KR20230062873A - 염기 편집 효소 - Google Patents

염기 편집 효소 Download PDF

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Publication number
KR20230062873A
KR20230062873A KR1020237012244A KR20237012244A KR20230062873A KR 20230062873 A KR20230062873 A KR 20230062873A KR 1020237012244 A KR1020237012244 A KR 1020237012244A KR 20237012244 A KR20237012244 A KR 20237012244A KR 20230062873 A KR20230062873 A KR 20230062873A
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South Korea
Prior art keywords
endonuclease
nucleic acid
seq
glu
ala
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Pending
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KR1020237012244A
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English (en)
Korean (ko)
Inventor
쥰 리앙 린
앨런 브룩스
크리스티나 버터필드
크리스토퍼 브라운
신디 캐스텔
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메타지노미, 인크.
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Publication of KR20230062873A publication Critical patent/KR20230062873A/ko
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2497—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing N- glycosyl compounds (3.2.2)
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    • C12Y302/02—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2)
    • C12Y302/02027—Uracil-DNA glycosylase (3.2.2.27)
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    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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KR1020237012244A 2020-09-11 2021-09-10 염기 편집 효소 Pending KR20230062873A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063077057P 2020-09-11 2020-09-11
US63/077,057 2020-09-11
US202163222351P 2021-07-15 2021-07-15
US63/222,351 2021-07-15
PCT/US2021/049962 WO2022056324A1 (en) 2020-09-11 2021-09-10 Base editing enzymes

Publications (1)

Publication Number Publication Date
KR20230062873A true KR20230062873A (ko) 2023-05-09

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KR1020237012244A Pending KR20230062873A (ko) 2020-09-11 2021-09-10 염기 편집 효소

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US (3) US12286654B2 (https=)
EP (1) EP4211234A4 (https=)
JP (1) JP2023540797A (https=)
KR (1) KR20230062873A (https=)
AU (1) AU2021339819A1 (https=)
CA (1) CA3192224A1 (https=)
GB (1) GB2605340B (https=)
MX (1) MX2023002913A (https=)
WO (1) WO2022056324A1 (https=)

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AU2020215730A1 (en) 2019-01-31 2021-07-29 Beam Therapeutics Inc. Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors
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JP2023540797A (ja) 2020-09-11 2023-09-26 メタゲノミ，インコーポレイテッド 塩基編集酵素
CA3196831A1 (en) 2020-09-25 2022-03-31 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
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WO2023081855A1 (en) * 2021-11-05 2023-05-11 Metagenomi, Inc. Base editing enzymes
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CN121241133A (zh) * 2023-03-31 2025-12-30 阿伯生物技术公司 Crispr核酸酶多肽和包含此类crispr核酸酶多肽的基因编辑系统
WO2025003344A1 (en) * 2023-06-28 2025-01-02 Alia Therapeutics Srl Type ii cas proteins and applications thereof
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WO2025240372A1 (en) * 2024-05-13 2025-11-20 Metagenomi, Inc. Compositions and methods for editing t cells

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US20230348876A1 (en) 2023-11-02
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AU2021339819A1 (en) 2023-05-25
CA3192224A1 (en) 2022-03-17
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