다.In addition, interest and demand for functional cosmetics related to the skin for new natural substances that can protect the skin from environmental harmful factors that are in the limelight as the people's living standards have recently improved are rapidly increasing. As the side effects are continuously raised, research on the development of cosmetics using natural products that are effective and non-toxic is being actively conducted.
따라서, 천연물을 이용한 화장품 개발연구는 안전함과 동시에 피부노화를 지연시키는 효과적인 화장품 소재 발굴의 일환으로 기능성 천연물에 대한 지속적인 개발이 필요하다.Therefore, research on the development of cosmetics using natural products requires continuous development of functional natural products as part of discovering safe and effective cosmetic materials that delay skin aging.
본 발명의 목적은 며느리배꼽 추출물을 유효성분으로 포함하여 피부 진정 효과를 나타내는 것으로, 피부 진정용 화장료 조성물을 제공하는 것이다. An object of the present invention is to provide a cosmetic composition for calming the skin, which contains a daughter-in-law's navel extract as an active ingredient and exhibits a skin soothing effect.
본 발명의 다른 목적은 며느리배꼽 추출물을 유효 성분으로 포함하여, 미세먼지, 황사와 같은 환경 유해인자로부터 손상된 피부 세포를 개선시키는 것으로, 피부 안티폴루션용 화장료 조성물을 제공하는 것이다.Another object of the present invention is to improve skin cells damaged from environmental harmful factors such as fine dust and yellow dust, including daughter-in-law's navel extract as an active ingredient, to provide a cosmetic composition for skin anti-pollution.
상기 목적을 달성하기 위하여, 본 발명의 일 실시예에 따른 피부 진정 및 안티폴루션용 화장료 조성물은 며느리배꼽(Persicaria perfoliata) 추출물을 유효성분으로 포함한다.In order to achieve the above object, the cosmetic composition for skin soothing and anti-pollution according to an embodiment of the present invention contains Persicaria perfoliata extract as an active ingredient.
상기 조성물은 분홍애기풀 추출물, 물잔디 추출물, 덜스 추출물, 꼬시래기 추출물 및 이들의 혼합으로 이루어진 군으로부터 선택되는 해조류 추출물을 더 포함한다.The composition further comprises a seaweed extract selected from the group consisting of pink celandine extract, water grass extract, dulse extract, sea string extract, and mixtures thereof.
상기 추출물은 물, 탄소수 1 내지 6의 알코올 및 이들의 혼합물로 이루어진 군으로부터 선택된 추출 용매를 이용하여 추출된다. The extract is extracted using an extraction solvent selected from the group consisting of water, alcohols having 1 to 6 carbon atoms, and mixtures thereof.
상기 조성물은 포름알데히드, 아세탈알데히드, 프로피온알데히드, 벤질알데히드, 알데히드류, 중금속, 미세먼지, 황사 및 이들의 혼합으로 이루어진 군으로부터 선택되는 환경 유해인자로 인한 피부세포의 사멸 억제 효능을 나타내는 것이다.The composition exhibits an effect of inhibiting death of skin cells due to environmental harmful factors selected from the group consisting of formaldehyde, acetalaldehyde, propionaldehyde, benzylaldehyde, aldehydes, heavy metals, fine dust, yellow dust, and mixtures thereof.
상기 피부세포는 각질형성세포인 것을 특징으로 하는 것이다.The skin cells are characterized in that they are keratinocytes.
본 발명의 다른 일 실시예에 따른 재생 크림은 상기 화장료 조성물을 포함하여 제조한 것이다.A regenerating cream according to another embodiment of the present invention is prepared by including the cosmetic composition.
본 발명의 다른 일 실시예에 따른 보습 크림은 상기 화장료 조성물을 포함하여 제조한 것이다.A moisturizing cream according to another embodiment of the present invention is prepared by including the cosmetic composition.
이하, 본 발명을 더욱 상세하게 설명한다.Hereinafter, the present invention will be described in more detail.
본 명세서에서 사용되는 용어 '추출물'은 상술한 바와 같이 당업계에서 조추출물(crude extract)로 통용되는 의미를 갖지만, 광의적으로는 추출물을 추가적으로 분획(fractionation)한 분획물도 포함한다. 즉, 식물 추출물은 상술한 추출용매를 이용하여 얻은 것뿐만 아니라, 여기에 정제과정을 추가적으로 적용하여 얻은 것도 포함한다. 예컨대, 상기 추출물을 일정한 분자량 컷-오프 값을 갖는 한 외 여과막을 통과시켜 얻은 분획, 다양한 크로마토그래피(크기, 전하, 소수성 또는 친화성에 따른 분리를 위해 제작된 것)에 의한 분리 등, 추가적으로 실시된 다양한 정제 방법을 통해 얻어진 분획도 본 발명의 식물 추출물에 포함되는 것이다.As used herein, the term 'extract' has a meaning commonly used in the art as a crude extract in the art as described above, but also includes fractions obtained by additional fractionation of the extract in a broad sense. That is, the plant extract includes not only those obtained using the above-described extraction solvent, but also those obtained by additionally applying a purification process thereto. For example, a fraction obtained by passing the extract through an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatography (made for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through various purification methods are also included in the plant extract of the present invention.
본 발명에서 이용되는 추출물은 감압 증류 및 동결 건조 또는 분무 건조 등과 같은 추가적인 과정에 의해 분말 상태로 제조될 수 있다.The extract used in the present invention may be prepared in a powder state by additional processes such as distillation under reduced pressure and freeze drying or spray drying.
본 발명에서 말하는 '피부 안티폴루션(Anti-pollution)'은 미세먼지, 유기오염원 또는 무기오염원 등의 오염물질에 의한 피부 오염, 피부 세포 사멸 또는 피부 세포 증식 저해, 또는 피부상태 저하를 개선하는 것을 말한다.'Skin anti-pollution' as used in the present invention refers to improving skin contamination by pollutants such as fine dust, organic pollutants or inorganic pollutants, skin cell death or inhibition of skin cell proliferation, or skin condition deterioration. say
본 발명에서 사용되는 용어 "재생"은, 피부 외부 및 내부 원인에 의해 발생된 피부(세포) 손상에 대한 피부 조직의 회복 과정을 의미한다. 상기 외부 원인에 의한 손상은 자외선, 외부 오염 물질, 창상, 외상 등을 들 수 있으며, 상기 내부 원인에 의한 손상은 스트레스 등을 들 수 있다.The term "regeneration" used in the present invention refers to a skin tissue recovery process for skin (cell) damage caused by external and internal skin causes. The damage caused by the external cause may include ultraviolet rays, external contaminants, wounds, trauma, and the like, and the damage caused by the internal cause may include stress.
또한, 본 발명에서 사용되는 용어 "보습"은, 수분손실(수분 증발) 등을 적절히 조절하여 생체의 향상성을 유지하는 것을 의미한다.In addition, the term "moisturizing" used in the present invention means maintaining the improvement of the living body by appropriately controlling water loss (moisture evaporation) and the like.
본 발명에서 말하는 "세포 보호"는 세포독성이 없고, 환원력 및 DPPH 라디칼 소거능이 높아 항산화 활성이 뛰어나며, 활성산소종 생산, DNA 손상, 세포사멸 및 미토콘드리아 막 손상을 억제하는 효과를 나타내는 것을 포함하는 것으로 한다."Cell protection" as referred to in the present invention includes no cytotoxicity, high reducing power and DPPH radical scavenging ability, excellent antioxidant activity, and an effect of inhibiting the production of reactive oxygen species, DNA damage, apoptosis, and mitochondrial membrane damage. do.
본 발명의 일 실시예에 따른 피부 진정 및 안티폴루션 화장료 조성물은 며느리배꼽(Persicaria perfoliata) 추출물을 유효성분으로 포함한다.The skin soothing and anti-pollution cosmetic composition according to an embodiment of the present invention contains Persicaria perfoliata extract as an active ingredient.
며느리배꼽(Persicaria perfoliata)은 원산지가 아시아지역인 마디풀과의 한 종류이다. 며느리배꼽은 전통적으로 해독제, 해열제, 이뇨제 등으로 사용되어 왔으며, 기침이나 백일해 등 호흡기 질환에도 사용되어 왔다. 며느리배꼽 추출물의 주요 성분으로는 퀘르세틴(quercetin), 카페산(caffeic acid) 등이 함유되어 있다고 알려져 있다. 상기 퀘르세틴(quercetin)는 식물성 항산화제로 파이토케미컬 중에서도 플라보노이드 계열에 속한다. 퀘르세틴은 적절한 세포 기능에 필요한 효소와 막 단백질의 두 가지 유형인 키나아제와 포스파타제라고 불리는 세포 신호 전달 경로를 통해 외부 스트레스 요인에 대한 면역 체계의 반응을 조절하는 역할을 한다.Persicaria perfoliata is a member of the Asiatic plant family. Daughter-in-law's belly button has traditionally been used as an antidote, antipyretic, and diuretic, and has also been used for respiratory diseases such as cough and whooping cough. It is known that daughter-in-law's navel extract contains quercetin, caffeic acid, and the like as major components. The quercetin (quercetin) is a plant antioxidant and belongs to the flavonoid family among phytochemicals. Quercetin plays a role in regulating the immune system's response to external stressors through cell signaling pathways called kinases and phosphatases, two types of enzymes and membrane proteins required for proper cell function.
상기 며느리배꼽 추출물을 포함하는 경우, 며느리배꼽 추출물 내에 포함되어 있는 유효성분에 의해 피부 세포의 손상 개선 및 진정 효능이 우수하여, 미세먼지, 황사와 같은 환경 유해인자로부터 피부 상태 저하를 개선할 수 있다.In the case of including the daughter-in-law's belly button extract, the active ingredient contained in the daughter-in-law's belly button extract has excellent skin cell damage improvement and soothing effect, so it is possible to improve skin condition deterioration from environmental harmful factors such as fine dust and yellow dust .
상기 조성물은 분홍애기풀 추출물, 물잔디 추출물, 덜스 추출물, 꼬시래기 추출물 및 이들의 혼합으로 이루어진 군으로부터 선택되는 해조류 추출물을 더 포함한다.The composition further comprises a seaweed extract selected from the group consisting of pink celandine extract, water grass extract, dulse extract, sea string extract, and mixtures thereof.
상기 해조류 추출물을 더 포함할 경우, 상호작용에 의한 상승 효과로서, 항산화 및 세포 보호 활성이 증진될 뿐만 아니라, 피부 안티폴루션 효과가 크게 증진되는 효과를 나타낼 수 있다.When the seaweed extract is further included, as a synergistic effect due to the interaction, not only antioxidant and cell protection activities are enhanced, but also the effect of greatly enhancing the skin anti-pollution effect can be exhibited.
특히, 상기 분홍애기풀 추출물, 물잔디 추출물, 덜스 추출물, 꼬시래기 추출물의 해조류 추출물에 주로 함유되어 있는 다당류는 후코이단(Fucoidan)으로, 해조류가 파도, 햇빛으로부터 스스로를 보호하기 위하여 분비하는 물질로서 매우 탁월한 천연 보습제 역할을 할 수 있다.In particular, the polysaccharide mainly contained in the seaweed extracts of the pink grass extract, water grass extract, dulse extract, and sea chinensis extract is fucoidan, which is a very excellent natural substance secreted by seaweed to protect itself from waves and sunlight. It can act as a moisturizer.
상기 분홍애기풀(Binghamia californica J. Agardh)은 홍조식물 분홍치목 마디잘록이과의 바닷말로 조간대 하부에 자란다. 식물체는 막질이며 분홍색으로 끈 모양의 가는 뿌리에서 납작한 줄기가 여러 개 나온다, 이리저리 굽고 서로 붙으며 얽혀서 덩어리로 된다. 줄기는 두 갈래로 가지를 낸다. 구술모양의 세포가 2~3겹으로 피층을 이루고 수조직은 둥근 세포와 막대 모양의 세포가 어우러져 양쪽 피층조직을 연결한다.The pink baby plant (Binghamia californica J. Agardh) grows in the lower intertidal zone as a seaweed of the red algae plant pink algae family. The plant body is membranous, pink, and several flat stems come out from the string-shaped thin roots. The stem branches into two branches. Oral-shaped cells form 2-3 layers of cortex, and medullary tissue is composed of round cells and rod-shaped cells, connecting both cortical tissues.
상기 물잔디(Gelidiopsis variabilis (J. Agardh) Schmitz)의 식물체는 적갈색의 연골질로 조금 납작하고 꾸물꾸물한 가시 모양으로 가는 줄기에서 모여나 작은 개체군을 이룬다. 가지는 드물게 나며 길이와 나는 곳이 불규칙하다. 구슬모양의 세포가 한 두겹으로 피층을 이루고 안쪽으로 갈수록 조금씩 길어지면서 가운데 부분은 긴 막댕모양인 세포가 수조직을 이룬다. 조하대의 조개껍질에 자란다.Plants of the water grass (Gelidiopsis variabilis (J. Agardh) Schmitz) are reddish-brown, cartilaginous, slightly flattened, and form small populations gathered from thin thorn-like stems. Branches grow sparsely, and the length and place of growth are irregular. Bead-shaped cells form a cortex in one or two layers, and gradually lengthen toward the inside, and the middle part forms a medullary tissue. Grows on clamshells in the subtidal zone.
상기 덜스(Palmaria palmata)는 팔손이풀목과 적색 해조류로 대서양과 태평양의 북부 해안에서 자란다. 덜스는 단백질, 칼슘, 마그네슘, 철분이 풍부하며, 오랫동안 유럽 해안 지역 사람들이 식용해오고 있다. 특히 덜스는 질감 부드럽고 향이 강해 수프와 샐러드에 주로 사용되고 있다.The dulse (Palmaria palmata) grows on the northern coasts of the Atlantic and Pacific Oceans as a limb and a red seaweed. Dulse is rich in protein, calcium, magnesium and iron, and has long been eaten by people in coastal regions of Europe. In particular, dulse has a soft texture and strong fragrance, so it is mainly used in soups and salads.
상기 꼬시래기(Gracilaria verrucosa (Hudson) Paperfuss)는 홍조식물 꼬시래기과의 해조류로 장흥, 완도, 해남, 진도에서는 꼬시락이라 하며, 부산근처에서는 망둑어를 꼬시래기라고 부르기도 한다. 직경 1-3㎜의 줄기가 보통 20cm 정도 성장하며 최대 2-3m까지 자란다. 몸통은 작은 쟁반 모양의 뿌리에서 모여나고 원기둥 모양이다. 촘촘하게 깃꼴로 갈라지고 가지는 한쪽으로 치우쳐 나기도 한다. 몸에서 뻗어나온 가지는 지름 1~2mm 정도의 철사 모양으로 검은빛을 띤 자주색 또는 짙은 갈색이다. 조간대의 돌, 조개껍데기 등에 붙어 사는데, 특히 강물이 바다로 흘러 드는 얕은 바닷가의 자갈이나 말뚝 등에서 번식하며, 외해(外海)의 암초 위에서도 자란다. 특히 내만에서는 큰 군락을 이루며 민물이 흘러 드는 곳에는 간혹 매우 큰 개체들이 있다. 서식장소에서 떨어진 몸통과 가지는 바다 속 어디나 떠돌아다닐 수 있고, 그 사이의 생장이 빨라서 보통의 붙어 사는 식물체보다 더 커진다. 식용하거나 한천을 만드는 데 우뭇가사리와 섞어 쓴다. 채취된 것들은 건조시켜서 보관한다. 뜨거운 물에 데치면 붉은색을 띠는 색소인 피코피린이 파괴되고, 녹색을 띠는 색소인 클로로필만 남아 녹색으로 바뀐다. 초봄부터 늦가을까지가 제철이다. 지방과 탄수화물의 함량이 낮고 칼슘과 식이섬유를 다량 함유하고 있으며 체내 중금속배출 등의 효과도 있다고 한다.The seaweed (Gracilaria verrucosa (Hudson) Paperfuss) is a seaweed of the red algae family, and is called seaweed in Jangheung, Wando, Haenam, and Jindo, and is also called seaweed near Busan. A stem with a diameter of 1-3 mm usually grows about 20 cm and grows up to 2-3 m. The body is gathered from a small tray-shaped root and has a cylindrical shape. It is densely branched into a feather shape, and the branches are biased to one side. Branches extending from the body are wire-shaped with a diameter of 1 to 2 mm, and are blackish purple or dark brown. It lives attached to stones and shells in the intertidal zone, especially breeds on pebbles or piles of shallow beaches where river water flows into the sea, and grows on reefs in the open sea. In particular, it forms a large colony in the inner bay, and there are sometimes very large individuals where fresh water flows. The body and branches separated from the habitat can wander anywhere in the sea, and the growth between them is fast, so they grow larger than normal attached plants. It is edible or mixed with agar to make agar. The harvested ones are dried and stored. When blanched in hot water, the red pigment, picopyrin, is destroyed, leaving only the green pigment, chlorophyll, which turns green. It is in season from early spring to late fall. It is low in fat and carbohydrates, contains a large amount of calcium and dietary fiber, and is said to be effective in excreting heavy metals from the body.
본 발명의 며느리배꼽 추출물을 유효성분으로 포함하는 피부 진정 및 안티폴루션용 화장료 조성물은 상기 분홍애기풀 추출물, 물잔디 추출물, 덜스 추출물, 꼬시래기 추출물 및 이들의 혼합으로 이루어진 군으로부터 선택되는 해조류 추출물을 더 포함하고, 털큰앵초 추출물 및 파드득나물 추출물을 추가로 포함할 수 있다.The cosmetic composition for skin soothing and anti-pollution comprising the daughter-in-law's belly button extract as an active ingredient of the present invention further comprises a seaweed extract selected from the group consisting of the pink celandine extract, water grass extract, dulse extract, seaweed extract, and mixtures thereof. Including, and may further include a hairy primrose extract and a paddock herb extract.
상기 털큰앵초(Primula PJsoana var. pubescens)는 쌍떡잎식물 합판화군 앵초목 앵초과의 여러해살이로, 큰앵초에 비하여 잎자루와 꽃줄기에 긴 털이 많으며, 원줄기는 없이 뿌리줄기가 옆으로 뻗는다. 꽃은 통꽃으로 지름 1.5~2.5cm의 붉은 자주색 꽃이 7~8월에 핀다. 열매는 길이 7~12mm의 긴 타원형의 삭과(果)를 맺는다. 한국, 일본, 중국 등지에 분포한다.The hairy primrose (Primula PJsoana var. pubescens) is a perennial of the dicotyledonous plant plywood group Primrose primrose family, has many long hairs on the petiole and peduncle compared to the large primrose, and the rhizome extends to the side without a main stem. The flower is a whole flower, and reddish purple flowers with a diameter of 1.5~2.5cm bloom in July~August. The fruit bears a long oval capsule with a length of 7 to 12 mm. Distributed in Korea, Japan and China.
상기 파드득나물(Cryptotaenia japonica)은 반디나물이라고도 일컬어지는 우리나라 산지에서 자라는 나물이다. 높이는 약 30 내지 60cm이다. 줄기는 곧추서고 약간 갈라지며 전체에 털이 없고 향기가 있다. 줄기와 잎은 녹색이고 뿌리는 굵은 것이 특징이다. 잎은 어긋나고 잎자루가 5 내지 17cm로 길며 3 개의 작은 잎으로 되는데 뒷면에 윤기가 있는 것이 특징이다. 한편, 끝쪽의 작은 잎은 잎자루가 없고 달걀 모양으로서 길이 3 내지 8cm이며, 나비 2 내지 6cm이다. 끝이 뾰족하고 밑부분은 급히 좁아지며 가장 자리에 날카롭고 불규칙한 톱니가 있다. 곁쪽의 작은 잎은 크기와 모양이 서로 같고 잎자루가 없으며 때로 불규칙한 톱니가 있는 가장자리가 2 내지 3개로 얕게 갈라진다. 꽃은 흰색 또는 연한 자주색이며 6 내지 7월에 가지 끝에 복산형꽃차례[複傘形花序]로 달린다. 작은 꽃자루는 1 내지 4개로서 길고 짧은 것이 있는데 길이 3 내지 15mm이고 곧추서는 특징을 갖는다. 작은 총포조각은 줄 모양이고 짧다. 꽃잎은 5개로서 끝부분이 안으로 굽고 꽃받침은 5개이며 수술도 5개이다. 열매는 분열과로서 길이 3 내지 4mm의 긴 타원형이며, 털이 없고 8 내지 9월에 익는 것이 특징이다. 어린 잎은 식용하고 야채로 재배하기도 한다. 여름에 채취한 것은 그늘에 말려서 갑상선종 등에 약재로 이용하기도 한다.The Padduk herb (Cryptotaenia japonica) is an herb that grows in the mountainous regions of Korea, also known as Bandinamul. The height is about 30 to 60 cm. The stem is upright, slightly split, hairless, and fragrant. The stem and leaves are green and the root is thick. The leaves are alternate, the petiole is 5 to 17 cm long, and there are 3 small leaves, which are characterized by the glossy back side. On the other hand, the small leaf at the end has no petiole, is egg-shaped, and is 3 to 8 cm long and 2 to 6 cm wide. The tip is pointed, the lower part narrows rapidly, and there are sharp and irregular teeth at the edge. Side small leaves are the same size and shape, have no petioles, and sometimes have irregularly sawtoothed edges that are shallowly split into 2 or 3 pieces. Flowers are white or light purple, and hang in a double inflorescence [複傘形花序] at the end of branches in June or July. There are 1 to 4 small peduncles, long and short ones, 3 to 15mm long, and stand upright. Small gun pieces are line-shaped and short. There are 5 petals, the ends of which are bent inward, and there are 5 calyxes and 5 stamens. The fruit is a divisional fruit with a long oval shape of 3 to 4 mm in length, and is characterized by being hairless and ripening in August to September. The young leaves are edible and are also grown as vegetables. It is collected in summer and dried in the shade to be used as a medicine for goiter.
바람직하게 상기 피부 진정 및 안티폴루션용 화장료 조성물은 며느리배꼽 추출물 100 중량부, 분홍애기풀 추출물 30 내지 50 중량부, 물잔디 추출물 30 내지 50 중량부, 덜스 추출물 30 내지 50 중량부, 꼬시래기 추출물 30 내지 50 중량부, 털큰앵초 추출물 5 내지 10 중량부 및 파드득나물 추출물 5 내지 10 중량부로 포함할 수 있다. Preferably, the cosmetic composition for skin soothing and anti-pollution includes 100 parts by weight of daughter-in-law extract, 30 to 50 parts by weight of pink grass extract, 30 to 50 parts by weight of water grass extract, 30 to 50 parts by weight of dulse extract, 30 to 50 parts by weight of St. 50 parts by weight, 5 to 10 parts by weight of hairy primrose extract and 5 to 10 parts by weight of Padduknamul extract.
상기 범위에 의하는 경우 각 추출물의 상호 작용에 의한 상승효과로 임계적 의의가 있는 정도의 상승효과가 발현되며, 상기 범위를 벗어나는 경우 상승효과가 급격히 저하되거나 거의 없게 된다.In the case of the above range, a synergistic effect of critical significance is expressed as a synergistic effect due to the interaction of each extract, and when it is out of the above range, the synergistic effect is rapidly reduced or almost absent.
상기 추출물은 물, 탄소수 1 내지 6의 알코올 및 이들의 혼합물로 이루어진 군으로부터 선택된 추출 용매를 이용하여 추출된다.The extract is extracted using an extraction solvent selected from the group consisting of water, alcohols having 1 to 6 carbon atoms, and mixtures thereof.
상기 추출물은 건조한 해조류를 분쇄한 분쇄물을 물, 에탄올, 메탄올 등과 같은 탄소수 1 내지 6의 알코올과 같은 극성 용매 또는 알코올과 물의 1:0.1 내지 1:10의 혼합비를 갖는 혼합 용매로 용출할 수 있으며, 보다 상세하게는 추출 용매로 물을 이용할 수 있다. 이때, 추출 온도는 10℃ 내지 100℃, 바람직하게는 실온에서 추출한 추출물일 수 있다. The extract can be eluted from pulverized dried seaweed with a polar solvent such as water, ethanol or methanol having 1 to 6 carbon atoms, or a mixed solvent having a mixing ratio of 1:0.1 to 1:10 of alcohol and water, , More specifically, water can be used as the extraction solvent. At this time, the extraction temperature may be 10 ℃ to 100 ℃, preferably the extract extracted at room temperature.
상기 추출 용매는 시료의 중량 기준으로 2 내지 50 배를 사용할 수 있으며, 바람직하게는 2 내지 20 배이다. 추출을 위해 시료는 추출 용매에서 침출을 위해 1 내지 72 시간 동안 방치될 수 있으며, 상세하게는 1 내지 24시간 동안 방치될 수 있다.The extraction solvent may be used in an amount of 2 to 50 times, preferably 2 to 20 times, based on the weight of the sample. For extraction, the sample may be left for leaching in the extraction solvent for 1 to 72 hours, specifically 1 to 24 hours.
여과된 추출물을 진공 회전 농축기로 감압 농축하여 수득한 결과물일 수 있으나, 본 발명의 해조류 추출물을 유효성분으로 포함하는 화장료 조성물인 한, 이에 제한되지 않고, 추출액, 추출액의 희석액 또는 농축액, 추출액을 건조하여 얻어지는 건조물, 이의 조정제물 또는 정제물을 모두 포함한다.It may be a product obtained by concentrating the filtered extract under reduced pressure with a vacuum rotary evaporator, but is not limited thereto, as long as it is a cosmetic composition containing the seaweed extract of the present invention as an active ingredient, and the extract, dilution or concentrate of the extract, and drying the extract It includes all of the dried product obtained by doing, and its crude product or purified product.
본 발명의 피부 진정 및 안티폴루션용 화장료 조성물은 포름알데히드, 아세탈알데히드, 프로피온알데히드, 벤질알데히드, 알데히드류, 중금속, 미세먼지, 황사 및 이들의 혼합으로 이루어진 군으로부터 선택되는 환경 유해인자로 인해 증가된 세포 사멸을 저해하는 효능을 갖는 것이다.The cosmetic composition for skin soothing and anti-pollution of the present invention increases due to environmental harmful factors selected from the group consisting of formaldehyde, acetalaldehyde, propionaldehyde, benzylaldehyde, aldehydes, heavy metals, fine dust, yellow dust, and mixtures thereof. It has the effect of inhibiting cell death.
상기 환경 유해인자는 알데히드류일 수 있으며, 상기 알데히드류는 포름알데히드, 아세탈알데히드, 프로피온알데히드 벤질알데히드로 이루어진 군에서 선택되는 1종 이상일 수 있다. The environmental harmful factor may be aldehydes, and the aldehydes may be at least one selected from the group consisting of formaldehyde, acetalaldehyde, propionaldehyde and benzylaldehyde.
또한, 환경 유해인자는 미세먼지, 차량 배기가스, 황사, 벤조피렌 또는 중금속일 수 있고, 이들 환경 유해인자에 알데히드류가 포함 또는 혼합된 것일 수 다. 또한 상기 중금속은 비중이 4 이상인 금속류로서 수은(13.5), 카드뮴(8.7), 납(11.3), 구리(8.9) 등의 최대 23의 비중을 갖는 것일 수 있다. 상기 환경 유해인자는 알데히드가 포함된 것일 수 있다.In addition, the environmental harmful factors may be fine dust, vehicle exhaust gas, yellow dust, benzopyrene, or heavy metals, and aldehydes may be included or mixed with these environmental harmful factors. In addition, the heavy metal is a metal having a specific gravity of 4 or more, and may have a specific gravity of up to 23, such as mercury (13.5), cadmium (8.7), lead (11.3), and copper (8.9). The environmental harmful factor may include aldehyde.
상기 피부세포는 각질형성세포인 것을 특징으로 하는 것이다.The skin cells are characterized in that they are keratinocytes.
상기 각질형성세포 (Keratinocyte)는 표피의 90% 이상을 차지하는 주된 구성 세포로서, 기저층에서 유래된 각질형성세포는 혈액으로부터 영양소 및 산소를 제공받아 세포분열을 하며, 이는 유극층과 과립층을 거쳐 가장 바깥쪽인 각질층까지 이동하여 각 층마다 특성을 가진 구조로 분화한다. 이러한 과정은 약 14일 정도가 소요되며, 기저층에서 형성된 각질형성세포가 인체에서 완전히 탈락되는 각화 과정까지는 약 28일 정도가 소요된다. 각질형성세포는 주로 피부 장벽 기능을 하며, 이외에도 UV에 의한 면역학적 반응을 조절하는 사이토카인 분비와 염증성 인자를 유도하는 생리조절물질을 생성하고 분비하는 역할도 수행한다. 각질형성세포의 증식은 콜라겐 및 피브로넥틴과 같은 피부 구성 단백질의 합성을 촉진하여 피부 재생과 상처 치유 등의 항노화를 유도하고, 피부 주름 및 탄력 개선에 도움을 준다.The keratinocytes are the main constituent cells that occupy more than 90% of the epidermis, and the keratinocytes derived from the basal layer receive nutrients and oxygen from the blood and divide, which is the outermost layer through the spinous layer and the granular layer. It moves to the stratum corneum, which is the side, and differentiates into structures with characteristics for each layer. This process takes about 14 days, and it takes about 28 days for the keratinization process in which keratinocytes formed in the basal layer are completely eliminated from the human body. Keratinocytes mainly function as a skin barrier, and in addition, secrete cytokines that regulate immunological responses by UV and produce and secrete physiological regulators that induce inflammatory factors. The proliferation of keratinocytes promotes the synthesis of skin constituent proteins such as collagen and fibronectin, thereby inducing anti-aging such as skin regeneration and wound healing, and helping to improve skin wrinkles and elasticity.
상기 각질형성세포의 분화가 비정상적으로 일어나게 되면 피부 장벽 기능에 결함이 생기게 되고, 이는 피부 건조를 유발하여 아토피 등과 같은 만성 피부질환으로 이어질 수 있다. 또한, 피부가 자외선과 외부로부터 자극을 받게 되면 멜라닌형성세포가 멜라닌을 형성하며, 이러한 멜라닌은 각질형성세포로 전달되고, 멜라닌이 함유된 각질형성세포는 각질층으로 이동하여 최종적으로 각질층에서 탈락되는데, 각질형성세포의 각화 주기가 길어지게 되면 피부에 각질층이 쌓여 기미, 주근깨 등의 색소 침착이 생길 수 있다.If the differentiation of the keratinocytes occurs abnormally, a defect in the skin barrier function may occur, which may cause skin dryness and lead to chronic skin diseases such as atopy. In addition, when the skin is stimulated from ultraviolet rays and external sources, melanocytes form melanin, and these melanin are transferred to keratinocytes, and keratinocytes containing melanin move to the stratum corneum and are finally eliminated from the stratum corneum. When the keratinization cycle of keratinocytes is prolonged, the stratum corneum accumulates on the skin, resulting in pigmentation such as spots and freckles.
본 발명의 피부 진정 및 안티폴루션용 화장료 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어, 용액, 현탁액, 페이스트, 겔, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌증, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 및 스프레이 등으로 제형화될 수 있으나, 이에 한정되는 것은 아니다. 보다 상세하게는, 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이크림, 클렌징 크림, 클렌징 포옴, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형, 수중유(O/W)형 또는 유중수(W/O)형의 제형 또는 연고로 제조될 수 있다.The cosmetic composition for skin soothing and anti-pollution of the present invention can be prepared in any formulation commonly prepared in the art, for example, a solution, suspension, paste, gel, cream, lotion, powder, soap, interface It may be formulated as an active agent-containing cleanser, oil, powder foundation, emulsion foundation, wax foundation, and spray, but is not limited thereto. More specifically, softening lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder formulation, oil-in-water (O/W) type or water-in-oil (W/O) type formulation or ointment.
또한, 필요에 따라 기능적 물질, 예컨대 미백제, 보습제, 항염증제, 항박테리아제, 항진 균제, 비타민, 자외선 차단제, 항생제, 여드름 방지제, 향수, 염료가 포함될 수도 있으며, 이들은 화장품 분야에서 통상적으로 사용되는 양으로 본 발명에 따른 화장용 조성물에 포함될 수 있다.In addition, if necessary, functional substances such as whitening agents, moisturizing agents, anti-inflammatory agents, antibacterial agents, antifungal agents, vitamins, sunscreens, antibiotics, anti-acne agents, perfumes, and dyes may be included, which are in amounts commonly used in the cosmetic field. It may be included in the cosmetic composition according to the present invention.
본 발명의 다른 일 실시예에 따른 재생 크림은 상기 화장료 조성물을 포함하여 제조한 것이다.A regenerating cream according to another embodiment of the present invention is prepared by including the cosmetic composition.
본 발명의 다른 일 실시예에 따른 보습 크림은 상기 화장료 조성물을 포함하여 제조한 것이다.A moisturizing cream according to another embodiment of the present invention is prepared by including the cosmetic composition.
상기 피부학적으로 허용된 담체는 정제수, 오일, 왁스, 지방산, 지방산 알코올, 지방산 에스테르, 계면활 성제, 흡습제, 증점제, 항산화제, 점도 안정화제, 킬레이팅제, 완충제, 방부제, 저급 알코올 등이 포함될 수 있지만, 이에 한정되는 것은 아니며, 그 종류와 농도는 다양하고, 당업자가 본 발명의 범위 내에서 변경할 수 있는 부분을 포함한다. The dermatologically acceptable carrier may include purified water, oil, wax, fatty acid, fatty alcohol, fatty acid ester, surfactant, moisture absorbent, thickener, antioxidant, viscosity stabilizer, chelating agent, buffer, preservative, lower alcohol, and the like. However, it is not limited thereto, and the type and concentration are various, and include parts that can be changed by those skilled in the art within the scope of the present invention.
본 발명의 화장료 조성물로부터 제조되는 화장품은 일반적인 유화 제형 및 가용화 제형의 형태로 제조할 수 있다. 유화 제형의 화장품으로는 영양화장수, 크림, 에센스 등이 있으며, 가용화 제형의 화장품으로는 유연화장수가 있다.Cosmetics prepared from the cosmetic composition of the present invention can be prepared in the form of general emulsified formulations and solubilized formulations. Emulsified cosmetics include nutrition lotion, cream, essence, etc., and solubilized cosmetics include softening lotion.
상기 화장품은 본 발명의 추출물 이외에도 피부학적으로 허용된 매질 또는 기제를 함유함으로써 당업계에서 통상적으로 사용되는 국소 적용 또는 전신 적용할 수 있는 보조제 형태로 제조될 수 있다.The cosmetic may be prepared in the form of an adjuvant that can be applied topically or systemically, which is commonly used in the art, by containing a dermatologically acceptable medium or base in addition to the extract of the present invention.
적합한 화장품의 제형으로는 예를 들면, 용액, 겔, 고체 또는 반죽 무수 생성물, 수상에 유상을 분산시켜 얻은 에멀젼, 현탁액, 마이크로에멀젼, 마이크로캡슐, 미세과립구 또는 이온형(리포좀), 비이온형의 소낭 분산제의 형태, 크림, 스킨, 로션, 파우더, 연고, 스프레이 또는 콘실 스틱(conceal stick)의 형태로 제공될 수 있다. 또한, 포말(foam)의 형태 또는 압축된 추진제를 더 함유한 에어로졸 조성물의 형태로도 제조될 수 있다.Suitable cosmetic formulations include, for example, solutions, gels, solid or pasty anhydrous products, emulsions obtained by dispersing an oil phase in an aqueous phase, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes), non-ionic forms. It may be provided in the form of a follicular dispersion, cream, toner, lotion, powder, ointment, spray or conceal stick. In addition, it can be prepared in the form of a foam (foam) or the form of an aerosol composition further containing a compressed propellant.
본 발명의 화장료 조성물을 첨가할 수 있는 제품으로는, 예를 들어, 수렴화장수, 유연화장수, 영양화장수, 각종 크림, 에센스, 팩, 파운데이션 등과 같은 화장품류와 클렌징, 세안제, 비누, 트리트먼트 또는 미용액 등이 있다. 구체적인 제형으로서는 스킨로션, 스킨 소프너, 스킨토너, 아스트린젠트, 로션, 밀크로션, 모이스처 로션, 영양로션, 맛사지크림, 영양크림, 모이스처 크림, 핸드크림, 에센스, 영양에센스, 팩, 비누, 샴푸, 클렌징 폼, 클렌징로션, 클 렌징크림, 바디로션, 바디클렌저, 유액, 프레스파우더, 루스파우더 또는 아이섀도 등의 제형을 포함한다.Products to which the cosmetic composition of the present invention can be added include, for example, cosmetics such as astringent lotion, softening lotion, nutrient lotion, various creams, essences, packs, foundations, etc., and cleansing, face wash, soap, treatment or beauty essence etc. Specific formulations include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion, massage cream, nutrient cream, moisture cream, hand cream, essence, nutrient essence, pack, soap, shampoo, and cleansing foam. , cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder, or eye shadow.
본 발명의 며느리배꼽 추출물을 유효성분으로 포함하는 피부 진정 및 안티폴루션용 화장료 조성물에 의하면 며느리배꼽 추출물을 유효성분으로 포함하여 피부세포의 손상 개선 및 진정 효능이 우수하고, 미세먼지, 황사와 같은 환경 유해인자로부터 피부 건강을 유지할 수 있는 안티폴루션 화장료 조성물을 제공할 수 있다.According to the cosmetic composition for skin soothing and anti-pollution containing the daughter-in-law's navel extract as an active ingredient, the cosmetic composition for skin soothing and anti-pollution contains the daughter-in-law's navel extract as an active ingredient and has excellent skin cell damage improvement and soothing effects, It is possible to provide an anti-pollution cosmetic composition capable of maintaining skin health from environmental harmful factors.
도 1은 본 발명의 일 실시예에 따른 피부 진정 및 안티폴루션용 조성물의 세포 생존율에 대한 실험 결과이다.
도 2는 본 발명의 일 실시예에 따른 피부 진정 및 안티폴루션용 조성물의 세포 보호 효과를 나타낸 것이다.
도 3은 본 발명의 일 실시예에 따른 피부 진정 및 안티폴루션용 조성물의 안티폴루션 효능을 나타낸 것이다.Figure 1 is an experimental result for the cell viability of the skin soothing and anti-pollution composition according to an embodiment of the present invention.
Figure 2 shows the cell protection effect of the composition for skin soothing and anti-pollution according to an embodiment of the present invention.
Figure 3 shows the anti-pollution efficacy of the skin soothing and anti-pollution composition according to an embodiment of the present invention.
이하, 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 본 발명의 실시예에 대하여 상세히 설명한다. 그러나 본 발명은 여러 가지 상이한 형태로 구현될 수 있으며 여기에서 설명하는 실시예에 한정되지 않는다.Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be embodied in many different forms and is not limited to the embodiments described herein.
[제조예: 추출물의 제조][Preparation Example: Preparation of extract]
1. 며느리배꼽 추출물의 제조One. Preparation of daughter-in-law's belly button extract
며느리배꼽(Persicaria perfoliata)을 물로 씻은 후 실온에서 공기로 건조하였다. 건조된 며느리배꼽을 분쇄기를 사용하여 분쇄하고 분말을 얻었다. 상기 분말 100g을 에탄올 2L에 넣고, 25℃에서 24시간동안 100rpm에서 혼합하였다. 이후, 진공회전농축기(N-1000S)를 통해 용매를 제거하여, 며느리배꼽 추출물(PE) 제조하였다.After washing the daughter-in-law's navel (Persicaria perfoliata) with water, it was air-dried at room temperature. The dried navel of the daughter-in-law was pulverized using a grinder to obtain a powder. 100 g of the powder was put into 2 L of ethanol and mixed at 100 rpm for 24 hours at 25°C. Thereafter, the solvent was removed through a vacuum rotary concentrator (N-1000S) to prepare daughter-in-law's belly button extract (PE).
2. 기타 해조류 추출물의 제조2. Preparation of other seaweed extracts
분홍애기풀을 세척하고 건조한 뒤 이를 분쇄하였다. 상기 분쇄물을 에탄올에 혼합하고 이를 2시간 동안 98 내지 100℃를 유지하고, 이를 냉각시킨 뒤 와트만 여과지로 여과하여 그 여액을 수득하여 분홍애기풀 추출물(BE)로 제조하였다. After washing and drying the pink Arabidopsis, it was pulverized. The pulverized product was mixed with ethanol, maintained at 98 to 100° C. for 2 hours, cooled, and then filtered with Whatman filter paper to obtain the filtrate, which was prepared as a pink calendula extract (BE).
상기 분홍애기풀 추출물(BE)과 동일한 방법으로 물잔디 추출물(GE) 및 덜스 추출물(DE), 꼬시래기 추출물(VE), 털큰앵초 추출물(FE) 및 파드득나물 추출물(CE)을 제조하였다.A water grass extract (GE), a dulse extract (DE), a seaweed extract (VE), a hairy primrose extract (FE), and a paddock extract (CE) were prepared in the same manner as the pink Arabidopsis extract (BE).
3. 복합 추출물의 제조3. Preparation of complex extracts
상기 제조된 추출물을 하기 표 1과 같은 함량 범위로 혼합하여 복합 추출물을 제조하였다.A composite extract was prepared by mixing the prepared extracts in the content ranges shown in Table 1 below.
(단위: 중량부)(unit: parts by weight)
[실험예 1: 세포 독성 분석][Experimental Example 1: Cytotoxicity analysis]
상기 제조예에서 제조된 며느리배꼽 추출물(PE), 물잔디 추출물(GE), 덜스 추출물(DE), 꼬시래기 추출물(VE), 털큰앵초 추출물(FE) 및 파드득나물 추출물(CE)의 안전성 평가를 위해 MTT 분석을 통해 인간 상피세포의 추출물에 따른 세포 생존율을 확인하였다. To evaluate the safety of daughter-in-law's navel extract (PE), water grass extract (GE), dulse extract (DE), seaweed extract (VE), hairy primrose extract (FE) and paddock extract (CE) prepared in the above Preparation Example Cell viability was confirmed according to the extract of human epithelial cells through MTT analysis.
구체적으로, 피부 각질형성세포주인 HaCaT 세포를 12-웰 플레이트에 1×104cells/well의 농도로 접종하여 24시간 배양한 후, PBS로 세척하였다. 그리고 각 추출물의 농도를 20 ㎍/㎖로, 희석한 70% 에탄올과 각 웰이 첨가한 후 (음성 대조군은 비처리군), 24시간 및 48시간 배양하였다.Specifically, HaCaT cells, a skin keratinocyte line, were inoculated into a 12-well plate at a concentration of 1×10 4 cells/well, cultured for 24 hours, and then washed with PBS. Then, each well was added with diluted 70% ethanol at a concentration of 20 μg/ml of each extract (negative control group was untreated), followed by incubation for 24 hours and 48 hours.
24시간 및 48시간 배양 후 0.5% MTT 용액을 각 웰에 40㎕씩 첨가하여, 5% CO2, 37℃ 배양기에서 1시간 동안 배양하였다. 배양액을 제거한 다음 DMSO를 150㎕씩을 넣고 10분간 흔들어 준 다음, ELISA plate reader를 이용하여 595 nm에서 흡광도를 측정하였다.After culturing for 24 hours and 48 hours, 40 μl of 0.5% MTT solution was added to each well, and cultured for 1 hour in a 5% CO 2 , 37° C. incubator. After removing the culture medium, 150 μl of DMSO was added and shaken for 10 minutes, and then the absorbance was measured at 595 nm using an ELISA plate reader.
그 결과, 도 1에서 확인할 수 있는 바와 같이, 음성 대조군과 며느리배꼽 추출물(PE), 물잔디 추출물(GE), 덜스 추출물(DE), 꼬시래기 추출물(VE), 털큰앵초 추출물(FE) 및 파드득나물 추출물(CE) 처리군 모두에서 세포 증식에 별다른 영향을 미치지 않은 것으로 나타났다. As a result, as can be seen in Figure 1, the negative control and mother-of-pearl extract (PE), water grass extract (GE), dulse extract (DE), string extract (VE), hairy primrose extract (FE) and padduck sprouts It was found that there was no significant effect on cell proliferation in all of the extract (CE) treatment groups.
[실험예 2: 과산화수소에 대한 세포 보호 활성 평가][Experimental Example 2: Evaluation of cytoprotective activity against hydrogen peroxide]
세포배양cell culture
본 실험에 사용한 인간 피부각질세포(HaCaT human keratinocyte cell line) 세포주는 아메리칸 타입 컬쳐 컬렉션 (American Type Culture Collection, ATCC)에서 구입하였으며, 인간 피부각질세포 (HaCaT)를 10% 소태아 혈청 (가열하여 불활성화시킴), 스트렙토마이신(100 μg/mL) 및 페니실린 (100 unit/mL)이 함유된 로스웰 파크 메모리얼인스티튜트(Roswell Park Memorial Institute, RPMI) 1640 배지를 사용하여, 이산화탄소 배양기에서 5% CO2 및 37℃를 유지하며 배양하였다.The HaCaT human keratinocyte cell line cell line used in this experiment was purchased from the American Type Culture Collection (ATCC). activation), using Roswell Park Memorial Institute (RPMI) 1640 medium containing streptomycin (100 μg/mL) and penicillin (100 unit/mL) at 5% CO2 and 37° C. in a carbon dioxide incubator. maintained and cultured.
과산화수소에 대한 저항활성 평가Evaluation of resistance activity to hydrogen peroxide
며느리배꼽 추출물(PE)이 과산화수소 처리된 인간 각질 세포주에 미치는 영향을 알아보기 위해 60 μg/ml 농도로 맞춰서 실험을 진행하였다. In order to investigate the effect of daughter-in-law's belly button extract (PE) on the hydrogen peroxide-treated human keratin cell line, an experiment was conducted at a concentration of 60 μg/ml.
먼저 며느리배꼽 추출물(PE)이 과산화수소를 30분동안 처리하여 산화 스트레스가 유도된 HaCaT 세포에 미치는 영향을 알아보기 위해, 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) 분석을 수행하였다. 세포에 MTT 0.5 mg/ml를 처리한 뒤 37℃에서 3시간 동안 배양하였다. 배양이 끝난 뒤, 배지를 제거하고 포르마잔(formazan) 침전물을 디메틸설폭사이드에 용해시켰다. 포르마잔 생성물의 흡광도를 Cytation-3 마이크로플레이트 리더(microplate reader)를 사용하여 540 nm 파장에서 측정하였다. 무처리된 세포를 정상군, 과산화수소 0.5 mM을 처리한 세포를 대조군 1, 과산화수소 0.5 mM을 처리한 뒤 항산화제인 N-아세틸-L-시스테인 (N-acetyl-L-cysteine, NAC) 10mM을 처리한 세포를 대조군 2, 과산화수소 0.5 mM을 처리한 뒤 며느리배꼽 추출물(PE)를 처리한 세포를 실험군으로 정하였다.First, to investigate the effect of daughter-in-law's belly button extract (PE) on HaCaT cells induced by oxidative stress by treating hydrogen peroxide for 30 minutes, 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide ( MTT) assay was performed. The cells were treated with 0.5 mg/ml of MTT and incubated at 37°C for 3 hours. After the incubation, the medium was removed and the formazan precipitate was dissolved in dimethyl sulfoxide. The absorbance of the formazan product was measured at a wavelength of 540 nm using a Cytation-3 microplate reader. Untreated cells were treated with normal group, cells treated with 0.5 mM hydrogen peroxide as control group 1, treated with 0.5 mM hydrogen peroxide, and then treated with 10 mM N-acetyl-L-cysteine (NAC), an antioxidant. Cells treated with control 2, 0.5 mM hydrogen peroxide, and then treated with daughter-in-law's belly extract (PE) were selected as the experimental group.
그 결과, 도 2에서 확인할 수 있는 바와 같이, 며느리배꼽 추출물(PE)이 과산화수소 처리하여 산화 스트레스를 유도한 HaCaT 세포의 생존율에 미치는 효과는 과산화수소를 처리한 대조군 1에서 생존력이 감소한 반면, 며느리배꼽 추출물(PE)을 처리한 실험군은 NAC를 처리한 대조군 2와 마찬가지로 생존율을 증가시키는 것을 확인하였다.As a result, as can be seen in FIG. 2, the effect of the daughter-in-law extract (PE) on the survival rate of HaCaT cells treated with hydrogen peroxide to induce oxidative stress was reduced in the control group 1 treated with hydrogen peroxide, whereas the mother-in-law extract It was confirmed that the survival rate of the experimental group treated with (PE) increased as in the control group 2 treated with NAC.
위와 동일한 방법으로 며느리배꼽 추출물(PE, MX1)과 동일한 농도로 설정된 복합 추출물 MX2 내지 MX11에 대한 저항활성을 평가하였으며, 객관적인 비교를 위하여 며느리배꼽 추출물(PE, MX1)의 지수를 5로 두고, 복합 추출물 MX2 내지 MX11의 결과를 1 내지 10의 지수로 평가하여 하기 표 2에 나타내었다.In the same way as above, the resistance activity to the complex extracts MX2 to MX11 set at the same concentration as the daughter-in-law's belly extract (PE, MX1) was evaluated. The results of extracts MX2 to MX11 were evaluated on a scale of 1 to 10 and are shown in Table 2 below.
하기 지수는 그 숫자가 높을수록 과산화수소에 대한 세포 보호 활성이 우수한 것이다.In the index below, the higher the number, the better the cytoprotective activity against hydrogen peroxide.
(단위: 지수)(Unit: index)
상기 표 2를 살펴본 결과, 며느리배꼽 추출물(PE)만을 포함하는 경우(MX1)에 비해 복합 추출물을 구성하는 MX2 내지 MX11에서 과산화수소에 대한 우수한 세포 보호 활성을 나타내었다.As a result of examining Table 2, MX2 to MX11 constituting the composite extract exhibited excellent cytoprotective activity against hydrogen peroxide compared to the case containing only the daughter-in-law's belly extract (PE) (MX1).
특히, MX8 내지 MX10에 의하는 경우 상호작용에 의한 상승효과가 나타나는 점을 확인하였다.In particular, in the case of MX8 to MX10, it was confirmed that a synergistic effect due to the interaction appeared.
[실험예 3: 며느리배꼽 추출물의 안티폴루션 효능][Experimental Example 3: Anti-pollution efficacy of daughter-in-law's navel extract]
알데히드 복합물의 세포독성 확인Confirmation of cytotoxicity of aldehyde complexes
각질형성세포를 96-웰 플레이트에서 10%(v/v) fetal bovine serum(FBS)를 함유하는 DMEM(Dulbeco's Modified Eagle's Media)을 사용하여 18시간 동안 배양한 후, FBS가 없는 각질형성세포 배양용 멸균 액체 배지 154CF로 교체하였다. After culturing keratinocytes in a 96-well plate using DMEM (Dulbeco's Modified Eagle's Media) containing 10% (v/v) fetal bovine serum (FBS) for 18 hours, FBS-free keratinocyte culture Replaced with sterile liquid medium 154CF.
다음으로는 포름알데히드, 아세탈알데히드, 프로피온알데히드 및 벤질알데히드가 동일 몰비로 포함된 알데히드 복합물을 농도 2 mM로 처리한 군과 상기 알데히드 복합물을 처리 후 본 발명의 복합 추출물 MX1(PE) 및 MX2 내지 MX11 60 μg/ml를 처리한 군으로 나누어, 24시간 동안 배양하였다.Next, a group treated with an aldehyde complex containing formaldehyde, acetalaldehyde, propionaldehyde and benzylaldehyde in the same molar ratio at a concentration of 2 mM, and the complex extracts MX1 (PE) and MX2 to MX11 of the present invention after treatment with the aldehyde complex Divided into groups treated with 60 μg/ml, and cultured for 24 hours.
그 결과, 도 3에서 확인할 수 있는 바와 같이 며느리배꼽 추출물(MX1, PE)이 처리된 군에서 각질형성세포의 생존율이 70% 이상 회복되는 것을 확인하였으며, 복합 추출물을 구성하는 MX2 내지 MX11에서 더욱 우수한 효과를 나타내는 것을 확인하였다. As a result, as can be seen in FIG. 3, it was confirmed that the survival rate of keratinocytes was recovered by more than 70% in the group treated with daughter-in-law's belly button extract (MX1, PE), and more excellent in MX2 to MX11 constituting the complex extract. It was confirmed that the effect was shown.
중금속 흡착성 특성Heavy metal adsorption properties
본 발명의 복합 추출물 MX1(PE) 및 MX2 내지 MX11의 중금속 흡착성을 다음과 같이 측정하였다.The heavy metal adsorbability of the composite extracts MX1 (PE) and MX2 to MX11 of the present invention was measured as follows.
20ppm의 납과 카드뮴 이온 용액을 각각 100㎖씩 삼각 플라스크에 취하고, 여기에 며느리배꼽 추출물(PE)의 분말을 1g 주입한 다음 진탕기에서 약 200rpm의 속도로 진탕 흡착시켰다. 흡착 후 일정 시간 후 진탕을 중지하고, 0.45㎛ 막여과지를 사용하여 진공 흡인 여과하였으며, 이때 삼각플라스크의 내벽과 흡착제의 표면에 부착되어 있는 중금속 이온을 증류수로 수 회 세척하며 여과하였다.100 ml each of 20 ppm lead and cadmium ion solutions was taken into an Erlenmeyer flask, 1 g of powder of daughter-in-law's belly extract (PE) was injected thereinto, and shaken and adsorbed in a shaker at a speed of about 200 rpm. After a certain period of time after adsorption, shaking was stopped, and vacuum suction filtration was performed using a 0.45 μm membrane filter paper. At this time, heavy metal ions attached to the inner wall of the Erlenmeyer flask and the surface of the adsorbent were washed several times with distilled water and filtered.
각각의 이온이 들어있는 여액을 200㎖로 정용한 다음 여액 중에 포함된 중금속의 양을 ICP-OES(Inductively coupled plasma-OES, TJA polyscan 61E)로 정량하였으며, 중금속의 흡착량은 시료 1g당 흡착량으로 환산하였다. 또한 흡착 후 여과지에 흡착된 중금속을 여과지 채로 0.5N 질산 용액 50㎖와 함께 250㎖ 삼각 플라스크에 넣고, 200rpm의 속도로 30분간 진탕하여 흡착된 중금속을 회수하였다. 진탕된 용액을 여과지로 여과하고, 여액 중에 포함된 중금속의 양을 AA(Atomic Absorption Spectrophotometer, contrAA-300, analytik- jena, Germany)로 측정하였다. 이 때 Pb(II)와 Cd(II) 이온의 농도는 각각 228.8nm과 324.0 nm의 파장에서 각각 측정하였고, 이 결과로 얻은 며느리배꼽 추출물(PE)에 흡착된 Pb(II)와 Cd(II) 이온의 회수율을 하기 표 3에 나타내었다.After 200 ml of the filtrate containing each ion was fixed, the amount of heavy metal contained in the filtrate was quantified by ICP-OES (Inductively coupled plasma-OES, TJA polyscan 61E). converted. In addition, after the adsorption, the heavy metal adsorbed on the filter paper was put into a 250 ml Erlenmeyer flask along with 50 ml of 0.5N nitric acid solution with the filter paper, and the adsorbed heavy metal was recovered by shaking at a speed of 200 rpm for 30 minutes. The shaken solution was filtered with filter paper, and the amount of heavy metals contained in the filtrate was measured by AA (Atomic Absorption Spectrophotometer, contrAA-300, analytik-jena, Germany). At this time, the concentrations of Pb(II) and Cd(II) ions were measured at wavelengths of 228.8 nm and 324.0 nm, respectively. The recovery rate of ions is shown in Table 3 below.
(단위: %)(unit: %)
상기 표 3을 살펴본 결과, 며느리배꼽 추출물(PE)의 흡착 반응 시간이 증가할수록 납과 카드뮴 이온의 회수율이 현저하게 증가함을 확인하였다.As a result of examining Table 3, it was confirmed that the recovery rate of lead and cadmium ions significantly increased as the adsorption reaction time of the daughter-in-law's belly extract (PE) increased.
이 결과를 통해, 며느리배꼽 추출물(PE)이 화장료 조성물로서 피부에 공급될 경우, 대기 중의 중금속을 흡착함으로써 피부세포를 보호하는 기능이 있음을 확인하였다.Through this result, it was confirmed that when the daughter-in-law's navel extract (PE) is supplied to the skin as a cosmetic composition, it has a function of protecting skin cells by adsorbing heavy metals in the air.
위와 동일한 방법으로 며느리배꼽 추출물(PE, MX1)과 동일한 농도로 설정된 복합 추출물 MX2 내지 MX11에 대한 안티폴루션 효능을 평가하였으며, 객관적인 비교를 위하여 며느리배꼽 추출물(PE, MX1)의 지수를 5로 두고, 복합 추출물 MX2 내지 MX11의 결과를 1 내지 10의 지수로 평가하여 하기 표 4에 나타내었다.In the same way as above, the anti-pollution efficacy of the complex extracts MX2 to MX11 set at the same concentration as the daughter-in-law's belly extract (PE, MX1) was evaluated. , The results of the composite extracts MX2 to MX11 were evaluated on an index of 1 to 10 and are shown in Table 4 below.
하기 지수는 그 숫자가 높을수록 안티폴루션 효능이 우수한 것이다.In the index below, the higher the number, the better the anti-pollution efficacy.
(단위: 지수)(Unit: index)
상기 표 4를 살펴본 결과, 며느리배꼽 추출물(PE)만을 포함하는 경우(MX1)에 비해 복합 추출물을 구성하는 MX2 내지 MX11에서 우수한 안티폴루션 효능을 나타내었다.As a result of examining Table 4, MX2 to MX11 constituting the composite extract showed excellent anti-pollution efficacy compared to the case of containing only the daughter-in-law's belly extract (PE) (MX1).
특히, MX8 내지 MX10에 의하는 경우 상호작용에 의한 상승효과가 나타나는 점을 확인하였다.In particular, in the case of MX8 to MX10, it was confirmed that a synergistic effect due to the interaction appeared.
[실험예 4: 관능성 평가][Experimental Example 4: Sensory evaluation]
피부 진정 효과skin soothing effect
본 발명에 따른 며느리배꼽 추출물(MX1, PE) 및 MX2 내지 MX11의 피부 진정 효과를 확인하기 위하여 건강한 20대 내지 30대 성인 남자 10명 및 여자 10명으로 구성된 20명을 대상으로 실험을 진행하였다. In order to confirm the skin soothing effect of daughter-in-law's belly button extracts (MX1, PE) and MX2 to MX11 according to the present invention, an experiment was conducted on 20 healthy adult men and 10 women in their 20s and 30s.
실험자들의 전박부에 본 발명에 따른 며느리배꼽 추출물(MX1, PE) 및 MX2 내지 MX11이 함유된 크림을 10mg/5cm2씩 도포하고 그 외의 부위는 알루미늄 호일로 차폐하였다. 30분 경과 후 자외선 조사기를 이용하여 장파장 자외선을 10.2J/cm2의 용량으로 조사하고 다시 24시간 후에 홍반, 부종, 구진 등의 피부 상태를 관찰하였다. 관찰 결과 피부에 홍반 등의 부작용이 발생되지 않았으며 상기 느리배꼽 추출물(MX1, PE) 및 MX2 내지 MX11을 함유하는 크림은 광독성이 없으며 피부 진정 효과가 있음을 확인하였다.10mg/5cm 2 of cream containing daughter-in-law's belly button extracts (MX1, PE) and MX2 to MX11 according to the present invention were applied to the forearms of the experimenters, and the other parts were covered with aluminum foil. After 30 minutes, long-wavelength ultraviolet rays were irradiated at a dose of 10.2 J/cm 2 using an ultraviolet irradiator, and skin conditions such as erythema, edema, and papules were observed after another 24 hours. As a result of the observation, side effects such as erythema did not occur, and it was confirmed that the cream containing the navel extract (MX1, PE) and MX2 to MX11 was not phototoxic and had a skin soothing effect.
관능 평가sensory evaluation
상기 피부 진정 효과 실험과 더불어, 눈가 부분에 보습 크림을 바르고, 발림성 및 흡수성에 대한 관능 시험을 진행하였다. In addition to the skin soothing effect test, a moisturizing cream was applied to the eye area, and a sensory test for application and absorption was conducted.
평가 점수는 1 내지 10점으로 평가를 요청하였으며, 점수가 높을수록 우수한 평가를 의미한다고 할 것이다.The evaluation score was requested for evaluation on a scale of 1 to 10, and the higher the score, the better the evaluation.
(단위: 지수)(Unit: Index)
상기 관능 평가에 따르면, 복합 추출물 MX2 내지 MX11는 며느리배꼽 추출물(PE)만을 포함한 MX1 보다 발림성 및 흡수성이 우수한 평가를 나타냄을 확인하였다.According to the above sensory evaluation, it was confirmed that the complex extracts MX2 to MX11 exhibited better applicability and absorbability than MX1 containing only the daughter-in-law's belly extract (PE).
또한, 복합 추출물 MX8 내지 MX10에 의하는 경우, 해조류의 특유의 이취가 중화되면서 기호도를 상승시킬 수 있다.In addition, in the case of using the complex extracts MX8 to MX10, the degree of acceptability can be increased while neutralizing the peculiar odor of seaweed.
따라서, 복합 추출물 MX8 내지 MX10을 함유하는 보습 크림의 경우, 기호도가 높은 기능성 보습 크림으로의 제공이 가능함을 확인할 수 있다고 할 것이다.Therefore, in the case of a moisturizing cream containing the complex extracts MX8 to MX10, it can be confirmed that it is possible to provide a functional moisturizing cream with high preference.
제형예 1. 보습크림Formulation Example 1. Moisturizing Cream
상기 MX1 내지 MX11를 함유하는 보습 크림을 하기 조성 성분 및 조성비에 따라 통상적인 방법으로 제조하였다. Moisturizing creams containing the MX1 to MX11 were prepared in a conventional manner according to the following compositional ingredients and composition ratios.
MX1 3.0 중량%MX1 3.0% by weight
글리세린 8.0 중량%Glycerin 8.0% by weight
부틸렌글라이콜 5.0 중량%Butylene glycol 5.0% by weight
글리세릴스테아레이트/피이지-100스테아레이트 1.0 중량%Glyceryl Stearate/PEG-100 Stearate 1.0% by weight
폴리솔베이트60 0.5 중량%
소르비탄 스테아레이트 0.5 중량%0.5% by weight of sorbitan stearate
피토스쿠알란 5.0 중량%Phytosqualane 5.0% by weight
호호바 오일 3.0 중량%Jojoba oil 3.0% by weight
카프릴/카프릭 트리글리세라이드 15.0 중량%15.0% by weight of caprylic/capric triglyceride
알로에 버터 2.0 중량%Aloe butter 2.0% by weight
밀납 1.0 중량%1.0% by weight of beeswax
스테아릴 알코올 0.5 중량%Stearyl alcohol 0.5% by weight
베헤릴 알코올 0.5 중량%Beheryl alcohol 0.5% by weight
스테아린산 0.5 중량%Stearic acid 0.5% by weight
카르복실비닐폴리머 0.2 중량%Carboxylvinyl polymer 0.2% by weight
잔탄검 0.1 중량%Xanthan Gum 0.1% by weight
아르기닌 0.5 중량%Arginine 0.5% by weight
디메치콘 0.5 중량%Dimethicone 0.5% by weight
베타글루칸 0.2 중량%Beta glucan 0.2% by weight
방부제 0.5 중량%Preservative 0.5% by weight
정제수 잔량Remaining amount of purified water
이상에서 본 발명의 바람직한 실시예에 대하여 상세하게 설명하였지만 본 발명의 권리범위는 이에 한정되는 것은 아니고 다음의 청구범위에서 정의하고 있는 본 발명의 기본 개념을 이용한 당업자의 여러 변형 및 개량 형태 또한 본 발명의 권리범위에 속하는 것이다.Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements of those skilled in the art using the basic concept of the present invention defined in the following claims are also made according to the present invention. falls within the scope of the rights of
Claims (7)
피부 진정 및 안티폴루션용 화장료 조성물.Contains daughter-in-law's navel extract (Persicaria perfoliata) as an active ingredient
A cosmetic composition for skin soothing and anti-pollution.
상기 조성물은 분홍애기풀 추출물, 물잔디 추출물, 덜스 추출물, 꼬시래기 추출물 및 이들의 혼합으로 이루어진 군으로부터 선택되는 해조류 추출물을 더 포함하는
피부 진정 및 안티폴루션용 화장료 조성물.According to claim 1,
The composition further comprises a seaweed extract selected from the group consisting of pink celandine extract, water grass extract, dulse extract, seaweed extract, and mixtures thereof
A cosmetic composition for skin soothing and anti-pollution.
상기 추출물은 물, 탄소수 1 내지 6의 알코올 및 이들의 혼합물로 이루어진 군으로부터 선택된 추출 용매를 이용하여 추출된
피부 진정 및 안티폴루션용 화장료 조성물.According to claim 1,
The extract is extracted using an extraction solvent selected from the group consisting of water, alcohol having 1 to 6 carbon atoms, and mixtures thereof.
A cosmetic composition for skin soothing and anti-pollution.
상기 조성물은 포름알데히드, 아세탈알데히드, 프로피온알데히드, 벤질알데히드, 알데히드류, 중금속, 미세먼지, 황사 및 이들의 혼합으로 이루어진 군으로부터 선택되는 환경 유해인자로 인한 피부세포의 사멸 억제 효능을 나타내는
피부 진정 및 안티폴루션용 화장료 조성물.According to claim 1,
The composition exhibits an effect of inhibiting the death of skin cells due to environmental harmful factors selected from the group consisting of formaldehyde, acetalaldehyde, propionaldehyde, benzylaldehyde, aldehydes, heavy metals, fine dust, yellow dust, and mixtures thereof.
A cosmetic composition for skin soothing and anti-pollution.
상기 피부세포는 각질형성세포인 것을 특징으로 하는
피부 진정 및 안티폴루션용 화장료 조성물.According to claim 4,
Characterized in that the skin cells are keratinocytes
A cosmetic composition for skin soothing and anti-pollution.
재생 크림.Comprising the cosmetic composition according to any one of claims 1 to 5
regenerating cream.
보습 크림.
Comprising the cosmetic composition according to any one of claims 1 to 5
moisturizing cream.
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| KR20120098311A (en) * | 2011-02-28 | 2012-09-05 | 대전대학교 산학협력단 | Pharmaceutical composition contaning extract of persicaria perfoliata for preventing and treating inflammatory disease |
| KR20200038435A (en) | 2020-03-27 | 2020-04-13 | 주식회사 한동 | Antibiotics composition for animals |
| KR20210005933A (en) * | 2018-04-30 | 2021-01-15 | 몬테로에더, 에스.엘. | Compositions comprising vegetable extracts with flavonoids for alleviating the effects of multiple air pollution on the skin |
| KR20210053705A (en) * | 2019-11-04 | 2021-05-12 | 김성윤 | Composition for improved atopy skin and skin moisturizing comprising asiatic tearthumb |
| KR20210070133A (en) * | 2019-12-04 | 2021-06-14 | 주식회사 아데나 | Personal Cleansing composition for skin moisturizing or skin soothing comprising seaweed-derived polysaccharide as an active ingredient |
| KR20220070122A (en) * | 2020-11-20 | 2022-05-30 | 동의대학교 산학협력단 | A composition for skin anti-pollution containing a daughter-in-law navel extract |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120098311A (en) * | 2011-02-28 | 2012-09-05 | 대전대학교 산학협력단 | Pharmaceutical composition contaning extract of persicaria perfoliata for preventing and treating inflammatory disease |
| KR20210005933A (en) * | 2018-04-30 | 2021-01-15 | 몬테로에더, 에스.엘. | Compositions comprising vegetable extracts with flavonoids for alleviating the effects of multiple air pollution on the skin |
| KR20210053705A (en) * | 2019-11-04 | 2021-05-12 | 김성윤 | Composition for improved atopy skin and skin moisturizing comprising asiatic tearthumb |
| KR20210070133A (en) * | 2019-12-04 | 2021-06-14 | 주식회사 아데나 | Personal Cleansing composition for skin moisturizing or skin soothing comprising seaweed-derived polysaccharide as an active ingredient |
| KR20200038435A (en) | 2020-03-27 | 2020-04-13 | 주식회사 한동 | Antibiotics composition for animals |
| KR20220070122A (en) * | 2020-11-20 | 2022-05-30 | 동의대학교 산학협력단 | A composition for skin anti-pollution containing a daughter-in-law navel extract |
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