KR20230051238A - 오토파지 활성화제 - Google Patents

오토파지 활성화제 Download PDF

Info

Publication number
KR20230051238A
KR20230051238A KR1020237008543A KR20237008543A KR20230051238A KR 20230051238 A KR20230051238 A KR 20230051238A KR 1020237008543 A KR1020237008543 A KR 1020237008543A KR 20237008543 A KR20237008543 A KR 20237008543A KR 20230051238 A KR20230051238 A KR 20230051238A
Authority
KR
South Korea
Prior art keywords
salt
ascorbic acid
gene
autophagy
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020237008543A
Other languages
English (en)
Korean (ko)
Inventor
유코 나카가미
Original Assignee
가부시끼가이샤 레조낙
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가부시끼가이샤 레조낙 filed Critical 가부시끼가이샤 레조낙
Publication of KR20230051238A publication Critical patent/KR20230051238A/ko
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020237008543A 2020-09-17 2021-09-17 오토파지 활성화제 Ceased KR20230051238A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2020-156457 2020-09-17
JP2020156457 2020-09-17
PCT/JP2021/034211 WO2022059763A1 (ja) 2020-09-17 2021-09-17 オートファジー活性化剤

Publications (1)

Publication Number Publication Date
KR20230051238A true KR20230051238A (ko) 2023-04-17

Family

ID=80776039

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237008543A Ceased KR20230051238A (ko) 2020-09-17 2021-09-17 오토파지 활성화제

Country Status (5)

Country Link
JP (1) JPWO2022059763A1 (https=)
KR (1) KR20230051238A (https=)
CN (1) CN116437912A (https=)
TW (1) TW202228676A (https=)
WO (1) WO2022059763A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018510902A (ja) 2015-04-08 2018-04-19 バイオメンディクス エルエルシー 創傷治癒調節のための製剤および方法
JP2018080204A (ja) 2011-08-01 2018-05-24 株式会社林原 α−グルコシルヘスペリジンの結晶とその用途
WO2018173653A1 (ja) 2017-03-24 2018-09-27 株式会社林原 オートファジー誘導剤とその用途
JP2019529514A (ja) 2015-10-05 2019-10-17 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク オートファジーフラックス及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06271466A (ja) * 1993-03-23 1994-09-27 Asahi Chem Ind Co Ltd 神経成長因子活性増強剤
JP4111856B2 (ja) * 2002-04-12 2008-07-02 昭和電工株式会社 安定化されたアスコルビン酸誘導体
JP6018800B2 (ja) * 2012-05-25 2016-11-02 ライオン株式会社 経口投与組成物
KR20170025604A (ko) * 2015-08-31 2017-03-08 연세대학교 원주산학협력단 아스코르브산 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 퇴행성 신경질환 치료용 약학적 조성물
JP2019011254A (ja) * 2017-06-29 2019-01-24 ちふれホールディングス株式会社 表皮肥厚抑制剤
JP2019081718A (ja) * 2017-10-30 2019-05-30 日光ケミカルズ株式会社 ヒアルロン酸合成酵素発現促進剤
JP7497850B2 (ja) * 2019-12-23 2024-06-11 株式会社アイ・ティー・オー 細胞送達用キャリア

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018080204A (ja) 2011-08-01 2018-05-24 株式会社林原 α−グルコシルヘスペリジンの結晶とその用途
JP2018510902A (ja) 2015-04-08 2018-04-19 バイオメンディクス エルエルシー 創傷治癒調節のための製剤および方法
JP2019529514A (ja) 2015-10-05 2019-10-17 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク オートファジーフラックス及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法
WO2018173653A1 (ja) 2017-03-24 2018-09-27 株式会社林原 オートファジー誘導剤とその用途

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Aaron Barnett et al., Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?. J Alzheimers Dis. 2011; 25(3): 385-394.
Marta M. Lipinski et al., Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci USA. 2010, 107, 14164-14169.
Xiangqing Li et al., Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer's disease. Cytotechnology (2019) 71: 679-686.
Yogendra S. Rajawat et al., Aging: Central role for autophagy and the lysosomal degradative system. Ageing Research Reviews 8 (2009) 199-213.
카게야마 외, 「오토파지와 질환」, 영역 융합 리뷰, 2014년, 3, e006

Also Published As

Publication number Publication date
TW202228676A (zh) 2022-08-01
JPWO2022059763A1 (https=) 2022-03-24
WO2022059763A1 (ja) 2022-03-24
CN116437912A (zh) 2023-07-14

Similar Documents

Publication Publication Date Title
WO1999059580A1 (en) Preventives/remedies for skin diseases
JP6262414B2 (ja) 抗菌用組成物
JP6850262B2 (ja) 皮膚の抗老化剤及び抗老化組成物
KR20250073168A (ko) 추피 및 주름의 외관을 감소시키기 위한 저분자 화학 화합물의 용도 방법
JP3998085B2 (ja) ヒアルロン酸量増加促進剤
KR20230054431A (ko) 오토파지 활성화제
KR20230051238A (ko) 오토파지 활성화제
EP4289434A1 (en) Barrier function improver
TWI844795B (zh) 自噬活化劑
JP2022119110A (ja) バリア機能改善剤
CA3059291A1 (en) Compositions and methods for treatment of infection and novel cosmeceutical preparations
KR20230060659A (ko) 각질제거용 화장료 조성물 및 이를 포함하는 패드
KR20230051237A (ko) 오토파지 활성화제
JPWO2022168846A5 (https=)
JP7690469B2 (ja) ヒアルロン酸産生促進剤およびコラーゲン産生促進剤
KR102957774B1 (ko) 카르니틴살리실레이트(ca-sa)를 유효성분으로 포함하는 피부 개선용 조성물
JPH07242542A (ja) 化粧料
EP3863725B1 (en) Nail compositions having antifungal properties
JP5167042B2 (ja) セラミド産生促進剤、保湿剤及び皮膚外用剤
KR101984276B1 (ko) 베르베린 하이드로클로라이드를 유효성분으로 포함하는 체모성장 저해용 조성물
JP2020193182A (ja) 糖化反応抑止剤
KR20150051075A (ko) 팔마틴을 유효성분으로 포함하는 체모성장 저해용 조성물
JPH1029923A (ja) 抗老化剤
HK40059997B (en) Nail compositions having antifungal properties
HK40059997A (en) Nail compositions having antifungal properties

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

D21 Rejection of application intended

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

B15 Application refused following examination

Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B15-EXM-PE0601 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601