KR20230029616A - 종간 호환가능한 아데노-관련 바이러스 조성물 및 이의 사용 방법 - Google Patents

종간 호환가능한 아데노-관련 바이러스 조성물 및 이의 사용 방법 Download PDF

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KR20230029616A
KR20230029616A KR1020227042650A KR20227042650A KR20230029616A KR 20230029616 A KR20230029616 A KR 20230029616A KR 1020227042650 A KR1020227042650 A KR 1020227042650A KR 20227042650 A KR20227042650 A KR 20227042650A KR 20230029616 A KR20230029616 A KR 20230029616A
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아라빈드 아소칸
트레버 곤잘레스
로렌스 패트릭 하블리크
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듀크 유니버시티
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
KR1020227042650A 2020-05-05 2021-05-05 종간 호환가능한 아데노-관련 바이러스 조성물 및 이의 사용 방법 Pending KR20230029616A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063020062P 2020-05-05 2020-05-05
US63/020,062 2020-05-05
PCT/US2021/030937 WO2021226267A2 (en) 2020-05-05 2021-05-05 Cross-species compatible adeno-associated virus compositions and methods of use thereof

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KR20230029616A true KR20230029616A (ko) 2023-03-03

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US (3) US12577586B2 (https=)
EP (1) EP4125977A4 (https=)
JP (1) JP7756439B2 (https=)
KR (1) KR20230029616A (https=)
CN (1) CN116096377B (https=)
AR (1) AR122013A1 (https=)
AU (1) AU2021268946A1 (https=)
BR (1) BR112022022644A2 (https=)
CA (1) CA3177869A1 (https=)
IL (1) IL297577A (https=)
MX (1) MX2022013963A (https=)
TW (1) TWI910162B (https=)
WO (1) WO2021226267A2 (https=)

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Publication number Priority date Publication date Assignee Title
CA3177869A1 (en) * 2020-05-05 2021-11-11 Duke University Cross-species compatible adeno-associated virus compositions and methods of use thereof
KR20240095539A (ko) 2021-10-08 2024-06-25 디노 테라퓨틱스, 인코포레이티드 캡시드 변이체 및 이의 사용 방법
US20260055144A1 (en) * 2022-08-24 2026-02-26 Regenxbio Inc. Recombinant adeno-associated viruses and uses thereof
WO2024168089A2 (en) * 2023-02-07 2024-08-15 Duke University Compositions comprising aavs and methods for treating gastrointestinal diseases
EP4661916A1 (en) * 2023-02-08 2025-12-17 Ginkgo Bioworks, Inc. Gene therapy for angelman syndrome
WO2024191778A1 (en) 2023-03-10 2024-09-19 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
AU2024242227A1 (en) * 2023-03-31 2025-11-13 Duke University Compositions comprising brain-tropic aavs and methods of use thereof
AU2024332181A1 (en) 2023-08-31 2026-02-12 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
TW202545971A (zh) 2024-02-08 2025-12-01 美商戴諾治療公司 殼體多肽及其使用方法
WO2025250454A1 (en) * 2024-05-28 2025-12-04 University Of Rochester Adeno-associated viruses evolved to specifically target human glial progenitor cells in vivo
WO2026064442A2 (en) 2024-09-18 2026-03-26 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof

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US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
AU780231B2 (en) 1998-11-10 2005-03-10 University Of North Carolina At Chapel Hill, The Virus vectors and methods of making and administering the same
US7314912B1 (en) 1999-06-21 2008-01-01 Medigene Aktiengesellschaft AAv scleroprotein, production and use thereof
ATE318923T1 (de) 2000-06-01 2006-03-15 Univ North Carolina Doppelsträngige parvovirus-vektoren
EP2345731B1 (en) * 2003-09-30 2015-10-21 The Trustees of the University of Pennsylvania Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
EP2018421B1 (en) * 2006-04-28 2012-12-19 The Trustees of the University of Pennsylvania Scalable production method for aav
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
WO2012109570A1 (en) 2011-02-10 2012-08-16 The University Of North Carolina At Chapel Hill Viral vectors with modified transduction profiles and methods of making and using the same
WO2013170078A1 (en) 2012-05-09 2013-11-14 Oregon Health & Science University Adeno associated virus plasmids and vectors
EP3003391B1 (en) 2013-05-31 2021-09-22 The Regents of The University of California Adeno-associated virus variants and methods of use thereof
WO2015164757A1 (en) 2014-04-25 2015-10-29 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
EP3151866B1 (en) * 2014-06-09 2023-03-08 Voyager Therapeutics, Inc. Chimeric capsids
ES2865487T3 (es) 2015-09-28 2021-10-15 Univ North Carolina Chapel Hill Métodos y composiciones para vectores virales que evaden los anticuerpos
US11905312B2 (en) 2017-02-15 2024-02-20 The University Of North Carolina At Chapel Hill Methods and compositions for gene transfer across the vasculature
JP2020510424A (ja) * 2017-02-28 2020-04-09 アドヴェラム バイオテクノロジーズ， インコーポレイテッド 改変ａａｖカプシドおよびその使用
WO2018170015A1 (en) 2017-03-14 2018-09-20 The Regents Of The University Of California Engineering crispr cas9 immune stealth
US10550405B2 (en) 2017-03-15 2020-02-04 The University Of North Carolina At Chapel Hill Rational polyploid adeno-associated virus vectors and methods of making and using the same
NZ756587A (en) * 2017-03-15 2025-12-19 Univ North Carolina Chapel Hill Polyploid adeno-associated virus vectors and methods of making and using the same
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
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CA3177869A1 (en) 2020-05-05 2021-11-11 Duke University Cross-species compatible adeno-associated virus compositions and methods of use thereof

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Publication number Publication date
AR122013A1 (es) 2022-08-03
JP7756439B2 (ja) 2025-10-20
US20240067988A1 (en) 2024-02-29
US12037598B2 (en) 2024-07-16
AU2021268946A1 (en) 2022-12-01
TW202208631A (zh) 2022-03-01
EP4125977A4 (en) 2024-09-25
MX2022013963A (es) 2023-02-22
JP2023524291A (ja) 2023-06-09
TWI910162B (zh) 2026-01-01
US12577586B2 (en) 2026-03-17
IL297577A (en) 2022-12-01
EP4125977A2 (en) 2023-02-08
US20230151389A1 (en) 2023-05-18
BR112022022644A2 (pt) 2023-01-17
US20240076695A1 (en) 2024-03-07
CA3177869A1 (en) 2021-11-11
CN116096377A (zh) 2023-05-09
CN116096377B (zh) 2026-01-02
WO2021226267A2 (en) 2021-11-11
US12146151B2 (en) 2024-11-19
WO2021226267A3 (en) 2021-12-16

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