KR20230043914A - App 발현을 감소시키기 위한 화합물 및 방법 - Google Patents
App 발현을 감소시키기 위한 화합물 및 방법 Download PDFInfo
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- KR20230043914A KR20230043914A KR1020237006049A KR20237006049A KR20230043914A KR 20230043914 A KR20230043914 A KR 20230043914A KR 1020237006049 A KR1020237006049 A KR 1020237006049A KR 20237006049 A KR20237006049 A KR 20237006049A KR 20230043914 A KR20230043914 A KR 20230043914A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063057816P | 2020-07-28 | 2020-07-28 | |
| US63/057,816 | 2020-07-28 | ||
| US202063106616P | 2020-10-28 | 2020-10-28 | |
| US63/106,616 | 2020-10-28 | ||
| US202063129255P | 2020-12-22 | 2020-12-22 | |
| US63/129,255 | 2020-12-22 | ||
| US202163148514P | 2021-02-11 | 2021-02-11 | |
| US63/148,514 | 2021-02-11 | ||
| PCT/US2021/043520 WO2022026589A1 (en) | 2020-07-28 | 2021-07-28 | Compounds and methods for reducing app expression |
Publications (1)
| Publication Number | Publication Date |
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| KR20230043914A true KR20230043914A (ko) | 2023-03-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020237006049A Pending KR20230043914A (ko) | 2020-07-28 | 2021-07-28 | App 발현을 감소시키기 위한 화합물 및 방법 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12384814B2 (https=) |
| EP (1) | EP4189090A4 (https=) |
| JP (1) | JP2023536472A (https=) |
| KR (1) | KR20230043914A (https=) |
| AU (1) | AU2021315992A1 (https=) |
| BR (1) | BR112023001624A2 (https=) |
| CA (1) | CA3189922A1 (https=) |
| IL (1) | IL299686A (https=) |
| MX (1) | MX2023001222A (https=) |
| UY (1) | UY39344A (https=) |
| WO (1) | WO2022026589A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11732260B2 (en) | 2018-03-02 | 2023-08-22 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-β precursor protein |
| KR20220062517A (ko) | 2019-08-15 | 2022-05-17 | 아이오니스 파마수티컬즈, 인코포레이티드 | 결합 변형된 올리고머 화합물 및 이의 용도 |
| CA3189922A1 (en) | 2020-07-28 | 2022-02-03 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing app expression |
| US20240117349A1 (en) * | 2021-01-29 | 2024-04-11 | Alnylam Pharmaceuticals, Inc. | iRNA COMPOSITIONS AND METHODS FOR SILENCING AMYLOID PRECURSOR PROTEIN (APP) |
| KR20240158340A (ko) * | 2022-03-17 | 2024-11-04 | 알리고스 테라퓨틱스 인코포레이티드 | 변형 갭머 올리고머 및 이의 사용 방법 |
| KR20250148653A (ko) * | 2023-02-17 | 2025-10-14 | 아이오니스 파마수티컬즈, 인코포레이티드 | App 발현을 감소시키기 위한 화합물 및 방법 |
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| US12384814B2 (en) | 2025-08-12 |
| UY39344A (es) | 2022-02-25 |
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| AU2021315992A1 (en) | 2023-02-09 |
| MX2023001222A (es) | 2023-04-26 |
| IL299686A (en) | 2023-03-01 |
| EP4189090A1 (en) | 2023-06-07 |
| BR112023001624A2 (pt) | 2023-02-23 |
| EP4189090A4 (en) | 2025-02-26 |
| TW202221014A (zh) | 2022-06-01 |
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